probe design

By Targets:	Cholinesterase (ChE) (1) Fluorescent Dye (4) Fungal (2)
By Research Areas:	Cancer (2) Infection (2) Inflammation/Immunology (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134418

NOTA	Others	Cancer
NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect .

HY-135235

Cysteine thiol probe	Others	Others
Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites .

HY-D2316

Flipper-TR probe	Fluorescent Dye	Others
Flipper-TR probe (Compound FliptR probe) is a fluorescent probe specifically designed to measure cell membrane tension. Flipper-TR probe reports changes in membrane tension through variations in its fluorescence lifetime. Flipper-TR probe is applicable to a wide range of organisms including bacteria, yeast, mammals, and plants .

HY-D2303

mgc(3Me)TMR

Fluorescent Dye Others

mgc(3Me)TMR is a Golgi probe designed based on tetramethylrhodamine .
HY-145407A

ent-Heronamide C

Fungal Infection

ent-Heronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C .
HY-145407

16,17-Dihydroheronamide C

Fungal Infection

16,17-Dihydroheronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C .

mgc(3Me)TMR	Fluorescent Dye	Others
mgc(3Me)TMR is a Golgi probe designed based on tetramethylrhodamine .

ent-Heronamide C	Fungal	Infection
ent-Heronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C .

16,17-Dihydroheronamide C	Fungal	Infection
16,17-Dihydroheronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C .

HY-18551

DAGLβ-IN-1	Others	Inflammation/Immunology
DAGLβ-IN-1 is an inhibitor of diacylglycerol lipase-β (DAGLβ), serves as a versatile intermediate for the design of DAGL-tailored activity-based probes .

HY-D1041

ICG-OSu ICG NHS ester	Fluorescent Dye	Cancer
ICG-OSu (ICG NHS ester) is a near-infrared fluorescent agent ICG derivative. ICG-OSu is amine-reactive and has been widely used to design in vivo imaging probes .

HY-D2324

EE-Flipper 33	Fluorescent Dye	Others
EE-Flipper 33 is a Flipper probe designed to evaluate the mechanism of early endocytosis. EE-Flipper has a pKa value of 10.6 and is capable of tracking approximately 70% of early endosomes (EE) in live cells. Furthermore, EE-Flipper 33 can also label the Golgi apparatus in live cells with an internal pH ranging from 6.0 to 6.7 .

HY-155368

BChE-IN-20	Cholinesterase (ChE)	Neurological Disease
BChE-IN-20 (compound 7c) is a highly potent BChE-selective inhibitor and exhibits IC₅₀s of 105 and 2.3 nM for eqBChE and hBChE, respectively. BChE-IN-20 inhibits P glycoprotein with IC₅₀ of 0.27 μM. BChE-IN-20 is a promising template to improve design and development of BChE-selective ligands of pharmaceutical interest, including inhibitors and fluorogenic probes.

Cat. No.	Product Name

HY-L903

3D Diverse Fragment Library	5196 compounds
Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function. 3-dimensionality (3D) diversity is pivotal because the molecular shape is one of the most important factors in molecular recognition by a biomolecule. There is a developing appreciation that 3D fragments could offer opportunities that are not provided by 2D fragments. MCE 3D Diverse Fragment Library consists of 5,196 non-flat fragment-like molecules (average Fsp3 value 0.58). More than 4,700 fragment compounds contain at least one chiral center in the structure. The key concepts that underlie the library design were 3D shape, structural diversity, reactive functionality and fragment-like. This 3D Diverse Fragment Library brings higher fragment hit optimization and increases the likelihood to find innovative hits in FBDD.

3D Diverse Fragment Library

5196 compounds

Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function. 3-dimensionality (3D) diversity is pivotal because the molecular shape is one of the most important factors in molecular recognition by a biomolecule. There is a developing appreciation that 3D fragments could offer opportunities that are not provided by 2D fragments.

MCE 3D Diverse Fragment Library consists of 5,196 non-flat fragment-like molecules (average Fsp3 value 0.58). More than 4,700 fragment compounds contain at least one chiral center in the structure. The key concepts that underlie the library design were 3D shape, structural diversity, reactive functionality and fragment-like. This 3D Diverse Fragment Library brings higher fragment hit optimization and increases the likelihood to find innovative hits in FBDD.

Cat. No.	Product Name	Type

HY-D1041

ICG-OSu ICG NHS ester	Fluorescent Dyes/Probes
ICG-OSu (ICG NHS ester) is a near-infrared fluorescent agent ICG derivative. ICG-OSu is amine-reactive and has been widely used to design in vivo imaging probes .

HY-D2316

Flipper-TR probe	Fluorescent Dyes/Probes
Flipper-TR probe (Compound FliptR probe) is a fluorescent probe specifically designed to measure cell membrane tension. Flipper-TR probe reports changes in membrane tension through variations in its fluorescence lifetime. Flipper-TR probe is applicable to a wide range of organisms including bacteria, yeast, mammals, and plants .

HY-D2303

mgc(3Me)TMR

Fluorescent Dyes/Probes

mgc(3Me)TMR is a Golgi probe designed based on tetramethylrhodamine .

mgc(3Me)TMR	Fluorescent Dyes/Probes
mgc(3Me)TMR is a Golgi probe designed based on tetramethylrhodamine .

HY-D2324

EE-Flipper 33	Fluorescent Dyes/Probes
EE-Flipper 33 is a Flipper probe designed to evaluate the mechanism of early endocytosis. EE-Flipper has a pKa value of 10.6 and is capable of tracking approximately 70% of early endosomes (EE) in live cells. Furthermore, EE-Flipper 33 can also label the Golgi apparatus in live cells with an internal pH ranging from 6.0 to 6.7 .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

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