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exchange

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Angiotensin Receptor (3) Antibiotic (3) Apoptosis (5) Autophagy (3) Bacterial (3) Biochemical Assay Reagents (5) c-Fms (4) Calcium Channel (3) Chloride Channel (1) COX (2) DNA/RNA Synthesis (4) DOCK (1) Enterovirus (2) ERK (1) Eukaryotic Initiation Factor (eIF) (1) Ferroptosis (1) Fluorescent Dye (1) Fungal (2) GLUT (2) HCV (1) HIV (1) Isotope-Labeled Compounds (1) Na+/Ca2+ Exchanger (14) Na+/H+ Exchanger (NHE) (22) NO Synthase (1) NOD-like Receptor (NLR) (1) P2X Receptor (1) Parasite (2) Phosphodiesterase (PDE) (1) PKC (1) Potassium Channel (3) Prostaglandin Receptor (3) Pyroptosis (1) RAD51 (2) Ras (18) SHP2 (1) Sodium Channel (6) TRP Channel (2) VDAC (2) Wnt (3) β-catenin (1)
By Research Areas:	Cancer (40) Cardiovascular Disease (26) Endocrinology (5) Infection (7) Inflammation/Immunology (12) Metabolic Disease (18) Neurological Disease (12)
Click Chemistry:	Azide (1) Alkynes (3)

118

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157240

CEX Ion-exchange resin

Others Others

CEX Ion-exchange resin is a filler that can be used in cation exchange chromatography (Particle size: 60 μm) .

*CEX Ion-exchange* resin**	Others	Others
CEX Ion-exchange resin is a filler that can be used in cation exchange chromatography (Particle size: 60 μm) .

HY-157239

*AEX HQ Anion-exchange* resin**	Others	Cancer
AEX HQ Anion-exchange resin (POROS 50HQ) is AEX commonly used filler. AEX HQ Anion-exchange resin is HQ strong anion exchange resin and can purify targeting protein .

HY-157238

*AEX Anion-exchange* resin 2**	Others	Others
AEX anion-exchange resin 2 is a AEX commonly used filler and is a strong anion exchange medium, Particle size: ~90μm. AEX anion-exchange resin 2 can be used in Ion exchange chromatography

HY-157243

*CEX Cation-exchange* resin 2**	Others	Others
CEX Cation-exchange resin 2 is a CEX strong cation exchange resin, ADC purification resin. CEX Cation-exchange resin 2 contains cross-linked poly(styrene-divinylbenzene), which has good hydrophobicity .

HY-157241

*CEX Cation-exchange* resin 1**	Others	Others
CEX Cation-exchange resin 1 is an ion exchange chromatography resin based on monodisperse polystyrene/divinylbenzene (PS-DVB). The particle size of CEX Cation-exchange resin 1 is 50μm and the ligand is -CH2CH2CH2SO3-. CEX Cation-exchange resin 1 can be used for the separation and purification of antibodies, VLPs, viruses and proteins .

HY-157237

AEX Ion-exchange resin

Others Neurological Disease

AEX Ion-exchange resin is a commonly used AEX filler, which is a hydrophilic polymethacrylate. Particle size: 60μm.

*AEX Ion-exchange* resin**	Others	Neurological Disease
AEX Ion-exchange resin is a commonly used AEX filler, which is a hydrophilic polymethacrylate. Particle size: 60μm.

HY-157236

*AEX Anion-exchange* resin 1**	Others	Others
AEX Anion-exchange resin 1 is a strong anion exchange chromatography resin, based on monodisperse polystyrene/divinylbenzene (PS-DVB), with a particle size of 50 μm and an ionic ligand of –CH₂N ⁺ (CH₃)₃. AEX Anion-exchange resin 1 can be used for the separation and purification of biological macromolecules such as proteins, antibodies, and viral vaccines.

HY-111671

SOS1 activator 1	Ras	Cancer
SOS1 activator 1 (Compound 64) is a potent activator of SOS1-mediated nucleotide exchange with a K_d of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS .

HY-W042301

Xipamide

Others Cardiovascular Disease

Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

Xipamide	Others	Cardiovascular Disease
Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the *anion exchanger* (AE)** .

HY-W042301R

Xipamide (Standard)	Others	Cardiovascular Disease
Xipamide (Standard) is the analytical standard of Xipamide. This product is intended for research and analytical applications. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the *anion exchanger* (AE)** .

HY-162321

ZINC57632462	Ras	Cancer
ZINC57632462 (ACA-6) is a non-covalent allosteric KRAS inhibitor. ZINC57632462 disrupts nucleotide exchange and inhibits RAS-effector interaction. ZINC57632462 can be used for the research of cancer .

HY-121693

DIDS MDL101114ZA free base	VDAC RAD51	Cancer
DIDS is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .

HY-154912

PAT1inh-B01	Others	Inflammation/Immunology
PAT1inh-B01 is a selective SLC26A6 inhibitor. PAT1inh-B01 inhibits PAT1 (a Cl ^-/HCO3 ^- exchanger)-mediated anion exchange (IC₅₀: 350 nM). PAT1inh-B01 blocks fluid absorption in small intestine. PAT1inh-B01 can be used for research of small intestinal hyposecretory disorders .

HY-D0086

DIDS sodium salt 5+ Cited Publications MDL101114ZA	VDAC RAD51	Cancer
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .

HY-112939

Colestilan MCI-196; Colestimide	Others	Metabolic Disease
Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research .

HY-154912A

PAT1inh-B01 hydrochloride	Others	Inflammation/Immunology
PAT1inh-B01 hydrocholide is a selective SLC26A6 inhibitor. PAT1inh-B01 hydrocholide inhibits PAT1 (a Cl ^-/HCO3 ^- exchanger)-mediated anion exchange (IC₅₀: 350 nM). PAT1inh-B01 hydrocholide blocks fluid absorption in small intestine. PAT1inh-B01 hydrocholide can be used for research of small intestinal hyposecretory disorders .

HY-W076836

4-Aminobenzaldehyde p-aminobenzaldehyde	Biochemical Assay Reagents	Others
4-Aminobenzaldehyde (p-aminobenzaldehyde) is a useful synthetic reagent and monomer that can be used to synthesize monoazo dyes and photocurable ion exchange resins. 4-Aminobenzaldehyde is also a corrosion inhibitor of metals .

HY-138665

HHS-0701	Prostaglandin Receptor	Endocrinology
HHS-0701, a sulfur-triazole exchange (SuTEx) ligand, is a potent tyrosine-reactive prostaglandin reductase 2 (PTGR2) inhibitor. HHS-0701 blocks PTGR2 metabolism of the lipid substrate 15-Keto-PGE2 .

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase	Inflammation/Immunology
1,3,5-Trihydroxy-4-prenylxanthone is a *Na ⁺/H ⁺ exchange* system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC₅₀ value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056)**)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

HY-119572

Sodium zirconium cyclosilicate	Others	Inflammation/Immunology
Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K ⁺ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD) .

HY-151360

NHE3-IN-3	Sodium Channel	Metabolic Disease
NHE3-IN-3 (Compound 1) is a *Na ⁺/H ⁺ exchanger* isoform 3 (NHE3) inhibitor with pIC₅₀** of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats .

HY-136182A

YM-244769	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice .

HY-107659

YM-244769 hydrochloride	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 hydrochloride is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice .

HY-117656

ESI-05 3 Publications Verification NSC 116966	Acyltransferase	Neurological Disease Metabolic Disease
ESI-05 is a specific exchange proteins directly activated by cAMP 2 (EPAC2) inhibitor. ESI-05 inhibits cAMP-mediated EPAC2 GEF activity with an IC₅₀ of 0.43 μM. ESI-05 can be used for the research of diabetes, insulin secretion and neurological disorders .

HY-139337

SMCy5.5	Fluorescent Dye	Metabolic Disease
SMCy5.5 is an SMCy dye used for lipid droplet labeling with a very high two-photon absorption cross-section. SMCy, unlike the well-known lipid droplet marker Nile Red, has narrow absorption and emission bands in visible light, allowing for multicolor imaging. SMCy is shown to be compatible with fixation, producing high-quality 3D images of lipid droplets in cells and tissues. The high brightness of SMCy5.5 enables efficient tracking and imaging of lipid droplet exchange between adipocytes .

HY-101044

PPADS tetrasodium 1 Publications Verification	P2X Receptor Na+/Ca2+ Exchanger	Neurological Disease
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca ²⁺ exchanger in guinea pig airway smooth muscle .

HY-118778

KR-32568

Na+/H+ Exchanger (NHE) Cardiovascular Disease

KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC₅₀ of 230 nM. KR-32568 has cardioprotective effects .

KR-32568	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
KR-32568 is a *sodium/hydrogen exchanger-1 (NHE-1)* inhibitor with an IC₅₀ of 230 nM. KR-32568 has cardioprotective effects .

HY-136182

YM-244769 dihydrochloride	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 dihydrochloride is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 dihydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 dihydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 dihydrochloride can also increase urine volume and urinary excretion of electrolytes in mice .

HY-146243

TH-Z835	Ras Apoptosis	Cancer
TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC₅₀ of 1.6 μM. TH-Z835 inhibits both mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange .

HY-153606

SOS1 agonist-1	Others	Cancer
SOS1 agonist-1 (compound 79) is an agonist for the Son of sevenless homologue SOS1. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP to GTP on RAS and regulates RAS activation. SOS1 agonists increase nucleotide exchange on RAS, enhance cellular RAS-GTP levels, and trigger biphasic signaling changes in ERK1/2 phosphorylation. Play an anti-cancer role ^{[1] ^.}

HY-139313

NHE3-IN-2

Na+/H+ Exchanger (NHE) Metabolic Disease

NHE3-IN-2 is a Na ⁺/H ⁺ exchanger-3 (NHE3) inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin) .

NHE3-IN-2	Na+/H+ Exchanger (NHE)	Metabolic Disease
NHE3-IN-2 is a *Na ⁺/H ⁺ exchanger-3 (NHE3)* inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin) .

HY-19693

Cariporide 5 Publications Verification HOE-642 Free Base	Na+/H+ Exchanger (NHE)	Cardiovascular Disease Inflammation/Immunology Cancer
Cariporide (HOE-642) is a selective Na ⁺/H ⁺ exchange inhibitor.

HY-106150B

Eniporide hydrochloride 1 Publications Verification EMD-96785 hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na ⁺/H ⁺ exchange inhibitor.

HY-103703

DEAE Cross-linked dextran A 25

Others Others

DEAE Cross-linked dextran A 25 is a weak anion exchanger .

DEAE Cross-linked dextran A 25	Others	Others
DEAE Cross-linked dextran A 25 is a weak anion exchanger .

HY-E70095

T4 UvsY Protein	Others	Others
T4 UvsY Protein is an accessory protein for in vitro catalysis of strand exchange. T4 UvsY Protein enhances strand exchange by UvsX protein by interacting specifically with UvsX protein. UvsY protein enhances the rate of single-stranded-DNA-dependent ATP hydrolysis by UvsX protein .

HY-19273A

Rimeporide hydrochloride EMD-87580 hydrochloride	Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-19273

Rimeporide 1 Publications Verification EMD-87580	Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-100298

Caldaret

MCC-135
Na+/Ca2+ Exchanger Cardiovascular Disease

Caldaret is an intracellular Ca ²⁺ handling modulator that acts through reverse mode Na ⁺/Ca ²⁺ exchanger inhibition.

Caldaret MCC-135	Na+/Ca2+ Exchanger	Cardiovascular Disease
Caldaret is an intracellular Ca ²⁺ handling modulator that acts through reverse mode Na ⁺/Ca ²⁺ exchanger inhibition.

HY-141490

Beta-D-Glucopyranosyl nitromethane	Others	Others
Beta-D-Glucopyranosyl nitromethane, as a salt of a strongly basic anion exchanger in the OH cycle, is a glycosyl derivative of nitromethane .

HY-148162

Kayexalate

Others Others

Kayexalate, a cation-exchange resin, is an orally active plasma potassium inhibitor. Kayexalate can be used in the research of hyperkalemia .
HY-157242

CEX Polishing resin

Others Others

CEX Polishing resin is an agarose filler that can be used in cation exchange chromatography (The average particle size: 50 μm) .
HY-163365

UTX-143

Na+/H+ Exchanger (NHE) Cancer

UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity .

Kayexalate	Others	Others
Kayexalate, a cation-exchange resin, is an orally active plasma potassium inhibitor. Kayexalate can be used in the research of hyperkalemia .

CEX Polishing resin	Others	Others
CEX Polishing resin is an agarose filler that can be used in cation exchange chromatography (The average particle size: 50 μm) .

UTX-143	Na+/H+ Exchanger (NHE)	Cancer
UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity .

HY-19062

SM-6586	Calcium Channel Na+/Ca2+ Exchanger	Cardiovascular Disease
SM-6586 is a calcium channel antagonist and inhibitor of Na ⁺/H ⁺ and *Na ⁺/Ca ²⁺ exchange* transport**, potentially for the treatment of cerebrovasular diseases and hypertension.

HY-112961

Patiromer	Potassium Channel	Others
Patiromer is an orally active and potent hyperkalemia inhibitor and a nonabsorbed potassium binder. Patiromer polymer is bound with calcium which is released in the colon in exchange for binding potassium .

HY-117958

HJC0197 1 Publications Verification	Ras	Cardiovascular Disease Metabolic Disease Cancer
HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC₅₀=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP .

HY-107929

Calcium polystyrene sulfonate Poly(styrenesulfonic acid) calcium salt	Others	Cardiovascular Disease
Calcium polystyrene sulfonate is an *ion-exchange* resin** used for reducing blood levels of potassium. Calcium polystyrene sulfonate is used to treat hyperkalemia in patients with chronic kidney disease (CKD).

HY-100325

NHE3-IN-1

Na+/H+ Exchanger (NHE) Neurological Disease

NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1.

HY-100322

H100	Chloride Channel	Cardiovascular Disease
H100 is a Cl ^- transport inhibitor, with partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger, but no effect against KCl cotransporter, in human erythrocytes.

HY-15754

CGP37157 3 Publications Verification	Na+/Ca2+ Exchanger	Neurological Disease Cancer
CGP37157 is a potent, selective inhibitor of Na ⁺/Ca ²⁺ exchanger, inhibiting the Na ⁺-induced Ca ²⁺-release from guinea-pig heart mitochondria, with an IC₅₀ of 0.8 μM.

HY-D0836

EDTA dipotassium dihydrate 3 Publications Verification Ethylenediaminetetraacetic acid dipotassium dihydrate	DNA/RNA Synthesis	Others
EDTA (Ethylenediaminetetraacetic acid) dipotassium dihydrate is anticoagulants, chelating heavy metal and relieve toxicity. EDTA dipotassium dihydrate can damage chromosomes, interfere with the DNA repair process, increase the incidence of meiosis exchange .

Cat. No.	Product Name	Type

HY-W076836

4-Aminobenzaldehyde p-aminobenzaldehyde	Biochemical Assay Reagents
4-Aminobenzaldehyde (p-aminobenzaldehyde) is a useful synthetic reagent and monomer that can be used to synthesize monoazo dyes and photocurable ion exchange resins. 4-Aminobenzaldehyde is also a corrosion inhibitor of metals .

HY-D0836

EDTA dipotassium dihydrate 3 Publications Verification Ethylenediaminetetraacetic acid dipotassium dihydrate	Biochemical Assay Reagents
EDTA (Ethylenediaminetetraacetic acid) dipotassium dihydrate is anticoagulants, chelating heavy metal and relieve toxicity. EDTA dipotassium dihydrate can damage chromosomes, interfere with the DNA repair process, increase the incidence of meiosis exchange .

HY-157915

HFPB Tetrakis[3,5-bis(1,1,1,3,3,3-hexafluoro-2-methoxy-2-propyl)phenyl]borate, sodium salt, trihydrate	Chelators
HFPB (Compound 2) is a type of cation exchanger with high lipophilicity and acid resistivity, which can be used in membrane electrode research .

HY-156045A

Cross-linked dextran G 10	Filter Medium
Cross-linked dextran G 10 is a weak cation exchanger and a hydrophilic gel that can be used as a gel filter filler (Particle size range: 40-120 μm; Sphere protein separation range: ＜700 Da) .

HY-106150

Eniporide

EMD-96785

Biochemical Assay Reagents

Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest .

HY-12495A

ISRIB

Maximum Cited Publications

7 Publications Verification

Biochemical Assay Reagents

ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .

Cat. No.	Product Name	Target	Research Area

HY-P1382A

Rac1 Inhibitor W56 TFA	Ras	Cancer
Rac1 Inhibitor W56 TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 TFA inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P4856

pTH-Related Protein (1-40) (human, mouse, rat)	PKC	Endocrinology
pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1) .

HY-P1382

Rac1 Inhibitor W56	Ras	Cancer
Rac1 Inhibitor W56 is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam .

HY-P5985

mSIRK	ERK	Others
mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC₅₀ of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1383

Rac1 Inhibitor F56, control peptide	Peptides	Others
Rac1 Inhibitor F56, control peptide is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor F56, control peptide contains a Trp ⁵⁶ to Phe ⁵⁶ mutation. Rac1 Inhibitor F56, control peptide has no effect on Rac1 interaction with its guanine nucleotide exchange factors (GEFs) .

HY-P1383A

Rac1 Inhibitor F56, control peptide TFA	Peptides	Others
Rac1 Inhibitor F56, control peptide TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor F56, control peptide TFA contains a Trp ⁵⁶ to Phe ⁵⁶ mutation. Rac1 Inhibitor F56, control peptide TFA has no effect on Rac1 interaction with its guanine nucleotide exchange factors (GEFs) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0150

Monensin sodium 15+ Cited Publications Monensin A sodium	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics Plant agriculture research Cancer	Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt
Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Flavonoids Leguminosae Source classification Plants Other Flavonoids Erythrina variegata Linn.	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase
1,3,5-Trihydroxy-4-prenylxanthone is a *Na ⁺/H ⁺ exchange* system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC₅₀ value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056)**)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

HY-N3918

γ-Fagarine	Infection Alkaloids other families Classification of Application Fields Source classification Quinoline Alkaloids Plants Disease Research Fields	HCV
γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC₅₀ of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer .

HY-N4302

Monensin Monensin A	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt
Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

Cat. No.	Product Name	Chemical Structure

HY-B0684S

Iopamidol-d8
Iopamidol-d₈ (B-15000-d8) is the deuterium labeled Iopamidol. Iopamidol is a nonionic, X-Ray iodinated contrast agent (CA) for a wide variety of diagnostic applications. Iopamidol contains amide and hydroxyl functionalities that can be exploited for the generation of the chemical exchange saturation transfer (CEST) contrast[1].

Cat. No.	Product Name		Classification

HY-134813

MRTX1133 3 Publications Verification		Alkynes
MRTX1133 is a noncovalent, potent, and selective KRAS G12D inhibitor. MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein, resulting in an estimated K_D against KRAS G12D of 0.2 pM. MRTX1133 prevents SOS1-catalyzed nucleotide exchange and/or formation of the KRAS G12D/GTP/RAF1 complex, thereby inhibiting mutant KRAS-dependent signal transduction. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells. MRTX1133 has single digit nanomolar activity in cellular assays and marked in vivo efficacy in tumor models harboring KRAS G12D mutations .

HY-139337

SMCy5.5		Alkynes
SMCy5.5 is an SMCy dye used for lipid droplet labeling with a very high two-photon absorption cross-section. SMCy, unlike the well-known lipid droplet marker Nile Red, has narrow absorption and emission bands in visible light, allowing for multicolor imaging. SMCy is shown to be compatible with fixation, producing high-quality 3D images of lipid droplets in cells and tissues. The high brightness of SMCy5.5 enables efficient tracking and imaging of lipid droplet exchange between adipocytes .

HY-162446

pan-KRAS-IN-13

Alkynes

pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC₅₀s of 2.75 nM and 2.89 nM for G12D and G12V, respectively

HY-134318B

8-Azido-ADP disodium		Azide
8-Azido-ADP (disodium) is a covalent-binding inhibitor of mitochondrial adenine nucleotide translocation. 8-Azido-ADP (disodium) causes irreversible inhibition of adenine nucleotide exchange in a light-dependent reaction. 8-Azido-ADP (disodium) inhibits the normal state 4 → 3 transitions of mitochondrial respiration induced by ADP . 8-Azido-ADP (disodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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