Search Result

Results for "

FGFR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FGFR (161) Akt (1) AMPK (1) Anaplastic lymphoma kinase (ALK) (2) Apoptosis (19) Aurora Kinase (3) Autophagy (11) Bcr-Abl (2) c-Fms (6) c-Kit (18) c-Met/HGFR (2) CDK (3) Checkpoint Kinase (Chk) (1) Cytochrome P450 (1) Discoidin Domain Receptor (1) Drug Metabolite (3) Drug-Linker Conjugates for ADC (1) EGFR (5) Endogenous Metabolite (3) FAK (1) FLT3 (12) GSK-3 (1) HDAC (1) Insulin Receptor (1) Isotope-Labeled Compounds (5) JAK (1) LIM Kinase (LIMK) (1) MAP3K (1) Nucleoside Antimetabolite/Analog (1) PDGFR (42) PROTACs (2) Raf (2) Reactive Oxygen Species (1) RET (6) Ribosomal S6 Kinase (RSK) (1) Small Interfering RNA (siRNA) (13) SNIPERs (1) Src (16) Syk (1) Trk Receptor (1) VEGFR (53)
By Research Areas:	Cancer (167) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (6) Metabolic Disease (2) Neurological Disease (4)

By Targets:

FGFR (161)

Akt (1)

AMPK (1)

Anaplastic lymphoma kinase (ALK) (2)

Apoptosis (19)

Aurora Kinase (3)

Autophagy (11)

Bcr-Abl (2)

c-Fms (6)

c-Kit (18)

c-Met/HGFR (2)

CDK (3)

Checkpoint Kinase (Chk) (1)

Cytochrome P450 (1)

Discoidin Domain Receptor (1)

Drug Metabolite (3)

Drug-Linker Conjugates for ADC (1)

EGFR (5)

Endogenous Metabolite (3)

FAK (1)

FLT3 (12)

GSK-3 (1)

HDAC (1)

Insulin Receptor (1)

Isotope-Labeled Compounds (5)

JAK (1)

LIM Kinase (LIMK) (1)

MAP3K (1)

Nucleoside Antimetabolite/Analog (1)

PDGFR (42)

PROTACs (2)

Raf (2)

Reactive Oxygen Species (1)

RET (6)

Ribosomal S6 Kinase (RSK) (1)

Small Interfering RNA (siRNA) (13)

SNIPERs (1)

Src (16)

Syk (1)

Trk Receptor (1)

VEGFR (53)

By Research Areas:

Cancer (167)

Cardiovascular Disease (4)

Infection (1)

Inflammation/Immunology (6)

Metabolic Disease (2)

Neurological Disease (4)

197

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: FGFR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148779

FGFR3-IN-5	FGFR	Cancer
FGFR3-IN-5 is a potent and selective *FGFR3* inhibitor with IC₅₀ values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer .

HY-156790

FGFR3-IN-6

FGFR Cancer

FGFR3-IN-6 is a potent and selective FGFR3 inhibitor with IC₅₀ value less than 350 nM. FGFR3-IN-6 can be used in research of cancer .
HY-156791

FGFR3-IN-7

FGFR Cancer

FGFR3-IN-7 is a potent and selective FGFR3 inhibitor with IC₅₀ value less than 350 nM. FGFR3-IN-7 can be used in research of cancer .

FGFR3-IN-6	FGFR	Cancer
FGFR3-IN-6 is a potent and selective FGFR3 inhibitor with IC₅₀ value less than 350 nM. FGFR3-IN-6 can be used in research of cancer .

FGFR3-IN-7	FGFR	Cancer
FGFR3-IN-7 is a potent and selective FGFR3 inhibitor with IC₅₀ value less than 350 nM. FGFR3-IN-7 can be used in research of cancer .

HY-163273

FGFR4-IN-17	FGFR	Cancer
FGFR4-IN-17 (Compound (S)-23) is a piperazinyl diflurindan derivative containing pyridinyl. FGFR4-IN-17 is a *FGFR* inhibitor with IC₅₀ values of 24.2, 16.1, 78.0, and 68.0 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FGFR4-IN-17 has antitumor activity .

HY-147619

FGFR-IN-4	FGFR	Cancer
FGFR-IN-4 is a potent inhibitor of *FGFR. Fibroblast growth factor receptor (FGFR) is a tyrosine kinase receptor that binds to fibroblast growth factor ligands. FGFR-IN-4 has the potential for the research of cancer diseases (extracted from patent WO2022033532A1, compound 20) . FGFR*-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147620

FGFR-IN-5	FGFR	Cancer
FGFR-IN-5 is a potent inhibitor of *FGFR. Fibroblast growth factor receptor (FGFR) is a tyrosine kinase receptor that binds to fibroblast growth factor ligands. FGFR-IN-5 has the potential for the research of cancer diseases (extracted from patent WO2022042612A1, compound 3) . FGFR*-IN-5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147684

FGFR-IN-7	FGFR	Neurological Disease
FGFR-IN-7 (compound 17) is an orally active, potent and BBB-penetrated *FGFR* (fibroblast growth factor receptor) modulator. FGFR-IN-7 shows neuroprotective activity. FGFR-IN-7 improves brain exposure and reduced risk of phospholidosis. FGFR-IN-7 can be used for neurodegenerative diseases research .

HY-147683

FGFR-IN-3	FGFR	Neurological Disease
FGFR-IN-3 (compound 6) is an orally active, potent and BBB-penetrated *FGFR* (fibroblast growth factor receptor) modulator. FGFR-IN-3 shows neuroprotective activity. FGFR-IN-3 can be used for neurodegenerative diseases research .

HY-142921

FGFR-IN-2	FGFR	Cancer
FGFR-IN-2 (compound 1) is a potent *FGFR* inhibitor with IC₅₀s of 7.3 nM, 4.3 nM, 7.6 nM, 11 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. FGFR-IN-2 has the potential for cancer research .

HY-145043

FGFR-IN-1

FGFR Cancer

FGFR-IN-1 is a potent FGFR inhibitor with an IC₅₀ of <100 nM for FGFR1, FGFR2, and FGFR3, respectively (patent US20130338134A1, example 219) .

FGFR-IN-1	FGFR	Cancer
FGFR-IN-1 is a potent *FGFR* inhibitor with an IC₅₀ of <100 nM for FGFR1, FGFR2, and FGFR3, respectively (patent US20130338134A1, example 219) .

HY-146541

FGFR4-IN-10	FGFR	Cancer
FGFR4-IN-10 (compound 5a) is a potent and selective *FGFR4* inhibitor with an IC₅₀ value of 70.7 nM. FGFR4-IN-10 shows no inhibition against other FGFR family members, i.e. FGFR1, FGFR2 and FGFR3 .

HY-152104

FGFR-IN-9	FGFR	Cancer
FGFR-IN-9 (Compound 19) is a potent, reversible and orally active *FGFR* inhibitor with an IC₅₀ of 17.1, 29.6, 30.7, 46.7 and 64.3 nM against FGFR4 ^WT, FGFR3, FGFR4 ^V550L, FGFR2 and FGFR1, respectively .

HY-155028

FGFR-IN-11	FGFR	Cancer
FGFR-IN-11 (compound I-5) is an orally active and covalent *FGFR* inhibitor with IC₅₀ values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models .

HY-148778

FGFR3-IN-4

FGFR Cancer

FGFR3-IN-4 is a selective FGFR3 inhibitor, with an IC₅₀ value of less than 50 nM. FGFR3-IN-4 is at least 10 fold more selective for FGFR3 than for FGFR1 .
HY-145231

FGFR2-IN-2

FGFR Cancer

FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor with IC₅₀s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively .

FGFR3-IN-4	FGFR	Cancer
FGFR3-IN-4 is a selective *FGFR3* inhibitor, with an IC₅₀ value of less than 50 nM. FGFR3-IN-4 is at least 10 fold more selective for FGFR3 than for FGFR1 .

FGFR2-IN-2	FGFR	Cancer
FGFR2-IN-2 (Compound 38) is a selective *FGFR2* inhibitor with IC₅₀s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively .

HY-147793

FGFR4-IN-12	FGFR	Cancer
FGFR4-IN-12 (Compound A34) is a potent inhibitor of *FGFR4. FGFR4-IN-12 exhibits improved FGFR4 inhibitory capability and selectivity and excellent anti-proliferative activities against FGFR4-dependent HCC cell lines. FGFR4-IN-12 has the potential for the research of cancer diseases . FGFR*4-IN-12 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-115902

FGFR4-IN-7	FGFR Apoptosis	Cancer
FGFR4-IN-7 (Compound C3) is a covalent reversible *FGFR4* inhibitor with an IC₅₀ value of 0.42 μM. FGFR4-IN-7 induces apoptosis via the FGFR4 signaling pathway blockage. FGFR4-IN-7 can be used for the research of hepatocellular carcinoma (HCC) .

HY-147515

FGFR4-IN-11	FGFR	Cancer
FGFR4-IN-11 (Compound 30) is a potent, selective, covalent *FGFR4* inhibitor with an IC₅₀ of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity .

HY-151903S

FGFR2/3-IN-1	FGFR	Cancer
FGFR2/3-IN-1 is a potent and selective FGFR2 and FGFR3 (FGFR) inhibitor with IC50s of 1 nM and 0.5 nM, respectively. FGFR2/3-IN-1 displays >40-fold selectivity over FGFR1/FGFR4 and other kinome. FGFR2/3-IN-1 also inhibits FGFR3 V555L and V555M mutants with IC50s of 2.7 nM and 6.1 nM, respectively[1].

HY-156704

FGFR4-IN-16

FGFR Cancer

FGFR4-IN-16 (CY-15-2) is a covalent inhibitor of FGFR-4 for cancer research .

FGFR4-IN-16	FGFR	Cancer
FGFR4-IN-16 (CY-15-2) is a covalent inhibitor of *FGFR-4* for cancer research .

HY-145836

FGFR4-IN-8	FGFR	Cancer
FGFR4-IN-8 (Compound 7v) is an ATP-competitive, highly selective covalent inhibitor of wild-type and gatekeeper mutant *FGFR4. FGFR4-IN-8 exhibits excellent potency against FGFR4, FGFR4 ^V550L, FGFR4 ^V550M and FGFR4 ^C552S with IC₅₀s of 0.5, 0.25, 1.6, 931 nM, respectively. FGFR4-IN-8 exhibits potent antiproliferative activity against Hep3B hepatocellular carcinoma cells with the IC₅₀ value of 29 nM. FGFR*4-IN-8 demonstrates modest in vivo antitumor efficacy in nude mice bearing the Huh-7 xenograft model .

HY-150652

FGFR-IN-8	FGFR Apoptosis	Cancer
FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC₅₀ values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities .

HY-147714

FGFR3-IN-2	FGFR VEGFR	Cancer
FGFR3-IN-2 (compound 18b) is a potent and selective *FGFR3* inhibitor, with IC₅₀s of 4.1 nM and 570 nM for *FGFR3* and VEGFR2, respectively. FGFR3-IN-2 can be used for the research of bladder cancer .

HY-144759

FGFR4-IN-9

FGFR Cancer

FGFR4-IN-9 (Compound 6O) is a selective FGFR4 inhibitor with an IC₅₀ of 75.3 nM. FGFR4-IN-9 effectively inhibits both the growth and angiogenesis of HCC .
HY-145230

FGFR2-IN-1

FGFR Others

FGFR2-IN-1 is a selective FGFR2 inhibitor with an IC₅₀ of 140 nM.

FGFR4-IN-9	FGFR	Cancer
FGFR4-IN-9 (Compound 6O) is a selective *FGFR4* inhibitor with an IC₅₀ of 75.3 nM. FGFR4-IN-9 effectively inhibits both the growth and angiogenesis of HCC .

FGFR2-IN-1	FGFR	Others
FGFR2-IN-1 is a selective *FGFR2* inhibitor with an IC₅₀ of 140 nM.

HY-147713

FGFR3-IN-1	FGFR	Cancer
FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor, with IC₅₀s of 40 nM, 5.1 nM, and 12 nM for *FGFR1, 2, and 3, respectively. FGFR*3-IN-1 can be used for the research of bladder cancer .

HY-155046

FGFR4-IN-14	FGFR	Cancer
FGFR4-IN-14 (Compound 27i) is a *FGFR4* inhibitor (IC₅₀: 2.4 nM. FGFR4-IN-14 inhibits the proliferation of V550L and N535K mutant strains, with IC₅₀s of 21 nM, 2.5 nM, 171 nM against huh7, BaF3/ETV6-FGFR4-V550L and BaF3/ETV6-FGFR4-N535K cells respectively. FGFR4-IN-14 has potent antitumor efficacy in the Huh7 xenograft model. FGFR4-IN-14 can be used for research of hepatocellular carcinoma (HCC) .

HY-100631

FGFR4-IN-1

FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC₅₀ of 0.7 nM.
HY-158010

FGFR3-IN-8

FGFR Cancer

FGFR3-IN-8 (example91) is a selective FGFR3 inhibitor .
HY-158011

FGFR3-IN-9

FGFR Cancer

FGFR3-IN-9 (example27) is a selective FGFR3 inhibitor .

FGFR4-IN-1
FGFR4-IN-1 is a potent inhibiotr of *FGFR4* with IC₅₀ of 0.7 nM.

FGFR3-IN-8	FGFR	Cancer
FGFR3-IN-8 (example91) is a selective *FGFR3* inhibitor .

FGFR3-IN-9	FGFR	Cancer
FGFR3-IN-9 (example27) is a selective *FGFR3* inhibitor .

HY-147715

FGFR3-IN-3	FGFR	Cancer
FGFR3-IN-3 (compound 40a) is a potent and pan-FGFR inhibitor, with IC₅₀s of 2.1 nM, 3.1 nM, 4.3 nM and 74 nM for *FGFR1, 2, 3, and 4, respectively. FGFR*3-IN-3 can be used for the research of bladder cancer .

HY-131704

FGFR4-IN-5	FGFR	Cancer
FGFR4-IN-5 is a potent and selective covalent *FGFR4* inhibitor with an IC₅₀ of 6.5 nM. FGFR4-IN-5 exhibits strong anti-tumor activity in vivo and can be used for hepatocellular carcinoma research .

HY-149487

FGFR1 inhibitor-8	FGFR	Cancer
FGFR1 inhibitor-8 (Compound 9) is a *FGFR1* inhibitor (IC₅₀s: 0.5 nM). FGFR1 inhibitor-8 binds to the ATP-binding pocket of FGFR1. FGFR1 inhibitor-8 has anticancer activity .

HY-149488

FGFR1 inhibitor-9	FGFR	Cancer
FGFR1 inhibitor-9 (Compound 7) is an *FGFR1* inhibitor (IC₅₀s: 0.85 nM). FGFR1 inhibitor-9 binds to the ATP-binding pocket of FGFR1. FGFR1 inhibitor-9 has anticancer activity .

HY-162283

FGFR4-IN-18

FGFR Cancer

FGFR4-IN-18 (compound 8z) is an inhibitor of FGFR4 and can be used in cancer research .

FGFR4-IN-18	FGFR	Cancer
FGFR4-IN-18 (compound 8z) is an inhibitor of FGFR4 and can be used in cancer research .

HY-156019

FGFR1 inhibitor-10	FGFR	Cancer
FGFR1 inhibitor-10 (Compound 4i) is an *FGFR1* inhibitor (IC₅₀: 28 nM). FGFR1 inhibitor-10 inhibits the phosphorylation of FGFR1. FGFR1 inhibitor-10 has anti-angiogenic, anti-invasion activity, and anti-tumor effect .

HY-143881

FGFR4-IN-6	FGFR	Cancer
FGFR4-IN-6 (Compound 9ka) is a covalently reversible *FGFR4* inhibitor with an IC₅₀ value of 5.4 nM. FGFR4-IN-6 also exhibits good oral pharmacokinetic properties. FGFR4-IN-6 induces significant tumor regressions in a xenograft mouse model of Hep3B2.1-7 HCC cell line without an obvious sign of toxicity . FGFR4-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-160013

FGFR-IN-12

FGFR Cancer

FGFR-IN-12 (example 14), a pyrimidinyl aryl urea derivative, is a potent FGFR inhibitor .
HY-129181

FGFR4-IN-4

FGFR Cancer

FGFR4-IN-4 (compound 693) is a FGFR4 inhibitor with anti-tumor activity, extracted from patent WO2018113584A1 .

FGFR-IN-12	FGFR	Cancer
FGFR-IN-12 (example 14), a pyrimidinyl aryl urea derivative, is a potent *FGFR* inhibitor .

FGFR4-IN-4	FGFR	Cancer
FGFR4-IN-4 (compound 693) is a *FGFR4* inhibitor with anti-tumor activity, extracted from patent WO2018113584A1 .

HY-147621

FGFR-IN-6	FGFR	Cancer
FGFR-IN-6 (Compound 5) is a *FGFR* inhibitor . FGFR-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-149512

FGFR1/VEGFR2-IN-1

FGFR VEGFR Cancer

FGFR1/VEGFR2-IN-1 (compound 2b) is an FGFR1/VEGFR2 inhibitor. FGFR1/VEGFR2-IN-1 can be used for cancer research .

FGFR1/VEGFR2-IN-1	FGFR VEGFR	Cancer
FGFR1/VEGFR2-IN-1 (compound 2b) is an *FGFR1/VEGFR2* inhibitor. FGFR1/VEGFR2-IN-1 can be used for cancer research .

HY-148597

FGFR-IN-10	FGFR Cytochrome P450	Cancer
FGFR-IN-10 is an orally active inhibitor of *FGFR* and Cytochrome P450 (CYPs). FGFR-IN-10 inhibits wide type and V564F mutant *FGFR2* with IC₅₀s of 104.1 nM and 43.6 nM, respectively. FGFR-IN-10 also inhibits CYPs with IC₅₀s of 3.33 μM (CYP2C9), 18.75 μM (CYP2C19), 4.34 μM (CYP2CD6), and 0.69 μM (CYP3A4), respectively .

HY-143272

FGFR1 inhibitor-6	FGFR	Cancer
FGFR1 inhibitor-6 is a potent *FGFR1* inhibitor with an IC₅₀ value of 16.31 nM. FGFR1 inhibitor-6 shows cytotoxic activities. FGFR1 inhibitor-6 induces apoptosis and cell cycle arrest at pre-G1 and G2/M phase .

HY-139376

FGFR1 inhibitor-2	FGFR	Cancer
FGFR1 inhibitor-2 is a *FGFR1* inhibitor (IC₅₀ is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer .

HY-158098

FGFR1 inhibitor-11	FGFR	Metabolic Disease
FGFR1 inhibitor-11 (compound 5g) binds to *FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR*1 inhibitor-11 has oral bioactivity .

HY-15813

FIIN-1 FGFR irreversible inhibitor-1	FGFR	Cancer
FIIN-1 is a potent, irreversible, selective *FGFR* inhibitor. FIIN-1 binds to *FGFR1/2/3/4* and Flt1/4 with K_ds of 2.8/6.9/5.4/120 nM and 32/120 nM respectively. The biochemical IC₅₀s of FIIN-1 are 9.2, 6.2, 11.9, and 189 nM against FGFR1/2/3/4, respectively .

HY-149486

FGFR1 inhibitor 7	FGFR	Cancer
FGFR1 inhibitor 7 (compound 5) is an inhibitor of FGFR1 Tyrosine Kinase with IC₅₀ value of 0.33 nM. FGFR1 inhibitor 7 shows broad-spectrum cytotoxicity agasinst human cancer cell lines, and inhibits MOLT3 cells with IC₅₀ of 2.1 μM .

HY-114311

FGFR1/DDR2 inhibitor 1	FGFR Discoidin Domain Receptor	Cancer
FGFR1/DDR2 inhibitor 1 is an orally active inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC₅₀ values of 31.1 nM and 3.2 nM, respectively. Antitumor activity .

HY-RS04911

FGFR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FGFR1 Human Pre-designed siRNA Set A contains three designed siRNAs for FGFR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FGFR1 Human Pre-designed siRNA Set A FGFR1 Human Pre-designed siRNA Set A

HY-RS04912

Fgfr1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fgfr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fgfr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgfr1 Mouse Pre-designed siRNA Set A Fgfr1 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L016

Protein Tyrosine Kinase Compound Library

1055 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1055 compounds that act as a useful tool for PTKs-related drug screening and disease research.

HY-L150

Membrane Receptor-targeted Compound Library

4627 compounds

Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules.

There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery.

MCE provides a unique collection of 4627 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

HY-L088

1984 compounds

Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer).

MCE offers a unique collection of 1984 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0060A

Ferulic acid sodium 5 Publications Verification Coniferic acid sodium	Structural Classification Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Endogenous metabolite Disease Research Fields Cancer	FGFR Endogenous Metabolite Reactive Oxygen Species
Ferulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively.

HY-N0060

Ferulic acid 5 Publications Verification Coniferic acid	Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Monophenols other families Simple Phenylpropanols Sunscreen Phenols Phenylpropanoids Cosmetic Research Disease Research Fields Cancer	FGFR Endogenous Metabolite
Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively.

HY-N7715

Ferulic acid acyl-β-D-glucoside Ferulic acid glucoside	Monophenols Classification of Application Fields Simple Phenylpropanols Source classification Other Diseases Rosaceae Phenols Phenylpropanoids Plants Aruncus sylvester Kostel. Disease Research Fields	Drug Metabolite
Ferulic acid acyl-β-D-glucoside is a metabolite of Ferulic Acid (HY-N0060) . Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively .

HY-N0183

Formononetin Maximum Cited Publications 9 Publications Verification Biochanin B; Flavosil; Formononetol	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Flavonoids other families Sunscreen Leguminosae Cosmetic Research Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones	FGFR Apoptosis
Formononetin is a potent *FGFR2* inhibitor with an IC₅₀ of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth .

HY-N9507

Picrasidine Q	Alkaloids other families Classification of Application Fields Source classification Quinoline Alkaloids Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis FGFR
Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits *FGFR2* kinase activity .

Recombinant Proteins Recommended:

FGFR

Species:	Human (50) Rhesus Macaque (5) Mouse (11) Rat (3) Cynomolgus (2)
Tag:	His (51) Tag Free (2) Avi (19) GST (2) Fc (20) Flag (2) B2M (1)
Source:	HEK293 (63) Sf9 insect cells (6) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72645

	FGFR-2 alpha IIIc Protein, Human (HEK293, Fc) BEK, FGFR2IIIc; CD332; FGF R2b; FGFR2 beta; FGFR2; FGFR2b; Fibroblast growth factor receptor 2 (IIIc)	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIc Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-2 alpha IIIc Protein, Human (HEK293, Fc) is 356 a.a., with molecular weight of 85-120 kDa.

HY-P72646

	FGFR-2 beta IIIb Protein, Human (HEK293, His) BFR-1; FGFR2IIIb; KGFR; CD332; FGF R2b; FGFR2 beta; FGFR2; FGFR2b; Fibroblast growth factor receptor 2 (IIIb)	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta IIIb Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 beta IIIb protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGFR-2 beta IIIb Protein, Human (HEK293, His) is 227 a.a., with molecular weight of 40-70 kDa.

HY-P78441

	FGFR-4 Protein, Human (HEK293, His-Avi) CD334; FGF R4; FGFR4; FGFR-4; MGC20292; JTK2; TKF	Human	HEK293
	The FGFR-4 protein is a tyrosine protein kinase and cell surface receptor for fibroblast growth factor that regulates diverse cellular processes such as proliferation, differentiation, migration, lipid metabolism, and bile acid biosynthesis. Notably, it contributes to the downregulation of the bile acid synthase CYP7A1 in response to FGF19. FGFR-4 Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-4 Protein, Human (HEK293, His-Avi) is 348 a.a., with molecular weight of 60-75 kDa.

HY-P70817

	FGFR-3 Protein, Human (HEK293, Fc) 1 Publications Verification Fibroblast growth factor receptor 3; FGFR-3; CD333; FGFR3; JTK4; IIIc	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-3 Protein, Human (HEK293, Fc) is 353 a.a., with molecular weight of 95-110 kDa.

HY-P78127

	FGFR-4 Protein, Human (Biotinylated, HEK293, His-Avi) CD334; FGF R4; FGFR4; FGFR-4; MGC20292; JTK2; TKF	Human	HEK293
	The FGFR-4 protein is a tyrosine protein kinase and cell surface receptor for fibroblast growth factor that regulates diverse cellular processes such as proliferation, differentiation, migration, lipid metabolism, and bile acid biosynthesis. Notably, it contributes to the downregulation of the bile acid synthase CYP7A1 in response to FGF19. FGFR-4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of FGFR-4 Protein, Human (Biotinylated, HEK293, His-Avi) is 348 a.a., with molecular weight of 55-72 kDa.

HY-P72647

	FGFR-2 beta IIIc Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 2; FGFR-2; FGF R2a; FGFR2 alpha	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta IIIc Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 beta IIIc protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-2 beta IIIc Protein, Human (HEK293, Fc) is 226 a.a., with molecular weight of 72-95 kDa.

HY-P75763

	FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 2; FGFR-2; FGF R2a; FGFR2 alpha	Human	HEK293
	FGFR-1 alpha, a conserved member of the FGFR family, binds acidic and basic fibroblast growth factors, influencing mitogenesis and differentiation. Mutations in FGFR1 cause syndromes and disorders. It exhibits ubiquitous expression, with notable levels in ovary (RPKM 21.8), fat (RPKM 21.4), and 25 other tissues. Alternatively spliced variants contribute to its functional diversity. FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FGFR-1 alpha, expressed by HEK293, with C-hFc labeled tag. FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc), has molecular weight of ~113.3 kDa.

HY-P75764

	FGFR-1 alpha (IIIb) Protein, Human (HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; FGF R2a; FGFR2 alpha	Human	HEK293
	FGFR-1 alpha, a conserved member of the FGFR family, binds acidic and basic fibroblast growth factors, influencing mitogenesis and differentiation. Mutations in FGFR1 cause syndromes and disorders. It exhibits ubiquitous expression, with notable levels in ovary (RPKM 21.8), fat (RPKM 21.4), and 25 other tissues. Alternatively spliced variants contribute to its functional diversity. FGFR-1 alpha (IIIb) Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FGFR-1 alpha, expressed by HEK293 , with C-His, C-10*His labeled tag. FGFR-1 alpha (IIIb) Protein, Human (HEK293, His), has molecular weight of 60-90 kDa.

HY-P75765

	FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 1; FGFR-1; FGF R1b; FGFR1 beta	Human	HEK293
	FGFR-1 beta, a member of the FGFR family, interacts with fibroblast growth factors and regulates mitogenesis and differentiation. It specifically binds to acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene are associated with several syndromes and disorders. Chromosomal aberrations involving this gene are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. FGFR-1 beta is expressed in various tissues, including the ovary and fat. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293, with C-hFc labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc), has molecular weight of 76-106 kDa.

HY-P75766

	FGFR-1 beta (IIIb) Protein, Human (HEK293, His) Fibroblast growth factor receptor 1; FGFR-1; FGF R1b; FGFR1 beta	Human	HEK293
	FGFR-1 beta, a member of the FGFR family, interacts with fibroblast growth factors and regulates mitogenesis and differentiation. It specifically binds to acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene are associated with several syndromes and disorders. Chromosomal aberrations involving this gene are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. FGFR-1 beta is expressed in various tissues, including the ovary and fat. FGFR-1 beta (IIIb) Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293, with C-His labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, His), has molecular weight of 45-60 kDa.

HY-P702758

FGFR-1 alpha Protein, Human (Biotinylated, sf9, Flag)

FGF R1a; FGFR1 alpha
Human Sf9 insect cells

HY-P77659

	FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) FGF R1a; FGFR1 alpha	Human	HEK293
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is 353 a.a., with molecular weight of 65-85 kDa.

HY-P77660

	FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) FGF R1a; FGFR1 alpha	Human	HEK293
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is 353 a.a., with molecular weight of 68-80 kDa.

HY-P71954

	FGFR-3 Protein, Human (HEK293, hFc) ACH; CD 333; CD333; CD333 antigen; CEK 2; CEK2; FGFR 3; FGFR-3; FGFR3; FGFR3_HUMAN; Fibroblast growth factor receptor 3 achondroplasia thanatophoric dwarfism; ; Fibroblast growth factor receptor 3; Heparin binding growth factor receptor; HSFGFR3EX; Hydroxyaryl protein kinase; JTK 4; JTK4; MFR 3; SAM 3; Tyrosine kinase JTK 4; Tyrosine kinase JTK4; Z FGFR 3	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (HEK293, hFc) is the recombinant human-derived FGFR-3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-3 Protein, Human (HEK293, hFc) is 353 a.a., with molecular weight of ~90 kDa.

HY-P72196

	FGFR-3 Protein, Human (His-B2M) ACH; CD 333; CD333; CD333 antigen; CEK 2; CEK2; FGFR 3; FGFR-3; FGFR3; FGFR3_HUMAN; Fibroblast growth factor receptor 3 achondroplasia thanatophoric dwarfism; ; Fibroblast growth factor receptor 3; Heparin binding growth factor receptor; HSFGFR3EX; Hydroxyaryl protein kinase; JTK 4; JTK4; MFR 3; SAM 3; Tyrosine kinase JTK 4; Tyrosine kinase JTK4; Z FGFR 3	Human	E. coli
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (His-B2M) is the recombinant human-derived FGFR-3 protein, expressed by E. coli , with N-6*His, N-B2M labeled tag. The total length of FGFR-3 Protein, Human (His-B2M) is 410 a.a., with molecular weight of ~59.4 kDa.

HY-P72644

	FGFR-3 Protein, Human (HEK293, His) Fibroblast growth factor receptor 3; FGFR-3; CD333; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (HEK293, His) is the recombinant human-derived FGFR-3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGFR-3 Protein, Human (HEK293, His) is 353 a.a., with molecular weight of 60-75 kDa.

HY-P73056

	FGFR-3 Protein, Mouse (HEK293, His-Fc) Fibroblast growth factor receptor 3; FGFR-3; CD333; JTK4	Mouse	HEK293
	The FGFR-3 Protein is a member of the fibroblast growth factor receptor family. FGFR-3 Protein regulates chondrocyte differentiation and chondrocyte proliferation by activating the MAPK/STAT signaling pathway. FGFR-3 mutations are also associated with sperm cell tumors. FGFR-3 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived FGFR-3 protein, expressed by HEK293, with C-hFc, C-His labeled tag. The total length of FGFR-3 Protein, Mouse (HEK293, His-Fc) is 367 a.a., with molecular weight of 100-110 kDa.

HY-P73057

	FGFR-4 Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF	Human	HEK293
	The leptin R/LEPR protein is a receptor protein that binds to the hormone leptin. It plays a vital role in regulating energy balance and body weight. FGFR-4 Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-4 Protein, Human (HEK293, Fc) is 348 a.a., with molecular weight of 95-112 kDa.

HY-P73059

	FGFR-4 Protein, Human (HEK293, His) Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF	Human	HEK293
	The FGFR-4 protein is a tyrosine protein kinase and cell surface receptor for fibroblast growth factor that regulates diverse cellular processes such as proliferation, differentiation, migration, lipid metabolism, and bile acid biosynthesis. Notably, it contributes to the downregulation of the bile acid synthase CYP7A1 in response to FGF19. FGFR-4 Protein, Human (HEK293, His) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-4 Protein, Human (HEK293, His) is 369 a.a., with molecular weight of ~60 kDa.

HY-P75190

	FGFR-4 Protein, Rat (HEK293, His) Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF	Rat	HEK293
	The FGFR-4 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that regulates cellular processes, lipid metabolism, bile acid biosynthesis, and more. Its effects include downregulation of CYP7A1 in response to FGF19. FGFR-4 Protein, Rat (HEK293, His) is the recombinant rat-derived FGFR-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-4 Protein, Rat (HEK293, His) is 367 a.a., with molecular weight of 64-68 kDa.

HY-P75191

	FGFR-4 Protein, Mouse (HEK293, His) Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF	Mouse	HEK293
	FGFR-4 protein is a tyrosine protein kinase that serves as a cell surface receptor for fibroblast growth factor and controls proliferation, differentiation, migration, lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism, and phosphate and other cellular processes homeostasis. It significantly downregulates CYP7A1 in response to FGF19. FGFR-4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-4 Protein, Mouse (HEK293, His) is 196 a.a., with molecular weight of 58-80 kDa.

HY-P76339

	FGFR-2 Protein, Mouse (HEK293, Fc) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Mouse	HEK293
	FGFR2, also known as CD332 (differentiated cluster 332), is a receptor for fibroblast growth factor. FGFR2 is involved in activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR2 up-regulates PAI-1 via JAK2/STAT3 signaling and induces M2 polarization in colorectal cancer macrophages. FGFR-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-2 Protein, Mouse (HEK293, Fc) is 242 a.a., with molecular weight of ~89.9 KDa.

HY-P76340

FGFR-2 Protein, Mouse (HEK293, His)

Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
Mouse HEK293

HY-P76927

	FGFR1OP Protein, Human (sf9, His-GST) Centrosomal protein 43; FGFR1 oncogene partner; CEP43; FOP	Human	Sf9 insect cells
	FGFR1OP is critical for microtubule dynamics, anchoring microtubules at centrosomes, which is critical for cell organization. It plays an integral role in cilia formation and helps control the complex process of cilia formation. FGFR1OP Protein, Human (sf9, His-GST) is the recombinant human-derived FGFR1OP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of FGFR1OP Protein, Human (sf9, His-GST) is 378 a.a., with molecular weight of ~69 kDa.

HY-P702759

FGFR-2 Protein, Human (Biotinylated, sf9)

Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
Human Sf9 insect cells
HY-P702760

FGFR-3 Protein, Human (sf9, His, Flag)

Fibroblast growth factor receptor 3; FGFR-3; CD333; JTK4
Human Sf9 insect cells
HY-P702761

FGFR-4 Protein, Human (Biotinylated, sf9)

Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF
Human Sf9 insect cells

HY-P73060

	FGFR-4 Protein, Mouse (HEK293, His-Fc) Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF	Mouse	HEK293
	FGFR-4 protein is a tyrosine protein kinase that serves as a cell surface receptor for fibroblast growth factor and controls proliferation, differentiation, migration, lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism, and phosphate and other cellular processes homeostasis. It significantly downregulates CYP7A1 in response to FGF19. FGFR-4 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived FGFR-4 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of FGFR-4 Protein, Mouse (HEK293, His-Fc) is 366 a.a., with molecular weight of 100-110 kDa.

HY-P73061

	FGFR-4 Protein, Rat (HEK293, Fc, Solution) Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF	Rat	HEK293
	The FGFR-4 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that regulates cellular processes, lipid metabolism, bile acid biosynthesis, and more. Its effects include downregulation of CYP7A1 in response to FGF19. FGFR-4 Protein, Rat (HEK293, Fc, Solution) is the recombinant rat-derived FGFR-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-4 Protein, Rat (HEK293, Fc, Solution) is 351 a.a., with molecular weight of ~110 kDa.

HY-P74153

	FGFR-3 Protein, Mouse (HEK293, His) Fibroblast growth factor receptor 3; FGFR-3; CD333; Mfr3; Sam3	Mouse	HEK293
	The FGFR-3 protein is a tyrosine protein kinase that serves as a cell surface receptor for fibroblast growth factors and controls cellular processes, including proliferation, differentiation, and apoptosis. It is essential for chondrocyte differentiation, proliferation, apoptosis and normal bone development functions. FGFR-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-3 Protein, Mouse (HEK293, His) is 347 a.a., with molecular weight of 60-90 kDa.

HY-P75767

	FGFR-1 Protein, Mouse (HEK293, Fc) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Mouse	HEK293
	The FGFR-1 protein is a tyrosine-protein kinase receptor for fibroblast growth factors that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-1 Protein, Mouse (HEK293, Fc) is 376 a.a., with molecular weight of 100-110 kDa.

HY-P75768

	FGFR-1 Protein, Mouse (HEK293, His) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Mouse	HEK293
	The FGFR-1 protein is a tyrosine-protein kinase receptor for fibroblast growth factors that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-1 Protein, Mouse (HEK293, His) is 355 a.a., with molecular weight of 60-80 kDa.

HY-P76333

	FGFR-2 Protein, Human (sf9, His-GST) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	Sf9 insect cells
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 Protein, Human (sf9, His-GST) is the recombinant human-derived FGFR-2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of FGFR-2 Protein, Human (sf9, His-GST) is 422 a.a., with molecular weight of ~68 KDa.

HY-P76928

	FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF	Rhesus Macaque	HEK293
	The FGFR-4 protein is a cell surface receptor for tyrosine kinase and fibroblast growth factor. FGFR4, a receptor for FGF-1 and FGF-3 highly expressed in cancer cells, promotes tumor progression in colon cancer by activating Mek/Erk and MMP-7. FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived FGFR-4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) is 369 a.a., with molecular weight of ~65.6 KDa.

HY-P76929

	FGFR-4 Protein, Rhesus Macaque (HEK293, His) Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF	Rhesus Macaque	HEK293
	The FGFR-4 protein is a cell surface receptor for tyrosine kinase and fibroblast growth factor. FGFR4, a receptor for FGF-1 and FGF-3 highly expressed in cancer cells, promotes tumor progression in colon cancer by activating Mek/Erk and MMP-7. FGFR-4 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived FGFR-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-4 Protein, Rhesus Macaque (HEK293, His) is 348 a.a., with molecular weight of ~60-80 KDa.

HY-P77549

	FGFR-4 Protein, Human (Biotinylated, HEK293, His) Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF	Human	HEK293
	The FGFR-4 protein is a tyrosine protein kinase and cell surface receptor for fibroblast growth factor that regulates diverse cellular processes such as proliferation, differentiation, migration, lipid metabolism, and bile acid biosynthesis. Notably, it contributes to the downregulation of the bile acid synthase CYP7A1 in response to FGF19. FGFR-4 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-4 Protein, Human (Biotinylated, HEK293, His) is 369 a.a., with molecular weight of ~60.8 kDa.

HY-P73061A

	FGFR-4 Protein, Rat (HEK293, C-hFc) Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF	Rat	HEK293
	The FGFR-4 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that regulates cellular processes, lipid metabolism, bile acid biosynthesis, and more. Its effects include downregulation of CYP7A1 in response to FGF19. FGFR-4 Protein, Rat (HEK293, C-hFc) is the recombinant rat-derived FGFR-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-4 Protein, Rat (HEK293, C-hFc) is 351 a.a., with molecular weight of ~110 kDa.

HY-P72643

	FGFRL1 Protein, Human (HEK293, His) Fibroblast growth factor receptor-like 1; FGFR-5; FGFRL1; FGFR5; FHFR	Human	HEK293
	The FGFRL1 protein negatively affects cell proliferation, revealing its role as a potential regulator during cell growth. In addition, it interacts with FGF2, showing significant but low affinity for this fibroblast growth factor. FGFRL1 Protein, Human (HEK293, His) is the recombinant human-derived FGFRL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGFRL1 Protein, Human (HEK293, His) is 354 a.a., with molecular weight of ~65 kDa.

HY-P75769

	FGFR-1 Protein, Rhesus Macaque (HEK293, Fc) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Rhesus Macaque	HEK293
	FGFR-1 protein is a tyrosine-protein kinase that acts as a cell surface receptor for fibroblast growth factor and plays a critical role in the complex regulation of embryonic development, cell proliferation, differentiation, and migration. FGFR-1 mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived FGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-1 Protein, Rhesus Macaque (HEK293, Fc) is 283 a.a., with molecular weight of ~56.2 kDa.

HY-P75770

	FGFR-1 Protein, Rhesus Macaque (HEK293, His) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Rhesus Macaque	HEK293
	FGFR-1 protein is a tyrosine-protein kinase that acts as a cell surface receptor for fibroblast growth factor and plays a critical role in the complex regulation of embryonic development, cell proliferation, differentiation, and migration. FGFR-1 mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR-1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived FGFR-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-1 Protein, Rhesus Macaque (HEK293, His) is 262 a.a., with molecular weight of 50-75 kDa.

HY-P76334

	FGFR-2 alpha IIIb Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIb Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-2 alpha IIIb Protein, Human (HEK293, Fc) is 357 a.a., with molecular weight of 80-115 KDa.

HY-P76336

	FGFR-2 alpha IIIb Protein, Human (HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIb Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-2 alpha IIIb Protein, Human (HEK293, His) is 357 a.a., with molecular weight of 60-80 KDa.

HY-P76337

	FGFR-2 alpha IIIc Protein, Human (HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIc Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-2 alpha IIIc Protein, Human (HEK293, His) is 356 a.a., with molecular weight of 60-80 KDa.

HY-P76343

	FGFRL1 Protein, Mouse (HEK293, His) Fibroblast growth factor receptor-like 1; FGFR-5; FGFRL1; FGFR5; FHFR	Mouse	HEK293
	FGFRL1 protein significantly inhibits cell proliferation by interacting with FGF2 with low affinity, thereby regulating the proliferative signals associated with FGF2. This unique property positions FGFRL1 as a modulator of cellular growth, highlighting its intricate involvement in maintaining cellular homeostasis. FGFRL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFRL1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFRL1 Protein, Mouse (HEK293, His) is 354 a.a., with molecular weight of ~55-68 KDa.

HY-P700484

	FGFR-3 Protein, Human (P. pastoris, N-His) Fibroblast growth factor receptor 3; FGFR-3; CD333; Mfr3; Sam3	Human	P. pastoris
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (P. pastoris, N-His) is the recombinant human-derived FGFR-3 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of FGFR-3 Protein, Human (P. pastoris, N-His) is 410 a.a., with molecular weight of 47.4 kDa.

HY-P700720

	FGFR-1 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) FGFR-1; BFGFR; bFGF-R-1; FLT-2; N-sam; CD331;	Human	HEK293
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-1 beta, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is 198 a.a., with molecular weight of 45-55 kDa.

HY-P76338

	FGFR-2 alpha IIIc Protein, Human (HEK293, His-Fc) Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIc Protein, Human (HEK293, His-Fc) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of FGFR-2 alpha IIIc Protein, Human (HEK293, His-Fc) is 356 a.a., with molecular weight of 110-120 KDa.

HY-P76341

	FGFR-3 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) Fibroblast growth factor receptor 3; FGFR-3; CD333; Mfr3; Sam3	Cynomolgus	HEK293
	FGFR-3 is a member of the fibroblast growth factor receptor family and is expressed in tissues such as cartilage, brain, intestine and kidney. FGFR-3 regulates chondrocyte differentiation and proliferation by activating the MAPK/STAT signaling pathway. FGFR-3 is a tumor marker. FGFR-3 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant cynomolgus-derived FGFR-3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-3 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 375 a.a., with molecular weight of ~99.9 KDa.

HY-P76342

FGFR-3 Protein, Cynomolgus/Rhesus Macaque (HEK293, His)

Fibroblast growth factor receptor 3; FGFR-3; CD333; Mfr3; Sam3
Rhesus Macaque HEK293
HY-P73055

FGFR-1 beta Protein, Human (HEK293, His)

Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; CEK; FGFBR, FLG
Human HEK293

Cat. No.	Product Name	Chemical Structure

HY-151903S

FGFR2/3-IN-1
FGFR2/3-IN-1 is a potent and selective FGFR2 and FGFR3 (FGFR) inhibitor with IC50s of 1 nM and 0.5 nM, respectively. FGFR2/3-IN-1 displays >40-fold selectivity over FGFR1/FGFR4 and other kinome. FGFR2/3-IN-1 also inhibits FGFR3 V555L and V555M mutants with IC50s of 2.7 nM and 6.1 nM, respectively[1].

HY-13311S

Infigratinib-d3
Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the *FGFR* family, with IC₅₀ values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for *FGFR1, FGFR2, FGFR3, and FGFR4*, respectively .

HY-N0060S1

Ferulic acid-13C3
Ferulic acid- ¹³C₃ is the ¹³C-labeled Ferulic acid. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

HY-50905S

Dovitinib-d8
Dovitinib-d₈ is the deuterium labeled Dovitinib. Dovitinib (CHIR-258) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively[1][2].

HY-10981S1

Lenvatinib-d5
Lenvatinib-d₅ is the deuterium labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].

HY-10981S

Lenvatinib-d4
Lenvatinib-d₄ is the deuterium labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].

HY-W758126

(R)-Brivanib alaninate-d4
(R)-Brivanib alaninate-d₄ is the deuterium-labeled Brivanib (alaninate) (HY-10336). Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC₅₀ of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ .

HY-50904S

Nintedanib-d3
Nintedanib-d₃ is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

HY-50904S2

Nintedanib-d8
Nintedanib-d₈ is deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

HY-50904S1

Nintedanib-13C,d3
Nintedanib- ¹³C,d₃ is the ¹³C- and deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

HY-10208S

Pazopanib-d6
Pazopanib-d₆ is the deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

HY-10208S1

Pazopanib-13C,d3
Pazopanib- ¹³C,d₃ is the deuterium and ¹³C labeled Pazopanib[1]. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].

HY-12009S

Pazopanib-13C,d3 hydrochloride
Pazopanib- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Pazopanib hydrochloride[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].

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