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Pyk2

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By Targets:	Pyk2 (7) Apoptosis (1) FAK (6) IGF-1R (1) Insulin Receptor (1) Syk (2)
By Research Areas:	Cancer (7) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (1)

10

Inhibitors & Agonists

1

Peptides

1

Recombinant Proteins

2

Antibodies

Targets Recommended: Pyk2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-401485

Pyk2-IN-2

Pyk2 Cancer

Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2.

PF-4618433	Pyk2	Metabolic Disease
PF-4618433 is a potent and selective *PYK2* inhibitor, with an IC₅₀ of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration ^[2].

PF-562271 besylate Maximum Cited Publications 19 Publications Verification VS-6062 besylate	FAK Pyk2	Cancer
PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and *Pyk2* kinase, with an IC₅₀ of 1.5 nM and 13 nM, respectively .

Conteltinib CT-707	FAK	Cancer
Conteltinib (CT-707) is a multi-kinase inhibitor targeting FAK, ALK, and Pyk2. Conteltinib exerts significant inhibitory effect on FAK with an IC₅₀ of 1.6 nM .

PF-562271 Maximum Cited Publications 19 Publications Verification VS-6062	FAK Pyk2	Cancer
PF-562271 (VS-6062) is a potent, ATP-competitive and reversible FAK and *Pyk2* kinase inhibitor with IC₅₀s of 1.5 nM and 13 nM, respectively .

PF-562271 hydrochloride VS-6062(hydrochloride)	FAK Pyk2	Cancer
PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and *Pyk2* kinase inhibitor with IC₅₀s of 1.5 nM and 13 nM, respectively .

PF-431396 5+ Cited Publications	Pyk2 FAK	Cancer
PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC₅₀ values of 2 nM and 11 nM, respectively ^[2] .

PRT062607 P505-15; PRT-2607; BIIB-057	Syk	Inflammation/Immunology
PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.

NVP-TAE 226 5+ Cited Publications TAE226	FAK Pyk2 IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC₅₀s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits *Pyk2* and insulin receptor (InsR) with IC₅₀s of 3.5 nM and 44 nM, respectively ^[2].

Cevidoplenib SKI-O-703	Syk	Inflammation/Immunology
Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC₅₀s of 6.2 nM (Syk), 1.859 μM (Jak2), 5.807 μM (Jak3), 0.412 μM (RET), 0.687 μM (KOR), 1.783 μM (FLT3), 16.96 μM (FGFR1), 5.662 μM (FGFR3), and 0.709 μM (Pyk2), respectively ^[2] .

Cat. No.	Product Name	Target	Research Area

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

Cat. No.	Compare	Product Name	Species	Source

	PTK2B Protein, Human (sf9) PTK2B; PTK2B protein tyrosine kinase 2 beta; FAK2, protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; CADTK; CAKB; PTK; Pyk2; RAFTK; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; related adhesion focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; PKB; FAK2; FADK2	Human	Sf9 insect cells

Cat. No.	Product Name	Application	Reactivity

PYK2 Antibody (YA682) PTK2B; FAK2; Pyk2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P	Human
PYK2 Antibody (YA682) is a non-conjugated and Mouse origined monoclonal antibody about 116 kDa, targeting to PYK2 (4B4). It can be used for WB,IHC-P assays with tag free, in the background of Human.

PYK2 Antibody (YA115)	WB, ICC/IF, IHC-P	Human, Mouse
PYK2 Antibody (YA115) is a non-conjugated and Rabbit origined monoclonal antibody about 116 kDa, targeting to PYK2. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

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