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STIM1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CRAC Channel (4) Interleukin Related (2) Myosin (2) Small Interfering RNA (siRNA) (1) TRP Channel (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Inflammation/Immunology (1) Neurological Disease (1)

8

Inhibitors & Agonists

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Zegocractin Maximum Cited Publications 9 Publications Verification CM-4620	CRAC Channel	Neurological Disease
Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC₅₀s of 119 nM and 895 nM for *Orai1/STIM1* and Orai2/STIM1 channels, respectively ^[1].

RO2959 monohydrochloride	CRAC Channel Interleukin Related	Cardiovascular Disease
RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 monohydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 monohydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways ^[1] .

STIM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STIM1 Human Pre-designed siRNA Set A contains three designed siRNAs for STIM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STIM1 Human Pre-designed siRNA Set A STIM1 Human Pre-designed siRNA Set A

GSK-5503A	CRAC Channel	Inflammation/Immunology
GSK-5503A is a calcium-release activated calcium (CRAC) channel blocker. GSK-5503A effectively inhibits stromal interaction molecule 1 (STIM1) mediated Orai1 and Orai3 currents in vitro. GSK-5503A can be used for the research of asthma and allergic disorders ^[1].

RO2959 hydrochloride	CRAC Channel Interleukin Related	Cardiovascular Disease
RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways ^[1] .

ML-9 2 Publications Verification	Myosin	Cancer
ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity . ML-9 inhibits inhibits MLCK, PKA and PKC activity with K_i values of 4, 32 and 54 μM, respectively ^[1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation .

ML-9 Free Base	Myosin	Cancer
ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity . ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with K_i values of 4, 32 and 54 μM, respectively ^[1]. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation .

Pyr10 3 Publications Verification	TRP Channel	Others
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca ²⁺ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC₅₀ of 0.72 μM (IC₅₀ of 13.08 μM for store operated Ca ²⁺ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels ^[1].

Cat. No.	Compare	Product Name	Species	Source

	STIM1 Protein, Human (HEK293, His) Stromal interaction molecule 1; STIM1; GOK	Human	HEK293
	STIM1 (stromal interacting molecule 1) coordinates store-operated Ca(2+) entry (SOCE) and acts as a Ca(2+) sensor in the endoplasmic reticulum. Upon Ca(2+) depletion, STIM1 translocates to the plasma membrane and activates the Ca(2+)-releasing activated Ca(2+) (CRAC) channel subunit ORAI1. STIM1 Protein, Human (HEK293, His) is the recombinant human-derived STIM1 protein, expressed by HEK293 , with C-His labeled tag. The total length of STIM1 Protein, Human (HEK293, His) is 191 a.a., with molecular weight of 27-34 kDa.

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