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  3. Scospondistatin

Scospondistatin is an anti-angiogenic peptide that can inhibit proliferation and migration of human umbilical vein endothelial cells in vitro.

For research use only. We do not sell to patients.

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Scospondistatin Chemical Structure

Scospondistatin Chemical Structure

CAS No. : 929555-18-0

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Scospondistatin Related Antibodies

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Description

Scospondistatin is an anti-angiogenic peptide that can inhibit proliferation and migration of human umbilical vein endothelial cells in vitro[1].

In Vitro

Scospondistatin (0.01-40 μg/mL; 3 d) inhibits human umbilical vein endothelial cells (HUVECs) proliferation in a dose-dependent manner[1].
Scospondistatin (30 μg/mL; 20 h) significantly inhibits the migration of HUVECs in the presence of VEGF[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Scospondistatin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HUVECs
Concentration: 0.01, 0.1, 1, 10, 20, 30 and 40 μg/mL
Incubation Time: 3 days
Result: Showed a monotonic dose response, with the anti-proliferative activity increasing with increasing the peptide concentration.

Cell Migration Assay [1]

Cell Line: HUVECs
Concentration: 1, 10 and 30 μg/mL
Incubation Time: 20 h
Result: Significantly inhibited the migration of HUVECs in the presence of VEGF at 30 μg/mL.
Molecular Weight

2023.17

Formula

C81H127N27O30S2
CAS No.
Sequence Shortening

GPWEDCSVSCGGGEQLRSR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Scospondistatin929555-18-0OthersHUVECsanti-angiogenicVEGFInhibitorinhibitorinhibit

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