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EX527

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15452
    Selisistat
    165+ Cited Publications

    EX-527

    		 Sirtuin Inflammation/Immunology Cancer
    Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease .
    Selisistat
  • HY-15452B
    (R)-Selisistat

    (R)-EX-527

    		 Sirtuin Cancer
    (R)-Selisistat ((R)-EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
    (R)-Selisistat
  • HY-15452A
    (S)-Selisistat
    1 Publications Verification

    (S)-EX-527

    		 Sirtuin Cancer
    (S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.
    (S)-Selisistat
  • HY-111303
    CHIC35

    		Sirtuin Neurological Disease Inflammation/Immunology
    CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 µM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 µM) or SIRT3 (IC50>100 µM) . CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research .
    CHIC35

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