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Results for "

SH3

" in MedChemExpress (MCE) Product Catalog:

32

Inhibitors & Agonists

2

Peptides

1

Natural
Products

12

Recombinant Proteins

6

Antibodies

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Cat. No. Compare Product Name Species Source
  • HY-P71572
    SH3PXD2A Protein, Human (Myc, His)

    Adapter protein TKS5; Five SH3 domain-containing protein; SH3 and PX domain-containing protein 2A; SH3 multiple domains protein 1; SH3md1; SH3pxd2a; SPD2A_HUMAN; TKs5; Tyrosine kinase substrate with five SH3 domains

    		 Human E. coli
    SH3PXD2A is an adapter protein that plays a crucial role in the formation of invadopodia and podosomes, thereby enhancing the invasiveness of cancer cells. It interacts with ADAM, NOX and phosphoinositides and contributes to a variety of cellular processes. SH3PXD2A Protein, Human (Myc, His) is the recombinant human-derived SH3PXD2A protein, expressed by E. coli , with N-His, C-Myc labeled tag. The total length of SH3PXD2A Protein, Human (Myc, His) is 85 a.a., with molecular weight of ~14.0 kDa.
  • HY-P701568
    SH3RF3 Protein, Human

    SH3RF3; E3 ubiquitin-protein ligase SH3RF3; Plenty of SH3s 2; SH3 domain-containing RING finger protein 3; SH3 multiple domains protein 4

    		 Human E. coli
    SH3RF3 protein is an E3 ubiquitin protein ligase that plays a key role in mediating the transfer of ubiquitin to target proteins, affecting protein degradation, cell signaling, and various biological processes. As an E3 ligase, SH3RF3 may promote ubiquitin-mediated proteasomal degradation of specific substrate proteins, thereby affecting their cellular levels and activity. SH3RF3 Protein, Human is the recombinant human-derived SH3RF3 protein, expressed by E. coli , with tag free. The total length of SH3RF3 Protein, Human is 881 a.a., .
  • HY-P701569
    SH3RF3 Protein, Human (His)

    SH3RF3; E3 ubiquitin-protein ligase SH3RF3; Plenty of SH3s 2; SH3 domain-containing RING finger protein 3; SH3 multiple domains protein 4

    		 Human E. coli
    SH3RF3 protein is an E3 ubiquitin protein ligase that plays a key role in mediating the transfer of ubiquitin to target proteins, affecting protein degradation, cell signaling, and various biological processes. As an E3 ligase, SH3RF3 may promote ubiquitin-mediated proteasomal degradation of specific substrate proteins, thereby affecting their cellular levels and activity. SH3RF3 Protein, Human (His) is the recombinant human-derived SH3RF3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SH3RF3 Protein, Human (His) is 881 a.a., .
  • HY-P701776
    SBK3 Protein, Human (Sf9, His, GST)

    SBK3; Uncharacterized serine/threonine-protein kinase SBK3; SH3-binding domain kinase family member 3; Sugen kinase 110

    		 Human Sf9 insect cells
  • HY-P77099
    NCKIPSD Protein, Human (His)

    NCK-interacting protein with SH3 domain; VIP54; WISH; AF3P21; SPIN90

    		 Human E. coli
    NCKIPSD Protein, vital for stress fiber formation induced by active DRF1, stimulates N-WASP-induced ARP2/3 complex activation, independent of CDC42. Implicated in sarcomere maintenance, myofibril assembly, actin polymerization, and angiogenesis. Associates with vimentin, desmin, NCK, GRB2, and interacts with Helicobacter pylori toxin vacA, FHOD1, FASLG, and TMIGD2, showcasing its diverse cellular interactions. NCKIPSD Protein, Human (His) is the recombinant human-derived NCKIPSD protein, expressed by E. coli, with N-His labeled tag. The total length of NCKIPSD Protein, Human (His) is 244 a.a., with molecular weight of ~33-45 kDa.
  • HY-P701458
    AMSH Protein, Human

    STAMBP; STAM-binding protein; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase

    		 Human E. coli
    AMSH is a zinc metalloprotease that selectively cleaves "Lys-63"-linked polyubiquitin chains, but not "Lys-48"-linked chains. It plays a critical regulatory role in signaling in IL-2 and GM-CSF mediated pathways, acting as a positive BMP signaling modulator against SMAD6 and SMAD7 inhibition. AMSH Protein, Human is the recombinant human-derived AMSH protein, expressed by E. coli , with tag free. The total length of AMSH Protein, Human is 423 a.a., .
  • HY-P76687
    UBASH3A Protein, Human (His)

    Ubiquitin-associated and SH3 domain-containing protein A; CLIP4; STS-2; TULA-1

    		 Human E. coli
    UBASH3A interferes with CBL-mediated downregulation and degradation of receptor-type tyrosine kinases and promotes the accumulation of activating receptors such as T cell receptors, EGFR and PDGFRB on the cell surface. It exhibits minimal protein tyrosine phosphatase activity and may act as a dominant negative regulator of UBASH3B-dependent dephosphorylation. UBASH3A Protein, Human (His) is the recombinant human-derived UBASH3A protein, expressed by E. coli , with N-His labeled tag.
  • HY-P701459
    AMSHLP Protein, Human (His)

    STAMBP; STAM-binding protein; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase

    		 Human E. coli
    AMSHLP is a zinc metalloprotease that selectively cleaves "Lys-63" linked polyubiquitin chains and acts as a positive regulator of the TORC1 signaling pathway. It specifically deubiquitinates SESN2, disrupts its interaction with the GATOR2 complex and inhibits SESN2-mediated regulation of TORC1. AMSHLP Protein, Human (His) is the recombinant human-derived AMSHLP protein, expressed by E. coli , with N-6*His labeled tag. The total length of AMSHLP Protein, Human (His) is 435 a.a., .
  • HY-P74484
    UBASH3B/STS1 Protein, Human (His)

    Ubiquitin-associated and SH3 domain-containing protein B; STS-1; TULA-2; UBASH3B

    		 Human E. coli
    UBASH3B/STS1 protein blocks CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases, leading to the accumulation of activating receptors such as T cell receptors and EGFR on the cell surface. It exhibits tyrosine phosphatase activity against substrates such as EGFR, FAK, SYK and ZAP70. UBASH3B/STS1 Protein, Human (His) is the recombinant human-derived UBASH3B/STS1 protein, expressed by E. coli , with N-His, N-6*His labeled tag. The total length of UBASH3B/STS1 Protein, Human (His) is 268 a.a., with molecular weight of ~30 kDa.
  • HY-P70304
    NCK1 Protein, Human (His)

    rHuCytoplasmic protein NCK1/NCK1, His; Cytoplasmic Protein NCK1; NCK adaptor Protein 1; Nck-1; SH2/SH3 Adaptor Protein NCK-Alpha; NCK1; NCK

    		 Human E. coli
    NCK1 protein is an adapter protein that binds to tyrosine phosphorylated receptors (KDR, PDGFRB) and cellular substrates and plays a key role in the dephosphorylation of EIF2S1 by PP1. It contributes to the efficient activation of DNA damage response effector (CHEK2) and ELK1-dependent transcriptional activation in Ras signaling. NCK1 Protein, Human (His) is the recombinant human-derived NCK1 protein, expressed by E. coli , with N-6*His labeled tag.
  • HY-P70396
    Grb2 Protein, Human (His)

    rHuGrowth factor receptor-bound protein 2/GRB2, His; Growth Factor Receptor-Bound Protein 2; Adapter Protein GRB2; Protein ASH; SH2/SH3 Adapter GRB2; GRB2; ASH

    		 Human E. coli
    Grb2, an adapter protein, crucially connects cell surface growth factor receptors to the Ras signaling pathway. Despite no direct binding to phosphorylated EGFR, Grb2 inhibits EGF-induced transactivation of a RAS-responsive element. It acts as a dominant negative relative to GRB2, suppressing proliferative signals and potentially initiating programmed cell death. Grb2 Protein, Human (His) is the recombinant human-derived Grb2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Grb2 Protein, Human (His) is 217 a.a., with molecular weight of 25-29 kDa.
  • HY-P70290
    Neutrophil cytosol factor 1 Protein, Human (His)

    rHuNeutrophil cytosol factor 1/NCF1, His; NCF-1; 47 kDa autosomal chronic granulomatous disease protein/47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2/SH3 and PX domain-containing protein 1A; p47-phox

    		 Human E. coli
    Neutrophil cytoplasmic factor 1 (NCF1) is essential for activation of the NADPH oxidase complex, which is essential for superoxide production. It cooperates with NCF2 to form a core association in the complex, interacting with NCF4, CYBB and CYBA. Neutrophil cytosol factor 1 Protein, Human (His) is the recombinant human-derived Neutrophil cytosol factor 1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Neutrophil cytosol factor 1 Protein, Human (His) is 390 a.a., with molecular weight of 45-50 kDa.

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