AMSH Protein, Human

AMSH is a zinc metalloprotease that selectively cleaves "Lys-63"-linked polyubiquitin chains, but not "Lys-48"-linked chains. It plays a critical regulatory role in signaling in IL-2 and GM-CSF mediated pathways, acting as a positive BMP signaling modulator against SMAD6 and SMAD7 inhibition. AMSH Protein, Human is the recombinant human-derived AMSH protein, expressed by E. coli , with tag free. The total length of AMSH Protein, Human is 423 a.a., .

AMSH is a zinc metalloprotease with a specific affinity for cleaving 'Lys-63'-linked polyubiquitin chains, excluding 'Lys-48'-linked polyubiquitin chains. It plays a crucial role in signal transduction associated with cell growth, particularly in the context of IL-2 and GM-CSF-mediated pathways. Additionally, AMSH acts as a positive regulator of BMP signaling by counteracting the inhibitory effects of SMAD6 and SMAD7. The protein is instrumental in orchestrating cell surface receptor-mediated endocytosis, facilitating ubiquitin-dependent sorting of receptors to lysosomes. While the endosomal localization of AMSH is vital for efficient EGFR degradation, it is dispensable for receptor internalization. Moreover, AMSH is intricately involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.

Human

E. coli

Tag Free

O95630 (S2-R424)

10617

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.