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Results for "

Type II

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5 alpha Reductase (5) Adenylate Cyclase (1) Akt (3) AMPK (4) Amylases (2) Amylin Receptor (1) Androgen Receptor (1) Angiotensin Receptor (49) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (13) AP-1 (3) Apelin Receptor (APJ) (2) Apoptosis (33) Arrestin (3) Autophagy (17) Bacterial (19) Bcr-Abl (7) Biochemical Assay Reagents (9) BMX Kinase (1) c-Fms (3) c-Kit (3) c-Met/HGFR (1) Calcium Channel (4) CaMK (3) Carbonic Anhydrase (1) Caspase (3) CD20 (1) CDK (3) CRFR (3) Dipeptidyl Peptidase (1) Discoidin Domain Receptor (1) DNA/RNA Synthesis (2) Drug Metabolite (1) Endogenous Metabolite (7) FGFR (1) FLT3 (3) Fluorescent Dye (1) Free Fatty Acid Receptor (5) Fungal (1) GLP Receptor (3) Glucosidase (5) GnRH Receptor (2) HBV (1) HCV (1) HIV (1) HSV (1) Interleukin Related (2) IRAK (1) Isotope-Labeled Compounds (12) JAK (2) JNK (3) Ligands for Target Protein for PROTAC (2) Liposome (1) Lipoxygenase (1) LRRK2 (1) MAGL (1) MEK (3) mGluR (1) Mitochondrial Metabolism (2) MMP (4) nAChR (2) Neprilysin (2) NF-κB (3) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (2) p97 (1) PACAP Receptor (4) Parasite (4) PDGFR (4) Phosphatase (1) Phosphodiesterase (PDE) (1) PI3K (3) PKA (1) PKC (2) Potassium Channel (1) PPAR (3) Prostaglandin Receptor (1) Raf (2) Ras (1) Reactive Oxygen Species (9) RET (1) RIP kinase (3) SARS-CoV (1) Ser/Thr Protease (2) SGLT (1) Sodium Channel (4) Src (1) Stearoyl-CoA Desaturase (SCD) (1) TAM Receptor (1) TGF-beta/Smad (1) TGF-β Receptor (6) Topoisomerase (17) Trk Receptor (5) TrxR (1) VEGFR (2) Xanthine Oxidase (1)
By Research Areas:	Cancer (74) Cardiovascular Disease (44) Endocrinology (36) Infection (28) Inflammation/Immunology (28) Metabolic Disease (56) Neurological Disease (27)
Click Chemistry:	Alkynes (1)

223

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Photosystem II PCSK9 CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70005B

*Collagenase, Type* II** 1 Publications Verification	MMP	Others
Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-150044

Type II topoisomerase inhibitor 1	DNA/RNA Synthesis Topoisomerase Bacterial	Infection
Type II topoisomerase inhibitor 1 is a potent and selective E. coli DNA gyrase inhibitor (IC₅₀: 1.7 nM), and forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity (IC₅₀: 0.98 μM). Type II topoisomerase inhibitor 1 can be used in the research of antibacterial area .

HY-163004

Type II TRK inhibitor 2	Trk Receptor	Cancer
Type II TRK inhibitor 2 (compound 40l) is a selective type II TRK inhibitor with plasma stability and moderate hepatic microsomal stability. Type II TRK inhibitor 2 significantly inhibits Km-12, Ba/F3-TRKA ^G595R and Ba/F3-TRKA ^G667C cell proliferation (IC₅₀: 4.1 nM, 41.5 nM, 1.4 nM). Type II TRK inhibitor 2 can be used to study NTRK fusion cancers .

HY-146807

Type II TRK inhibitor 1	Trk Receptor	Cancer
Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKA ^G667C and ETV6-TRKC ^G696C fusion proteins with IC₅₀s of 6 nM and 1.7 nM, respectively . Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P5003

*Collagen Type* II Fragment**	MMP	Inflammation/Immunology
Collagen Type II Fragment is an anti-inflammatory peptide that potently inhibits collagen-induced arthritis (CIA) in mice. Collagen Type II Fragment can be used for research on inflammation and immunity .

HY-NP102

*Highly purified Type* II collagen, from bovine articular cartilage** Bovine Type II collagen, immunization grade	Biochemical Assay Reagents	Inflammation/Immunology
Highly purified Type II collagen, from bovine articular cartilage (Bovine Type II collagen, immunization grade), an immunization grade, is the major matrix protein in cartilage that can be used for the study of arthritis .

HY-114632

Oxeglitazar

Others Metabolic Disease

Oxeglitazar is an orally active compound that can be used for the research of type II diabetes .

Oxeglitazar	Others	Metabolic Disease
Oxeglitazar is an orally active compound that can be used for the research of type II diabetes .

HY-A0104J

*HPMC (Type* II,Viscosity:5mPa.s)** Hypromellose (Type II,Viscosity:5mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:5mPa.s); Celacol HPM 5000 (Type II,Viscosity:5mPa.s)	Biochemical Assay Reagents	Others
HPMC (Hypromellose) (Type II,Viscosity:5mPa.s) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices. HPMC (Type II,Viscosity:5mPa.s) is widely used in agent formulations due to its biocompatibility, uncharged nature, solubility in water and thermoplastic behavior .

HY-A0104I

*HPMC (Type* II,Viscosity:100000mPa.s)** Hypromellose (Type II,Viscosity:100000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:100000mPa.s); Celacol HPM 5000 (Type II,Viscosity:100000mPa.s)	Biochemical Assay Reagents	Others
Hydroxypropylmethylcellulose (Type II,Viscosity:100000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104E

*HPMC (Type* II,Viscosity:100mPa.s)** Hypromellose (Type II,Viscosity:100mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:100mPa.s); Celacol HPM 5000 (Type II,Viscosity:100mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:100mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104H

*HPMC (Type* II,Viscosity:15000mPa.s)** Hypromellose (Type II,Viscosity:15000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:15000mPa.s); Celacol HPM 5000 (Type II,Viscosity:15000mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:15000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104F

*HPMC (Type* II,Viscosity:400mPa.s)** Hypromellose (Type II,Viscosity:400mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:400mPa.s); Celacol HPM 5000 (Type II,Viscosity:400mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:400mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104G

*HPMC (Type* II,Viscosity:4000mPa.s)** Hypromellose (Type II,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:4000mPa.s); Celacol HPM 5000 (Type II,Viscosity:4000mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:4000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P9910

Obinutuzumab GA101; Anti-Human CD20 Type II, Humanized Antibody	CD20	Cancer
Obinutuzumab (GA101) a novel glycoengineered Type II CD20 humanized IgG1 monoclonal antibody in development for non-Hodgkin lymphoma.

HY-161057

HG-7-86-01

Bcr-Abl Inflammation/Immunology Cancer

HG-7-86-01 (Compound 26) is type II tyrosine kinase inhibitor. HG-7-86-01 has anti-proliferative activity .
HY-105010

FK-739 free base

Angiotensin Receptor Cardiovascular Disease

FK-739 (free base) is an angiotensin II type 1 (AT1) receptor antagonist used in the study of hypertension .

HG-7-86-01	Bcr-Abl	Inflammation/Immunology Cancer
HG-7-86-01 (Compound 26) is type II tyrosine kinase inhibitor. HG-7-86-01 has anti-proliferative activity .

FK-739 free base	Angiotensin Receptor	Cardiovascular Disease
FK-739 (free base) is an angiotensin II type 1 (AT1) receptor antagonist used in the study of hypertension .

HY-162042

AMPK activator 14	AMPK	Metabolic Disease
AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes .

HY-145985

CBR-3465

Bacterial Infection

CBR-3465 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.16 μM against Mtb .
HY-145986

CBR-6672

Bacterial Infection

CBR-6672 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.14 μM against Mtb .

CBR-3465	Bacterial	Infection
CBR-3465 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.16 μM against Mtb .

CBR-6672	Bacterial	Infection
CBR-6672 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.14 μM against Mtb .

HY-13635

Finasteride 4 Publications Verification MK-906	5 alpha Reductase	Cancer
Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-13635A

Finasteride acetate MK-906 acetate	5 alpha Reductase	Cancer
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-P3674

LH-RH (7-10)	GnRH Receptor	Endocrinology
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes .

HY-108196

PTP1B-IN-15	Phosphatase	Endocrinology
PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity .

HY-112603

AP5	Free Fatty Acid Receptor	Metabolic Disease
AP5 is a potent, orlly active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 demonstrates rat and human inositol monophosphate (IP1) EC₅₀ values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 has the potential for type II diabetes research .

HY-112603A

AP5 sodium	Free Fatty Acid Receptor	Metabolic Disease
AP5 sodium is a potent, orall active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 sodium demonstrates rat and human inositol monophosphate (IP1) EC₅₀ values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 sodium has the potential for type II diabetes research .

HY-14810

Atigliflozin AVE-2268	SGLT	Metabolic Disease
Atigliflozin (AVE-2268) is an orally active and selective SGLT-2 inhibitor, with IC₅₀s of 10 nM and 8.2 μM for hSGLT-2 and hSGLT-1) respectively. Atigliflozin can lower the blood glucose and improve the impaired oral glucose tolerance. Atigliflozin can be used for research of type II diabetes mellitus .

HY-16619

AM-5262

Free Fatty Acid Receptor Metabolic Disease

AM-5262 is a GPR40 full agonist with an EC₅₀ value of 0.081 μM. AM-5262 can be used for the research of type II diabetes .

AM-5262	Free Fatty Acid Receptor	Metabolic Disease
AM-5262 is a GPR40 full agonist with an EC₅₀ value of 0.081 μM. AM-5262 can be used for the research of type II diabetes .

HY-P2501

Amylin (8-37), human	Amylin Receptor	Metabolic Disease
Amylin (8-37), human is a fragment of human Amylin. Amylin (8-37), human has direct vasodilator effects in the isolated mesenteric resistance artery of the rat. Human Amylin is a small hormone secreted by pancreatic β-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus .

HY-147964

α-Glucosidase-IN-9	Glucosidase	Metabolic Disease
α-Glucosidase-IN-9 (compound 7) is a potent α-glucosidase inhibitor, with an IC₅₀ of 55.6 μM. α-Glucosidase-IN-9 can be used for type II diabetes research .

HY-147965

α-Glucosidase-IN-10	Glucosidase	Metabolic Disease
α-Glucosidase-IN-10 (compound 13) is a potent α-glucosidase inhibitor, with an IC₅₀ of 92.7 μM. α-Glucosidase-IN-10 can be used for type II diabetes research .

HY-148072

MM3122	SARS-CoV	Infection
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC₅₀ value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .

HY-109500

Masoprocol meso-Nordihydroguaiaretic acid; meso-NDGA	Lipoxygenase	Metabolic Disease
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes .

HY-114564

Satigrel E5510	Prostaglandin Receptor	Cardiovascular Disease
Satigrel (E5510) is a potent inhibitor of platelet aggregation. Satigrel inhibits collagen- and arachidonic acid-induced platelet aggregation through preventing thromboxane A2 synthesis by selective inhibition of the target enzyme, PGHS1, which exists in platelets. Satigrel inhibits PGHS1 (IC₅₀: 0.081 μM) and PGHS2 (IC₅₀: 5.9 μM). Satigrel is against Type III PDE, Type V and Type II (IC₅₀: 15.7 μM, 39.8 μM and 62.4 μM, respectively) .

HY-103195

NKY80 1 Publications Verification	Adenylate Cyclase	Metabolic Disease
NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC₅₀s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues .

HY-120160A

Darglitazone Sodium CP 86325 Sodium	PPAR	Neurological Disease Metabolic Disease
Darglitazone Sodium, a thiazolidinedione, is an orally active, potent, and selective PPAR-γ (peroxisome proliferator-activated receptor) agonist. Darglitazone Sodium is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research .

HY-128348

PK68	RIP kinase	Inflammation/Immunology Cancer
PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC₅₀ of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis .

HY-161118

MB327	Others	Neurological Disease
MB327 is a bipyridine nonoxime compound that restores neuromuscular function. MB327 restores the activity of nicotinamide acetylcholine receptors (nAChRs) for carbachol desensitization in a typical type II PAM manner. MB327 can neutralize nerve agent poisoning .

HY-18555

TMPA 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A AMPK	Metabolic Disease Inflammation/Immunology Cancer
TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPKα. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation .

HY-153335

Enpp-1-IN-16	Phosphodiesterase (PDE)	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Enpp-1-IN-16 (compound 54) is an ENPP1 inhibitor. Enpp-1-IN-16 has the potential to study cancer, especially in cases of high ENPP1 expression or elevated cytoplasmic DNA levels. Enpp-1-IN-16 can also be used in other diseases mediated by ENPP1, such as bacterial or viral infections, insulin resistance and type II diabetes, chondrocalcinosis and osteoarthritis, calcium pyrophosphate deposition disorder (CPPD), low Phosphatase disease and soft tissue calcification disorders .

HY-10326

GW788388 10+ Cited Publications	TGF-β Receptor	Cancer
GW788388 is a potent and selective inhibitor of ALK5 with IC₅₀ of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor.

HY-161398

TGFβRII-IN-3	TGF-β Receptor TGF-beta/Smad	Cancer
TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the *TGFβ type* II receptor (TGFβ RII)** (IC₅₀ = 4.1 μM). TGFβRII-IN-3 inhibits TGFβ signaling by promoting the proteolytic degradation of TGFβ RII. TGFβRII-IN-3 can block endothelial-to-mesenchymal transition and cell migration. TGFβRII-IN-3 can be used in cancer research .

HY-B0202

Irbesartan 5 Publications Verification SR-47436; BMS-186295	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology
Irbesartan (SR-47436) is an orally active *Ang II type* 1 (AT1) receptor blocker (ARB)**. Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-W011303

Phytosphingosine 1 Publications Verification 4-Hydroxysphinganine	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology Cancer
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-B0202A

Irbesartan hydrochloride SR-47436 hydrochloride; BMS-186295 hydrochloride	Angiotensin Receptor Apoptosis	Neurological Disease Metabolic Disease
Irbesartan (SR-47436) hydrochloride is an orally active *Ang II type* 1 (AT1) receptor blocker (ARB)**. Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-153530

LI-2242	Others	Neurological Disease Metabolic Disease
LI-2242 is an inositol hexakisphosphate kinase (IP6K) inhibitor. LI-2242 has inhibition effect for IP6K1, IP6K2, IP6K3 and IPMK with IC₅₀ values of 31 nM, 42 nM, 8.7 nM and 1944 nM, respectively. LI-2242 can be used for thew research of type II diabetes, obesity, metabolic complications, venous thrombosis, and psychiatric disorders .

HY-P0220

PACAP (6-38), human, ovine, rat	PACAP Receptor	Neurological Disease
PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC₅₀s of 30, 600, and 40 nM for *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂**, respectively.

HY-P0220A

PACAP (6-38), human, ovine, rat TFA 1 Publications Verification	PACAP Receptor	Neurological Disease
PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC₅₀s of 30, 600, and 40 nM for *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂**, respectively.

HY-B0202S3

Irbesartan-d7 SR-47436-d₇; BMS-186295-d₇	Apoptosis Angiotensin Receptor Isotope-Labeled Compounds	Cardiovascular Disease Endocrinology
Irbesartan-d₇ is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active *Ang II type* 1 (AT1) receptor blocker (ARB)**. Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0202AS

Irbesartan-d7 hydrochloride SR-47436-d₇ hydrochloride; BMS-186295-d₇ hydrochloride	Apoptosis Angiotensin Receptor Isotope-Labeled Compounds	Neurological Disease Metabolic Disease
Irbesartan-d₇ hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active *Ang II type* 1 (AT1) receptor blocker (ARB)**. Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-P0221

PACAP (1-38), human, ovine, rat 3 Publications Verification Pituitary Adenylate Cyclase Activating Polypeptide 38	PACAP Receptor	Neurological Disease
PACAP (1-38), human, ovine, rat is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀**s of 4 nM, 2 nM, and 1 nM, respectively.

Cat. No.	Product Name

HY-L040

Anti-diabetic Compound Library

748 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 748 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

HY-L018

TGF-beta/Smad Compound Library

226 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 226 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-NP003

*Collagen, Type* II, from bovine snout membrane** Collagen, Type II, substrate for collagenase	Native Proteins
Collagen, Type II, from bovine snout membrane is a protein used to treat osteoarthritis. Type II collagen shows significant efficacy in improving the pain and inflammation of collagen induced arthritis in mice .

HY-NP102

*Highly purified Type* II collagen, from bovine articular cartilage** Bovine Type II collagen, immunization grade	Native Proteins
Highly purified Type II collagen, from bovine articular cartilage (Bovine Type II collagen, immunization grade), an immunization grade, is the major matrix protein in cartilage that can be used for the study of arthritis .

HY-A0104I

*HPMC (Type* II,Viscosity:100000mPa.s)** Hypromellose (Type II,Viscosity:100000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:100000mPa.s); Celacol HPM 5000 (Type II,Viscosity:100000mPa.s)	Biochemical Assay Reagents
Hydroxypropylmethylcellulose (Type II,Viscosity:100000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104E

*HPMC (Type* II,Viscosity:100mPa.s)** Hypromellose (Type II,Viscosity:100mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:100mPa.s); Celacol HPM 5000 (Type II,Viscosity:100mPa.s)	Biochemical Assay Reagents
Hypromellose (Type II,Viscosity:100mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104H

*HPMC (Type* II,Viscosity:15000mPa.s)** Hypromellose (Type II,Viscosity:15000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:15000mPa.s); Celacol HPM 5000 (Type II,Viscosity:15000mPa.s)	Biochemical Assay Reagents
Hypromellose (Type II,Viscosity:15000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104F

*HPMC (Type* II,Viscosity:400mPa.s)** Hypromellose (Type II,Viscosity:400mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:400mPa.s); Celacol HPM 5000 (Type II,Viscosity:400mPa.s)	Biochemical Assay Reagents
Hypromellose (Type II,Viscosity:400mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104G

*HPMC (Type* II,Viscosity:4000mPa.s)** Hypromellose (Type II,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:4000mPa.s); Celacol HPM 5000 (Type II,Viscosity:4000mPa.s)	Biochemical Assay Reagents
Hypromellose (Type II,Viscosity:4000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-125857

Cytochrome C	Biochemical Assay Reagents
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis .

HY-W250316

Alpha-d-Glucopyranoside, beta-d-fructofuranosyl, octadecanoate Sucrose Stearate, Type II, USP	Biochemical Assay Reagents
Alpha-d-Glucopyranoside, beta-d-fructofuranosyl, octadecanoate is a carbohydrate.

HY-E70144

N-Acetylglucosaminyltransferase 1 EC:2.4.1.101; MGAT1	Enzyme Substrates
N-Acetylglucosaminyltransferase1 (EC:2.4.1.101, MGAT1) shows typical features of a type II transmembrane protein. N-Acetylglucosaminyltransferase1 is believed to be essential for normal embryogenesis .

HY-P2990

Enteropeptidase TMPRSS15	Biochemical Assay Reagents
Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .

HY-112764

DMG-PEG 2000 4 Publications Verification	Drug Delivery
DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .

Cat. No.	Product Name	Target	Research Area

HY-P5003

*Collagen Type* II Fragment**	MMP	Inflammation/Immunology
Collagen Type II Fragment is an anti-inflammatory peptide that potently inhibits collagen-induced arthritis (CIA) in mice. Collagen Type II Fragment can be used for research on inflammation and immunity .

HY-P3674

LH-RH (7-10)	GnRH Receptor	Endocrinology
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes .

HY-P2501

Amylin (8-37), human	Amylin Receptor	Metabolic Disease
Amylin (8-37), human is a fragment of human Amylin. Amylin (8-37), human has direct vasodilator effects in the isolated mesenteric resistance artery of the rat. Human Amylin is a small hormone secreted by pancreatic β-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus .

HY-P4767

Amylin (1-13) (human)	Peptides	Metabolic Disease
Amylin (1-13) (human) is a fragment and a residues within amyloid cores of Amylin (human IAPP). Amylin is a glucose-regulating hormone, deposits as amyloid fibrils in condition of type II diabetes (T2D). Amylin (1-13) (human) has no effect on firbl formation, as it cannot form fibrils by itself .

HY-P0220

PACAP (6-38), human, ovine, rat	PACAP Receptor	Neurological Disease
PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC₅₀s of 30, 600, and 40 nM for *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂**, respectively.

HY-P0220A

PACAP (6-38), human, ovine, rat TFA 1 Publications Verification	PACAP Receptor	Neurological Disease
PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC₅₀s of 30, 600, and 40 nM for *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂**, respectively.

HY-P0221

PACAP (1-38), human, ovine, rat 3 Publications Verification Pituitary Adenylate Cyclase Activating Polypeptide 38	PACAP Receptor	Neurological Disease
PACAP (1-38), human, ovine, rat is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀**s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P0221A

PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA	PACAP Receptor	Neurological Disease
PACAP (1-38), human, ovine, rat TFA is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀**s of 4 nM, 2 nM, and 1 nM, respectively.

HY-13948

Angiotensin II human Maximum Cited Publications 99 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-13948A

Angiotensin II human acetate Maximum Cited Publications 99 Publications Verification Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-13948B

Angiotensin II human TFA Maximum Cited Publications 99 Publications Verification Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1752

Urocortin II, human	CRFR	Metabolic Disease Endocrinology
Urocortin II (human) is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .

HY-P1752A

Urocortin II, human TFA	CRFR	Metabolic Disease Endocrinology
Urocortin II, human (TFA) is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P2847

Urocortin II, mouse	CRFR	Metabolic Disease Endocrinology
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca ²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow .

HY-P10312

SPN009

GLP Receptor Metabolic Disease

SPN009 (Sequence 3) is a GLP-1 Receptor agonist, with EC₅₀ of 2.84 nM. SPN009 attenuates the type II diabetes in DB/DB mice models .

HY-P4685

(Sar1,Ile4,8)-Angiotensin II	Angiotensin Receptor	Metabolic Disease
(Sar1,Ile4,8)-Angiotensin II is a functionally selective *angiotensin II type* 1 receptor (AT1R)** agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β .

HY-P2507

NY-ESO-1 (87-111)	Peptides	Cancer
NY-ESO-1 (87-111) is a pan-MHC class II-restricted peptide sequence. NY-ESO-1 (87-111) binds to multiple HLA-DR and HLA-DP4 molecules, and stimulates Th1-type and Th-2/Th0-type CD4 ⁺ T cells when presented in the context of HLA-DR and HLA-DP4 molecules .

HY-P3136

TRV055	Angiotensin Receptor	Cardiovascular Disease
TRV055, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling .

HY-P3136A

TRV055 hydrochloride	Angiotensin Receptor	Cardiovascular Disease
TRV055 hydrochloride, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 hydrochloride is efficacious in stimulating cellular Gq-mediated signaling .

HY-P3675

LH-RH (4-10)	GnRH Receptor	Endocrinology
LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes .

HY-P2990

Enteropeptidase TMPRSS15	Ser/Thr Protease	Metabolic Disease
Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .

HY-P3137

TRV056	Angiotensin Receptor	Cardiovascular Disease
TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists .

HY-P1745

InsB (9-23) Insulin B chain (9-23)	Peptides	Inflammation/Immunology
InsB (9-23) is an insulin B-chain peptide that binds to a class II histocompatibility complex (MHC) allele called I-Ag7. InsB (9-23) can be used to treat a number of autoimmune related diseases like Type 1 diabetes .

HY-P10269

GZR18	GLP Receptor	Metabolic Disease
GZR18 is an analog of glucagon-like peptide-1 (GLP-1), which exhibits agonistic activity for GLP-1 receptor, with an EC₅₀ of 0.677 nM. GZR18 ameliorates type 2 diabetes .

HY-P2525

GAD65 (206-220)	Peptides	Inflammation/Immunology
GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus .

HY-P5839

α-Conotoxin MrIC	nAChR	Neurological Disease
α-Conotoxin MrIC is an α7nAChR biased agonist. α-Conotoxin MrIC exclusively activates α7nAChR regulated by type II positive allosteric modulators, including PNU120596. α-Conotoxin MrIC can be used to study neurological diseases and also to probe the pharmacological properties of α7nAChR .

HY-P1110

AF12198 1 Publications Verification	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo .

HY-P1944A

Apelin-13 TFA 5 Publications Verification	Apelin Receptor (APJ)	Cardiovascular Disease Metabolic Disease
Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC₅₀ value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

HY-P1944

Apelin-13	Apelin Receptor (APJ)	Cardiovascular Disease Metabolic Disease
Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC₅₀ value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome .

HY-P2141A

TRV-120027 TFA 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027 TFA, a β-arrestin-1-biased agonist of *the angiotensin II receptor type* 1 (AT1R)**, engages ß-arrestins while blocking G-protein signaling . TRV120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the acute decompensated heart failure (ADHF) treatment .

HY-P2141

TRV-120027 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027, a β-arrestin-1-biased agonist of *the angiotensin II receptor type* 1 (AT1R)**, engages ß-arrestins while blocking G-protein signaling . TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment .

HY-P2200

Siamycin I BMY-29304	HIV Antibiotic	Infection Inflammation/Immunology
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED₅₀s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research .

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology Cancer
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-109500

Masoprocol meso-Nordihydroguaiaretic acid; meso-NDGA	other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Lipoxygenase
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes .

HY-W011303

Phytosphingosine 1 Publications Verification 4-Hydroxysphinganine	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-13948

Angiotensin II human Maximum Cited Publications 99 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Angiotensin Receptor Apoptosis
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-N7542

Praeroside II	Natural Products Chrysanthemum × morifolium (Ramat.) Hemsl. Plants Umbelliferae	Others
Praeroside II is an *angular-type* pyranocoumarm glycoside*. Praeroside II can be isolated from the n-butanol-extracts of P. praeruptorum Dunn*. Praeroside II can be used for pharmacological study .

HY-113767

Momordin II	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	Others
Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity .

HY-N0891

Tubeimoside II Tubeimoside-B	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Tubeimoside II (Tubeimoside-B) is a natural analogue of oleanane type of triterpenoid saponin; show anti-inflammatory, antitumor, and antitumor-promoting effects.

HY-N2589

Isosaponarin	Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae	TGF-β Receptor
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin increases collagen synthesis, caused by up-regulated *TGF-β type* II receptor (TβR-II) and prolyl 4-hydroxylase (P4H)** proteins production .

HY-N3269

Methyl p-hydroxyphenyllactate	Monophenols Classification of Application Fields Labiatae Source classification Other Diseases Phenols Peucephyllum schottii A.Gray Plants Disease Research Fields	Others
Methyl p-hydroxyphenyllactate (MeHPLA) is an important cell growth-regulating agent which binds to nuclear type II binding sites in normal and malignant cells .

HY-B0199A

Mycophenolate mofetil hydrochloride RS 61443 hydrochloride; TM-MMF hydrochloride	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Bacterial
Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-N12191

Cangorinine E-1	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Celastraceae Plants Tripterygium wilfordii Hook. f.	HSV
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) .

HY-131577

Neutral protease, Paenibacillus polymyxa Dispase II, Dispase	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum .

HY-42680

D-Tagatose D-(-)-Tagatose	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Sweeteners Saccharides Monosaccharides Food Research	Endogenous Metabolite
D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice, and beverages. D-Tagatose is also a potential antidiabetic agent for the research of type II diabetes and a prebiotic to help elevate beneficial bacteria in the colon, prevent colon cancer, and lower cholesterol .

HY-N6732

K-252a 10+ Cited Publications SF2370; Antibiotic K 252a; Antibiotic SF 2370	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Indole Alkaloids	PKC PKA CaMK Trk Receptor Autophagy Antibiotic
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

HY-W011303A

(Rac)-Phytosphingosine (Rac)-4-Hydroxysphinganine	Structural Classification Natural Products other families Source classification Plants	Others
(Rac)-Phytosphingosine ((Rac)-4-Hydroxysphinganine) is the racemate of Phytosphingosine (HY-W011303). Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-N0716

Berberine Natural Yellow 18	Structural Classification Classification of Application Fields Anti-aging Ranunculaceae Source classification Plants Endogenous metabolite Biological Pesticide Research Agricultural Research Alkaloids Coptis chinensis Franch. Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Cancer	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-N0716B

Berberine sulfate 35+ Cited Publications Natural Yellow 18 sulfate	Alkaloids Structural Classification Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

Species:	Human (31) Virus (1) Rhesus Macaque (5) Mouse (7) Rat (1) Cynomolgus (3)
Tag:	His (28) SUMO (3) Tag Free (6) Avi (2) Myc (1) GST (5) Fc (14)
Source:	HEK293 (28) E. coli Cell-free (2) CHO (1) Sf9 insect cells (2) Sf9 insect cells (7) E. coli (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P702298

	GNRHR2 Protein, Rhesus Macaque (Cell-Free, His) Gonadotropin-releasing hormone II receptor; Type II GnRH receptor	Rhesus Macaque	E. coli Cell-free
	The GNRHR2 Protein serves as a receptor for gonadotropin-releasing hormone II (GnRH II), initiating its action through association with G proteins that activate a phosphatidylinositol-calcium second messenger system. GNRHR2 Protein, Rhesus Macaque (Cell-Free, His) is the recombinant Rhesus Macaque-derived GNRHR2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of GNRHR2 Protein, Rhesus Macaque (Cell-Free, His) is 379 a.a., with molecular weight of 44.3 kDa.

HY-P72090

	Arginase-2/ARG2 Protein, Mouse (His-SUMO) Arg2Arginase-2; mitochondrial; EC 3.5.3.1; Arginase II; Kidney-Type arginase; Non-hepatic arginase; Type II arginase	Mouse	E. coli
	Arginase-2 (ARG2) is a multifunctional regulator central to the regulation of arginine metabolism and nitric oxide synthesis outside the urea cycle. In addition to its hepatic effects, ARG2 affects innate and adaptive immune responses, negatively affecting the survival of activated CD4(+) and CD8(+) T cells. Arginase-2/ARG2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Arginase-2/ARG2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Arginase-2/ARG2 Protein, Mouse (His-SUMO) is 332 a.a., with molecular weight of ~52.4 kDa.

HY-P72052

	KRT8 Protein, Human (Baculovirus, His-Myc) CARD2; CK 8; CK-8; CK8; CYK8; CYKER; Cytokeratin endo A; Cytokeratin-8; DreK8; EndoA; K2C8; K2C8_HUMAN; K8; Keratin 8; Keratin Type II cytoskeletal 8 ; Keratin; Type II cytoskeletal 8; Keratin-8; KO; Krt 2.8; KRT8; MGC118110; MGC174782; MGC53564; MGC85764; sb:cb186; Type-II keratin Kb8	Human	Sf9 insect cells
	The KRT8 protein, in cooperation with KRT19, critically links the contractile apparatus of the striated rib muscle to dystrophin. This heterotetramer consists of two type I keratins and two type II keratins, forming a heterodimer with KRT18. KRT8 Protein, Human (Baculovirus, His-Myc) is the recombinant human-derived KRT8 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag.

HY-P70483

	IFNAR1 Protein, Human (HEK293, His) Interferon Alpha/Beta Receptor 1; IFN-R-1; IFN-Alpha/Beta Receptor 1; Cytokine Receptor Class-II Member 1; Cytokine Receptor Family 2 Member 1; CRF2-1; Type I Interferon Receptor 1; IFNAR1; IFNAR	Human	HEK293
	IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2). Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2. IFNAR1 Protein, Human (HEK293, His) is a recombinant human IFNAR1 (K28-K436) with C-terminal 6*His tag, which is produced in HEK293 cells.

HY-P702180

NADH dehydrogenase Protein type II, Gluconobacter oxydans

GOX1675; NADH dehydrogenase Type II
Others E. coli

HY-P70228

	*Kanamycin kinase type* II/NEO protein, Klebsiella pneumoniae** rKlAminoglycoside 3'-phosphotransferase; Aminoglycoside 3'-phosphotransferase; APH(3')-II; APH(3')II; Kanamycin kinase Type II; Neomycin-kanamycin phosphotransferase Type II; neo	Others	E. coli
	The Kanamycin kinase type II/NEO protein imparts resistance to aminoglycoside antibiotics, including kanamycin, neomycin, paromomycin, ribostamycin, butirosin, and gentamicin B. It counteracts their inhibitory effects, showcasing the protein's versatility in mitigating the impact of various antibiotics and enabling the organism to thrive in their presence. Kanamycin kinase type II/NEO protein, Klebsiella pneumoniae is the recombinant Kanamycin kinase type II/NEO protein, expressed by E. coli , with tag free. The total length of Kanamycin kinase type II/NEO protein, Klebsiella pneumoniae is 264 a.a., with molecular weight of 26-30 kDa.

HY-P702181

NADH dehydrogenase Protein type II, Gluconobacter oxydans (His)

GOX1675; NADH dehydrogenase Type II
Others E. coli

HY-P7669

	BMPR-II Protein, Human (HEK293, His) rHuBMPR-II, His; BMP Type-2 Receptor; BMP Type II Receptor; BMPR-II; BMPR2	Human	HEK293
	BMP Type II Receptor (BMPR2) is a type II member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. BMPR2 is highly expressed in the heart and liver, and involves in osteogenesis and cell differentiation, essential for embryogenesis, development, and adult tissue homeostasis. BMPR2 is associated with tubulin stability, the inhibition of BMPR2 destabilizes the microtubules promoting cell death of cancer cells that involves the activation of the lysosomes. Human BMPR2 protein contains 1038 amino acids and a transmembrane domain (151-171 a.a.). BMPR-II Protein, Human (HEK293, His) is the extracellular part of the complete BMPR2 protein, produced by HEK293 cells (S27-I151) with C-terminal 6*His-tag.

HY-P70228A

	*Kanamycin kinase type* II/NEO protein, Klebsiella pneumoniae (Tag Free)** rKlAminoglycoside 3'-phosphotransferase; Aminoglycoside 3'-phosphotransferase; APH(3')-II; APH(3')II; Kanamycin kinase Type II; Neomycin-kanamycin phosphotransferase Type II; neo	Others	E. coli
	The Kanamycin kinase type II/NEO protein imparts resistance to aminoglycoside antibiotics, including kanamycin, neomycin, paromomycin, ribostamycin, butirosin, and gentamicin B. It counteracts their inhibitory effects, showcasing the protein's versatility in mitigating the impact of various antibiotics and enabling the organism to thrive in their presence. Kanamycin kinase type II/NEO protein, Klebsiella pneumoniae (Tag Free) is the recombinant Kanamycin kinase type II/NEO protein, expressed by E. coli , with tag free. The total length of Kanamycin kinase type II/NEO protein, Klebsiella pneumoniae (Tag Free) is 264 a.a., with molecular weight of approximately 29.68 kDa.

HY-P7426

	TGFBR2/TGF-beta RII Protein, Human (HEK293, Fc) TGFR-2; TGF-beta Type II receptor; TGF-beta receptor Type 2; TbetaR-II	Human	HEK293
	TGF-beta receptor 2 Protein, Human (HEK293, Fc), a fragment of transforming growth factor-beta receptor type 2 (TβRII), consists of amino acid of Thr23-Asp159 with an Fc tag at the C-terminus.

HY-P7427

	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc) TGFR-2; TGF-beta Type II receptor; TGF-beta receptor Type 2; TbetaR-II	Mouse	HEK293
	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc), a fragment of transforming growth factor-beta receptor type 2 (TβRII), consists of amino acid of Ile24-Asp159 with a 6His tag at the C-terminus.

HY-P7428

	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, His) TGFR-2; TGF-beta Type II receptor; TGF-beta receptor Type 2; TbetaR-II	Mouse	HEK293
	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, His), His consists of N-terminal ectodomain and C-terminal protein kinase domain with his tag. TGF-beta receptor type-2 is the ligand-binding receptor for all members of the TGF-β family.

HY-P73428

	TGFBR2/TGF-beta RII Protein, Human (sf9, His) TGFR-2; TGF-beta Type II receptor; TGF-beta receptor Type 2; TbetaR-II	Human	Sf9 insect cells
	The TGFBR2/TGF-β RII protein cooperates with TGFBR1 to form dedicated receptors for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer that coordinates diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. TGFBR2/TGF-beta RII Protein, Human (sf9, His) is the recombinant human-derived TGFBR2/TGF-beta RII protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Human (sf9, His) is 144 a.a., with molecular weight of ~24 kDa.

HY-P73430

	TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) TGFR-2; TGF-beta Type II receptor; TGF-beta receptor Type 2; TbetaR-II	Rat	HEK293
	TGFBR2 is a transmembrane kinase that forms the TGF-β receptor complex with TGFBR1 and regulates various processes. Upon binding to cytokines, this complex activates TGFBR2, initiating SMAD-dependent signaling through phosphorylation of TGFBR1, SMAD2, and SMAD4. TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is the recombinant rat-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is 166 a.a., with molecular weight of ~54 kDa.

HY-P77229

	TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc) TGFR-2; TGF-beta Type II receptor; TGF-beta receptor Type 2; TbetaR-II	Rhesus Macaque	HEK293
	TGFBR2/TGF-beta RII Protein collaborates with TGFBR1 to form a dedicated receptor for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer, orchestrating diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. Upon cytokine binding, the receptor complex activates TGFBR1 through TGFBR2 phosphorylation, initiating the canonical SMAD-dependent TGF-beta signaling cascade. Additionally, TGFBR2 participates in non-canonical, SMAD-independent pathways. TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc) is 136 a.a., with molecular weight of ~50-70 KDa.

HY-P79250

MCV-type II Chemokine-like Protein, Virus

C-C chemokine-like protein; MC148R; MC148; Molluscum Contagiosum Virus Type II
Virus E. coli

HY-P700953

	AMHR2/MISRII Protein, Human (HEK293) MIS Type II receptor; MISRII; MRII; AMHR; MISR2; AMHR2; AMH Type II receptor; AMHR2; AMHRII; C14	Human	HEK293
	AMHR2/MISRII Protein, upon ligand binding, forms a receptor complex with two type II and two type I kinases. Type II receptors activate type I receptors through phosphorylation, leading to autophosphorylation. Activated type I receptors engage SMAD transcriptional regulators, initiating downstream signaling pathways. Crucially, AMHR2/MISRII acts as a receptor for anti-Muellerian hormone, mediating cellular responses triggered by the hormone. AMHR2/MISRII Protein, Human (HEK293) is the recombinant human-derived AMHR2/MISRII protein, expressed by HEK293 , with tag free. The total length of AMHR2/MISRII Protein, Human (HEK293) is 127 a.a., with molecular weight of 30-40 kDa.

HY-P77870

	AMHR2/MISRII Protein, Human (HEK293, Fc) MIS Type II receptor; MISRII; MRII; AMHR; MISR2; AMHR2; AMH Type II receptor; AMHR2; AMHRII; C14	Human	HEK293
	AMHR2/MISRII Protein, upon ligand binding, forms a receptor complex with two type II and two type I kinases. Type II receptors activate type I receptors through phosphorylation, leading to autophosphorylation. Activated type I receptors engage SMAD transcriptional regulators, initiating downstream signaling pathways. Crucially, AMHR2/MISRII acts as a receptor for anti-Muellerian hormone, mediating cellular responses triggered by the hormone. AMHR2/MISRII Protein, Human (HEK293, Fc) is the recombinant human-derived AMHR2/MISRII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AMHR2/MISRII Protein, Human (HEK293, Fc) is 127 a.a., with molecular weight of 50-65 kDa.

HY-P72855

	BMPR-II Protein, Human (HEK293, His-Fc) Bone morphogenetic protein receptor Type-2; BMPR-2; BMPR-II; PPH1	Human	HEK293
	BMP Type II Receptor (BMPR2) is a type II member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. BMPR2 is highly expressed in the heart and liver, and involves in osteogenesis and cell differentiation, essential for embryogenesis, development, and adult tissue homeostasis. BMPR2 is associated with tubulin stability, the inhibition of BMPR2 destabilizes the microtubules promoting cell death of cancer cells that involves the activation of the lysosomes. Human BMPR2 protein contains 1038 amino acids and a transmembrane domain (151-171 a.a.). BMPR-II Protein, Human (HEK293, His-Fc) is the extracellular part of the complete BMPR2 protein, produced by HEK293 cells (M1-I151) with C-terminal hFc- and His-tag.

HY-P77560

	AMHR2/MISRII Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) MIS Type II receptor; MISRII; MRII; AMHR; MISR2; AMHR2; AMH Type II receptor; AMHR2; AMHRII; C14	Rhesus Macaque;Cynomolgus	HEK293
	AMHR2/MISRII Protein is expressed in a large number of female reproductive organs. AMHR2 Protein, upon ligand binding, assembles a receptor complex with two type II and two type I transmembrane serine/threonine kinases. Type II receptors initiate the signaling cascade by phosphorylating and activating type I receptors, which undergo autophosphorylation. Activated type I receptors then engage and activate SMAD transcriptional regulators, modulating downstream gene expression. Furthermore, AMHR2 serves as the receptor for anti-Muellerian hormone. AMHR2/MISRII Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant cynomolgus, Rhesus Macaque-derived AMHR2/MISRII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AMHR2/MISRII Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 127 a.a., with molecular weight of 55-60 kDa.

HY-P701750

	PIP4K2C Protein, Human PIP4K2C; Phosphatidylinositol 5-phosphate 4-kinase Type-2 gamma; Phosphatidylinositol 5-phosphate 4-kinase Type II gamma; PI(5)P 4-kinase Type II gamma; PIP4KII-gamma	Human	E. coli
	PIP4K2C protein is a low-activity phosphatidylinositol 5-phosphate 4-kinase that functions as a GTP sensor, and its GTP-dependent kinase activity is higher than ATP-dependent activity. In addition to its catalytic role, PIP4K2C independently negatively regulates insulin signaling by interacting with PIP5K and inhibits PIP5K-mediated PtdIns(4,5)P2 synthesis. PIP4K2C Protein, Human is the recombinant human-derived PIP4K2C protein, expressed by E. coli , with tag free. The total length of PIP4K2C Protein, Human is 420 a.a., .

HY-P76653

	SPINK2 Protein, Human (HEK293, Fc) Serine protease inhibitor Kazal-Type 2; Acrosin-trypsin inhibitor; HUSI-II	Human	HEK293
	SPINK2, a robust acrosin inhibitor, is vital for normal spermiogenesis, preventing premature activation of proacrosin and other proteases to avoid spermiogenesis defects. It likely regulates germ cell apoptosis mediated by serine proteases and displays inhibitory activity against trypsin, indicating involvement in diverse serine protease-dependent processes. SPINK2 Protein, Human (HEK293, Fc) is the recombinant human-derived SPINK2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of SPINK2 Protein, Human (HEK293, Fc) is 61 a.a., with molecular weight of ~33.6-38 kDa.

HY-P701720

	CAMK2D Protein, Human (Sf9, GST) CAMK2D; Calcium/calmodulin-dependent protein kinase Type II subunit delta; CaM kinase II subunit delta; CaMK-II subunit delta	Human	Sf9 insect cells
	CAMK2D protein regulates calcium levels and excitation-contraction coupling in the heart. CAMK2D Protein, Human (Sf9, GST) is the recombinant human-derived CAMK2D protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CAMK2D Protein, Human (Sf9, GST) is 498 a.a., .

HY-P702773

RNASEH1 Protein, Human (His)

Ribonuclease H Type II; Ribonuclease H1; RNH1; RNase H1
Human E. coli

HY-P78693

	AMHR2/MISRII Protein, Mouse (HEK293, His) MIS RII; MRII; AMHR2; AMHR; MISR2; AMH Type II receptor	Mouse	HEK293
	AMHR2/MISRII Protein, upon ligand binding, assembles a receptor complex with two type II and two type I transmembrane serine/threonine kinases. Type II receptors initiate the signaling cascade by phosphorylating and activating type I receptors, which undergo autophosphorylation. Activated type I receptors then engage and activate SMAD transcriptional regulators, modulating downstream gene expression. Notably, AMHR2/MISRII serves as the receptor for anti-Muellerian hormone, playing a pivotal role in mediating cellular responses to this hormone. AMHR2/MISRII Protein, Mouse (HEK293, His) is the recombinant mouse-derived AMHR2/MISRII protein, expressed by HEK293, with C-His labeled tag. The total length of AMHR2/MISRII Protein, Mouse (HEK293, His) is 132 a.a., with molecular weight of approximately 25 kDa & 30 kDa, respectively.

HY-P700597

	PIP4K2B Protein, Human (His) PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, Type II, beta; phosphatidylinositol 4 phosphate 5 kinase, Type II, beta , PIP5K2B; phosphatidylinositol-5-phosphate 4-kinase Type-2 beta; PIP5KIIB; PIP5KIIbeta; PIP4KII-beta; PTDINS(4)P-5-kinase; PI(5)P 4-kinase Type II beta; diphosphoinositide kinase 2-beta; ptdIns(5)P-4-kinase isoform 2-beta; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; phosphatidylinositol-4-phosphate 5-kinase, Type II, beta; PI5P4KB; PIP5K2B	Human	E. coli
	PIP4K2B Protein actively synthesizes phosphatidylinositol 4,5-bisphosphate, preferring GTP over ATP in PI(5)P phosphorylation, with enzymatic activity linked to physiological GTP levels. Its unique GTP-sensing ability critically aids metabolic adaptation. PIP4K2B, part of PIP4Ks, negatively influences insulin signaling via a catalytic-independent mechanism, interacting with PIP5Ks to suppress PIP5K-mediated PtdIns(4,5)P2 synthesis, hindering insulin-dependent conversion to PtdIns(3,4,5)P3. This multifaceted role emphasizes PIP4K2B's significance in modulating key signaling pathways for cellular homeostasis and metabolic responsiveness. PIP4K2B Protein, Human (His) is the recombinant human-derived PIP4K2B protein, expressed by E. coli, with N-10*His labeled tag. The total length of PIP4K2B Protein, Human (His) is 415 a.a., with molecular weight of 53.3 kDa.

HY-P76761

	CaMKII alpha/CAMK2A Protein, Human (sf9, GST) Calcium/calmodulin-dependent protein kinase Type II subunit alpha; CAMKA	Human	Sf9 insect cells
	CaMKII α/CAMK2A protein functions autonomously upon Ca(2+)/calmodulin binding and autophosphorylation. CaMKII alpha/CAMK2A Protein, Human (sf9, GST) is the recombinant human-derived CaMKII alpha/CAMK2A protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CaMKII alpha/CAMK2A Protein, Human (sf9, GST) is 478 a.a., with molecular weight of ~80 kDa.

HY-P74690

	NKG2A Protein, Mouse (HEK293, His) NKG2-A/NKG2-B Type II integral membrane protein; CD159a; KLRC1	Mouse	HEK293
	NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A Protein, Mouse (HEK293, His) is the recombinant mouse-derived NKG2A protein, expressed by HEK293 , with N-His labeled tag. The total length of NKG2A Protein, Mouse (HEK293, His) is 151 a.a., with molecular weight of 33-40 kDa.

HY-P72503

	NKG2D/CD314 Protein, Mouse (HEK293, His) NKG2-D Type II integral membrane protein; CD314; KLRK1; NKG2-D	Mouse	HEK293
	The NKG2D/CD314 protein activates and stimulates the innate immune response of NK cells by binding to stress-inducing ligands on tumor and virus-infected cells. It also acts as a costimulatory receptor for TCR, enhancing T cell activation and eliminating tumor cells. NKG2D/CD314 Protein, Mouse (HEK293, His) is the recombinant mouse-derived NKG2D/CD314 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of NKG2D/CD314 Protein, Mouse (HEK293, His) is 139 a.a., with molecular weight of 20-30 kDa.

HY-P72504

	NKG2D/CD314 Protein, Cynomolgus (HEK293, His) NKG2-D Type II integral membrane protein; CD314; KLRK1; NKG2-D	Cynomolgus	HEK293
	The NKG2D/CD314 protein serves as an important activating and costimulatory receptor in immune surveillance. It binds to stress-inducing ligands on tumor and virus-infected cells, activates NK cells and serves as a costimulatory receptor for CD8(+) T cell-mediated adaptive responses, thereby enhancing T cell activation. NKG2D/CD314 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived NKG2D/CD314 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of NKG2D/CD314 Protein, Cynomolgus (HEK293, His) is 139 a.a., with molecular weight of 22-35 kDa.

HY-P73319

	NKG2D/CD314 Protein, Human (sf9, His) CD314; KLRK1; NKG2-D Type II integral membrane protein; NKG2D	Human	Sf9 insect cells
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses. NKG2D/CD314 Protein, Human (sf9, His) is the recombinant human-derived NKG2D/CD314 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of NKG2D/CD314 Protein, Human (sf9, His) is 139 a.a., with molecular weight of ~22.6 kDa.

HY-P74691

	NKG2A Protein, Human (Biotinylated, HEK293, His) NKG2-A/NKG2-B Type II integral membrane protein; CD159a; KLRC1	Human	HEK293
	The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived NKG2A protein, expressed by HEK293 , with N-His labeled tag. The total length of NKG2A Protein, Human (Biotinylated, HEK293, His) is 140 a.a., with molecular weight of ~18.4 kDa.

HY-P75940

	NKG2D/CD314 Protein, Rhesus Macaque (sf9, His) NKG2-D Type II integral membrane protein; NK cell receptor D; KLRK1	Rhesus Macaque	Sf9 insect cells
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance. It binds to stress-inducing ligands on tumor and virus-infected cells and triggers the innate immune response of NK cells. NKG2D/CD314 Protein, Rhesus Macaque (sf9, His) is the recombinant Rhesus Macaque-derived NKG2D/CD314 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of NKG2D/CD314 Protein, Rhesus Macaque (sf9, His) is 139 a.a., with molecular weight of ~18.3 kDa.

HY-P76762

	CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) Calcium/calmodulin-dependent protein kinase Type II subunit beta; CAM2; CAMK2; CAMKB	Human	Sf9 insect cells
	CaMKII beta/CAMK2B, a calcium/calmodulin-dependent protein kinase, autonomously functions after Ca(2+)/calmodulin-binding and autophosphorylation. It plays vital roles in dendritic spine and synapse formation, neuronal plasticity, and the regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, it contributes to actin cytoskeleton reorganization, dendritic arborization, and migration of developing neurons. Additionally, it modulates skeletal muscle function in response to exercise and participates in the JAK-STAT signaling pathway by phosphorylating STAT1. Moreover, it phosphorylates RETREG1, enhancing its reticulophagy activity under endoplasmic reticulum stress conditions. CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) is the recombinant human-derived CaMKII beta/CAMK2B protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) is 503 a.a., with molecular weight of ~85 kDa.

HY-P77105

	NKG2A Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) NKG2-A/NKG2-B Type II integral membrane protein; CD159a; KLRC1	Rhesus Macaque	HEK293
	The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived NKG2A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NKG2A Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 140 a.a., with molecular weight of 50-55 kDa.

HY-P78182

	NKG2A Protein, Human (Biotinylated, HEK293, His-Avi) NKG2-A/NKG2-B Type II integral membrane protein; CD159a; KLRC1	Human	HEK293
	The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived NKG2A protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P72025

	TNFRII Protein, Human (HEK293, hFc) Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor Type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD120b; Etanercept; TBP-2; TBPII	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (HEK293, hFc) is expressed by HEK293 and has a transmembrane region (L23-D257) with hFc tag at the C-terminus.

HY-P700475

	IGF2 Protein, Human (GST) insulin-like growth factor 2 (somatomedin A); INSIGF; pp9974; C11orf43; FLJ22066; FLJ44734; IGF2; insulin-like growth factor 2; IGF-II; somatomedin A; somatomedin-A; insulin-like growth factor II; insulin-like growth factor Type 2; putative insulin-like growth factor II associated protein; chromosome 11 open reading frame 43; OTTHUMP00000011157; OTTHUMP00000011018	Human	E. coli
	The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. IGF2 Protein, Human (GST) is the recombinant human-derived IGF2 protein, expressed by E. coli , with N-GST labeled tag. The total length of IGF2 Protein, Human (GST) is 151 a.a., with molecular weight of 44.1 kDa.

HY-P702655

CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST)

Calcium/calmodulin-dependent protein kinase Type II subunit beta; CAM2; CAMK2; CAMKB
Human Sf9 insect cells

HY-P702365

	MARCH2 Protein, Human (Cell-Free, His, SUMO) E3 ubiquitin-protein ligase MARCHF2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; MARCH-II; RING finger protein 172; RING-Type E3 ubiquitin transferase MARCHF2	Human	E. coli Cell-free
	The MARCH2 protein acts as an E3 ubiquitin protein ligase, promoting endocytosis and sorting of TFRC and CD86 to lysosomes. MARCH2 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived MARCH2 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of MARCH2 Protein, Human (Cell-Free, His, SUMO) is 246 a.a., with molecular weight of 43 kDa.

HY-P76512

	NKG2D/CD314 Protein, Human (CHO, Fc) NKG2-D Type II integral membrane protein; NK cell receptor D; CD314; KLRK1; D12S2489E	Human	CHO
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses. NKG2D/CD314 Protein, Human (CHO, Fc) is the recombinant human-derived NKG2D/CD314 protein, expressed by CHO , with N-hFc labeled tag. The total length of NKG2D/CD314 Protein, Human (CHO, Fc) is 139 a.a., with molecular weight of 50-64 & 37 KDa, respectively.

HY-P71126

	TNFRII Protein, Human (174a.a, HEK293, His) Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor Type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; TNFRII; TNF RII	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (174a.a, HEK293, His) is expressed by HEK293 and has a transmembrane region (K288-S461) with 6*His tag at the C-terminus.

HY-P76513

NKG2D/CD314 Protein, Mouse (sf9, Fc)

NKG2-D Type II integral membrane protein; NK cell receptor D; CD314; KLRK1; D12S2489E
Mouse Sf9 insect cells

HY-P70952

	IFNAR1 Protein, Cynomolgus (HEK293, His) alpha-Type antiviral protein; AVP; beta-Type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC; IFN-alpha/beta R1; IFN-alpha/beta receptor 1; IFN-alpha-REC; I	Cynomolgus	HEK293
	IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2). Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2. IFNAR1 Protein, Cynomolgus (HEK293, His) is a recombinant Cynomolgus IFNAR1 (A25-K437) with C-terminal 6*His tag, which is produced in HEK293 cells.

HY-P70551

	NKG2A Protein, Human (HEK293, His) NKG2-A/NKG2-B Type II integral membrane protein; CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD159a; KLRC1; NKG2A	Human	HEK293
	The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A Protein, Human (HEK293, His) is the recombinant human-derived NKG2A protein, expressed by HEK293 , with N-8*His labeled tag.

HY-P72018

	NKG2D/CD314 Protein, Human (HEK293, Fc) CD314; CD314 antigen ; D12S2489E; Killer cell lectin like receptor subfamily K member 1; Killer cell lectin-like receptor subfamily K member 1; KLR; KLRC4 KLRK1 readthrough; KLRK1; NK cell receptor D; NK lectin-like receptor; NKG2 D activating NK receptor; NKG2 D Type II integral membrane protein; NKG2-D; NKG2-D Type II integral membrane protein; NKG2-D-activating NK receptor; Nkg2d; NKG2D_HUMAN; NKLLR; NKR P2; Nkrp2	Human	HEK293
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses. NKG2D/CD314 Protein, Human (HEK293, Fc) is the recombinant human-derived NKG2D/CD314 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NKG2D/CD314 Protein, Human (HEK293, Fc) is 139 a.a., with molecular weight of ~43.6 kDa.

HY-P71206

	PIP4K2A Protein, Human (HEK293, His) 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; PIP5KIII; Phosphatidylinositol 5-phosphate 4-kinase Type II alpha; PtdIns(4)P-5-kinase B isoform; PtdIns(4)P-5-kinase C isoform; PtdIns(5)P-4-kinase isoform 2-alpha	Human	HEK293
	The PIP4K2A protein phosphorylates phosphatidylinositol 5-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP4K2A Protein, Human (HEK293, His) is the recombinant human-derived PIP4K2A protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70536

	TNF RII/TNFRSF1B Protein, Human (183a.a, HEK293, mFc) TNF-RII; TNFRII; TNF RII; Tumor necrosis factor receptor superfamily member 1B; TNFRSF1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor Type II; p75; p80 TNF-alpha receptor; CD120b	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Human (183a.a, HEK293, mFc) is expressed by HEK293 and has a transmembrane region (P24-T206) with mFc tag at the C-terminus.

HY-P71559

	NAALADL2 Protein, Human (His-SUMO) Glutamate carboxypeptidase II Type non peptidase homologue; Inactive N acetylated alpha linked acidic dipeptidase like protein 2; Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2; N acetylated alpha linked acidic dipeptidase like 2; NAALADase L2; NAALADL 2; NAALADL2	Human	E. coli
	The NAALADL2 protein was identified as catalytically inactive, suggesting a role beyond enzymatic activity. The name implies that non-enzymatic functions contribute to different cellular processes. NAALADL2 Protein, Human (His-SUMO) is the recombinant human-derived NAALADL2 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of NAALADL2 Protein, Human (His-SUMO) is 653 a.a., with molecular weight of ~88.6 kDa.

HY-P78091

	CD40 Protein, Human (Biotinylated, HEK293, His-Avi) CD40; CD40L receptor; TNFRSF5; B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 Type II isoform; CDw40; MGC9013; nerve growth factor receptor-relat	Human	HEK293
	CD40 protein is a TNFSF5/CD40LG receptor that transduces signals through TRAF6 and MAP3K8-mediated pathways, activates ERK in macrophages and B cells, and induces immunoglobulin secretion. CD40 exists as monomers and homodimers and interacts with TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6). CD40 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD40 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD40 Protein, Human (Biotinylated, HEK293, His-Avi) is 173 a.a., with molecular weight of 35-40 kDa.

Cat. No.	Product Name	Chemical Structure

HY-13948BS

Angiotensin II human-13C6,15N TFA

Angiotensin II human- ¹³C₆, ¹⁵N TFA (Ang II- ¹³C₆, ¹⁵N TFA) is ¹³C- and ¹⁵N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .

HY-B0202S3

Irbesartan-d7
Irbesartan-d₇ is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active *Ang II type* 1 (AT1) receptor blocker (ARB)**. Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0202AS

Irbesartan-d7 hydrochloride

Irbesartan-d₇ hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-13635S

Finasteride-d9

Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

HY-17512AS

Losartan-d6 hydrochloride
Losartan-d₆ hydrochloride is deuterated labeled Losartan potassium (HY-17512A). Losartan potassium (DuP-753 potassium) is an *angiotensin II receptor type* 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀** of 20 nM.

HY-W005288S

4-Vinylphenol-d4
4-Vinylphenol-d₄ is deuterated labeled Losartan (potassium) (HY-17512A). Losartan potassium (DuP-753 potassium) is an *angiotensin II receptor type* 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀** of 20 nM.

HY-14914S

Azilsartan-d5

Azilsartan-d₅ is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.
HY-B0202S

Irbesartan-d4

Irbesartan-d₄ is the deuterium labeled Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist.
HY-B0202S1

Irbesartan-d6

Irbesartan-d₆ is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

HY-13955S1

Telmisartan-d4
Telmisartan-d₄ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

HY-13955S

Telmisartan-d3
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

HY-B0199AS

Mycophenolate Mofetil-d4 hydrochloride
Mycophenolate Mofetil-d₄ hydrochloride is deuterated labeled Mycophenolate mofetil hydrochloride (HY-B0199A). Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-13955S2

Telmisartan-13C,d3
Telmisartan- ¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

HY-13955S3

Telmisartan-d7
Telmisartan-d₇ (BIBR 277-d₇) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of *angiotensin II type* 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀** of 9.2 nM.

HY-12765S1

Losartan carboxylic acid-d4 hydrochloride

Losartan carboxylic acid-d₄ (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].

HY-14914S1

Azilsartan-d4
Azilsartan-d₄ is the deuterium labeled Azilsartan[1]. Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research[2][3][4][5][6].

HY-B0202S2

Irbesartan-d6-1
Irbesartan-d₆-1 is the deuterium labeled Irbesartan[1]. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[2].

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81047

	Collagen II Antibody Collagen II alpha 1; COL2A1; COL2A1 protein; collagen, Type II, alpha 1; collagen alpha-1(II); Type II collagen; alpha-1 Type II collagen; alpha1 Type II collagen; Col2a1; AOM; Cartilage collagen; Chondrocalcin; COL11A3; Collagen alpha 1(II) chain precursor; Collagen II alpha 1 polypeptide; Collagen Type II alpha 1 (primary osteoarthritis spondyloepiphyseal dysplasia congenital); MGC131516; SEDC; Collagen alpha-1(II) chain; Alpha-1 Type II collagen; CO2A1_HUMAN.; CollagenII;	WB, ELISA, IHC-P, ICC/IF	Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig
	Collagen II Antibody is an unconjugated, approximately 117 KDa, rabbit-derived, anti-Collagen II polyclonal antibody. Collagen II Antibody can be used for: WB, ELISA, IHC-P, IF expriments in human, mouse, rat, chicken, dog, pig, cow, rabbit, guinea pig background without labeling.

HY-P82926

	Cytokeratin 2e Antibody (YA2671) KRT2; KRT76; KRT3; KRT5; KRT6A; KRT6B; KRT6C; KRT71; KRT72; KRT73; KRT74; KRT75; KRT79; KRT8; KRT84; Keratin; Type II cytoskeletal 2 epidermal; Keratin; Type II cytoskeletal 2 oral; Keratin; Type II cytoskeletal 3; Keratin; Type II cytoskeletal 5; Keratin; Type II cytoskeletal 6A; Keratin; Type II cytoskeletal 6B; Keratin; Type II cytoskeletal 6C; Keratin; Type II cytoskeletal 71; Keratin; Type II cytoskeletal 72; Keratin; Type II cytoskeletal 73; Keratin; Type II cytoskeletal 74	WB, IHC-P	Human

HY-P81491

	INPP4B Antibody (YA1236) 4-bisphosphate 4-phosphatase; Inositol polyphosphate 4 phosphatase Type II 105kDa; Inositol polyphosphate 4-phosphatase Type II; Inpp4b; MGC132014; Type II inositol 3; 4 bisphosphate 4 phosphatase; Type II inositol-3	IHC-P	Human

HY-P83260

Cytokeratin 8 Antibody (YA3005)

KRT8; CYK8; Keratin; Type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
WB, IHC-P, ICC/IF, IP, FC Human, Mouse
HY-P83148

Arginase 2 Antibody (YA2893)

ARG2; Arginase-2; Type II arginase
WB, ICC/IF, FC Human
HY-P82890

Phospho-Cytokeratin 8 (Ser23) Antibody (YA2635)

KRT8; CYK8; Keratin; Type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
WB, IHC-F, IHC-P, ICC/IF, IP Human

HY-P82920

	Cytokeratin 1 Antibody (YA2665) 67 kDa cytokeratin; CK1; EHK; Epidermolytic hyperkeratosis 1; EPPK; Hair alpha protein; K1; Keratin; KRT 1; KRT1A; NEPPK; Type II cytoskeletal 1; Type-II keratin Kb1	WB	Human, Mouse, Rat

HY-P80984

	Cytokeratin 5 Antibody CK-5; CK5; Cytokeratin-5; Cytokeratin5; DDD; DDD1; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne Types; K2C5_HUMAN; K5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne Types); Keratin 5; Keratin ; keratin complex 2, basic, gene 5; keratin, Type II cytoskeletal 5 ; Keratin-5; Keratin5; KRT 5; Krt5; KRT5A; Type II cytoskeletal 5 ; Type-II keratin Kb5;	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Cytokeratin 5 Antibody is an unconjugated, approximately 62 kDa, rabbit-derived, anti-Cytokeratin 5 monoclonal antibody. Cytokeratin 5 Antibody can be used for: WB, IHC-P, IF-Tissue, IF-Cell, FC expriments in human, mouse, rat background without labeling.

HY-P81206

	SRD5A2 Antibody 5 alpha SR2; EC; SR Type 2; Steroid 5 alpha reductase 2; 3 oxo 5 alpha steroid 4 dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; 5ART2; e II 5 alpha reductase; EC; MGC138457; Micropenis, included; S5A2_HUMAN; S5AR 2; SR Type 2; SRD5A2; Steroid 5 alpha reductase 2; Steroid 5-alpha-reductase 2; Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); Type II 5-alpha reductase.	ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat, Pig, Horse
	SRD5A2 Antibody is an unconjugated, approximately 28 kDa, rabbit-derived, anti-SRD5A2 polyclonal antibody. SRD5A2 Antibody can be used for: ELISA, IHC-P, IHC-F, IF expriments in (predicted) human, mouse, rat, pig, horse background without labeling.

HY-P81111

	IFN gamma Antibody IFNG; IFG; IFI; IFN Gamma; IFN Immune; IFN-gamma; IFNG; IFNG_HUMAN; Immune Interferon; Interferon gamma; Interferon Gamma Precursor; Macrophage Activating Factor; MAF; T Cell Interferon; Type II Interferon.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human
	IFN gamma Antibody is an unconjugated, approximately 15 kDa, rabbit-derived, anti-IFN gamma polyclonal antibody. IFN gamma Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, background without labeling.

HY-P83367

	Interferon alpha/beta Receptor 1 Antibody (YA3112) IFNAR1; IFNAR; Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1	WB, IP	Human

HY-P83345

	AGTR2 Antibody (YA3090) AGTR2; Angiotensin II receptor Type 2; Angiotensin II Type-2 receptor; AT2 receptor; AT2; At2r; MRX88; Angiotensin II at2; Angiotensin receptor 2; Type-2 angiotensin II receptor; ATGR2	WB, IP	Human, Mouse, Rat

HY-P83613

Angiotensin II Type 1 Receptor Antibody (YA3358)

AGTR1; AGTR1A; AGTR1B; AT2R1; AT2R1B; Type-1 angiotensin II receptor; AT1AR; AT1BR; Angiotensin II Type-1 receptor; AT1
WB Human

HY-P82599

	CaMKII beta Antibody (YA2344) CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase Type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase Type II subunit gamma	WB	Mouse

HY-P81131

	TGF beta Receptor II Antibody TGF-beta receptor Type-2; TGF beta R2; TGFBR2; AAT 3; AAT3; FAA 3; FAA3; HNPCC6; MFS 2; MFS2; RIIC; TAAD 2; TAAD2; TbetaR II; TGF beta receptor Type 2; TGF beta receptor Type II; TGF beta Type II receptor; TGFB R2; TGFbeta RII; TGFBR 2; TGFR 2; TGFR2; Transforming growth factor beta receptor II; Transforming growth factor beta receptor Type II. TGF-βRⅡ; TGFβRⅡ; TGF βRⅡ; TGFβ RⅡ.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	TGF beta Receptor II Antibody is an unconjugated, approximately 65 kDa, rabbit-derived, anti-TGF beta Receptor II polyclonal antibody. TGF beta Receptor II Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, cow, and predicted: chicken, pig, horse, rabbit, sheep background without labeling.

HY-P80445

	CaMKII alpha Antibody 1 Publications Verification Alpha CaMKII; Calcium calmodulin dependent protein kinase II; Calcium/calmodulin dependent protein kinase II alpha B subunit; Calcium/calmodulin dependent protein kinase Type II alpha chain; Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; Calcium/calmodulin-dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase II-alpha; Calcium/calmodulin-dependent protein kinase Type II subunit alpha; Calcium/calmodulin-dependent protein kinase Type IIA; CaM kinase II alpha chain; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaMK II alpha subunit; CaMK-II subunit alpha; Camk2a; CAMKA; CaMKII; CaMKIINalpha; EC2.7.11.17; KCC2A_HUMAN; KIAA0968; MGC123320; MGC139375; MGC155201; mKIAA0968; PK2CDD; PKCCD; R74975; zgc:112538; zgc:123320;	WB, IP, FC, IHC-P	Human, Mouse, Rat
	CaMKII alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to CaMKII alpha. It can be used for WB,IP,FC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80978

PAX6 Antibody

PAX6; AN2; Paired box protein Pax-6; Aniridia Type II protein; Oculorhombin
WB, IHC-P, ICC/IF Human, Mouse, Rat

PAX6 Antibody is an antibody targeting to PAX6.

HY-P81267

	Cytokeratin 7 Antibody (YA950) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k Type II cytoskeletal; Keratin 7; Keratin simple epithelial Type 1 k7; Keratin Type II cytoskeletal 7	WB, ICC/IF	Human

HY-P81267A

	Cytokeratin 7 Antibody (YA951) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k Type II cytoskeletal; Keratin 7; Keratin simple epithelial Type 1 k7; Keratin Type II cytoskeletal 7	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

HY-P81267B

	Cytokeratin 7 Antibody (YA952) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k Type II cytoskeletal; Keratin 7; Keratin simple epithelial Type 1 k7; Keratin Type II cytoskeletal 7	WB, ICC/IF, IP	Human

HY-P81099

	CGRP-1/2 Antibody CGRP-I + CGRP-II; CGRP-1/2; Procalcitonin; Beta Type CGRP; CALC2; CALCB; Calcitonin 1; Calcitonin 2; Calcitonin gene related peptide; Calcitonin gene related peptide II; Calcitonin related polypeptide beta; CGRP; CGRP II; CGRP2; CT; Calcitonin/calcitonin related polypeptide alpha; Katacalcin; MGC126648; CALCA_HUMAN; CALCB_HUMAN; Calcitonin gene-related peptide 2; Beta-Type CGRP; Beta-CGRP; Calcitonin gene-related peptide II; CGRP-II; CGRP-I.	ELISA, IHC-P, IHC-F, ICC/IF	Human, Rat
	CGRP-1/2 Antibody is an unconjugated, approximately 3.8/14 kDa, rabbit-derived, anti-CGRP-1/2 polyclonal antibody. CGRP-1/2 Antibody can be used for: ELISA, IHC-P, IHC-F, IF expriments in human, rat, and predicted: mouse, chicken, pig, cow background without labeling.

HY-P80847

	Phospho-PKA RII alpha (Ser99) Antibody PRKAR2A; PKR2; PRKAR2; cAMP-dependent protein kinase Type II-alpha regulatory subunit	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Pig
	Phospho-PKA RII alpha (Ser99) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 46 kDa, targeting to Phospho-PKA RII alpha (Ser99). It can be used for WB,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat, Pig.

HY-P81724

	ALDH1A2 Antibody (YA1469) ALDH1A2; RALDH2; Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase Type 2; RALDH(II)	WB	Human, Mouse, Rat

HY-P80725

	iNOS Antibody NOS2; NOS2A; Nitric oxide synthase; inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS Type II; Peptidyl-cysteine S-nitrosylase NOS2	ICC/IF, WB, IHC-F, IHC-P, ELISA	Human, Mouse, Rat
	iNOS Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 131 kDa, targeting to iNOS. It can be used for ICC/IF,WB,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P83598

	ERAB Antibody (YA3343) HSD17B10; ERAB; HADH2; MRPP2; SCHAD; XH98G2; 3-hydroxyacyl-CoA dehydrogenase Type-2; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase Type II; Endoplasmic	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P81149

	NKG2D Antibody NKG2-D Type II integral membrane protein; KLRK1; natural killer cell group 2D; NKG2-D isoform b; Klrk1; Nkrp2; NKG2-D-activating NK receptor; NK cell receptor D; Killer cell lectin-like receptor subfamily K; NK lectin-like receptor; CD314; CD 314; CD314 antigen; D12S2489E; Killer cell lectin like receptor subfamily K member 1; Killer cell lectin-like receptor subfamily K member 1; KLR; Klrk1; NKG2 D activating NK receptor; NKG2 D Type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D_HUMAN; NKLLR; NKR P2; Nkrp2.	WB, ELISA, IHC-P, FC, ICC/IF	Human, Mouse
	NKG2D Antibody is an unconjugated, approximately 25 kDa, rabbit-derived, anti-NKG2D polyclonal antibody. NKG2D Antibody can be used for: WB, ELISA, IHC-P, Flow-Cyt, IF expriments in human, mouse, and predicted: rat background without labeling.

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