TMX1 Protein, Human (HEK293, Fc)

TMX1 Protein is a member of the protein disulfide isomerase (PDI) family and is a transmembrane thiol isomerase. TMX1 Protein can participate in various redox reactions, reversibly oxidizes to disulfide through its active center thiol, and catalyzes the thiol-disulfide exchange reaction. In addition, TMX1 Protein negatively regulates the activation of αibβ3 integrin and platelet aggregation outside the cell. TMX1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMX1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TMX1 Protein, Human (HEK293, Fc) is 154 a.a., with molecular weight of ~44.4 kDa.

TMX1 Protein can participate in various oxidation-reduction reactions, both oxidizing and reducing disulfide bonds, and selectively acting on membrane-associated polypeptides^[1].
As a thiol tumor suppressor, TMX1 Protein can increase mitochondrial ATP production and apoptosis progression. Under oxidative conditions, TMX1 Protein interacts with SERCA2b in a thiol-dependent manner, thereby reducing SERCA activity and reducing endoplasmic reticulum Ca2+ load^[2].
The extracellular TMX1 protein has a negative regulatory effect on the activation of αibβ3 integrin and platelet aggregation^[3].

Human

HEK293

C-mFc

AAH36460 (R27-S180)

81542  [NCBI]

Approximately 44.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.