Search Result
Results for "
mild
" in MedChemExpress (MCE) Product Catalog:
4
Biochemical Assay Reagents
13
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-128901
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F 14679 fumarate
|
5-HT Receptor
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Neurological Disease
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F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress .
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- HY-B0629
-
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Glucocorticoid Receptor
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Metabolic Disease
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Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis .
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- HY-B1191
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2,6-Lupetidine
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Others
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Cardiovascular Disease
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Nanofin is neuropathic blocker, with antihypertensive effect, used for mild to moderate hypertension.
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-
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- HY-100046
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Desmethyldoxepin hydrochloride
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Drug Metabolite
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Neurological Disease
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Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression .
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- HY-156634
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NYX-783
|
iGluR
|
Neurological Disease
|
Risevistinel (NYX-783) is a positive allosteric modulator of N-methyl-D-aspartate (NMDA) receptor. Nevadistinel can be used to inhibit cognitive impairment associated with neurodegenerative diseases, such as mild cognitive impairment, mild Alzheimer's disease, Parkinson's disease, Lewy body disease .
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-
-
- HY-156626
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NYX-458; NYX-3054
|
iGluR
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Neurological Disease
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Nevadistinel (NYX-458; NYX-3054) is a positive allosteric modulator of N-methyl-D-aspartate (NMDA) receptor. Nevadistinel can be used to inhibit cognitive impairment associated with neurodegenerative diseases, such as mild cognitive impairment, mild Alzheimer's disease, Parkinson's disease, Lewy body disease .
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- HY-145535
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C24 3'-sulfo Galactosylceramide (d18:1/24:0)
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Endogenous Metabolite
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Metabolic Disease
|
Tetracosanoyl-sulfatide is an endogenous metabolite present in Urine that can be used for the research of Mild Metachromatic Leukodystrophy .
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-
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- HY-B1804
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Trioctanoin; Glyceryl trioctanoate
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Endogenous Metabolite
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Neurological Disease
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Tricaprilin (Trioctanoin) is used in study for patients with mild to moderate Alzheimer's disease and has a role as an anticonvulsant and a plant metabolite .
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-
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- HY-W039454
-
|
Bacterial
|
Infection
|
2,4-Dichlorobenzyl alcohol is a mild antiseptic, with a broad spectrum for bacterial and virus associated with mouth and throat infections .
|
-
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- HY-122916
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-
-
- HY-D0235
-
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Fluorescent Dye
|
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Alizarin yellow GG is a dye that exhibits corrosion inhibition effects on mild steel against concentrated H2SO4.
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-
-
- HY-I0020
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(-)-Narwedine; Narwedin
|
Cholinesterase (ChE)
|
Neurological Disease
|
Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
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-
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- HY-N2622
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(+)-Oxypeucedanin hydrate
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Others
|
Cancer
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Oxypeucedanin hydrate ((+)-Oxypeucedanin hydrate) is a natural product isolated from D. anethifolia. Prangol exhibits mild toxicity on fibroblasts and parental lymphoma cells .
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-
-
- HY-B1530
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(±)-Ammonium lactate
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|
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Ammonium lactate is the ammonium salt of lactic acid, with mild anti-bacterial properties. Ammonium lactate can be used for the research of xerosis .
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- HY-108249
-
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Others
|
Inflammation/Immunology
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Tribenoside is a vasoprotective agent, can be used for the research of hemorrhoids. Tribenoside has mild anti-inflammatory, analgesic, and wound healing properties .
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- HY-B1316
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Trimetozine is an orally active sedative. Trimetozine has mild tranquilizing effects. Trimetozine can be used for the research of anxiety .
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- HY-N10928
-
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Parasite
|
Infection
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Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC50~20 μg/mL) .
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- HY-Z0478
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(S)-(-)-Limonene
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Others
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Cardiovascular Disease
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(-)-Limonene ((S)-(-)-Limonene) is a monoterpene found in citrus plants like lemon, orange, and grape. (-)-Limonene can induce a mild bronchoconstrictive effect .
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- HY-B0892S2
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-
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- HY-B0892S1
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-
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- HY-10933
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CX516
1 Publications Verification
BDP 12
|
iGluR
|
Neurological Disease
|
CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) .
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-
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- HY-B0575
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-
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- HY-129524
-
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Apoptosis
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Inflammation/Immunology
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Ethylene dimethane sulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs .
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- HY-W012896
-
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Others
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Others
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2-Thiohydantoin acts as an inhibitor for the corrosion of mild steel in 0.1 M HCl and its inhibition efficiency is both concentration and immersion time dependent .
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- HY-N5107
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(+)-epi-Magnolin
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Parasite
|
Infection
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Epimagnolin A, a furfuran lignan, shows mild antiplasmodial activities (IC50=5.7 μg/mL) without noticeable toxicity on mammalian normal cells .
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- HY-126460A
-
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Bacterial
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Others
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Myristoyl glutamic acid sodium is a common ingredient in cosmetics/creams. Myristoyl glutamic acid sodium, a surfactant belonging to the amino acid, has mild cleaning properties and is also foamy and mildly bacteriostatic .
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-
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- HY-106000
-
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Histamine Receptor
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Neurological Disease
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GSK239512 is a potent and brain penetrated H3 receptor antagonist. GSK239512 can be used for the research of mild-to-moderate Alzheimer's disease (AD) .
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-
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- HY-B0575S
-
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Sodium Channel
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Metabolic Disease
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Triamterene-d5 is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.
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- HY-110014
-
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Cannabinoid Receptor
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Neurological Disease
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Noladin ether is a potent and selective agonist of cannabinoid CB1 receptor, with a Ki of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception .
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-
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- HY-W040672
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Dytransin
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COX
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Inflammation/Immunology
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Ibufenac (Dytransin) is an analog of Ibuprofen. Ibuprofen is a non-steroidal anti-rheumatoid agen and non-selective COX inhibitor used to research mild-moderate pain, fever, and inflammation.
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- HY-N12426
-
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Others
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Metabolic Disease
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Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.
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- HY-13005
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D-Fagomine
|
Glucosidase
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Metabolic Disease
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Fagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively.
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-
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- HY-B1147
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Parasite
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Infection
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Diloxanide furoate is the proagent of Diloxanide. Diloxanide furoate is a potent and orally active anti-protozoal agent and can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers .
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-
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- HY-W017389
-
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Endogenous Metabolite
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Inflammation/Immunology
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Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
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-
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- HY-B0892S5
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-
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- HY-B1804S1
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Trioctanoin-d50; Glyceryl trioctanoate-d50
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Endogenous Metabolite
|
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Tricaprilin-d50 is the deuterium labeled Tricaprilin. Tricaprilin (Trioctanoin) is used in study for patients with mild to moderate Alzheimer's disease and has a role as an anticonvulsant and a plant metabolite[1][2].
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- HY-B1804S2
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Trioctanoin-d15; Glyceryl trioctanoate-d15
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Endogenous Metabolite
|
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Tricaprilin-d15 is the deuterium labeled Tricaprilin. Tricaprilin (Trioctanoin) is used in study for patients with mild to moderate Alzheimer's disease and has a role as an anticonvulsant and a plant metabolite[1][2].
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- HY-146686
-
|
Cholinesterase (ChE)
|
Neurological Disease
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BuChE-IN-3 (Compound C4) is a potent inhibitor of BuChE with an IC50 of 8.3 nM. BuChE-IN-3 exhibits mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity .
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- HY-146687
-
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Cholinesterase (ChE)
|
Neurological Disease
|
BuChE-IN-4 (Compound C6) is a potent inhibitor of BuChE with an IC50 of 7.7 nM. BuChE-IN-4 exhibits mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity .
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- HY-108243
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-
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- HY-123179
-
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Others
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Cardiovascular Disease
|
Mefruside is an orally active diuretic and has a mild hypotensive effect. Mefruside inhibits the synthesis of urea in an isolated rat liver perfusion model. Mefruside can be used in studies of oedema and hypertension .
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- HY-N4000
-
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Others
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Cancer
|
Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth . Digitonin is an natural detergent .
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-
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- HY-B0892S
-
-
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- HY-151682
-
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ADC Linker
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Others
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H-L-Lys(Norbornene-methoxycarbonyl)-OH, a norbornene-derivatized lysine, can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH can be used for the mild and selective modification of proteins in a copper-free click reaction .
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- HY-151682A
-
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ADC Linker
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Others
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H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride, a norbornene-derivatized lysine, can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride can be used for the mild and selective modification of proteins in a copper-free click reaction .
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- HY-B1796
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Thymol iodide is a compound of Iodide and Thymol. Thymol iodide acts as a substitute for iodoform . Thymol iodide is an iodine derivative of Thymol (a phenol derived from thyme oil), which is mostly used as mild antiseptic and fungicide .
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- HY-B0575R
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|
Sodium Channel
G protein-coupled Bile Acid Receptor 1
|
Metabolic Disease
|
Triamterene (Standard) is the analytical standard of Triamterene. This product is intended for research and analytical applications. Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene as an inhibitor of the TGR5 receptor.
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- HY-N0285S
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-
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- HY-149883
-
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Others
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Others
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IZS-L is a amino acid-derived corrosion inhibitor. IZS-L exhibits corrosion inhibition performance for metal at longer immersion. IZSs, the series of corrosion inhibitors, inhibit mild steel corrosion through the formation of an inhibitor film on the metal surface .
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- HY-155500
-
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Others
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Others
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Digoxigenin NHS ester is an activated ester which readily reacts with amino groups under mild conditions, attaching the digoxigenin (HY-B1025) moiety to proteins or amino-. Digoxigenin NHS ester can be used to label proteins and oligonucleotides .
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- HY-W019829
-
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Tyrosinase
Parasite
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Infection
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Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities .
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- HY-144011
-
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Liposome
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Others
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DSPE-PEG-Cyanur is a PEG derivative containing cyanur functional group. DSPE-PEG-Cyanur can be used for PEGylation of protein under mild basic conditions. DSPE-PEG-Cyanur can be used for nanostructured lipid carrier .
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- HY-W250170
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Octyldecyl glucoside
|
Biochemical Assay Reagents
|
Others
|
Decyl glucoside is a mild nonionic surfactant. Decyl glucoside can be derived from renewable raw materials such as glucose and fatty alcohols from coconut oil or palm kernel oil. Decyl glucoside is known for its excellent foaming and cleaning properties.
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- HY-B0892
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Benzenemethanol
|
|
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Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated Toll-Like Receptor 4 to reduce the inflammatory response of liver injury in mice .
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- HY-10933S
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BDP 12-d10
|
Isotope-Labeled Compounds
iGluR
|
Neurological Disease
|
CX516-d10 is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI)[1].
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- HY-N11019
-
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Others
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Others
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Erinacine P (compoud 1) is a parental metabolite of luteolin. Erinacine P can be isolated from the mycelia of basidiomycetous Hericium erinaceum YB4-6237. Under mild conditions, Erinacine P is able to be chemically converted to Erinacine B and then to Erinacine A .
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- HY-W014394
-
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Others
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Cardiovascular Disease
|
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether has been proposed as a mild warming agent providing a warming sensation and enhancing the blood circulation .
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- HY-50682
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Azeliragon
Maximum Cited Publications
9 Publications Verification
TTP488; PF-04494700
|
Amyloid-β
|
Neurological Disease
|
Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression in patients with mild Alzheimer’s disease (AD) . Azeliragon also can cross the blood-brain barrier (BBB) .
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- HY-W039454R
-
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Bacterial
|
Infection
|
2,4-Dichlorobenzyl alcohol (Standard) is the analytical standard of 2,4-Dichlorobenzyl alcohol. This product is intended for research and analytical applications. 2,4-Dichlorobenzyl alcohol is a mild antiseptic, with a broad spectrum for bacterial and virus associated with mouth and throat infections .
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- HY-109085
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OPA-15406
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD) .
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- HY-145576
-
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Others
|
Others
|
2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH .
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- HY-B1192S
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β-Estradiol 3-benzoate-d3; 17β-Estradiol 3-benzoate-d3
|
Estrogen Receptor/ERR
|
|
Estradiol benzoate-d3 is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3][4].
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- HY-P99776
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XmAb-13676
|
CD20
CD3
|
Cancer
|
Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20 + expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo .
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- HY-111081C
-
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Sigma Receptor
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Neurological Disease
|
(±)-PPCC oxalate is a sigma-1 agonist that mainly interacts with sigma-1 receptors with Ki of 1.5 nM. (±)-PPCC oxalate has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats .
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- HY-P99103
-
LY-3853113; LY-COV1404
|
SARS-CoV
|
Infection
|
Bebtelovimab a humanized IgG1-λ2 antibody targeting to SARS-CoV-2, especially COVID-19. Bebtelovimab potently neutralizes SARS-CoV-2 variants, and inhibits COVID-19 with mild-to-moderate efficacy .
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- HY-W008864
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β-Octaacetyllactose
|
Antibiotic
Fungal
|
Infection
|
Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1 .
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- HY-W017389S
-
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Isotope-Labeled Compounds
|
Cancer
|
Xanthine- 13C, 15N2 is a 15N-labeled and 13C-labled Xanthine (HY-W017389). Xanthine is a plant alkaloid with mild stimulant activity of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
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- HY-128784
-
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MDM-2/p53
Reactive Oxygen Species
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Cancer
|
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .
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- HY-149884
-
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Others
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Others
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IZS-P is an amino acid-derived corrosion inhibitor, based on the green chemistry principles. IZS-P inhibits mild steel corrosion via forming an inhibitor film on the metal surface. IZS series inhibitors following a corrosion inhibition performance as: IZS-P (82.46%) > IZS-M (67.19%) > IZS-L (24.77%) .
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- HY-149885
-
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Others
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Others
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IZS-M is an amino acid-derived corrosion inhibitor, based on the green chemistry principles. IZS-M inhibits mild steel corrosion via forming an inhibitor film on the metal surface. IZS series inhibitors following a corrosion inhibition performance as: IZS-P (82.46%) > IZS-M (67.19%) > IZS-L (24.77%) .
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- HY-B0892R
-
Benzenemethanol (Standard)
|
Toll-like Receptor (TLR)
Cytochrome P450
|
Inflammation/Immunology
|
Benzyl alcohol (Standard) is the analytical standard of Benzyl alcohol. This product is intended for research and analytical applications. Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated Toll-Like Receptor 4 to reduce the inflammatory response of liver injury in mice .
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- HY-143390
-
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iGluR
|
Neurological Disease
|
NMDA receptor modulator 2 (Compound 1) is a potent NMDA receptor modulator. NMDA receptor modulator 2 can be used for neurological disorder research .
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- HY-143391
-
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iGluR
|
Neurological Disease
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NMDA receptor modulator 3 (Compound 99) is a potent NMDA receptor modulator. NMDA receptor modulator 3 can be used for neurological disorder research .
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- HY-143393
-
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iGluR
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Neurological Disease
|
NMDA receptor modulator 4 (Compound 169) is a potent NMDA receptor modulator. NMDA receptor modulator 4 can be used for neurological disorder research .
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- HY-143396
-
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iGluR
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Neurological Disease
|
NMDA receptor modulator 5 (Compound 195) is a potent NMDA receptor modulator. NMDA receptor modulator 5 can be used for neurological disorder research .
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- HY-143397
-
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iGluR
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Neurological Disease
|
NMDA receptor modulator 6 (Compound 183) is a potent NMDA receptor modulator. NMDA receptor modulator 6 can be used for neurological disorder research .
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- HY-155466
-
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Dopamine Receptor
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Neurological Disease
|
Boc-MIF-1-Am (compound 2) is a human dopamine D2 receptor enhancer (EC50=17.82 nM) and is a bioconjugate of melanostatin (MIF-1) and amantadine. Boc-MIF-1-Am (200 μM) exhibited mild neurotoxicity in SH-SY5Y cells .
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- HY-151474
-
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SARS-CoV
|
Cancer
|
SARS-CoV-2-IN-31 is an effective COVID-19 inhibitor. SARS-CoV-2-IN-31 exhibits excellent to mild activity against various cancer cell lines with IC50 values range from 28.84 to 38.36 μM. SARS-CoV-2-IN-31 can be used for the research of cancer .
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- HY-17368
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S-Rivastigmine
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Cholinesterase (ChE)
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Neurological Disease
|
Rivastigmine (S-Rivastigmine) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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- HY-126377
-
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Biochemical Assay Reagents
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Others
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Sulfobetaine 10, is a zwitterionic surfactant commonly used in biochemistry and biophysics. It is commonly used to dissolve membrane proteins and other hydrophobic molecules in aqueous solutions. Sulfobetaine 10 has both positively and negatively charged groups in its structure, which allows it to maintain a neutral charge in solution and reduces its tendency to denature proteins. It is considered a mild, non-denaturing surfactant and is widely used in protein research.
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- HY-117059
-
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Dopamine Receptor
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Neurological Disease
|
SK609 hydrochloride is a dopamine D3 receptor (D3R) selective agonist with an EC50 of 1109 nM. SK609 hydrochloride has the potential for parkinson research .
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- HY-145576B
-
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Others
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Others
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2-Amino-8-oxononanoic acid (hydrochloride) is the hydrochloride form of 2-Amino-8-oxononanoic acid. 2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH .
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- HY-11017
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ENA 713; SDZ-ENA 713
|
Cholinesterase (ChE)
|
Neurological Disease
|
Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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- HY-17368S1
-
|
Isotope-Labeled Compounds
Cholinesterase (ChE)
|
Neurological Disease
|
(rac)-Rivastigmine-d6 is a labelled racemic Rivastigmine. Rivastigmine (S-Rivastigmine) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2].
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- HY-145414
-
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Others
|
Cancer
|
DYSP-C34 is a potent, biocompatible, and ultrasound (US)-triggered multifunctional molecular machine. DYSP-C34 has multiple favorable properties, such as improved lipophilic/hydrophilic balance, intensified US-induced ROS production capacity, and better cellular permeability, resulting in the excellent tumor target efficiency and notable sonodynamic therapy (SDT)-mediated tumor regression. DYSP-C34 exhibits mild immunogenicity by stimulating APCs directly .
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- HY-148642
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12-hydroxy-NVP; 12-OH-NVP
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Drug Metabolite
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Infection
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12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine .
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- HY-17368S2
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S-Rivastigmine-d3 hydrochloride
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Cholinesterase (ChE)
Isotope-Labeled Compounds
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Neurological Disease
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Rivastigmine-d3 hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (S-Rivastigmine) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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- HY-131030
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JF669, SE; JF669, NHS
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Fluorescent Dye
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Others
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Janelia Fluor 669, SE (JF669, SE), a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm) . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
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- HY-D1840
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Biochemical Assay Reagents
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Others
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Tyramide Amplification Buffer is a ready-to-use buffer primarily intended for immunostaining of cells and tissues by the technique of tyramide signal amplification (TSA). TSA Technology is based on a tyrosinase labeling system that reacts a tyrosine-labeled antibody with a fluorescently labeled tyramide using peroxidase to form a highly amplified fluorescent signal. For example, horseradish peroxidase (HRP) can catalyze the reaction of tyrosine and hydrogen peroxide under milder conditions to generate epoxy groups. Epoxy groups promote the binding of tyramide to adjacent amino acids to form fluorescently labeled products .
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- HY-11017R
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ENA 713 (Standard); SDZ-ENA 713 (Standard)
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Cholinesterase (ChE)
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Neurological Disease
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Rivastigmine (tartrate) (Standard) is the analytical standard of Rivastigmine (tartrate). This product is intended for research and analytical applications. Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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- HY-157936
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iGluR
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Neurological Disease
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GluN2B-NMDAR antagonist-2 (compound S-58) is a potent, selective and cross the blood-brain barrier NMDAR-GluN2B antagonist with an IC50 value of 74.01, nM. GluN2B-NMDAR antagonist-2 shows mild cytotoxicity. GluN2B-NMDAR antagonist-2 decreases the cerebral infarction rates and neurologic deficit scores. GluN2B-NMDAR antagonist-2 has the potential for the research of stroke .
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- HY-18698
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iGluR
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Neurological Disease
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L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity .
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HY-L0118V
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8,085 compounds
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A unique set of molecules containing mild electrophilic moieties that covalently interact with amino acid residues in the target protein. The diversity of our compounds for covalent drug discovery ranges from natural product-like scaffolds to macrocycles, creating multiple opportunities in hit generation for a selected target.
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Cat. No. |
Product Name |
Type |
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- HY-131030
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JF669, SE; JF669, NHS
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Fluorescent Dyes/Probes
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Janelia Fluor 669, SE (JF669, SE), a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm) . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
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- HY-D1840
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Dyes
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Tyramide Amplification Buffer is a ready-to-use buffer primarily intended for immunostaining of cells and tissues by the technique of tyramide signal amplification (TSA). TSA Technology is based on a tyrosinase labeling system that reacts a tyrosine-labeled antibody with a fluorescently labeled tyramide using peroxidase to form a highly amplified fluorescent signal. For example, horseradish peroxidase (HRP) can catalyze the reaction of tyrosine and hydrogen peroxide under milder conditions to generate epoxy groups. Epoxy groups promote the binding of tyramide to adjacent amino acids to form fluorescently labeled products .
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- HY-D0235
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Dyes
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Alizarin yellow GG is a dye that exhibits corrosion inhibition effects on mild steel against concentrated H2SO4.
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Cat. No. |
Product Name |
Type |
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- HY-126377
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Biochemical Assay Reagents
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Sulfobetaine 10, is a zwitterionic surfactant commonly used in biochemistry and biophysics. It is commonly used to dissolve membrane proteins and other hydrophobic molecules in aqueous solutions. Sulfobetaine 10 has both positively and negatively charged groups in its structure, which allows it to maintain a neutral charge in solution and reduces its tendency to denature proteins. It is considered a mild, non-denaturing surfactant and is widely used in protein research.
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- HY-144011
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Drug Delivery
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DSPE-PEG-Cyanur is a PEG derivative containing cyanur functional group. DSPE-PEG-Cyanur can be used for PEGylation of protein under mild basic conditions. DSPE-PEG-Cyanur can be used for nanostructured lipid carrier .
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- HY-W250170
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Octyldecyl glucoside
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Biochemical Assay Reagents
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Decyl glucoside is a mild nonionic surfactant. Decyl glucoside can be derived from renewable raw materials such as glucose and fatty alcohols from coconut oil or palm kernel oil. Decyl glucoside is known for its excellent foaming and cleaning properties.
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- HY-W008864
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β-Octaacetyllactose
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Cell Assay Reagents
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Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1 .
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- HY-K1002
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1 Publications Verification
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MCE NP-40 Lysis Buffer is a relatively mild reliable buffers used to lyse cells from animal, plant tissue and fungi, bacteria etc.
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- HY-KE7067
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Lambda DNA (λ DNA) a mild E. coli phage used as a restriction enzyme substrate.
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P99776
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XmAb-13676
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CD20
CD3
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Cancer
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Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20 + expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo .
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- HY-P99103
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LY-3853113; LY-COV1404
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SARS-CoV
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Infection
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Bebtelovimab a humanized IgG1-λ2 antibody targeting to SARS-CoV-2, especially COVID-19. Bebtelovimab potently neutralizes SARS-CoV-2 variants, and inhibits COVID-19 with mild-to-moderate efficacy .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-B0892S2
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Benzyl alcohol-d5 is the deuterium labeled Benzyl alcohol. Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.
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- HY-B0892S1
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Benzyl alcohol-d7 is the deuterium labeled Benzyl alcohol. Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.
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- HY-B0575S
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Triamterene-d5 is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.
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- HY-B0892S5
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Benzyl alcohol- 13C is the 13C labeled Benzyl alcohol (HY-B0892). Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor .
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- HY-B1804S1
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Tricaprilin-d50 is the deuterium labeled Tricaprilin. Tricaprilin (Trioctanoin) is used in study for patients with mild to moderate Alzheimer's disease and has a role as an anticonvulsant and a plant metabolite[1][2].
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- HY-B1804S2
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Tricaprilin-d15 is the deuterium labeled Tricaprilin. Tricaprilin (Trioctanoin) is used in study for patients with mild to moderate Alzheimer's disease and has a role as an anticonvulsant and a plant metabolite[1][2].
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- HY-B0892S
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Benzyl alcohol-α- 13C-α,α-d2 is the 13C-labeled Benzyl alcohol. Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.
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- HY-N0285S
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Imperatorin-d6 (Ammidin-d6) is the deuterium labeled Imperatorin. Imperatorin is a BChE inhibitor and HIV-1 replication inhibitor. Imperatorin shows mild activity against Gram-negative bacteria .
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- HY-10933S
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CX516-d10 is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI)[1].
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- HY-B1192S
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Estradiol benzoate-d3 is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3][4].
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- HY-W017389S
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Xanthine- 13C, 15N2 is a 15N-labeled and 13C-labled Xanthine (HY-W017389). Xanthine is a plant alkaloid with mild stimulant activity of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
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- HY-17368S1
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(rac)-Rivastigmine-d6 is a labelled racemic Rivastigmine. Rivastigmine (S-Rivastigmine) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2].
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- HY-17368S2
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Rivastigmine-d3 hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (S-Rivastigmine) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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Cat. No. |
Product Name |
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Classification |
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- HY-151682
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Labeling and Fluorescence Imaging
TCO
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H-L-Lys(Norbornene-methoxycarbonyl)-OH, a norbornene-derivatized lysine, can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH can be used for the mild and selective modification of proteins in a copper-free click reaction .
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- HY-151682A
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TCO
Labeling and Fluorescence Imaging
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H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride, a norbornene-derivatized lysine, can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride can be used for the mild and selective modification of proteins in a copper-free click reaction .
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