Ion transport

Pathways Recommended:	Membrane Transporter/Ion Channel

By Targets:	Calcium Channel (1) CCR (1) Endogenous Metabolite (2) Free Fatty Acid Receptor (1) Ligands for E3 Ligase (1) P-glycoprotein (1) Potassium Channel (1) PROTACs (1) TRP Channel (2)
By Research Areas:	Cancer (1) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (3)

Targets Recommended: FATP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19995

GSK137647A 1 Publications Verification GSK 137647	Free Fatty Acid Receptor	Metabolic Disease
GSK137647A (GSK 137647) is a potent, selective free fatty acid receptor 4 (FFA4) agonist with pEC₅₀ values of 6.3, 6.2, and 6.1 for human, mouse and rat FFA4, and pEC₅₀ values < 4.5 for all three species for FFA1, FFA2, and FFA3, respectively. GSK137647A has anti-inflammatory activity. GSK137647A induces insulin secretion and inhibits epithelial ion transport, GSK137647A is related to regulation of glucose homeostasis and anti-inflammatory response .

HY-100928

YS 035 hydrochloride	Calcium Channel	Neurological Disease
YS 035 hydrochloride is a Ca ²⁺ antagonist on cellular uptake and mitochondrial efflux of calcium ions. YS 035 hydrochloride inhibits Ca ²⁺ uptake by muscle cells and inhibits Na ⁺/Ca ²⁺ exchange (K_i=28 µM). YS 035 hydrochloride is a useful tool for research on the mitochondrial Ca ²⁺ transport .

HY-113469A

Cyclic GMP sodium	Endogenous Metabolite	Inflammation/Immunology
Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriuretic peptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation .

HY-154912

PAT1inh-B01	Others	Inflammation/Immunology
PAT1inh-B01 is a selective SLC26A6 inhibitor. PAT1inh-B01 inhibits PAT1 (a Cl ^-/HCO3 ^- exchanger)-mediated anion exchange (IC₅₀: 350 nM). PAT1inh-B01 blocks fluid absorption in small intestine. PAT1inh-B01 can be used for research of small intestinal hyposecretory disorders .

HY-P2837

Oxaloacetate decarboxylase	Endogenous Metabolite	Metabolic Disease
Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and COIC₂. Oxaloacetate decarboxylase is a member of the sodium ion transport decarboxylase (NaT-DC) enzyme family. Oxaloacetate decarboxylase converts the chemical energy of the decarboxylation reaction into an electrochemical gradient of Na ⁺ ions across the membrane .

HY-154912A

PAT1inh-B01 hydrochloride	Others	Inflammation/Immunology
PAT1inh-B01 hydrocholide is a selective SLC26A6 inhibitor. PAT1inh-B01 hydrocholide inhibits PAT1 (a Cl ^-/HCO3 ^- exchanger)-mediated anion exchange (IC₅₀: 350 nM). PAT1inh-B01 hydrocholide blocks fluid absorption in small intestine. PAT1inh-B01 hydrocholide can be used for research of small intestinal hyposecretory disorders .

HY-147373

DA-PROTAC	PROTACs Ligands for E3 Ligase	Cancer
DA-PROTAC is a potent PROTAC degrader of copper ion-transport proteins Atox1 and CCS. DA-PROTAC can bind both Atox1 and CCS proteins, and the complex can be bound to E3 ligase, leading to increased levels of ubiquitination of Atox1 and CCS and degradation of Atox1 and CCS proteins via the proteasome pathway. DA-PROTAC can be used for triple negative breast cancer research .

HY-119101

AZD-5672 1 Publications Verification	CCR Potassium Channel P-glycoprotein	Inflammation/Immunology
AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC₅₀=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC₅₀=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC₅₀=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis .

HY-12949

ML204 4 Publications Verification	TRP Channel	Neurological Disease
ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels .

HY-12949A

ML204 hydrochloride 4 Publications Verification	TRP Channel	Neurological Disease
ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels .

Cat. No.	Product Name

HY-L011

Membrane Transporter/Ion Channel Compound Library	1,404 compounds
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development. MCE designs a unique collection of 1,404 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Membrane Transporter/Ion Channel Compound Library

1,404 compounds

Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.

MCE designs a unique collection of 1,404 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Type

HY-P2837

Oxaloacetate decarboxylase	Biochemical Assay Reagents
Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and COIC₂. Oxaloacetate decarboxylase is a member of the sodium ion transport decarboxylase (NaT-DC) enzyme family. Oxaloacetate decarboxylase converts the chemical energy of the decarboxylation reaction into an electrochemical gradient of Na ⁺ ions across the membrane .

Cat. No.	Product Name	Target	Research Area

HY-P4309

H-Gly-Tyr-Gly-OH

Peptides Others

H-Gly-Tyr-Gly-OH, a tyrosine tripeptide, can be found in structural and transport proteins such as collagen and ion channels .

H-Gly-Tyr-Gly-OH	Peptides	Others
H-Gly-Tyr-Gly-OH, a tyrosine tripeptide, can be found in structural and transport proteins such as collagen and ion channels .

HY-P2837

Oxaloacetate decarboxylase	Endogenous Metabolite	Metabolic Disease
Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and COIC₂. Oxaloacetate decarboxylase is a member of the sodium ion transport decarboxylase (NaT-DC) enzyme family. Oxaloacetate decarboxylase converts the chemical energy of the decarboxylation reaction into an electrochemical gradient of Na ⁺ ions across the membrane .

HY-P2967

α-Hemolysin (Staphylococcus aureus)	Peptides	Others
α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K ⁺ and Ca ²⁺ ion transport, leading to necrotic death of target cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113469A

Cyclic GMP sodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriuretic peptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation .

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Ion transport

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

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Natural
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