editing

By Targets:	Adenosine Deaminase (1) Adrenergic Receptor (1) Biochemical Assay Reagents (2) CRISPR/Cas9 (9) DNA/RNA Synthesis (2) HIV (4) Isotope-Labeled Compounds (3) Liposome (4)
By Research Areas:	Cancer (6) Endocrinology (1) Infection (5) Inflammation/Immunology (2)
Click Chemistry:	Azide (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150279

PolQi2

DNA/RNA Synthesis Others

PolQi2 inhibits the helicase activity of Polθ. PolQi2 improves the precision of gene editing at various loci and in different cell lines .

PolQi2	DNA/RNA Synthesis	Others
PolQi2 inhibits the helicase activity of Polθ. PolQi2 improves the precision of gene editing at various loci and in different cell lines .

HY-115686

8-Azaadenosine 2 Publications Verification	Adenosine Deaminase	Inflammation/Immunology Cancer
8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells .

HY-153138

FTT5 LLNs

Biochemical Assay Reagents Others

FTT5 LLNs are functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing .
HY-E70220

AsCas12a Nuclease

CRISPR/Cas9 Others

AsCas12a Nuclease is a CRISPR nuclease, and can specifically cutting double-stranded DNA. AsCas12a Nuclease can be used for gene edited study .
HY-145692

Cas9-IN-3

CRISPR/Cas9 Others

Cas9-IN-3 is a potent Cas9 inhibitor (IC₅₀=28 μM). CRISPR/Cas systems have revolutionized gene editing in various species .

FTT5 LLNs	Biochemical Assay Reagents	Others
FTT5 LLNs are functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing .

AsCas12a Nuclease	CRISPR/Cas9	Others
AsCas12a Nuclease is a CRISPR nuclease, and can specifically cutting double-stranded DNA. AsCas12a Nuclease can be used for gene edited study .

Cas9-IN-3	CRISPR/Cas9	Others
Cas9-IN-3 is a potent Cas9 inhibitor (IC₅₀=28 μM). CRISPR/Cas systems have revolutionized gene editing in various species .

HY-139306

BAMEA-O16B	Liposome	Inflammation/Immunology
BAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing .

HY-17413

Zidovudine Maximum Cited Publications 6 Publications Verification Azidothymidine; AZT; ZDV	HIV CRISPR/Cas9	Infection Cancer
Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

HY-145794

ZA3-Ep10

Liposome Others

ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery and non-viral CRISPR/Cas gene editing.

ZA3-Ep10	Liposome	Others
ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery and non-viral CRISPR/Cas gene editing.

HY-156257

UNC9512	DNA/RNA Synthesis	Cancer
UNC9512 is a potent methyl-lysine reader p53 binding protein 1 (53BP1) antagonist. UNC9512 can be used to study the role of 53BP1 in DNA repair, gene editing and tumorigenesis .

HY-W590683

9A1P9	Liposome CRISPR/Cas9	Others
9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for CRISPR-Cas9 gene editing in mice .

HY-17413S2

Zidovudine-d4 Azidothymidine-d₄; AZT-d₄; ZDV-d₄	CRISPR/Cas9 HIV Isotope-Labeled Compounds	Infection Cancer
Zidovudine-d₄ is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

HY-19334

L755507 1 Publications Verification	Adrenergic Receptor CRISPR/Cas9	Endocrinology Cancer
L755507 is a potent, selective agonist of β₃-AR with an IC₅₀ of 35 nM. L755507 enhances the homology-directed repair (HDR)-mediated genome editing in CRISPR/Cas9 nickase system .

HY-P5307

Peptide A5K INF7-A5K-TAT	Biochemical Assay Reagents	Others
Peptide A5K (INF7-A5K-TAT) is an RNP delivery peptide that delivers CRISPR RNPs to T cells. Peptide A5K effectively edits T cells without substantial impact on T cell viability .

HY-150229

306-N16B	Liposome	Cancer
306-N16B is a lipid and allows systemic codelivery of Cas9 mRNA and sgRNA. 306-N16B can transport mRNA to the pulmonaryendothelial cell. 306-N16B can be used for research of genome editing-based therapies .

HY-145442

8-Azanebularine	Others	Others
8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC₅₀=15 mM). 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (K_D=2 nM). 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction .

HY-136251

BRD0539	CRISPR/Cas9	Infection
BRD0539 is a cell-permeable and non-toxic inhibitor of CRISPR-Cas9. BRD0539 inhibits Streptococcus pyogenes Cas9 (SpCas9) (apparent IC₅₀=22 μM) in an in vitro DNA cleavage assay .

HY-17413S

Zidovudine-d3 Azidothymidine-d₃; AZT-d₃; ZDV-d₃	Isotope-Labeled Compounds HIV CRISPR/Cas9	Infection
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-17413S1

Zidovudine-13C,d3 Azidothymidine-¹³C,d₃; AZT-¹³C,d₃; ZDV-¹³C,d₃	Isotope-Labeled Compounds HIV CRISPR/Cas9	Infection
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Type

HY-139306

BAMEA-O16B	Drug Delivery
BAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing .

HY-145794

ZA3-Ep10

Drug Delivery

ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery and non-viral CRISPR/Cas gene editing.

ZA3-Ep10	Drug Delivery
ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery and non-viral CRISPR/Cas gene editing.

HY-150229

306-N16B	Drug Delivery
306-N16B is a lipid and allows systemic codelivery of Cas9 mRNA and sgRNA. 306-N16B can transport mRNA to the pulmonaryendothelial cell. 306-N16B can be used for research of genome editing-based therapies .

Cat. No.	Product Name	Target	Research Area

HY-P5307

Peptide A5K INF7-A5K-TAT	Biochemical Assay Reagents	Others
Peptide A5K (INF7-A5K-TAT) is an RNP delivery peptide that delivers CRISPR RNPs to T cells. Peptide A5K effectively edits T cells without substantial impact on T cell viability .

Cat. No.	Product Name

HY-KE7066

FnCas12a

FnCas12a(Cpf1), is an RNA-guided, DNA-editable recombinant endonuclease that can be used for gene editing and detection.

FnCas12a
FnCas12a(Cpf1), is an RNA-guided, DNA-editable recombinant endonuclease that can be used for gene editing and detection.

Species:	Human (2)
Tag:	SUMO (1) His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P72080

	APOBEC3A Protein, Human (His-SUMO) A3A; ABC3A_HUMAN; APOBEC3A; Apolipoprotein B mRNA editing enzyme; Apolipoprotein B mRNA editing enzyme; catalytic polypeptide like 3A; ARP3; bK150C2.1; Catalytic polypeptide like 3A; Phorbolin 1; Phorbolin-1; PHRBN; Probable DNA dC >dU editing enzyme APOBEC-3A; Probable DNA dC->dU-editing enzyme APOBEC-3A	Human	E. coli
	APOBEC3A protein is a DNA deaminase that limits the mobility of viruses, foreign DNA, and retrotransposons. APOBEC3A Protein, Human (His-SUMO) is the recombinant human-derived APOBEC3A protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of APOBEC3A Protein, Human (His-SUMO) is 199 a.a., with molecular weight of ~39 kDa.

HY-P76131

	AARSD1 Protein, Human (His) Alanyl-tRNA editing protein Aarsd1; Alanyl-tRNA synthetase domain-containing protein 1; AARSD1	Human	E. coli
	AARSD1 Protein actively functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). AARSD1 Protein, Human (His) is the recombinant human-derived AARSD1 protein, expressed by E. coli , with N-His labeled tag. The total length of AARSD1 Protein, Human (His) is 350 a.a., with molecular weight of ~40 KDa.


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Cat. No.	Product Name	Chemical Structure

HY-17413S2

Zidovudine-d4
Zidovudine-d₄ is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

HY-17413S

Zidovudine-d3
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Zidovudine-d3

Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-17413S1

Zidovudine-13C,d3
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Zidovudine-13C,d3

Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-17413S

Zidovudine-d3 Azidothymidine-d₃; AZT-d₃; ZDV-d₃		Azide
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-17413S1

Zidovudine-13C,d3 Azidothymidine-¹³C,d₃; AZT-¹³C,d₃; ZDV-¹³C,d₃		Azide
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Biochemical Assay Reagents

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MCE Kits

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry