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Results for "

memory

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (16) Adenosine Receptor (1) Adenylate Cyclase (2) Adrenergic Receptor (2) Akt (2) Aminopeptidase (1) AMPK (2) Amyloid-β (10) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (13) Autophagy (9) Bacterial (1) Bcl-2 Family (4) Beta-lactamase (1) Biochemical Assay Reagents (1) Calcium Channel (3) CaMK (1) Cannabinoid Receptor (2) CDK (5) Chemerin Receptor (3) Cholinesterase (ChE) (24) CRFR (3) Dopamine Receptor (7) Dopamine Transporter (1) DYRK (1) EGFR (1) Endogenous Metabolite (7) Epoxide Hydrolase (2) ERK (3) Estrogen Receptor/ERR (1) GABA Receptor (1) GCGR (1) GnRH Receptor (1) GSK-3 (1) Guanylate Cyclase (1) HBV (1) HCN Channel (1) HDAC (2) Histamine Receptor (2) Histone Acetyltransferase (1) iGluR (17) IKK (1) Influenza Virus (2) Interleukin Related (2) Isotope-Labeled Compounds (3) JNK (1) Keap1-Nrf2 (2) Lipoxygenase (1) LPL Receptor (1) mAChR (4) Melatonin Receptor (1) mGluR (2) Microtubule/Tubulin (2) Monoamine Oxidase (6) nAChR (11) Neuropeptide Y Receptor (3) Neurotensin Receptor (1) NO Synthase (3) Notch (2) Opioid Receptor (1) Orexin Receptor (OX Receptor) (1) Organoid (2) Orthopoxvirus (2) Oxidative Phosphorylation (2) Oxytocin Receptor (2) p38 MAPK (3) PAI-1 (1) Parasite (1) PD-1/PD-L1 (1) Phosphodiesterase (PDE) (7) PKA (5) PKC (2) Potassium Channel (2) Prolyl Endopeptidase (PREP) (2) PROTACs (1) Pyruvate Kinase (1) Reactive Oxygen Species (5) ROR (1) SARS-CoV (2) Sigma Receptor (6) Sirtuin (1) Somatostatin Receptor (2) STAT (2) Steroid Sulfatase (1) STING (3) Tau Protein (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (26) Cardiovascular Disease (7) Endocrinology (2) Infection (6) Inflammation/Immunology (29) Metabolic Disease (9) Neurological Disease (164)
Click Chemistry:	Alkynes (1)

202

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W014941

(R)-(-)-α-Methylhistamine dihydrochloride	Histamine Receptor	Neurological Disease
(R)-(-)-α-Methylhistamine dihydrochloride is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a K_d of 50.3 nM . (R)-(-)-α-Methylhistamine dihydrochloride can enhance memory retention, attenuates memory impairment in rats .

HY-151518

Aminopeptidase-IN-1	Aminopeptidase	Neurological Disease
Aminopeptidase-IN-1 (compound 16o) is a potent insulin-regulated aminopeptidase (IRAP) inhibitor with an K_i value of 7.7 μM. Aminopeptidase-IN-1 can be used tor research cognitive and memory impairments .

HY-P3641

Kisspeptin 13	GnRH Receptor	Neurological Disease
Kisspeptin 13 is a GPR54 and GnRH receptor activator, an endogenous active isoform. Kisspeptin 13 enhances memory and can be used in Alzheimer's disease research .

HY-148331

Z-Thioprolyl-Thioproline	Prolyl Endopeptidase (PREP)	Neurological Disease
Z-Thioprolyl-Thioproline is a bovine brain prolyl endopeptidase (PEP) inhibitor (IC₅₀=16 µM; K_i=37 µM). Z-Thioprolyl-Thioproline is used in the study of neurological disorders such as memory disorders and cognitive disorders .

HY-129103

A-412997	Dopamine Receptor	Neurological Disease
A-412997 is a selective Dopamine D4 agonist with K_i values of 12 and 7.9 nM for the rat and human receptors. A-412997 improves short term memory and cognitive properties in rodent models .

HY-14559

PRX-07034 hydrochloride	5-HT Receptor	Neurological Disease
PRX-07034 hydrochloride is a highly selective and potent 5-HT6 receptor antagonist with a K_i= 4-8 nM and an IC₅₀ of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility .

HY-142066

4′-Demethylnobiletin	PKA ERK iGluR	Neurological Disease
4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling .

HY-21995

BGC20-761	5-HT Receptor Dopamine Receptor	Neurological Disease
BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor K_i values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent .

HY-N4134

Ciwujianoside C3	NO Synthase	Inflammation/Immunology
Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory .

HY-N3204

Neoechinulin A	Apoptosis	Neurological Disease
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-116463D

(Rac)-E1R	Sigma Receptor	Neurological Disease
(Rac)-E1R (Compound 2) is the racemate of E1R. (Rac)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) used for the research of cognition/memory disorders .

HY-124609

CAD031	Monoamine Oxidase Dopamine Transporter	Neurological Disease
CAD031 is a derivative of the Alzheimer's disease (AD) targeting agent J147 (HY-13779) with neuroprotective and memory-enhancing properties. CAD031 enhances memory in mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain in aged mice. CAD031 is more active than J147 in human neural stem cell assays .

HY-155330

PZ-1922	5-HT Receptor Monoamine Oxidase	Neurological Disease
PZ-1922 (Compound 16) is a BBB-penetrable 5-HT6R/5-HT3R antagonist (K_i: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 reversibly inhibits MAO-B (pIC₅₀: 8.93). PZ-1922 reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 prevents Aβ-induced memory decline in the T-maze test .

HY-P1437

Neuropeptide S(Mouse)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Mouse) is a bioactive peptide. Neuropeptide S (Mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction .

HY-155330A

PZ-1922 free base	5-HT Receptor Monoamine Oxidase	Neurological Disease
PZ-1922 free base is a BBB-penetrable 5-HT6R/5-HT3R antagonist (K_i: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 free base reversibly inhibits MAO-B (pIC₅₀: 8.93). PZ-1922 free base reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 free base prevents Aβ-induced memory decline in the T-maze test .

HY-120782

Yhhu-3792	Notch	Neurological Disease
Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction .

HY-120782A

Yhhu-3792 hydrochloride	Notch	Neurological Disease
Yhhu-3792 hydrochloride enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 hydrochloride activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 hydrochloride expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 hydrochloride increases the spatial and episodic memory abilities of mice. Yhhu-3792 hydrochloride has the potential for the research of impairment of learning and memory associated DG dysfunction .

HY-116463A

(2R,3S)-E1R	Sigma Receptor	Neurological Disease
(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders .

HY-116463B

(2S,3S)-E1R	Sigma Receptor	Neurological Disease
(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders .

HY-116463C

(2R,3R)-E1R	Sigma Receptor	Neurological Disease
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders .

HY-W010042

L-Glucose L-(-)-Glucose	Others	Metabolic Disease Cancer
L-Glucose (L-(-)-Glucose) is a stereoisomer of D-Glucose (HY-B0389), which does not readily enter the brain. L-Glucose can promote food intake. L-glucose is combined with a fluorescence detector to produce a fluorescent probe that can be used to visualize and characterize cancer cells. L-Glucose also can be used in the research to enhance memory in mice .

HY-145831

sEH/AChE-IN-1	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
sEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-1 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-1 has the potential for the research of Alzheimer's disease (AD) .

HY-160505

RO-275	HCN Channel	Neurological Disease
RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC₅₀ values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder .

HY-145832

sEH/AChE-IN-2	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
sEH/AChE-IN-2 (Compound 12b) is a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-2 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-2 has the potential for the research of Alzheimer's disease (AD) .

HY-115910

Y13g	Cholinesterase (ChE) Interleukin Related	Neurological Disease
Y13g is the potent inhibitor of both AChE and IL-6. Interleukin-6 (IL-6) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g reverses the STZ-induced memory deficit, and shows histopathology similarly as in normal animals .

HY-115910A

Y13g dihydrochloride	Interleukin Related Cholinesterase (ChE)	Neurological Disease
Y13g dihydrochloride is the potent inhibitor of both AChE and IL-6. Interleukin-6 (IL-6) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g dihydrochloride reverses the STZ-induced memory deficit, and shows histopathology similarly as in normal animals .

HY-155992

WLB-89462	Sigma Receptor	Neurological Disease
WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (K_i: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents) .

HY-D0873

HEPPS EPPS	Amyloid-β	Neurological Disease
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier .

HY-P3585

Epobis	TNF Receptor	Neurological Disease Inflammation/Immunology
Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties .

HY-10936

S 18986	iGluR	Neurological Disease
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests .

HY-N0691

Schisandrin 2 Publications Verification Schizandrin; Schizandrol; Schizandrol-A	Autophagy	Inflammation/Immunology Cancer
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

HY-15114

S 17092 S 17092-1	Prolyl Endopeptidase (PREP)	Neurological Disease
S 17092 (S 17092-1) is a potent cerebral prolyl-endopeptidase (PEP) inhibitor with an IC₅₀ of 1.2 nM. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging .

HY-P2259

TAT-GluA2 3Y	iGluR	Neurological Disease
TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression .

HY-135483A

AR-R17779 hydrochloride	nAChR	Neurological Disease
AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with K_is of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways .

HY-101528

IDRA 21	iGluR	Neurological Disease
IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging .

HY-108621

RS-25344 hydrochloride	Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC₅₀ of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC₅₀ of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects .

HY-149941

hNTS1R agonist-1	Neurotensin Receptor	Neurological Disease
hNTS1R agonist-1 (Compound 10) is a BBB permeable hNTS1R full agonist (K_i: 6.9 nM) . hNTS1R agonist-1 increases motor function and memory in a mouse model of Parkinson's disease (PD). hNTS1R agonist-1 is a Neurotensin(8-13) analog and is a neuroprotective agent .

HY-10295

SB 202190 Maximum Cited Publications 80 Publications Verification	Organoid p38 MAPK Autophagy Apoptosis	Neurological Disease Cancer
SB 202190 is a selective p38 MAP kinase inhibitor with IC₅₀s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 binds to the ATP pocket of the active recombinant human p38 kinase with a K_d of 38 nM. SB 202190 has anti-cancer activity and rescued memory deficits . SB202190 induces autophagy .

HY-146677

5-HT6R/MAO-B modulator 1	5-HT Receptor Monoamine Oxidase	Neurological Disease
5-HT6R/MAO-B modulator 1 (compound 48) is an antagonist of 5-HT₆R at Gs signaling and an irreversible MAO-B inhibitor. 5-HT6R/MAO-B modulator 1 exhibits glioprotective properties. 5-HT6R/MAO-B modulator 1 can reverse Scopolamine-induced memory deficits . 5-HT6R/MAO-B modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14759

Aleplasinin PAZ-417	PAI-1 Amyloid-β	Neurological Disease
Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research .

HY-151386

BChE-IN-13	Cholinesterase (ChE)	Neurological Disease
BChE-IN-13 (Compound 17c) is an orally active, potent and selective Butyrylcholinesterase (BChE) inhibitor with IC₅₀s of 0.22 and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 can improve memory and cognitive impairments, and be used in Alzheimer’s disease (AD) research .

HY-156017

5-HT6R antagonist 1	5-HT Receptor	Cardiovascular Disease Neurological Disease
5-HT6R antagonist 1 (Comopund 8) is a 5-HT6R antagonist (K_i: 5 nM). 5-HT6R antagonist 1 inhibits platelet aggregation. 5-HT6R antagonist 1 has excellent metabolic stability. 5-HT6R antagonist 1 reverses MK-801 (HY-15084B)-induced memory impairments in rats. 5-HT6R antagonist 1 can be used for Alzheimer's disease (AD) research .

HY-12363

U-69593	Opioid Receptor	Neurological Disease
U-69593 is a potent and selective κ1-opioid receptor agonist . U-69593 attenuates addictive agent-induced behavioral sensitization in the rat . U-69593 reduces anxiety and enhances spontaneous alternation memory in mice . U-69593 reduces calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum .

HY-P3355

p-fin4	iGluR	Neurological Disease
p-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators .

HY-N9410

Lysophosphatidylcholine 18:2 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC	Endogenous Metabolite	Metabolic Disease
Lysophosphatidylcholine 18:2 (1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC), a lysophospholipid, is a potential biomarker identified from insulin resistance (IR) polycystic ovary syndrome (PCOS). Low plasma Lysophosphatidylcholine 18:2 also has been shown to predict impaired glucose tolerance, insulin resistance, type 2 diabetes, coronary artery disease, and memory impairment .

HY-143464

BChE-IN-4	Cholinesterase (ChE)	Neurological Disease
BChE-IN-4 is a potent and cross the blood-brain barrier BChE inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease .

HY-143321

STING agonist-13	STING	Cancer
STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate STING downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .

HY-P3354

p3Ysh-3	iGluR	Neurological Disease
p3Ysh-3 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 1.09 μM. p3Ysh-3 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p3Ysh-3 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators .

HY-103308

TRAM-39	Potassium Channel	Neurological Disease
TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IK_Ca) channels. TRAM-39 inhibits KCa3.1 channel with an IC₅₀ value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease .

HY-142700

SSTR4 agonist 3	Somatostatin Receptor	Neurological Disease
SSTR4 agonist 3 is a potent agonist of SSTR4. SSTR4 is expressed at relatively high levels in the hippocampus and neocortex, memory and learning regions, and Alzheimer's disease pathology. SSTR4 agonists are potent in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and anti-inflammatory activity. SSTR4 agonist 3 has the potential for the research of pain (extracted from patent WO2021233427A1, compound 14) .

Cat. No.	Product Name	Target	Research Area

HY-P1437

Neuropeptide S(Mouse)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Mouse) is a bioactive peptide. Neuropeptide S (Mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction .

HY-P2259

TAT-GluA2 3Y	iGluR	Neurological Disease
TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression .

HY-P3641

Kisspeptin 13	GnRH Receptor	Neurological Disease
Kisspeptin 13 is a GPR54 and GnRH receptor activator, an endogenous active isoform. Kisspeptin 13 enhances memory and can be used in Alzheimer's disease research .

HY-P3585

Epobis	TNF Receptor	Neurological Disease Inflammation/Immunology
Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties .

HY-149941

hNTS1R agonist-1	Neurotensin Receptor	Neurological Disease
hNTS1R agonist-1 (Compound 10) is a BBB permeable hNTS1R full agonist (K_i: 6.9 nM) . hNTS1R agonist-1 increases motor function and memory in a mouse model of Parkinson's disease (PD). hNTS1R agonist-1 is a Neurotensin(8-13) analog and is a neuroprotective agent .

HY-P3355

p-fin4	iGluR	Neurological Disease
p-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators .

HY-P3354

p3Ysh-3	iGluR	Neurological Disease
p3Ysh-3 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 1.09 μM. p3Ysh-3 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p3Ysh-3 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators .

HY-P3201

PKCζ/ι pseudosubstrate inhibitor	Pyruvate Kinase	Neurological Disease
PKCζ/ι pseudosubstrate inhibitor has broad-spectrum effects on the PKC enzyme family and can induce memory impairment .

HY-P4009

[Lys8] Vasopressin Desglycinamide	Peptides	Neurological Disease
[Lys8] Vasopressin Desglycinamide is a vasopressin analog, used for the maintenance of active and passive avoidance behavior. [Lys8] Vasopressin Desglycinamide facilitates memory consolidation processes .

HY-P2712

Chemerin-9, mouse Chemerin148–156, mouse	Chemerin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin-9, mouse (Chemerin148-156, mouse) is a C-terminal nonapeptide of chemerin. Chemerin-9, mouse is a ligand for ChemR23 (EC₅₀ = 42 nM). Chemerin-9, mouse reduces basal lipolysis in primary mouse white adipocytes(IC₅₀ = 3.3 nM). Chemerin-9, mouse enhances memory and relieves Aβ1-42-induced memory impairment in AD mice. Chemerin-9, mouse also inhibits atherogenesis .

HY-P2497

Exendin (5-39) 1 Publications Verification	GCGR	Neurological Disease
Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats .

HY-P3684A

[DPro5] Corticotropin Releasing Factor, human, rat TFA	CRFR	Neurological Disease
[DPro5] Corticotropin Releasing Factor, human, rat TFA is a selective corticotropin releasing factor/hormone R2 (CRH-R2)agonist. [DPro5] Corticotropin Releasing Factor, human, rat TFA fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat .

HY-P3684

[DPro5] Corticotropin Releasing Factor, human, rat	CRFR	Endocrinology
[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat .

HY-P1025

M40	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .

HY-P1025A

M40 TFA	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .

HY-P1399

Pep2m, myristoylated Myr-Pep2m	PKC	Neurological Disease
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC) .

HY-P1399A

Pep2m, myristoylated TFA Myr-Pep2m TFA	PKC	Neurological Disease
Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide. Pep2m, myristoylated TFA can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC) .

HY-105066

Davunetide	Microtubule/Tubulin Amyloid-β	Neurological Disease
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity .

HY-P1844

Chemerin-9 (149-157)	Chemerin Receptor Akt ERK Reactive Oxygen Species Amyloid-β	Inflammation/Immunology
Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ_1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism .

HY-P1844A

Chemerin-9 (149-157) (TFA) 2 Publications Verification	Chemerin Receptor Akt ERK Reactive Oxygen Species Amyloid-β	Inflammation/Immunology
Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ_1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4134

Ciwujianoside C3	Structural Classification Natural Products Acanthopanax henryi (Oliv.) Harms Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NO Synthase
Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory .

HY-N3204

Neoechinulin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite Indole Alkaloids	Apoptosis
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-N0691

Schisandrin 2 Publications Verification Schizandrin; Schizandrol; Schizandrol-A	Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer	Autophagy
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

HY-N9410

Lysophosphatidylcholine 18:2 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC	Infection Natural Products Classification of Application Fields Source classification Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Lysophosphatidylcholine 18:2 (1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC), a lysophospholipid, is a potential biomarker identified from insulin resistance (IR) polycystic ovary syndrome (PCOS). Low plasma Lysophosphatidylcholine 18:2 also has been shown to predict impaired glucose tolerance, insulin resistance, type 2 diabetes, coronary artery disease, and memory impairment .

HY-N0459

3,5-O-Dicaffeoylquinic acid 1 Publications Verification	other families Simple Phenylpropanols Source classification Phenylpropanoids Plants	Others
3,5-O-Dicaffeoylquinic acid reverses Trimethyltin-induced learning and memory deficits .

HY-B1065

Aceglutamide α-N-Acetyl-L-glutamine; N2-Acetylglutamine	Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Autophagy Endogenous Metabolite
Aceglutamide (α-N-Acetyl-L-glutamine) is a psychostimulant and nootropic, used to improve memory and concentration .

HY-N0204

Pulchinenoside A Anemoside A3	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Ranunculaceae Other Diseases Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel	iGluR
Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.

HY-N9737

(−)-Acutumine	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Plants Menispermaceae	Others
(−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model .

HY-N0541

Pseudoginsenoside F11 1 Publications Verification Ginsenoside A1	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Plants Endogenous metabolite Disease Research Fields Araliaceae	Endogenous Metabolite
Pseudoginsenoside F11 (Ginsenoside A1), a component of Panax quinquefolium (American ginseng), has been demonstrated to antagonize the learning and memory deficits induced by scopolamine, morphine and methamphetamine in mice.

HY-N6608

Physostigmine Eserine	Alkaloids Lablab purpureus (L.) Sweet Leguminosae Source classification Plants Indole Alkaloids	Cholinesterase (ChE)
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning .

HY-N4268

Tenuifoliside B	Source classification Polygalaceae Phenols Polyphenols Plants Polygala tenuifolia Willd.	Others
Tenuifoliside B, a component isolated from Polygalae Radix, inhibits potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment. Tenuifoliside B shows potential cognitive improvement and cerebral protective effects. Tenuifoliside B has potential to become an anti-AD lead compound .

HY-113354

Anserine 1 Publications Verification	Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .

HY-N0824

Syringin 1 Publications Verification Eleutheroside B	Cardiovascular Disease Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Disease Research Fields Araliaceae	Autophagy
Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc .

HY-B1192

Estradiol benzoate 10+ Cited Publications β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Classification of Application Fields Disease Research Fields Cancer	Estrogen Receptor/ERR HBV Bcl-2 Family
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-N11872

Suffruticosol A	Structural Classification Paeonia lactiflora Pall. Source classification Phenols Polyphenols Plants Paeoniaceae	Others
Suffruticosol A is a neuroprotective agent that restores scopolamine-induced cellular neurodegenerative damage. Suffruticosol A ameliorates hippocampal cholinergic deficits and partially enhances BDNF signaling. Suffruticosol A has neuromodulatory effects in a Scopolamine (HY-N0296)-induced model, restoring memory and cognitive performance in mice. Suffruticosol A can be isolated from seeds of P. lactiflora .

HY-N6967

Levomenol (-)-α-Bisabolol	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants	Apoptosis
Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active .

HY-N0403

2,3,4',5-Tetrahydroxystilbene 2-O-β-D-glucoside	Structural Classification Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Polyphenols Plants	Apoptosis
2,3,4',5-Tetrahydroxystilbene 2-O-β-D-glucoside (TSG) is an active product that can be extracted from Polygonum multiflorum Thunb. TSG has anti-inflammatory, antioxidative, anti-atherosclerotic, anti-apoptotic, and free radical scavenging activities, TSG is also indicated to facilitate long-term potentiation and learning and memory in both normal and pathological conditions .

HY-B0528A

Octopamine hydrochloride 1 Publications Verification (±)-p-Octopamine hydrochloride	Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-N0155

Nobiletin Maximum Cited Publications 16 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavones Source classification Rutaceae Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco	ROR Reactive Oxygen Species Apoptosis Autophagy
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-N0307

Ciwujianoside B	Triterpenes Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Bcl-2 Family
Ciwujianoside B is isolated from Eleutherococcus senticosus leaf, is able to penetrate and work in the brain after the oral administration. Ciwujianoside B significantly enhances object recognition memory . Ciwujianoside B shows radioprotective effects on the hematopoietic system in mice, which is associated with changes in the cell cycle, reduces DNA damage and down-regulates the ratio of Bax/Bcl-2 in bone marrow cells exposed to radiation .

HY-N4126

6-Demethoxytangeretin	Flavonoids other families Neurological Disease Classification of Application Fields Flavones Source classification Rutaceae Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco Cancer	Anaplastic lymphoma kinase (ALK)
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus reticulata. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways . 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons .

HY-N11997

Feralolide	Structural Classification Liliaceae Source classification Coumarins Phenols Polyphenols Aloe vera (L.) Burm. f. Phenylpropanoids Plants	Cholinesterase (ChE)
Feralolide is a dihydroisocoumarin isolated from the methanolic extract of aloe vera resin. Feralolide is also a dual inhibitor of AChE and BuChE, with IC₅₀s of 55 μg/mL and 52 μg/mL respectively. Feralolide has antioxidant activity and inhibits 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Feralolide could be used in research into cognitive disorders such as Alzheimer's disease, potentially restoring and enhancing memory .

HY-106353

Smilagenin 1 Publications Verification	Structural Classification Pelargonium hortorum Bailey Liliaceae Neurological Disease Classification of Application Fields Anemarrhena asphodeloides Bunge Plants Disease Research Fields Geraniaceae Steroids	mAChR Endogenous Metabolite
Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases . Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density . Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD .

HY-N6074

Soyasapogenol B	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants Disease Research Fields Cancer	Autophagy Apoptosis
Soyasapogenol B is a component of soy that has oral activity. Soyasapogenol B promotes autophagy and apoptosis. Soyasapogenol B has anti-inflammatory, antioxidant and antitumor activities .

HY-N0006

Demethoxycurcumin 3 Publications Verification Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin	Zingiber officinale Roscoe Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Zingiberaceae Cancer	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase
Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

Cat. No.	Product Name	Chemical Structure

HY-113354S

Anserine-d4

Anserine-d₄ is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].

HY-N6608S

Physostigmine-d3

Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].

HY-113354S1

Anserine-d4 hydrochloride

Anserine-d₄ hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .

HY-W653905

Amantadine-d15 hydrochloride

Amantadine-d₁₅ hydrochloride is deuterated labeled Amantadine. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .

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