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Sorcin/SRI Protein, Human (sf9)

Cat. No.: HY-P77210
Handling Instructions

Sorcin/SRI protein, a calcium-binding modulator, intricately regulates excitation-contraction coupling in the heart and plays a crucial role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI exerts its influence on the activity of RYR2 calcium channels, contributing to the precise control of calcium dynamics in cardiac muscle cells. Its interactions with GCA, RYR2, and ANXA7 underscore its involvement in complex molecular networks, suggesting a multifaceted role in cellular processes related to calcium signaling and homeostasis. In the context of the heart, Sorcin/SRI emerges as a key player in the orchestration of calcium-dependent events, emphasizing its significance in the fine-tuning of excitation-contraction coupling and intracellular calcium regulation. Sorcin/SRI Protein, Human (sf9) is the recombinant human-derived Sorcin/SRI protein, expressed by Sf9 insect cells , with tag free. The total length of Sorcin/SRI Protein, Human (sf9) is 198 a.a., with molecular weight of ~20 kDa.

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Description

Sorcin/SRI protein, a calcium-binding modulator, intricately regulates excitation-contraction coupling in the heart and plays a crucial role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI exerts its influence on the activity of RYR2 calcium channels, contributing to the precise control of calcium dynamics in cardiac muscle cells. Its interactions with GCA, RYR2, and ANXA7 underscore its involvement in complex molecular networks, suggesting a multifaceted role in cellular processes related to calcium signaling and homeostasis. In the context of the heart, Sorcin/SRI emerges as a key player in the orchestration of calcium-dependent events, emphasizing its significance in the fine-tuning of excitation-contraction coupling and intracellular calcium regulation. Sorcin/SRI Protein, Human (sf9) is the recombinant human-derived Sorcin/SRI protein, expressed by Sf9 insect cells , with tag free. The total length of Sorcin/SRI Protein, Human (sf9) is 198 a.a., with molecular weight of ~20 kDa.
Background

Sorcin/SRI protein, a calcium-binding modulator, intricately regulates excitation-contraction coupling in the heart and plays a crucial role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI exerts its influence on the activity of RYR2 calcium channels, contributing to the precise control of calcium dynamics in cardiac muscle cells. Its interactions with GCA, RYR2, and ANXA7 underscore its involvement in complex molecular networks, suggesting a multifaceted role in cellular processes related to calcium signaling and homeostasis. In the context of the heart, Sorcin/SRI emerges as a key player in the orchestration of calcium-dependent events, emphasizing its significance in the fine-tuning of excitation-contraction coupling and intracellular calcium regulation.
Species

Human
Source

Sf9 insect cells
Tag

Tag Free
Accession

P30626 (M1-V198)
Gene ID
Molecular Construction
N-term
SRI (M1-V198)
Accession # P30626
C-term
Synonyms
22 kDa protein; CP22; V19
Molecular Weight

Approximately 20 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Sorcin/SRI Protein, Human (sf9) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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