BACE-1 Protein, Human (HEK293, Fc)

BACE1 protein is crucial in proteolytic processing of amyloid precursor protein (APP), initiating cleavage at the N-terminus of the A-beta peptide sequence. This process results in the extracellular release of beta-cleaved soluble APP and a cell-associated C-terminal fragment. BACE1's cleavage activity extends to CHL1, demonstrating its versatility in substrate processing. BACE-1 Protein, Human (HEK293, Fc) is the recombinant human-derived BACE-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BACE-1 Protein, Human (HEK293, Fc) is 436 a.a., with molecular weight of 85-100 kDa.

The BACE1 protein plays a pivotal role in the proteolytic processing of the amyloid precursor protein (APP). It initiates cleavage at the N-terminus of the A-beta peptide sequence, specifically between residues 671 and 672 of APP, resulting in the production and subsequent extracellular release of beta-cleaved soluble APP. Simultaneously, BACE1 generates a corresponding cell-associated C-terminal fragment, subsequently released by gamma-secretase. In addition to its primary target, BACE1 also exhibits cleavage activity on CHL1, as observed through its similarity in cleaving this substrate.

Human

HEK293

C-hFc

P56817 (T22-T457)

23621  [NCBI]

85-100 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.