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Results for "

camptothecin-based

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163099
    P5(PEG24)-VC-PAB-exatecan

    		Drug-Linker Conjugates for ADC Topoisomerase Cancer
    P5(PEG24)-VC-PAB-exatecan is a camptothecin-based linker-payload platform based on the highly potent camptothecin derivative exatecan. P5(PEG24)-VC-PAB-exatecan has linker-payload structures. P5(PEG24)-VC-PAB-exatecan can be used for the research of tumor .
    P5(PEG24)-VC-PAB-exatecan
  • HY-42487A
    (rac)-Exatecan Intermediate 1

    		ADC Cytotoxin Topoisomerase Cancer
    (rac)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer .
    (rac)-Exatecan Intermediate 1
  • HY-42487B
    (R)-Exatecan Intermediate 1

    		ADC Cytotoxin Topoisomerase Cancer
    (R)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer .
    (R)-Exatecan Intermediate 1
  • HY-153360
    MC-GGFG-AM-(10Me-11F-Camptothecin)

    		Drug-Linker Conjugates for ADC Topoisomerase Cancer
    MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells .
    MC-GGFG-AM-(10Me-11F-<em>Camptothecin</em>)

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