2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. RMC-7977

RMC-7977 is a reversible, tri-complex RAS inhibitor with broad spectrum activity for both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants.RMC-7977 can lead to tumor regressions and was well tolerated in diverse RAS-addicted preclinical cancer models. RMC-7977 also can inhibit the growth of KRASG12C cancer models.

For research use only. We do not sell to patients.

RMC-7977 Chemical Structure

RMC-7977 Chemical Structure

CAS No. : 2765082-12-8

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5 mg USD 780 In-stock
10 mg USD 1250 In-stock
25 mg USD 2500 In-stock
50 mg USD 4000 In-stock
100 mg USD 6400 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

RMC-7977 is a reversible, tri-complex RAS inhibitor with broad spectrum activity for both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants.RMC-7977 can lead to tumor regressions and was well tolerated in diverse RAS-addicted preclinical cancer models. RMC-7977 also can inhibit the growth of KRASG12C cancer models[1].

Molecular Weight

865.09

Formula

C47H60N8O6S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CO[C@H](C1=[C@@](C=C(N2CCN(C3CC3)CC2)C=N1)[C@@](N4CC)=C(C5=C4C=CC6=C5)CC(C)(C)COC([C@@H](N7)CCCN7C([C@@H](NC([C@@H]8[C@@H]9[C@H]8COC9)=O)CC%10=NC6=CS%10)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (144.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1559 mL 5.7797 mL 11.5595 mL
5 mM 0.2312 mL 1.1559 mL 2.3119 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.12%

COA (254 KB) HNMR (323 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1559 mL 5.7797 mL 11.5595 mL 28.8987 mL
5 mM 0.2312 mL 1.1559 mL 2.3119 mL 5.7797 mL
10 mM 0.1156 mL 0.5780 mL 1.1559 mL 2.8899 mL
15 mM 0.0771 mL 0.3853 mL 0.7706 mL 1.9266 mL
20 mM 0.0578 mL 0.2890 mL 0.5780 mL 1.4449 mL
25 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1559 mL
30 mM 0.0385 mL 0.1927 mL 0.3853 mL 0.9633 mL
40 mM 0.0289 mL 0.1445 mL 0.2890 mL 0.7225 mL
50 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5780 mL
60 mM 0.0193 mL 0.0963 mL 0.1927 mL 0.4816 mL
80 mM 0.0144 mL 0.0722 mL 0.1445 mL 0.3612 mL
100 mM 0.0116 mL 0.0578 mL 0.1156 mL 0.2890 mL
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RMC-7977 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RMC-79772765082-12-8RMC7977RMC 7977Rasreversibletri-complexRASbroad spectrumKRASNRASHRAS variantscancerInhibitorinhibitorinhibit

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