Notch2

By Targets:	Antibiotic (1) Apoptosis (1) Bacterial (1) Fungal (1) NF-κB (1) Notch (2) PKA (1) Small Interfering RNA (siRNA) (3) γ-secretase (1)
By Research Areas:	Cancer (3) Infection (1) Inflammation/Immunology (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS09448

NOTCH2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NOTCH2 Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NOTCH2 Human Pre-designed siRNA Set A NOTCH2 Human Pre-designed siRNA Set A

HY-P99320

Tarextumab OMP 59R5; Anti-Human Notch2 Recombinant Antibody	Notch	Cancer
Tarextumab (OMP-59R5) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab shows anti-tumor activity .

HY-N6727

Gliotoxin Aspergillin	Apoptosis PKA NF-κB Bacterial Fungal Antibiotic	Infection Inflammation/Immunology Cancer
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis ^[2]. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .

HY-RS09449

NOTCH2NLA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NOTCH2NLA Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH2NLA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NOTCH2NLA Human Pre-designed siRNA Set A NOTCH2NLA Human Pre-designed siRNA Set A

HY-RS09450

NOTCH2NLC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NOTCH2NLC Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH2NLC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NOTCH2NLC Human Pre-designed siRNA Set A NOTCH2NLC Human Pre-designed siRNA Set A

HY-15670

BMS-906024 2 Publications Verification	γ-secretase Notch	Cancer
BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC₅₀s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity ^[2].

Cat. No.	Product Name	Target	Research Area

HY-P99320

Tarextumab OMP 59R5; Anti-Human Notch2 Recombinant Antibody	Notch	Cancer
Tarextumab (OMP-59R5) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab shows anti-tumor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6727

Gliotoxin Aspergillin	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Biological Pesticide Research Agricultural Research Infection Microorganisms Antibiotics Inflammation/Immunology Disease Research Fields	Apoptosis PKA NF-κB Bacterial Fungal Antibiotic
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis ^[2]. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .

Recombinant Proteins Recommended:

Notch-2

Species:	Human (4)
Tag:	His (3) Avi (1) Fc (1)
Source:	HEK293 (3) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71167

	NOTCH2 Protein, Human (HEK293, His) AGS2; hN2; Notch homolog 2; Notch2; Notch-2; HJCYS	Human	HEK293
	NOTCH2 protein is a receptor for ligands such as JAG1, JAG2 and DLL1 and is critical for cell fate determination. Ligand activation promotes cleavage and releases NICD, which forms a transcription activator complex with RBPJ/RBPSUH, affecting cell differentiation, proliferation and apoptosis. NOTCH2 Protein, Human (HEK293, His) is the recombinant human-derived NOTCH2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NOTCH2 Protein, Human (HEK293, His) is 505 a.a., with molecular weight of 60-70 kDa.

HY-P77107

	NOTCH2NL Protein, Human (HEK293, Fc) Notch homolog 2 N-terminal-like protein A; Notch2NLA; N2N	Human	HEK293
	NOTCH2NL is a human-specific protein that promotes neural progenitor cell proliferation through Notch signaling regulation, thereby crucially driving the evolutionary expansion of the neocortex. By enhancing self-renewal and downregulating neuronal differentiation genes, NOTCH2NL delays progenitor cell maturation and promotes increased neuronal production. NOTCH2NL Protein, Human (HEK293, Fc) is the recombinant human-derived NOTCH2NL protein, expressed by HEK293 , with N-mFc labeled tag. The total length of NOTCH2NL Protein, Human (HEK293, Fc) is 236 a.a., with molecular weight of 55-75 KDa.

HY-P76519

	NOTCH2 Protein, Human (sf9, His) AGS2; hN2; Notch homolog 2; Notch2; Notch-2; HJCYS	Human	Sf9 insect cells
	NOTCH2 protein is a receptor for ligands such as JAG1, JAG2 and DLL1 and is critical for cell fate determination. Ligand activation promotes cleavage and releases NICD, which forms a transcription activator complex with RBPJ/RBPSUH, affecting cell differentiation, proliferation and apoptosis. NOTCH2 Protein, Human (sf9, His) is the recombinant human-derived NOTCH2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of NOTCH2 Protein, Human (sf9, His) is 530 a.a., with molecular weight of ~55.5 KDa.

HY-P78185

	NOTCH2 Protein, Human (Biotinylated, HEK293, His-Avi) AGS2; Notch-2; Notch2; N2ECD; HJCYS; N2	Human	HEK293
	NOTCH2 protein is a receptor for ligands such as JAG1, JAG2 and DLL1 and is critical for cell fate determination. Ligand activation promotes cleavage and releases NICD, which forms a transcription activator complex with RBPJ/RBPSUH, affecting cell differentiation, proliferation and apoptosis. NOTCH2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived NOTCH2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of NOTCH2 Protein, Human (Biotinylated, HEK293, His-Avi) is 505 a.a., with molecular weight of 70-80 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins