2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Ro 25-6981

Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD).

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Ro 25-6981 Maleate) that retains the same biological activity.

For research use only. We do not sell to patients.

Ro 25-6981 Chemical Structure

Ro 25-6981 Chemical Structure

CAS No. : 169274-78-6

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Description

Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD)[1][2][3].

IC50 & Target

NMDA Receptor

 

In Vivo

Ro 25-6981 (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1].
Ro 25-6981 (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2].
Ro 25-6981 (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-OHDA-lesioned rats[1]
Dosage: 0.39-12.5 mg/kg
Administration: I.p.
Result: Dose-dependently induced contraversive tight nose-to-tail rotations, and induced a weak ipsiversive circling response indicating a mild unspecific stimulatory action of the compound.
Animal Model: Male albino rats of Wistar strain[2]
Dosage: 1, 3 mg/kg
Administration: I.p.
Result: Caused a significant decrease of N1–P2 amplitude at higher stimulation intensities AT 3 mg/kg, and exhibited age- and activation-dependent anticonvulsant action at early postnatal development.
Molecular Weight

339.47

Formula

C22H29NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C([C@H](O)[C@@H](C)CN2CCC(CC3=CC=CC=C3)CC2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ro 25-6981 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 25-6981169274-78-6iGluRIonotropic glutamate receptorsparkinson's diseaseanticonvulsantanti-parkinsonianInhibitorinhibitorinhibit

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