2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Protease Inhibitors
  5. Serpin (Protease Inhibitor)
  6. Antithrombin III
  7. Antithrombin III/Serpin C1 Protein, Human (HEK293, C-His)

Antithrombin III/Serpin C1 Protein, Human (HEK293, C-His)

Cat. No.: HY-P72831A
Handling Instructions

Antithrombin III/Serpin C1 protein, the main plasma serine protease inhibitor, regulates the blood coagulation cascade. It inhibits thrombin, matriptase-3/TMPRSS7, and factors IXa, Xa, and XIa, with enhanced potency in the presence of heparin. Furthermore, it forms a protease-inhibiting heterodimer with TMPRSS7. Antithrombin III/Serpin C1 Protein, Human (HEK293, C-His) is the recombinant human-derived Antithrombin III/Serpin C1 protein, expressed by HEK293, with C-6*His labeled tag. The total length of Antithrombin III/Serpin C1 Protein, Human (HEK293, C-His) is 430 a.a., with molecular weight of 55-60 kDa.

For research use only. We do not sell to patients.

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This product has been "discontinued". Optimized version of product available: HY-P72831

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Description

Antithrombin III/Serpin C1 protein, the main plasma serine protease inhibitor, regulates the blood coagulation cascade. It inhibits thrombin, matriptase-3/TMPRSS7, and factors IXa, Xa, and XIa, with enhanced potency in the presence of heparin. Furthermore, it forms a protease-inhibiting heterodimer with TMPRSS7. Antithrombin III/Serpin C1 Protein, Human (HEK293, C-His) is the recombinant human-derived Antithrombin III/Serpin C1 protein, expressed by HEK293, with C-6*His labeled tag. The total length of Antithrombin III/Serpin C1 Protein, Human (HEK293, C-His) is 430 a.a., with molecular weight of 55-60 kDa.
Background

Antithrombin III/Serpin C1 protein, the principal serine protease inhibitor in plasma, plays a crucial role in regulating the blood coagulation cascade. It effectively inhibits thrombin, matriptase-3/TMPRSS7, and factors IXa, Xa, and XIa, with its inhibitory activity significantly potentiated in the presence of heparin. Additionally, Antithrombin III/Serpin C1 forms a protease-inhibiting heterodimer with TMPRSS7.
Species

Human
Source

HEK293
Tag

C-6*His
Accession

P01008 (S35-K464)
Gene ID

462
Molecular Construction
N-term
AT-III (S35-K464)
Accession # P01008
6*His
C-term
Synonyms
Antithrombin-III; ATIII; Serpin C1; SERPINC1; AT3
AA Sequence

SPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK

Molecular Weight

55-60 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Antithrombin III/Serpin C1 Protein, Human (HEK293, C-His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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