Search Result
Results for "
formyl
" in MedChemExpress (MCE) Product Catalog:
3
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P0224
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fMLP; N-formyl-MLF
|
TNF Receptor
|
Inflammation/Immunology
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N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.
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-
-
- HY-P1744
-
-
-
- HY-P1591
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-
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- HY-W285163S
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formyl Ciprofloxacin-d8
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Isotope-Labeled Compounds
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Others
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1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
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-
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- HY-P1591A
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-
-
- HY-129043R
-
|
Antibiotic
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Infection
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3-Formyl rifamycin (Standard) is the analytical standard of 3-Formyl rifamycin. This product is intended for research and analytical applications. 3-Formyl rifamycin is an intermediate of Rifampicin.
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-
-
- HY-129043
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-
-
- HY-160596
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5-formyl-deoxycytidine
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DNA/RNA Synthesis
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Others
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5-Formyl-dCTP is a modified nucleotide that can be used for DNA synthesis .
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-
-
- HY-151454S
-
-
-
- HY-137129
-
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Endogenous Metabolite
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Metabolic Disease
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10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3). 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate .
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-
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- HY-143207
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-
-
- HY-W141975
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-
-
- HY-I0591
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-
-
- HY-152714
-
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Nucleoside Antimetabolite/Analog
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Others
|
5-Formyl-2’-O-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .
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-
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- HY-N2220
-
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|
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6-Formyl-isoophiopogonanone A is a homoisoflavonoidal extracted from Ophiopogon japonicas, with antioxidant activity .
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-
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- HY-N11533
-
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Others
|
Others
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6-Formyl-isoophiopogonanone B is a homoisoflavonoid, which can be isolated from Ophiopogon japonicus .
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-
-
- HY-128113
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-
-
- HY-P2355A
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-
-
- HY-N9355
-
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Others
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Others
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(+)-N-Formylnorglaucine is an aporphine alkaloid isolated from the leaves of Unonopsis stipitata. (+)-N-Formylnorglaucine contains a formyl group linked to the heterocyclic nitrogen .
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-
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- HY-P2355
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-
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- HY-N10880
-
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Others
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Others
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2-((1R,2R)-2-Formyl-1,3,3-trimethylcyclohexyl)-4-hydroxy-5-isopropylbenzaldehyde is a natural product .
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-
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- HY-135108
-
|
Neurokinin Receptor
|
Neurological Disease
|
QWF Peptide (Compound 4a) is a substance P antagonist with an IC50 of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC50 of 4.7 μM .
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-
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- HY-112169
-
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Endogenous Metabolite
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Metabolic Disease
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10-Formyltetrahydrofolic acid is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines .
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- HY-112169A
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Endogenous Metabolite
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Metabolic Disease
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10-Formyltetrahydrofolic acid disodium is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid disodium can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines .
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-
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- HY-Y0051S
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2-Hydroxymethyl-5-furfural-13C6; 2-formyl-5-hydroxymethylfuran-13C6
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Isotope-Labeled Compounds
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Others
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5-Hydroxymethylfurfural- 13C6 (2-Hydroxymethyl-5-furfural- 13C6; 2-Formyl-5-hydroxymethylfuran- 13C6) is a 13C labeled 5-Hydroxymethylfurfural (HY-Y0051). 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
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- HY-19574
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FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist .
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-
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- HY-103473A
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Boc-Met-Leu-Phe-OH TFA
|
Formyl Peptide Receptor (FPR)
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Inflammation/Immunology
|
Boc-MLF (TFA) is a peptide, used as a specific formyl peptide receptor (FPR) antagonist, also inhibits the signaling through formyl peptide receptor like 1 (FPRL1) at higher concentrations .
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-
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- HY-122309
-
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Antibiotic
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Infection
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A-71497 is the 3-formyl derivative of the antibiotic Tosufloxacin (HY-B1802). A-71497 can produce high plasma levels of tosufloxacin upon both oral and subcutaneous administration to mice .
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- HY-P1117
-
|
Formyl Peptide Receptor (FPR)
Calcium Channel
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Neurological Disease
Inflammation/Immunology
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MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .
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- HY-P1117A
-
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Formyl Peptide Receptor (FPR)
Calcium Channel
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Neurological Disease
Inflammation/Immunology
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MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .
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- HY-103473
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-
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- HY-Y0051
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2-Hydroxymethyl-5-furfural; 2-formyl-5-hydroxymethylfuran
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Fungal
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Others
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5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
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-
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- HY-P1118
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-
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- HY-N7576
-
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Reactive Oxygen Species
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Inflammation/Immunology
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Anemarrhenasaponin Ia, isolated from Anemarrhenae rhizome, inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation. Anemarrhenasaponin Ia is an useful anti-inflammation reagent .
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-
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- HY-P1118A
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-
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- HY-N8152
-
|
Reactive Oxygen Species
|
Inflammation/Immunology
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Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo .
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- HY-P1795
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-
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- HY-P1120
-
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Formyl Peptide Receptor (FPR)
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Inflammation/Immunology
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WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .
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- HY-N2100
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Reactive Oxygen Species
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Metabolic Disease
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6'-O-beta-D-Glucosylgentiopicroside is a secoiridoid isolated from the roots of G. straminea. 6'-O-beta-D-Glucosylgentiopicroside strongly suppresses N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation .
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- HY-P1120A
-
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
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WKYMVM (TFA) is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .
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- HY-N3464
-
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Phosphodiesterase (PDE)
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Metabolic Disease
|
Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity .
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- HY-116730
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|
Reactive Oxygen Species
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Others
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CHS-111 is a benzyl indazole inhibitor of superoxide anion O 2- generation. CHS-111 inhibits the cell migration, and reduces the formyl-Met-Leu-Phe- but not phorbol ester-stimulated phospholipase D activity, with the IC50 of 3.9 μM .
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- HY-P1121A
-
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Formyl Peptide Receptor (FPR)
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Inflammation/Immunology
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WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .
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- HY-103472
-
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Formyl Peptide Receptor (FPR)
|
Neurological Disease
|
FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca 2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation .
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-
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- HY-156293
-
|
Formyl Peptide Receptor (FPR)
Apoptosis
|
Cancer
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FPR1 antagonist 1 (compound 24a) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 25 nM. FPR1 antagonist 1 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis .
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-
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- HY-131180
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LAR-1219
|
Formyl Peptide Receptor (FPR)
|
Cardiovascular Disease
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BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure .
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- HY-156294
-
|
Formyl Peptide Receptor (FPR)
Apoptosis
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Cancer
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FPR1 antagonist 2 (compound 25b) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 70 nM. FPR1 antagonist 2 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis .
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- HY-124071
-
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Formyl Peptide Receptor (FPR)
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Inflammation/Immunology
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ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders .
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- HY-P1119
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WRW4
4 Publications Verification
|
Formyl Peptide Receptor (FPR)
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Neurological Disease
|
WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .
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- HY-P1116
-
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Bacterial
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Infection
Inflammation/Immunology
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PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .
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- HY-P1116A
-
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Bacterial
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Infection
Inflammation/Immunology
|
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .
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- HY-P1119A
-
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Formyl Peptide Receptor (FPR)
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Neurological Disease
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WRW4 TFA, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .
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- HY-P5469
-
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Formyl Peptide Receptor (FPR)
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Others
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WRW4-OH is a biological active peptide. (This peptide inhibits binding of one of formyl peptide receptor-like 1 (FPRL1) agonists WKYMVm to its specific receptor. FPRL1 is an important classical chemoattractant receptor that is expressed in phagocytic cells in the peripheral blood and brain. Activation of FPRL1 is closely related to inflammatory responses in the host defense mechanism and neurodegenerative disorders.)
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- HY-110246
-
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Others
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Inflammation/Immunology
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Quin C1 is a highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX). Quin-C1 significantly reduces the neutrophil and lymphocyte counts in BALF, diminishes expression of TNF-α, IL-1β, KC, and TGF-β1, and decreases collagen deposition in lung tissue. Quin C1 has the potential for the research of lung injury .
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- HY-101283
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HCH6-1
3 Publications Verification
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|
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HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .
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- HY-P1122
-
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Formyl Peptide Receptor (FPR)
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Infection
Inflammation/Immunology
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Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
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- HY-103286
-
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Bombesin Receptor
|
Cancer
|
PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
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- HY-146196
-
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Bacterial
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Infection
|
Anticandidal agent-1 (compound c2) is a potent and broad-spectrum anticandidal agent. Anticandidal agent-1 shows anticandidal activity against C. albicans and C. glabrata, with MIC50 values of 8.65 and 13.51 μg/mL, respectively. Anticandidal agent-1 inhibits biofilm by blocking hyphal elongation and filamentation .
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- HY-P5740
-
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Bacterial
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Infection
|
Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .
|
-
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P0224
-
fMLP; N-formyl-MLF
|
TNF Receptor
|
Inflammation/Immunology
|
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.
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- HY-P1744
-
-
- HY-P1591
-
-
- HY-W142169
-
formyl-L-histidine
|
Peptides
|
Others
|
N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a Ki value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a Ki value of 4.26 mM .
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- HY-P1591A
-
-
- HY-P1756
-
-
- HY-W141975
-
-
- HY-I0591
-
-
- HY-P2355A
-
-
- HY-P2355
-
-
- HY-W009215
-
L-Met-L-Ala-L-Ser
|
Peptides
|
Others
|
H-Met-Ala-Ser-OH (L-Met-L-Ala-L-Ser) is a tripeptide. H-Met-Ala-Ser-OH can act as a formyl receptor .
|
-
- HY-135108
-
|
Neurokinin Receptor
|
Neurological Disease
|
QWF Peptide (Compound 4a) is a substance P antagonist with an IC50 of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC50 of 4.7 μM .
|
-
- HY-P1117
-
|
Formyl Peptide Receptor (FPR)
Calcium Channel
|
Neurological Disease
Inflammation/Immunology
|
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .
|
-
- HY-P1117A
-
|
Formyl Peptide Receptor (FPR)
Calcium Channel
|
Neurological Disease
Inflammation/Immunology
|
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .
|
-
- HY-P1118
-
-
- HY-P1118A
-
-
- HY-P1795
-
-
- HY-P1120
-
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .
|
-
- HY-P1120A
-
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
WKYMVM (TFA) is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .
|
-
- HY-P1121A
-
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .
|
-
- HY-P1119
-
WRW4
4 Publications Verification
|
Formyl Peptide Receptor (FPR)
|
Neurological Disease
|
WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .
|
-
- HY-P1116
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .
|
-
- HY-P1116A
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .
|
-
- HY-P1119A
-
|
Formyl Peptide Receptor (FPR)
|
Neurological Disease
|
WRW4 TFA, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .
|
-
- HY-P5469
-
|
Formyl Peptide Receptor (FPR)
|
Others
|
WRW4-OH is a biological active peptide. (This peptide inhibits binding of one of formyl peptide receptor-like 1 (FPRL1) agonists WKYMVm to its specific receptor. FPRL1 is an important classical chemoattractant receptor that is expressed in phagocytic cells in the peripheral blood and brain. Activation of FPRL1 is closely related to inflammatory responses in the host defense mechanism and neurodegenerative disorders.)
|
-
- HY-P1122
-
|
Formyl Peptide Receptor (FPR)
|
Infection
Inflammation/Immunology
|
Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
|
-
- HY-P5740
-
|
Bacterial
|
Infection
|
Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W285163S
-
|
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
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-
-
- HY-151454S
-
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N-Formyl palbociclib-d8 is the deuterium-labeled N-Formyl palbociclib.
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-
-
- HY-Y0051S
-
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5-Hydroxymethylfurfural- 13C6 (2-Hydroxymethyl-5-furfural- 13C6; 2-Formyl-5-hydroxymethylfuran- 13C6) is a 13C labeled 5-Hydroxymethylfurfural (HY-Y0051). 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
|
-
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