BMF Protein, Human (His)

BMF proteins may play a key role in apoptosis, with isoform 1 being the major promoter. It interacts with anti-apoptotic proteins (including MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w), suggesting involvement in the regulatory network of cell death. BMF Protein, Human (His) is the recombinant human-derived BMF protein, expressed by E. coli , with N-His labeled tag. The total length of BMF Protein, Human (His) is 184 a.a., with molecular weight of ~25 kDa.

The BMF protein is implicated in potentially playing a crucial role in apoptosis, with isoform 1 identified as the primary initiator in this cellular process. BMF interacts with various anti-apoptotic proteins, including MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1, and BCL2L2/BCL-w, suggesting its involvement in the intricate regulatory network governing cell death. Notably, BMF engages with the myosin V actin motor complex through its binding to DLC2, indicating potential interactions with cytoskeletal elements. These molecular associations highlight the versatility of BMF in participating not only in apoptosis but also in potential interactions with the cellular machinery involved in cytoskeletal dynamics.

Human

E. coli

N-His

Q96LC9 (M1-R184)

90427  [NCBI]

Approximately 25 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.