NLRP1

By Targets:	NOD-like Receptor (NLR) (2) p38 MAPK (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (1) Inflammation/Immunology (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156798

ADS032	NOD-like Receptor (NLR)	Inflammation/Immunology
ADS032 is a dual inhibitor of NLRP1 and NLRP3 that can rapidly, reversibly and stably inhibit inflammasome formation. ADS032 can reduce NLPR1 and NLRP3 activation of human macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduce NLRP3-induced ASC speck formation. ADS032 protected mice against the deadly influenza A virus, reducing inflammation in the lungs and improving survival. ADS032 inhibits Nigericin (HY-127019)-induced IL-1β secretion with IC50s of 94.6 μM (No wash out) and 354 μM (Wash out) respectively ^[1].

HY-127090

Muramyl dipeptide 2 Publications Verification MDP	p38 MAPK NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a *NLRP1* agonist ^[1] .

HY-RS09349

NLRP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NLRP1 Human Pre-designed siRNA Set A contains three designed siRNAs for NLRP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NLRP1 Human Pre-designed siRNA Set A NLRP1 Human Pre-designed siRNA Set A

HY-RS09354

Nlrp1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nlrp1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nlrp1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nlrp1a Mouse Pre-designed siRNA Set A Nlrp1a Mouse Pre-designed siRNA Set A

HY-RS09355

Nlrp1a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nlrp1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Nlrp1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nlrp1a Rat Pre-designed siRNA Set A Nlrp1a Rat Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L175

Inflammasomes related Compound Library	68 compounds
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response. MCE designs a unique collection of 68 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Inflammasomes related Compound Library

68 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 68 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702188

	NLRP1 Protein, Human NLRP1; NACHT; LRR and PYD domains-containing protein 1; Caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein; Nucleotide-binding domain and caspase recruitment domain	Human	E. coli
	The NLRP1 protein is a key sensor in the NLRP1 inflammasome and can trigger pyroptosis in response to multiple pathogen-related signals. It acts as a pattern recognition receptor (PRR), recognizes pathogens and damage-related signals, and initiates inflammasome complex formation and CASP1 activation. NLRP1 Protein, Human is the recombinant human-derived NLRP1 protein, expressed by E. coli , with tag free. The total length of NLRP1 Protein, Human is 84 a.a., .

HY-P702189

	NLRP1 Protein, Human (His) NLRP1; NACHT; LRR and PYD domains-containing protein 1; Caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein; Nucleotide-binding domain and caspase recruitment domain	Human	E. coli
	The NLRP1 protein is a key sensor in the NLRP1 inflammasome and can trigger pyroptosis in response to multiple pathogen-related signals. It acts as a pattern recognition receptor (PRR), recognizes pathogens and damage-related signals, and initiates inflammasome complex formation and CASP1 activation. NLRP1 Protein, Human (His) is the recombinant human-derived NLRP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of NLRP1 Protein, Human (His) is 84 a.a., .


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