Search Result

Results for "

circulation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Apical Sodium-Dependent Bile Acid Transporter (1) Apoptosis (3) Autophagy (3) Biochemical Assay Reagents (1) Calcium Channel (6) CXCR (2) Endogenous Metabolite (7) Free Fatty Acid Receptor (1) GCGR (1) Glucocorticoid Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (3) Liposome (5) NF-κB (4) p38 MAPK (1) PAI-1 (1) TNF Receptor (2) Toll-like Receptor (TLR) (1) Tyrosinase (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (14) Inflammation/Immunology (7) Metabolic Disease (9) Neurological Disease (3)

By Targets:

Angiotensin-converting Enzyme (ACE) (1)

Apical Sodium-Dependent Bile Acid Transporter (1)

Apoptosis (3)

Autophagy (3)

Biochemical Assay Reagents (1)

Calcium Channel (6)

CXCR (2)

Endogenous Metabolite (7)

Free Fatty Acid Receptor (1)

GCGR (1)

Glucocorticoid Receptor (1)

Interleukin Related (1)

Isotope-Labeled Compounds (3)

Liposome (5)

NF-κB (4)

p38 MAPK (1)

PAI-1 (1)

TNF Receptor (2)

Toll-like Receptor (TLR) (1)

Tyrosinase (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (14)

Inflammation/Immunology (7)

Metabolic Disease (9)

Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141892A

DSPE-PEG Carboxylic acid (sodium), MW 2000	Liposome	Others
DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid that can be used to form micelles as nanoparticles for drug delivery. DSPE-PEG Carboxylic acid (sodium), MW 2000 increases the blood circulation time of liposomes .

HY-W014394

Vanillyl butyl ether	Others	Cardiovascular Disease
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether has been proposed as a mild warming agent providing a warming sensation and enhancing the blood circulation .

HY-108011

Naftazone	Others	Cardiovascular Disease
Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation .

HY-B0233

Isradipine PN 200-110	Calcium Channel Autophagy	Cardiovascular Disease Neurological Disease
Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-124265S2

4β-Hydroxycholesterol-d4	Endogenous Metabolite	Metabolic Disease
4β-Hydroxycholesterol-d₄ is the deuterium labeled 4β-Hydroxycholesterol. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].

HY-124265S1

4β-Hydroxycholesterol-d5	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
4β-Hydroxycholesterol-d₅ is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].

HY-U00134

Benzcyclane Bencyclane; Benzcyclan	Others	Cardiovascular Disease
Benzcyclane (Bencyclane; Benzcyclan) is a platelet aggregation inhibitor and a vasodilator effective in a variety of peripheral circulation disorders.

HY-124265

4β-Hydroxycholesterol	Endogenous Metabolite	Metabolic Disease
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation .

HY-121660

Hexyl nicotinate	Others	Others
Hexyl nicotinate, a nicotinic acid ester with vasodilatory effect. Hexyl nicotinate improves blood circulation, usually serves as an active ingredient in topical preparations, such as creams and lotions .

HY-N8875

Scillascilloside B-1	Others	Inflammation/Immunology
Scillascilloside B-1 can be isolated from Scilla scilloides. Scilla scilloides promotes blood circulation, and is an analgesic and anti-inflammatory agent .

HY-U00172

Ipramidil C80-1324	Others	Cardiovascular Disease
Ipramidil (C80-1324) is a furoxan compound. Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts.

HY-N0298

Stachydrine 3 Publications Verification	NF-κB Endogenous Metabolite	Cardiovascular Disease Cancer
Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.

HY-144004

DSPE-PEG2000-Mal ammonium 1 Publications Verification DSPE-PEG2000 Maleimide ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] ammonium	Liposome	Others
DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents .

HY-P2625

GLP-2(3-33) 1 Publications Verification	GCGR	Metabolic Disease
GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC₅₀=5.8 nM) .

HY-P2625S1

GLP-2(3-33) (Leu-13C6,15N) (TFA)	Isotope-Labeled Compounds	Metabolic Disease
GLP-2(3-33) (Leu- ¹³C₆, ¹⁵N) TFA is ¹³C and ¹⁵N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC₅₀=5.8 nM).

HY-P2625S

GLP-2(3-33) (Leu-13C6,15N)	Isotope-Labeled Compounds	Metabolic Disease
GLP-2(3-33) (Leu- ¹³C₆, ¹⁵N) is ¹³C and ¹⁵N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC₅₀=5.8 nM).

HY-140740

DSPE-PEG-Maleimide, MW 5000 1 Publications Verification	Others	Cancer
DSPE-PEG-Maleimide, MW 5000 has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-maleimide extends blood circulation time and higher stability for encapsulated agents .

HY-143209

DSPE-PEG	Liposome	Others
DSPE-PEG is a phospholipids-polymer conjugate that can be used in drug delivery applications. DSPE-PEG is a material for the formulation of nanocarriers for achieving prolonged blood circulation time, improved stability and enhanced encapsulation efficiency .

HY-144012

16:0 PEG2000 PE DPPE-PEG2000; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium	Liposome	Others
16:0 PEG2000 PE (DPPE-PEG2000) is a PEG-modified lipids. 16:0 PEG2000 PE can reduce the nonspecific adsorption of protein and prolong circulation time in vivo .

HY-160041A

Olaptesed pegol sodium	CXCR	Cancer
Olaptesed pegol sodium A pegylated-based L-oligoribonucleotide aptamer targeting CXCL12. Olaptesed pegol sodium neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment .

HY-B1448

Benidipine hydrochloride KW-3049	Calcium Channel Apoptosis	Cardiovascular Disease
Benidipine hydrochloride is an orally active calcium channel antagonist. Benidipine hydrochloride can inhibit cell proliferation and apoptosis. Benidipine hydrochloride has antioxidant activity and can increase nitric oxide synthase activity and improve coronary circulation in hypertensive rats .

HY-B1448A

Benidipine KW-3049 free base	Apoptosis Calcium Channel	Cardiovascular Disease
Benidipine is a potent and orally active calcium channel antagonist . Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells . Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats .

HY-N0029

Forsythoside B 5 Publications Verification	TNF Receptor NF-κB	Inflammation/Immunology
Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.

HY-N2101

Benzoyloxypaeoniflorin	Tyrosinase NF-κB	Inflammation/Immunology
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .

HY-144004A

DSPE-PEG5000-Mal ammonium DSPE-PEG5000 Maleimide ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-5000] ammonium	Liposome	Others
DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents . DSPE-PEG5000-Mal ammonium contains PEG5000.

HY-160041

Olaptesed pegol	CXCR	Cancer
Olaptesed pegol (NOX-A12) L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment .

HY-B1829

Dexamethasone phosphate Dexamethasone 21-phosphate	Glucocorticoid Receptor	Inflammation/Immunology
Dexamethasone phosphate (Dexamethasone 21-phosphate) is a biologically inactive compound which undergoes dephosphorylation by intra-erythrocyte enzymes. The active metabolite, dexamethasone, is then released into the circulation by simple passive diffusion through cell membranes. Dexamethasone phosphate-encapsulated erythrocyte has the potential for steroid-dependent ulcerative colitis research .

HY-P2752

Lipoprotein lipase, Pseudomonas sp LPL	Endogenous Metabolite	Metabolic Disease
Lipoprotein lipase, Pseudomonas sp (LPL) is a multifunctional enzyme from adipose tissue, heart and skeletal muscle, islets and macrophages. Lipoprotein lipase promotes normal lipoprotein metabolism, delivery and utilization of tissue-specific substrates. Lipoprotein lipase catalyzes the rate-limiting step of lipids in blood circulation .

HY-N0518

Toddalolactone 1 Publications Verification	PAI-1	Cardiovascular Disease
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ value of 37.31 μM .

HY-N0391A

L-Citrulline DL-malate 3 Publications Verification	Biochemical Assay Reagents Endogenous Metabolite	Others
L-Citrulline (DL-malate) is an organic compound commonly used as a nutritional supplement. It boosts the body's production of nitrogen oxides, improves circulation and athletic performance, and reduces muscle fatigue. In addition, L-Citrulline DL-malate also plays an important role in some industrial fields, for example, it is used in the field of agriculture to enhance plant immunity.

HY-N7971

2-Hydroxy-1-Methoxyaporphine	Endogenous Metabolite	Cardiovascular Disease
2-Hydroxy-1-Methoxyaporphine is an alkaloid that can be isolated from Nelumbo nucifera. 2-Hydroxy-1-Methoxyaporphine is the major active ingredient of the Chinese traditional medicine Jiang-Zhi-Ning .

HY-B0233S1

Isradipine-d6 PN 200-110-d₆	Calcium Channel Autophagy
Isradipine-d₆ is the deuterium labeled Isradipine[1]. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[2][3][4].

HY-14905

Uridine triacetate Tri-O-acetyl uridine	Others	Neurological Disease
Uridine triacetate (Tri-O-acetyl uridine) is an orally active proagent of Uridine (HY-B1449). Uridine triacetate is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate is used for the research of 5-fluorouracil (5-FU) and capecitabine toxicity, or early-onset cardiac or central nervous system (CNS) .

HY-B1448AS

(Rac)-Benidipine-d7	Apoptosis Calcium Channel	Cardiovascular Disease
(Rac)-Benidipine-d₇ is the deuterium labeled Benidipine[1]. Benidipine is a potent and orally active calcium channel antagonist[2]. Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells[3]. Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats[4].

HY-B0233S

Isradipine-d3	Calcium Channel Autophagy	Cardiovascular Disease Neurological Disease
Isradipine-d₃ (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3].

HY-N0631

Cornuside 1 Publications Verification	p38 MAPK NF-κB	Inflammation/Immunology
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases .

HY-105266

Zabicipril	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Zabicipril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Zabicipril can be used for the study of blood pressure and peripheral arterial insufficiency .

HY-110207

SM-324405	Toll-like Receptor (TLR)	Inflammation/Immunology
SM-324405 is a TLR7 agonistic antedrug (EC₅₀ = 50 nM), with pEC₅₀ values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively. SM-324405 is used for immunoresearch of allergic diseases. An antedrug is defined as a locally active compound that is designed to be rapidly metabolized to an inactive form upon entry into the circulation and prevents systemic toxicity by losing its agonistic activity in a plasmatic environment .

HY-B1021

Vincamine	Free Fatty Acid Receptor	Cardiovascular Disease Metabolic Disease
Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation . Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research .

HY-16940

24(S)-Hydroxycholesterol 24S-OHC; 24S-HC; Cerebrosterol
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators .

HY-15790

Elobixibat A 3309; AZD 7806	Apical Sodium-Dependent Bile Acid Transporter Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
Elobixibat (A 3309; AZD 7806) is an orally effective Apical Sodium-Dependent Bile (IBAT) inhibitor, with an IC₅₀ value of 0.53 nM (human IBAT ), 0.13 nM (mouse IBAT), 5.8 nM (canine IBAT). Elobixibat lowers LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors .

DSPE-PEG Carboxylic acid (sodium), MW 2000	Drug Delivery
DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid that can be used to form micelles as nanoparticles for drug delivery. DSPE-PEG Carboxylic acid (sodium), MW 2000 increases the blood circulation time of liposomes .

DSPE-PEG2000-Mal ammonium 1 Publications Verification DSPE-PEG2000 Maleimide ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] ammonium	Drug Delivery
DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents .

16:0 PEG2000 PE DPPE-PEG2000; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium	Drug Delivery
16:0 PEG2000 PE (DPPE-PEG2000) is a PEG-modified lipids. 16:0 PEG2000 PE can reduce the nonspecific adsorption of protein and prolong circulation time in vivo .

DSPE-PEG5000-Mal ammonium DSPE-PEG5000 Maleimide ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-5000] ammonium	Drug Delivery
DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents . DSPE-PEG5000-Mal ammonium contains PEG5000.

Cat. No.	Product Name	Category	Target	Chemical Structure