Search Result
Results for "
NOP
" in MedChemExpress (MCE) Product Catalog:
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-156993
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- HY-156972
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Opioid Receptor
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Metabolic Disease
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NOP agonist-1(compound 4) is a nociceptin opioid receptor (NOP) partial agonist. NOP agonist-1attenuate parkinsonian disabilities in 6-OHDA hemilesioned rats .
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- HY-RS09426
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Small Interfering RNA (siRNA)
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Others
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NOP10 Human Pre-designed siRNA Set A contains three designed siRNAs for NOP10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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NOP10 Human Pre-designed siRNA Set A
NOP10 Human Pre-designed siRNA Set A
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- HY-RS09427
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Small Interfering RNA (siRNA)
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Others
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NOP14 Human Pre-designed siRNA Set A contains three designed siRNAs for NOP14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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NOP14 Human Pre-designed siRNA Set A
NOP14 Human Pre-designed siRNA Set A
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- HY-RS09428
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Small Interfering RNA (siRNA)
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Others
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NOP16 Human Pre-designed siRNA Set A contains three designed siRNAs for NOP16 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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NOP16 Human Pre-designed siRNA Set A
NOP16 Human Pre-designed siRNA Set A
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- HY-RS09429
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Small Interfering RNA (siRNA)
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Others
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NOP2 Human Pre-designed siRNA Set A contains three designed siRNAs for NOP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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NOP2 Human Pre-designed siRNA Set A
NOP2 Human Pre-designed siRNA Set A
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- HY-RS09430
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Small Interfering RNA (siRNA)
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Others
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NOP56 Human Pre-designed siRNA Set A contains three designed siRNAs for NOP56 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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NOP56 Human Pre-designed siRNA Set A
NOP56 Human Pre-designed siRNA Set A
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- HY-RS09431
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Small Interfering RNA (siRNA)
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Others
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NOP58 Human Pre-designed siRNA Set A contains three designed siRNAs for NOP58 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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NOP58 Human Pre-designed siRNA Set A
NOP58 Human Pre-designed siRNA Set A
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- HY-RS09432
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Small Interfering RNA (siRNA)
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Others
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NOP9 Human Pre-designed siRNA Set A contains three designed siRNAs for NOP9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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NOP9 Human Pre-designed siRNA Set A
NOP9 Human Pre-designed siRNA Set A
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- HY-156992
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- HY-11052A
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Opioid Receptor
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Neurological Disease
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Trap-101 hydrochloride is a potent, selective and competitive antagonist of NOP receptors over classical opioid receptors. Trap-101 stimulates GTPγ 35S binding to CHOhNOP membranes with pKi values of 8.65, 6.60, 6.14 and <5 for NOP, μ-, κ-, and δ-opioid receptors, respectively. Trap-101 attenuates motor deficits in a rat model of parkinson's disease and can be used for the research of nervous system diseases .
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- HY-P1302
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Opioid Receptor
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Neurological Disease
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Orphanin FQ(1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a Ki of 55 nM. Orphanin FQ(1-11) has no affinity for μ, δ, κ1 and κ3 receptors (Ki>1000 nM). Orphanin FQ(1-11) is analgesic in CD-1 mice .
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- HY-P1302A
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Opioid Receptor
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Neurological Disease
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Orphanin FQ(1-11) TFA, a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a Ki of 55 nM. Orphanin FQ(1-11) TFA has no affinity for μ, δ, κ1 and κ3 receptors (Ki>1000 nM). Orphanin FQ(1-11) TFA is analgesic in CD-1 mice .
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- HY-118987
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- HY-139566
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3-Nitroxypropanol; 3-NOP
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Others
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Others
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Abrucomstat (3-Nitroxypropanol) is an orally active methyl coenzyme M reductase inhibitor. Abrucomstat decreases ruminal methanogenesis .
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- HY-P1319
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Opioid Receptor
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Inflammation/Immunology
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Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo .
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- HY-13222
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Opioid Receptor
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Neurological Disease
Cancer
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BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic .
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- HY-P1319A
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Opioid Receptor
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Inflammation/Immunology
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Nociceptin (1-7) TFA is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) TFA is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) TFA combines with nociceptin reduces hyperalgesia in vivo .
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- HY-13222A
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Opioid Receptor
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Cancer
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BAN ORL 24 free base is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 free base has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 free base can be used for the research of cancer and analgesic .
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- HY-15536
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GRT6005
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Opioid Receptor
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Neurological Disease
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Cebranopadol is an analgesic NOP and opioid receptor agonist with Kis/EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively.
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- HY-12844
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Opioid Receptor
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Neurological Disease
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Ro 64-6198 is a potent, selective, nonpeptide, high-affinity, high cellular permeability and brain penetration N/OFQ receptor (NOP) agonist with an EC50 value of 25.6 nM. Ro 64-6198 is at least 100 times more selective for the NOP receptor over the classic opioid receptors. Ro 64-6198 can be used for stress and anxiety, addiction, neuropathic pain, cough, and anorexia .
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- HY-P1301
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Opioid Receptor
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Neurological Disease
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[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively .
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- HY-N1239
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Longiside B; Sitoindoside; Daucosterol 6'-O-palmitate
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Sitoindoside I (Longiside B; Sitoindoside; Daucosterol 6'-O-palmitate) is a compound that can be isolated from Gyn'nops walla Gaertn .
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- HY-P1301A
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Opioid Receptor
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Neurological Disease
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[Arg14,Lys15]Nociceptin TFA is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin TFA displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively .
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- HY-107094
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W-212393 hydrochloride
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Opioid Receptor
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Neurological Disease
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MT-7716 hydrochloride (W-212393 hydrochloride) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention .
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- HY-107722
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Opioid Receptor
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Neurological Disease
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SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect .
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- HY-10886
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Opioid Receptor
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Neurological Disease
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MCOPPB is an orally active and selective agonist of Nociceptin/Orphanin FQ–Receptor. MCOPPB inhibits signaling through the NOP receptor in the mouse brain. MCOPPB is used in anxiety disorders research .
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- HY-107094A
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W-212393
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Opioid Receptor
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Neurological Disease
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MT-7716 free base (W-212393) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention .
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- HY-P1299
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Opioid Receptor
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Neurological Disease
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UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pKi of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect .
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- HY-114452
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BTRX-246040
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Opioid Receptor
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Neurological Disease
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LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models .
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- HY-P1316
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Opioid Receptor
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Neurological Disease
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Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [ 3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors .
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- HY-P1316A
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Opioid Receptor
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Neurological Disease
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Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [ 3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors .
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- HY-128865
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Opioid Receptor
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Neurological Disease
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BPR1M97 is a dual-acting mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively. BPR1M97 shows high potency and blood-brain barrier penetration, and produces potent antinociceptive effects .
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- HY-P1299A
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Opioid Receptor
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Neurological Disease
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UFP-101 TFA is a potent, selective, and competitive antagonist of the N/OFQ peptide (NOP) receptor, with a pKi of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect .
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- HY-114452A
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BTRX-246040 tartrate
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Opioid Receptor
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Neurological Disease
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LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models .
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- HY-P1300
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Opioid Receptor
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Neurological Disease
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[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold) .
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- HY-P1300A
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Opioid Receptor
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Neurological Disease
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[(pF)Phe4]Nociceptin(1-13)NH2 TFA is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 TFA displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold) .
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Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1302
-
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Opioid Receptor
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Neurological Disease
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Orphanin FQ(1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a Ki of 55 nM. Orphanin FQ(1-11) has no affinity for μ, δ, κ1 and κ3 receptors (Ki>1000 nM). Orphanin FQ(1-11) is analgesic in CD-1 mice .
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- HY-P1302A
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Opioid Receptor
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Neurological Disease
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Orphanin FQ(1-11) TFA, a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a Ki of 55 nM. Orphanin FQ(1-11) TFA has no affinity for μ, δ, κ1 and κ3 receptors (Ki>1000 nM). Orphanin FQ(1-11) TFA is analgesic in CD-1 mice .
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- HY-P1319
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Opioid Receptor
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Inflammation/Immunology
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Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo .
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- HY-P1319A
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Opioid Receptor
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Inflammation/Immunology
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Nociceptin (1-7) TFA is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) TFA is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) TFA combines with nociceptin reduces hyperalgesia in vivo .
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- HY-P1301
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Opioid Receptor
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Neurological Disease
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[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively .
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- HY-P1301A
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Opioid Receptor
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Neurological Disease
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[Arg14,Lys15]Nociceptin TFA is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin TFA displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively .
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- HY-P1299
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Opioid Receptor
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Neurological Disease
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UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pKi of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect .
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- HY-P1316
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Opioid Receptor
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Neurological Disease
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Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [ 3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors .
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- HY-P1316A
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Opioid Receptor
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Neurological Disease
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Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [ 3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors .
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- HY-P1299A
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Opioid Receptor
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Neurological Disease
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UFP-101 TFA is a potent, selective, and competitive antagonist of the N/OFQ peptide (NOP) receptor, with a pKi of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect .
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- HY-P1300
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Opioid Receptor
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Neurological Disease
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[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold) .
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* This product has been "discontinued".
Optimized version of product available:
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Cat. No. |
Product Name |
Application |
Reactivity |
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- HY-P83371
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DKCB1; NOLA3; NOP10P
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WB, IHC-P
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Human |
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- HY-P80673
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FIB; FLRN; NOP1; RNU3IP1
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WB, IP
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Human, Mouse, Rat |
Fibrillarin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to Fibrillarin. It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.
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