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Results for "

MNK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MNK (15) Apoptosis (5) Bcl-2 Family (1) Btk (1) Casein Kinase (1) Dengue virus (1) Eukaryotic Initiation Factor (eIF) (1) Flavivirus (1) FLT3 (1) Fungal (1) LRRK2 (1) MAPKAPK2 (MK2) (2) p38 MAPK (1) PD-1/PD-L1 (1) PI3K (1) Pim (1) PKC (1) STAT (1) Survivin (1) VEGFR (1)
By Research Areas:	Cancer (17) Infection (3) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

21

Inhibitors & Agonists

2

Natural
Products

3

Recombinant Proteins

Targets Recommended: MNK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

MNK8	STAT Apoptosis Bcl-2 Family Survivin	Cancer
MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells .

HY-139684

MNK1/2-IN-5

MNK Infection Inflammation/Immunology Cancer

MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent.

MNK1/2-IN-6	MNK Apoptosis	Cancer
MNK1/2-IN-6 is a potent and selective *MNK1/2* inhibitor with IC₅₀s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner .

MNK inhibitor 9	MNK	Cancer
MNK inhibitor 9 is a potent and selective inhibitor of *MNK1/2* with IC₅₀ values of 0.003 µM and 0.003 µM for *MNK1* and *MNK2* respectively. MNK inhibitor 9 has good cell permeability. MNK inhibitor 9 can be used in tumor related research .

HY-162260

MNK-IN-4

MNK Cancer

MNK-IN-4 (compound D25) is a potent and selective MNK inhibitor for the treatment of sepsis-related acute splenic injury .
HY-132867

MNK/PIM-IN-1

Pim Cancer

MNK/PIM-IN-1 represents an innovative dual MNK/PIM inhibitor with a good pharmacokinetic profile.

ETC-168	MNK	Cancer
ETC-168 is a selective and oral active *MNK* inhibitor with the IC₅₀ values of 23 and 43 nM against MNK1 and MNK2, respectively. ETC-168 shows antiproliferative efficacy in vivo and in vitro .

HY-112424

Tinodasertib

ETC-206
MNK Cancer

Tinodasertib (ETC-206) is a selective MNK1 and MNK2 inhibitor with IC₅₀s of 64 nM and 86 nM, respectively.
HY-112113

SLV-2436

SEL201-88; SEL-201
MNK Cancer

SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC₅₀s of 10.8 nM and 5.4 nM, respectively.

EB1	MNK Eukaryotic Initiation Factor (eIF) Apoptosis	Cancer
EB1 is the inhibitor of kinases *MNK* with IC₅₀s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation .

QL-X-138	Flavivirus Dengue virus Btk MNK	Infection Cancer
QL-X-138 is a potent and selective *BTK/MNK* dual kinase** inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC₅₀s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti-dengue virus 2 activity, with an IC₅₀ of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies .

HY-148105

DS12881479

MNK Cancer

DS12881479 is a potent and selective Mnk1 inhibitor with an IC₅₀ value of 21 nM. DS12881479 can be used in cancer research .

Cercosporamide (-)-Cercosporamide	Fungal MNK PKC	Infection Cancer
Cercosporamide is a highly potent, ATP-competitive PKC kinase inhibitor targeting to PKC1, with an IC₅₀ of <50 nM and a K_i of <7 nM. Cercosporamide is a unique *Mnk* inhibitor.

Tomivosertib Maximum Cited Publications 6 Publications Verification eFT508	MNK PD-1/PD-L1	Cancer
Tomivosertib (eFT508) is a potent, highly selective, and orally active *MNK1* and *MNK2* inhibitor, with IC₅₀s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC₅₀=2-16 nM) in tumor cell lines . Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance .

MK2-IN-3 hydrate 2 Publications Verification	MAPKAPK2 (MK2)	Inflammation/Immunology
MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC₅₀ of 0.85 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC₅₀=0.21 μM), MK-5 (IC₅₀=0.081 μM), ERK2 (IC₅₀=3.44 μM), MNK1(IC₅₀=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2 .

CGP 57380 4 Publications Verification	MNK Apoptosis	Cancer
CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of *Mnk1* with IC₅₀ of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.

(R)-STU104	p38 MAPK	Cancer
(R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC₅₀s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis .

HG-10-102-01 1 Publications Verification	LRRK2 MNK	Neurological Disease
HG-10-102-01 is a highly potent, selective, and brain-penetrable LRRK2 inhibitor, with IC₅₀ values of 20.3 and 3.2 nM against wild-type LRRK2 and LRRK2[G2019S], respectively. HG-10-102-01 also inhibits *MNK2* and MLK1, with IC₅₀ values of 0.6 and 2.1 μM. HG-10-102-01 can be used for Parkinson's disease (PD) research .

K783-0308	FLT3 MNK Apoptosis	Cancer
K783-0308 is a potent and selective dual inhibitor of FLT3 and *MNK2* with IC₅₀ values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC₅₀=10.5 µM) and MV-4-11 (IC₅₀=10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase .

Orobol	Casein Kinase PI3K VEGFR	Metabolic Disease
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) .

MK2-IN-3 2 Publications Verification	MAPKAPK2 (MK2)	Inflammation/Immunology
MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC₅₀ of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC₅₀s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC₅₀s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo .

Species:	Human (3)
Tag:	His (1) Tag Free (1) GST (1)
Source:	Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	MKNK2 Protein, Human (His) MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; MNK2	Human	E. coli
	MKNK2 is a serine/threonine protein kinase that centrally affects cellular processes by phosphorylating SFPQ/PSF, HNRNPA1, and EIF4E. MKNK2 sits at the intersection of environmental stress and cytokine signaling and regulates translation by enhancing the affinity of EIF4E for the mRNA cap, thereby affecting the translation machinery. MKNK2 Protein, Human (His) is the recombinant human-derived MKNK2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MKNK2 Protein, Human (His) is 314 a.a., .

	MKNK1 Protein, Human (Sf9, GST) MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1; MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; MNK1	Human	Sf9 insect cells
	MKNK1 (MAP Kinase Interacting Serine/Threonine Kinase 1) plays a central role in coordinating cellular responses to environmental stress and cytokines. It exerts regulatory control over translation processes by phosphorylating EIF4E, enhancing its affinity for mRNA cap structures with 7-methylguanosine. This highlights MKNK1's crucial involvement in finely tuning translation machinery in response to diverse cellular stimuli. MKNK1 Protein, Human (Sf9, GST) is the recombinant human-derived MKNK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of MKNK1 Protein, Human (Sf9, GST) is 424 a.a., .

	MKNK2 Protein, Human MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; MNK2	Human	E. coli
	MKNK2 is a serine/threonine protein kinase that centrally affects cellular processes by phosphorylating SFPQ/PSF, HNRNPA1, and EIF4E. MKNK2 sits at the intersection of environmental stress and cytokine signaling and regulates translation by enhancing the affinity of EIF4E for the mRNA cap, thereby affecting the translation machinery. MKNK2 Protein, Human is the recombinant human-derived MKNK2 protein, expressed by E. coli , with tag free. The total length of MKNK2 Protein, Human is 314 a.a., .

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