BRET

By Targets:	Epigenetic Reader Domain (3) Fluorescent Dye (1) GHSR (1) HDAC (1) Histone Acetyltransferase (2) Reactive Oxygen Species (1) RET (1)
By Research Areas:	Cancer (6) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128763

HDAC-IN-4

HDAC Cancer

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC₅₀s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity .

HDAC-IN-4	HDAC	Cancer
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC₅₀s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity .

HY-108435

GNE-049 3 Publications Verification	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
GNE-049 is a highly potent and selective CBP inhibitor with an IC₅₀ of 1.1 nM in TR-FRET assay. GNE-049 also inhibits *BRET* and BRD4(1) with IC₅₀s of 12 nM and 4200 nM, respectively .

HY-18743

Coelenterazine 2 Publications Verification	Reactive Oxygen Species	Cancer
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

HY-108696

GNE-781 2 Publications Verification	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
GNE-781 is an orally active, highly potent and selective CBP inhibitor with an IC₅₀ of 0.94 nM in TR-FRET assay. GNE-781 also inhibits *BRET* and BRD4(1) with IC₅₀s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model .

HY-153948

CBP-IN-1	Epigenetic Reader Domain	Cancer
CBP-IN-1 (compound 12) is a potent CBP inhibitor, with an IC₅₀ of 1.5 nM. CBP-IN-1 also inhibits CBP BRET and BRD4(1), with IC₅₀ values of 690 and 3100 nM, respectively .

HY-118462A

Coelenteramine 400a hydrochloride Coelenterazine 400a hydrochloride; Bisdeoxycoelenterazine hydrochloride	Others	Others
Coelenteramine (Coelenterazine) 400a hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm . Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-10957

L-692429 MK-0751	GHSR	Metabolic Disease
L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a K_i of 63 nM .

HY-118462

Coelenteramine 400a Coelenterazine 400a; Bisdeoxycoelenterazine	Fluorescent Dye	Others
Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-133551

WF-47-JS03	RET	Cancer
WF-47-JS03 is a potent and selective RET kinase inhibitor with IC₅₀s of 1.7 nM and 5.3 nM for KIF5B-RET transfected Ba/F3 cells and CCDC6-RET transfected LC-2/ad lung cancer cells, respectively. WF-47-JS03 demonstrates >500-fold selectivity against kinase insert domain receptor (KDR). Effective brain penetration .

Cat. No.	Product Name	Type

HY-18743

Coelenterazine 2 Publications Verification	Fluorescent Dyes/Probes
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

Coelenterazine

2 Publications Verification

Fluorescent Dyes/Probes

Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

HY-118462

Coelenteramine 400a Coelenterazine 400a; Bisdeoxycoelenterazine	Dyes
Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

Coelenteramine 400a

Coelenterazine 400a; Bisdeoxycoelenterazine

Dyes

Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18743

Coelenterazine 2 Publications Verification	Alkaloids Structural Classification Monophenols Classification of Application Fields Animals Source classification Phenols Polyphenols Disease Research Fields Cancer	Reactive Oxygen Species
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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BRET

Inhibitors & Agonists

Fluorescent Dye

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