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Tomaralimab (OPN-305) is a humanised anti-TLR2 IgG4 monoclonal antibody. Tomaralimab has the potential for the research of Myelodysplastic Syndromes (MDS) .
OPN expression inhibitor 1 (Compound 11) is an osteopontin (OPN) expression inhibitor. OPN expression inhibitor 1 can be used for breast cancer research .
OPN3 Human Pre-designed siRNA Set A contains three designed siRNAs for OPN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
OPN4 Human Pre-designed siRNA Set A contains three designed siRNAs for OPN4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
OPN5 Human Pre-designed siRNA Set A contains three designed siRNAs for OPN5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
OPN1LW Human Pre-designed siRNA Set A contains three designed siRNAs for OPN1LW gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
OPN1MW Human Pre-designed siRNA Set A contains three designed siRNAs for OPN1MW gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
OPN1SW Human Pre-designed siRNA Set A contains three designed siRNAs for OPN1SW gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
5-Aminosalicylic acid-d3 disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer promotes the Wnt/β-catenin signaling pathway through abnormal O-glycosylation of CD44, thereby enhancing malignancy. N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 .
Tomaralimab (OPN-305) is a humanised anti-TLR2 IgG4 monoclonal antibody. Tomaralimab has the potential for the research of Myelodysplastic Syndromes (MDS) .
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
Osteopontin/OPN Protein, a vital member of the osteopontin family, plays a pivotal role in cell adhesion, immune response modulation, and tissue mineralization. Sharing conserved features within the family, Osteopontin's versatile nature contributes to both homeostatic and pathological conditions. Its study provides valuable insights into the broader understanding of the osteopontin family's roles in biological functions, offering potential therapeutic avenues and further exploration of intricate interactions within cellular pathways. Osteopontin/OPN Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Osteopontin/OPN protein, expressed by HEK293, with C-His labeled tag. The total length of Osteopontin/OPN Protein, Cynomolgus (HEK293, His) is 284 a.a., with molecular weight of 45-55 kDa.
Osteopontin/OPN Protein, a crucial non-collagenous bone protein, binds strongly to hydroxyapatite, integral to the mineralized matrix. It likely plays a vital role in mediating cell-extracellular matrix interactions. Moreover, as a cytokine, OPN efficiently induces interferon-gamma and interleukin-12 production while inhibiting interleukin-10, pivotal in promoting type I immunity. Osteopontin/OPN Protein, Mouse (HEK293, His) is the recombinant mouse-derived Osteopontin/OPN protein, expressed by HEK293 , with C-His labeled tag. The total length of Osteopontin/OPN Protein, Mouse (HEK293, His) is 278 a.a., with molecular weight of 50-60 kDa.
Osteopontin/OPN Protein, a key non-collagenous bone protein, strongly binds to hydroxyapatite, contributing to the mineralized matrix. Its significant role in cell-matrix interactions is evident. Acting as a cytokine, OPN promotes interferon-gamma and interleukin-12 production while suppressing interleukin-10, crucial for type I immunity. Osteopontin/OPN Protein, Human (HEK293, His) is the recombinant human-derived Osteopontin/OPN protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Osteopontin/OPN Protein, Human (HEK293, His) is 298 a.a., with molecular weight of 50-65 kDa.
OPN4 Protein, a photoreceptor with affinity for cis-retinaldehydes, crucially mediates light responses like the pupillary reflex and photoentrainment. Its multifaceted role includes potential participation in optokinetic visual tracking response. Moreover, OPN4 may regulate retinal hyaloid vessel growth, emphasizing its significance in intricate aspects of ocular physiology. OPN4 Protein, Rat (Cell-Free, His) is the recombinant rat-derived OPN4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of OPN4 Protein, Rat (Cell-Free, His) is 474 a.a., with molecular weight of 53.9 kDa.
OPN3 protein is a UV-sensitive G protein-coupled receptor that regulates melanogenesis in melanocytes by inhibiting α-MSH-induced cAMP signaling and regulating calcium flux following UVA light activation. OPN3 is critical for melanocyte survival, regulating intracellular calcium levels, affecting BCL2/RAF1 signaling and apoptosis through caspase cascade activation. OPN3 Protein, Human (Cell-Free, His) is the recombinant human-derived OPN3 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of OPN3 Protein, Human (Cell-Free, His) is 402 a.a., with molecular weight of 47.7 kDa.
OPN1LW protein, crucial for vision, is a vital element of visual pigments responsible for light absorption. The pigments consist of opsin, forming a covalent bond with cis-retinal. This molecular mechanism is indispensable for perceiving light stimuli in vision. OPN1LW Protein, Human (Cell-Free, His) is the recombinant human-derived OPN1LW protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of OPN1LW Protein, Human (Cell-Free, His) is 364 a.a., with molecular weight of 43.4 kDa.
OPN1MW protein, vital for vision, plays a crucial role in visual pigments, absorbing light and facilitating vision. These pigments consist of opsin, forming a covalent bond with cis-retinal. The OPN1MW protein, along with cis-retinal, contributes to the intricate molecular mechanism essential for perceiving light stimuli, enabling the visual process. OPN1MW Protein, Human (Cell-Free, His) is the recombinant human-derived OPN1MW protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of OPN1MW Protein, Human (Cell-Free, His) is 364 a.a., with molecular weight of 46.6 kDa.
Osteopontin/OPN Protein, a crucial non-collagenous bone protein, binds strongly to hydroxyapatite, integral to the mineralized matrix. It likely plays a vital role in mediating cell-extracellular matrix interactions. Moreover, as a cytokine, OPN efficiently induces interferon-gamma and interleukin-12 production while inhibiting interleukin-10, pivotal in promoting type I immunity. Osteopontin/OPN Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Osteopontin/OPN protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Osteopontin/OPN Protein, Mouse (P.pastoris, His) is 274 a.a., with molecular weight (glycosylation form) of ~60 kDa.
Osteopontin/OPN Protein, a key non-collagenous bone protein, strongly binds to hydroxyapatite, crucial for the mineralized matrix. It likely plays a vital role in mediating cell-extracellular matrix interactions. Additionally, as a cytokine, OPN stimulates interferon-gamma and interleukin-12 production, while inhibiting interleukin-10, pivotal for the type I immunity pathway. Osteopontin/OPN Protein, Rat (CHO, His) is the recombinant rat-derived Osteopontin/OPN protein, expressed by CHO , with C-6*His labeled tag. The total length of Osteopontin/OPN Protein, Rat (CHO, His) is 301 a.a., with molecular weight of approximately 34.83 kDa.
5-Aminosalicylic acid-d3 disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
SPP1; BNSP; OPN; PSEC0156; Osteopontin; Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin
WB, IHC-P, ELISA
Human, Mouse, Rat
Osteopontin Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 35 kDa, targeting to Osteopontin. It can be used for WB,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.
