LATS

By Targets:	Apoptosis (3) ASCT (1) PROTAC Linkers (1) Small Interfering RNA (siRNA) (4) YAP (5)
By Research Areas:	Cancer (10) Cardiovascular Disease (1)
Click Chemistry:	PROTAC Synthesis (1) Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138489

TRULI Maximum Cited Publications 11 Publications Verification LATS-IN-1	YAP	Others
TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of *Lats1* and *Lats2* kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues .

HY-W011391

GPNA hydrochloride 5 Publications Verification	Apoptosis ASCT	Cancer
GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na ⁺-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na ⁺-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells .

HY-RS07538

LATS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LATS1 Human Pre-designed siRNA Set A contains three designed siRNAs for LATS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LATS1 Human Pre-designed siRNA Set A LATS1 Human Pre-designed siRNA Set A

HY-RS07539

LATS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LATS2 Human Pre-designed siRNA Set A contains three designed siRNAs for LATS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LATS2 Human Pre-designed siRNA Set A LATS2 Human Pre-designed siRNA Set A

HY-147165A

VT02956 hydrochloride	YAP	Cancer
VT02956 is a *LATS* inhibitor (IC₅₀: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147082

GA-017	YAP	Cancer
GA-017 is a potent and selective *LATS1* and *LATS2* (large tumor suppressor kinase 1/2) inhibitor, with IC₅₀ values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids .

HY-RS07536

LAT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LAT Human Pre-designed siRNA Set A contains three designed siRNAs for LAT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LAT Human Pre-designed siRNA Set A LAT Human Pre-designed siRNA Set A

HY-RS07537

LAT2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for LAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LAT2 Human Pre-designed siRNA Set A LAT2 Human Pre-designed siRNA Set A

HY-147165

VT02956	YAP	Cancer
VT02956 is a *LATS* inhibitor (IC₅₀: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-120139

KMH-233	Others	Cancer
KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC₅₀=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM) .

HY-N3999

Venuloside A

ESK246
Others Cancer

Venuloside A is a potent inhibitor of LAT3. Venuloside A inhibits the leucine uptake in LNCaP prostate cancer cells with an IC₅₀ of 8.12 μM .

Venuloside A ESK246	Others	Cancer
Venuloside A is a potent inhibitor of *LAT3. Venuloside A inhibits the leucine uptake in LNCaP prostate cancer cells with an IC₅₀* of 8.12 μM .

HY-139330

MGH-CP1	Apoptosis	Cancer
MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC₅₀s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion .

HY-120139A

(R)-KMH-233	Others	Cancer
(R)-KMH-233 is the isomer of KMH-233 (HY-120139), and can be used as an experimental control. KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC₅₀=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM) .

HY-150042

TDI-011536	YAP	Cardiovascular Disease Others
TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration .

HY-108540

BCH 4 Publications Verification 2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1	Apoptosis	Cancer
BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis .

HY-16929

Latrunculin A 5+ Cited Publications LAT-A
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

HY-130504

Propargyl-PEG1-acid 1 Publications Verification	PROTAC Linkers	Cancer
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM . Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3999

Venuloside A ESK246	Structural Classification Other Monoterpenes Terpenoids Source classification Pittosporaceae Plants Pittosporum venulosum F.Muell.	Others
Venuloside A is a potent inhibitor of *LAT3. Venuloside A inhibits the leucine uptake in LNCaP prostate cancer cells with an IC₅₀* of 8.12 μM .

Cat. No.	Product Name	Application	Reactivity

HY-P81210

*phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody* LATS1 +LATS2 (phospho T1079 + T1041); Serine/threonine protein kinase LATS2; KPM; Large tumor supressor, homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS, large tumor suppressor, homolog 2 (Drosophila); LATS1 +LATS2 (phospho T1079 + T1041); p-LATS1 +LATS2(Thr1079 +Thr1041); RGD1564085; Serine/threonine protein kinase LATS1; WARTS; WARTS protein kinase; wts; 4932411G09Rik; AV277261; AW208599; AW228608; FLJ13161; LATS1_HUMAN.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse(predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit)
phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody is an unconjugated, approximately 124 kDa, rabbit-derived, anti-phospho-LATS1+LATS2 (Thr1079 +Thr1041) polyclonal antibody. phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, and predicted: rat, chicken, dog, pig, cow, horse, rabbit background without labeling.

Cat. No.	Product Name		Classification

HY-130504

Propargyl-PEG1-acid 1 Publications Verification		Alkynes PROTAC Synthesis
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM . Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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