EPDR1 Protein, Human (186a.a, HEK293, His)

In the rat model, the EPDR1 protein plays a key regulator role by binding to and activating the TIE2 receptor, initiating its tyrosine phosphorylation. This interaction affects processes of endothelial development that are distinct from the effects of VEGF, which mediates interactions between the endothelium and the surrounding matrix and interstitium. EPDR1 Protein, Human (186a.a, HEK293, His) is the recombinant human-derived EPDR1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of EPDR1 Protein, Human (186a.a, HEK293, His) is 186 a.a., with molecular weight of 28 & 33 kDa, respectively.

ANGPT1, specifically in the rat model, acts as a pivotal regulator by binding to and activating the TIE2 receptor, thereby initiating its tyrosine phosphorylation. This molecular interaction is implicated in endothelial developmental processes, distinct from those influenced by VEGF, and plays a crucial role in mediating reciprocal interactions between the endothelium and the surrounding matrix and mesenchyme. ANGPT1's involvement extends to mediating blood vessel maturation and stability, indicating its significance in vascular development. Additionally, there is emerging evidence suggesting its potential importance in the early development of the heart.

Human

HEK293

C-6*His

Q9UM22 (A38-S223)

54749  [NCBI]

APRPCQAPQQWEGRQVMYQQSSGRNSRALLSYDGLNQRVRVLDERKALIPCKRLFEYILLYKDGVMFQIDQATKQCSKMTLTQPWDPLDIPQNSTFEDQYSIGGPQEQITVQEWSDRKSARSYETWIGIYTVKDCYPVQETFTINYSVILSTRFFDIQLGIKDPSVFTPPSTCQMAQLEKMSEDCS

28 &33 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.