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CXCR2-IN-2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-120878
    CXCR2-IN-2
    1 Publications Verification

    		 CXCR Inflammation/Immunology
    CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM .
    <em>CXCR2-IN-2</em>
  • HY-120878A
    (R,R)-CXCR2-IN-2

    		CXCR Inflammation/Immunology
    (R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively .
    (R,R)-<em>CXCR2-IN-2</em>
  • HY-139873
    CXCR2 antagonist 2

    		CXCR Cancer
    CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunoresearch with an IC50 value of 95 nM.
    <em>CXCR2 antagonist 2</em>
  • HY-139874
    CXCR2 antagonist 3

    		CXCR Inflammation/Immunology Cancer
    CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3 + T lymphocytes into the Pan02 tumor tissues .
    <em>CXCR2</em> antagonist 3

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