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intestinal epithelial

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Aryl Hydrocarbon Receptor (3) Autophagy (2) Bacterial (3) Cytochrome P450 (1) Endogenous Metabolite (4) Estrogen Receptor/ERR (2) Fungal (5) Histone Acetyltransferase (1) Interleukin Related (1) Isotope-Labeled Compounds (1) p38 MAPK (3) RIP kinase (1) Somatostatin Receptor (1)
By Research Areas:	Cancer (1) Infection (4) Inflammation/Immunology (4) Metabolic Disease (1)

14

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

3

Natural
Products

2

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

DHMB 2,3-Dihydroxy-4-methoxybenzaldehyde	Fungal	Infection Inflammation/Immunology
DHMB (2,3-Dihydroxy-4-methoxybenzaldehyde) is a small organic molecule with anti-fungal and anti-inflammatory activity. DHMB has protective effect on intestinal epithelial cells .

Bezlotoxumab	Bacterial	Infection Inflammation/Immunology
Bezlotoxumab is a human monoclonal antibody directed against C. difficile toxin B. Bezlotoxumab binds to C. difficile toxin B preventing intestinal epithelial damage and colitis .

HY-W007355S1

Skatole-d8 3-Methylindole-d₈; 3-Methyl-1H-indole-d₈	Isotope-Labeled Compounds Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Autophagy Bacterial Fungal	Others
Skatole-d₈ is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

HY-W007355S

Skatole-d3 3-Methylindole-d₃; 3-Methyl-1H-indole-d₃	Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Autophagy Bacterial Fungal	Others
Skatole-d₃ is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

BAA473	Interleukin Related	Inflammation/Immunology
BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells .

6α-Hydroxypolyporenic acid C	Others	Others
6α-Hydroxypolyporenic acid C, a lanostane triterpenoid, is a nature product that could be isolated from the sclerotium of Poria cocos. 6α-Hydroxypolyporenic acid C can be absorbed across intestinal epithelial cells .

Skatole 3 Publications Verification 3-Methylindole; 3-Methyl-1H-indole	Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Apoptosis	Others
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .

Zharp1-211	RIP kinase	Inflammation/Immunology
Zharp1-211 is a potent inhibitor of RIPK1 kinase. Zharp1-211 significantly reduces the expression of JAK/STAT1-mediated chemokines and MHC class II molecules in intestinal epithelial cells .

Chlorothalonil 1 Publications Verification	Fungal Estrogen Receptor/ERR	Infection
Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity .

2-Me PeER	Cytochrome P450	Others
2-Me PeER is a rhodamine dye-based fluorescent probe that detects CYP3A4 activity. In fluorescence-activated cell sorting (FACS) based on CYP3A4 activity, homogeneous and functional human induced pluripotent stem cell (hiPSC)-derived hepatocytes and intestinal epithelial cells can be obtained with the aid of 2-Me PeER .

NiCur	Histone Acetyltransferase	Cancer
NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC₅₀ value of 0.35 μΜ. NiCur, which blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur can be used for performing mechanistic studies without affecting the expression of target proteins .

Chlorothalonil (Standard)	Fungal Estrogen Receptor/ERR	Infection
Chlorothalonil (Standard) is the analytical standard of Chlorothalonil. This product is intended for research and analytical applications. Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity .

Indole-3-carboxaldehyde 3-Formylindole	Endogenous Metabolite	Others
Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract .

Somatostatin-28 (sheep, human rat mouse)	Somatostatin Receptor	Metabolic Disease
Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion .

Cat. No.	Product Name	Category	Target	Chemical Structure

Skatole 3 Publications Verification 3-Methylindole; 3-Methyl-1H-indole	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Apoptosis
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .

Indole-3-carboxaldehyde 3-Formylindole	Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Indole Alkaloids Alkaloids Human Gut Microbiota Metabolites Microorganisms Cruciferae Other Diseases Isatis tinctoria L. Disease Research Fields	Endogenous Metabolite
Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract .

6α-Hydroxypolyporenic acid C	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
6α-Hydroxypolyporenic acid C, a lanostane triterpenoid, is a nature product that could be isolated from the sclerotium of Poria cocos. 6α-Hydroxypolyporenic acid C can be absorbed across intestinal epithelial cells .

Cat. No.	Product Name	Chemical Structure

HY-W007355S1

Skatole-d8
Skatole-d₈ is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

HY-W007355S

Skatole-d3
Skatole-d₃ is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

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