CD27/TNFRSF7 Protein, Human (HEK293, His-Fc)

The CD27/TNFRSF7 protein is a receptor for CD70/CD27L and may ensure the survival of activated T cells, suggesting that it plays a crucial role in immune responses. Its association with SIVA1 suggests a regulatory function in the apoptotic pathway. CD27/TNFRSF7 Protein, Human (HEK293, His-Fc) is the recombinant human-derived CD27/TNFRSF7 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of CD27/TNFRSF7 Protein, Human (HEK293, His-Fc) is 172 a.a., with molecular weight of ~60 kDa.

CD27/TNFRSF7 Protein, serving as the receptor for CD70/CD27L, potentially plays a critical role in the survival of activated T-cells, implicating its involvement in immune responses. Additionally, it may contribute to apoptosis through its association with SIVA1, suggesting a regulatory function in programmed cell death pathways. Existing as a homodimer, CD27/TNFRSF7 interacts with key proteins such as SIVA1 and TRAF2, indicating its engagement in intricate signaling cascades. The multifaceted roles of CD27/TNFRSF7 in T-cell survival and apoptosis underscore its significance in immune regulation and highlight its potential as a target for therapeutic interventions aimed at modulating immune responses.

Human

HEK293

C-hFc;C-6*His

P26842 (T21-I192)

939  [NCBI]

TPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSDFIRI

Approximately 60 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.