Search Result

Results for "

proton

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Proton Pump (54) ADC Cytotoxin (1) Antibiotic (2) Apoptosis (17) Autophagy (10) Bacterial (34) Bcl-2 Family (2) Biochemical Assay Reagents (2) Carbonic Anhydrase (1) CDK (2) Cuproptosis (1) DNA Alkylator/Crosslinker (1) Drug Metabolite (7) Endogenous Metabolite (14) Estrogen Receptor/ERR (11) Fluorescent Dye (6) Fungal (3) GPR68 (1) Histamine Receptor (1) HIV (2) Influenza Virus (3) Isotope-Labeled Compounds (15) Liposome (5) Mitochondrial Metabolism (1) Na+/H+ Exchanger (NHE) (2) Necroptosis (1) Orthopoxvirus (3) Parasite (1) Phospholipase (5) SARS-CoV (3) Sodium Channel (3) TOPK (2) TRP Channel (2) Wnt (1)
By Research Areas:	Cancer (48) Cardiovascular Disease (1) Endocrinology (11) Infection (25) Inflammation/Immunology (36) Metabolic Disease (23) Neurological Disease (11)

By Targets:

Proton Pump (54)

ADC Cytotoxin (1)

Antibiotic (2)

Apoptosis (17)

Autophagy (10)

Bacterial (34)

Bcl-2 Family (2)

Biochemical Assay Reagents (2)

Carbonic Anhydrase (1)

CDK (2)

Cuproptosis (1)

DNA Alkylator/Crosslinker (1)

Drug Metabolite (7)

Endogenous Metabolite (14)

Estrogen Receptor/ERR (11)

Fluorescent Dye (6)

Fungal (3)

GPR68 (1)

Histamine Receptor (1)

HIV (2)

Influenza Virus (3)

Isotope-Labeled Compounds (15)

Liposome (5)

Mitochondrial Metabolism (1)

Na+/H+ Exchanger (NHE) (2)

Necroptosis (1)

Orthopoxvirus (3)

Parasite (1)

Phospholipase (5)

SARS-CoV (3)

Sodium Channel (3)

TOPK (2)

TRP Channel (2)

Wnt (1)

By Research Areas:

Cancer (48)

Cardiovascular Disease (1)

Endocrinology (11)

Infection (25)

Inflammation/Immunology (36)

Metabolic Disease (23)

Neurological Disease (11)

112

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Proton Pump

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13662S

Lansoprazole-d4 AG-1749-d₄	Proton Pump Bacterial	Inflammation/Immunology Cancer
Lansoprazole-d₄ is a deuterium labeled Lansoprazole. Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid[1].

HY-136367

Diclofop-methyl	Others	Others
Diclofop-methyl, a common post-emergence herbicide, is widely used in agriculture production. Diclofop-methyl increases the proton permeability of isolated oat-root tonoplast .

HY-139557

Zastaprazan JP-1366	Proton Pump	Inflammation/Immunology
Zastaprazan (JP-1366) is a proton pump inhibitor (WO2018008929). Zastaprazan can be used for the research of gastrointestinal inflammatory diseases or gastric acid-related diseases .

HY-109079A

Abeprazan hydrochloride DWP14012 hydrochloride; Fexuprazan hydrochloride	Proton Pump	Metabolic Disease
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H ⁺, K ⁺- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases .

HY-17507E

S-Pantoprazole sodium trihydrate	Proton Pump Bacterial	Infection
S-Pantoprazole (sodium trihydrate) is related to Pantoprazole (HY-17507) that plays an important roles in gastric acid secretion disorder-related diseases, or as proton pump inhibitor .

HY-109079

Abeprazan DWP14012; Fexuprazan	Proton Pump	Metabolic Disease
Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H ⁺, K ⁺- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases .

HY-157933

SF-C5-TPP	Mitochondrial Metabolism	Infection
SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillus subtilis with a MIC of 2 μM ^>[1].

HY-D1560

FG 488 DHPE	Fluorescent Dye	Others
FG 488 DHPE is a lipid-coupled fluorochrome, has be used as a fluorophore Oregon Green 488. FG 488 DHPE monitors acidification of lipid vesicles with λex/λem=508/534 nm.FG 488 DHPE is also used for Hv1-induced proton translocation quantificatio with λex/λem=508/534 nm as well .

HY-B0656

Rabeprazole 2 Publications Verification LY307640	Proton Pump Apoptosis Bacterial	Inflammation/Immunology Cancer
Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H ⁺/K ⁺-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-B0656A

Rabeprazole sodium 2 Publications Verification LY307640 sodium	Proton Pump Apoptosis Bacterial	Inflammation/Immunology Cancer
Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H ⁺/K ⁺-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-B0656S

Rabeprazole-d4 LY307640-d₄	Proton Pump Apoptosis	Inflammation/Immunology Cancer
Rabeprazole-d₄ is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-19223

Pumaprazole

BY-841
Proton Pump Inflammation/Immunology

Pumaprazole is a reversible proton pump antagonist.

Pumaprazole BY-841	Proton Pump	Inflammation/Immunology
Pumaprazole is a reversible proton pump antagonist.

HY-15295

Vonoprazan Fumarate 3 Publications Verification TAK-438	Proton Pump	Metabolic Disease
Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H ⁺,K ⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease .

HY-G0007

Omeprazole sulfone

Omeprazole sulphone
Drug Metabolite Infection Cancer

Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.

Omeprazole sulfone Omeprazole sulphone	Drug Metabolite	Infection Cancer
Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.

HY-100007A

Vonoprazan hydrochloride TAK-438 hydrochloride	Proton Pump Bacterial	Infection Endocrinology
Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H ⁺,K ⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori .

HY-100007

Vonoprazan 3 Publications Verification TAK-438 free base	Proton Pump Bacterial	Endocrinology
Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H ⁺,K ⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori .

HY-G0006

Omeprazole sulfide

Ufiprazole
Drug Metabolite Others

Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.
HY-Y1309

1-Naphthol

Furro ER; NSC 9586; Nako TRB
Endogenous Metabolite Others

1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe.

Omeprazole sulfide Ufiprazole	Drug Metabolite	Others
Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.

1-Naphthol Furro ER; NSC 9586; Nako TRB	Endogenous Metabolite	Others
1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe.

HY-N6780

Ophiobolin B	Fungal	Infection
Ophiobolin B, a sesterterpene metabolite of Helminthosporium oryzae, inhibits proton extrusion from maize coleoptiles. Ophiobolin B inhibits fusicoccin (FC) promoted proton extrusion, potassium uptake and cell enlargement . The MIC values with the antifungal effect of Ophiobolins B on different zygomycetes is 25–50 μg/mL .

HY-105220

WY-47766

OST-766
Proton Pump Inflammation/Immunology

WY-47766(OST-766) is aproton pumpinhibitor .

WY-47766 OST-766	Proton Pump	Inflammation/Immunology
WY-47766(OST-766) is aproton pumpinhibitor .

HY-B0402S

Amantadine-d15 1-Adamantanamine-d₁₅; 1-Aminoadamantane-d₁₅	Influenza Virus Orthopoxvirus SARS-CoV Apoptosis	Infection Neurological Disease Cancer
Amantadine-d₁₅ is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].

HY-100560S

Abscisic acid-d6 (S)-(+)-Abscisic acid-d₆; ABA-d₆	Proton Pump	Metabolic Disease
Abscisic acid-d₆ is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H+-ATPase)[1].

HY-17421A

Tenatoprazole sodium TU-199 sodium	Proton Pump	Cardiovascular Disease
Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H ⁺/K ⁺-ATPase with an IC₅₀ of 6.2 μM.

HY-141776S

Omeprazole sulfide-d3 Ufiprazole-d₃	Drug Metabolite	Others
Omeprazole sulfide-d₃ is the deuterium labeled Omeprazole sulfide. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.

HY-121851

Revaprazan SB 641257	Proton Pump	Inflammation/Immunology
Revaprazan (SB 641257) is a reversible proton pump inhibitor with significant anti-inflammatory effects. Revaprazan can be used for chronic gastric inflammation research .

HY-W590680

ssPalmM	Liposome	Others
ssPalmM is a SS-cleavable proton-activated lipid-like materials. ssPalmM can be used to form lipid nanoparticles (LNPs) for nuclear targeting of plasmid DNA .

HY-100325

NHE3-IN-1

Na+/H+ Exchanger (NHE) Neurological Disease

NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1.

NHE3-IN-1	Na+/H+ Exchanger (NHE)	Neurological Disease
NHE3-IN-1 is a *sodium/proton* exchanger type 3 (NHE-3)** inhibitor extracted from patent WO 2011019784 A1.

HY-G0007S

Omeprazole sulfone-d3 Omeprazole sulfone-d₃; Omeprazole sulphone-d₃	Isotope-Labeled Compounds Drug Metabolite	Infection Cancer
Omeprazole metabolite Omeprazole sulfone-d₃ is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.

HY-B0113S2

Omeprazole metabolite Omeprazole sulfone (methoxy-d3) Omeprazole sulfone (methoxy-d₃); Omeprazole sulphone (methoxy-d₃)	Isotope-Labeled Compounds Drug Metabolite	Infection Cancer
Omeprazole metabolite Omeprazole sulfone (methoxy-d₃) is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.

HY-109546

Omeprazole magnesium	Proton Pump	Metabolic Disease
Omeprazole magnesium is an orally active proton pump inhibitor (PPI) and can suppress gastric acid. Omeprazole magnesium can be used for acid reflux-related symptoms and frequent heartburn research .

HY-B0572

Zinc Pyrithione 4 Publications Verification	Cuproptosis Proton Pump Bacterial Fungal	Infection Metabolic Disease
Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump . Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis .

HY-148051

Ilaprazole sulfone	Drug Metabolite	Inflammation/Immunology Cancer
Ilaprazole sulfone is the major metabolite of Ilaprazole (HY-101664), is predominantly catalysed by CYP3A4/5. Ilaprazole (IY-81149) is an orally active proton pump inhibitor .

HY-Y1309S

1-Naphthol-d8 Furro ER-d₈; NSC 9586-d₈; Nako TRB-d₈	Endogenous Metabolite	Others
1-Naphthol-d₈ is the deuterium labeled 1-Naphthol[1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe[2].

HY-120937

DC4 Crosslinker	Others	Others
DC4 Crosslinker is a stable crosslinking reagent with improved activity and solubility. DC4 Crosslinker is labile cleavable with collision-induced dissociation (CID), that will be fragmented into four rearrange products containing mobilized protons .

HY-W590678

ssPalmO-Phe	Liposome	Others
SSPalmO-Phe is an ionizable cationic self-degradable disulfide-cleavable (SS-cleavable) proton-activated lipid-like material. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for drug delivery.

HY-13662

Lansoprazole 1 Publications Verification AG-1749	Proton Pump Bacterial Phospholipase	Inflammation/Immunology Cancer
Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .

HY-U00193

Ro18-5362	Others	Metabolic Disease
Ro18-5362 is the less active proagent of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H ⁺+K ⁺)-ATPase activity and associated proton translocation.

HY-161135

TBAJ-5307	Bacterial	Infection
TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria inhibitor that can target the FO-domain of the engine and preventing rotation and proton-translocation. TBAJ-5307 inhibits non-tuberculous mycobacteria in vitro and in vivo .

HY-17021B

Esomeprazole potassium salt (S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt	Proton Pump Bacterial	Inflammation/Immunology Endocrinology Cancer
Esomeprazole potassium salt ((S)-Omeprazole potassium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole potassium salt has the potential for symptomatic gastroesophageal reflux disease research .

HY-17021

Esomeprazole (S)-Omeprazole; (-)-Omeprazole	Proton Pump Bacterial	Inflammation/Immunology Endocrinology Cancer
Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-N7031

(±)-Vasicine (±)-Peganine	Proton Pump	Inflammation/Immunology
(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H ⁺-K ⁺-ATPase activity in vitro with an IC₅₀ of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect .

HY-118283

5-Hydroxylansoprazole 1 Publications Verification AG1908	Proton Pump	Metabolic Disease
5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is metabolized by CYP2C19 forming 5-Hydroxylansoprazole. Lansoprazole is a gastric *proton-pump* inhibitor and is effective in the treatment of various peptic diseases .

HY-111036

AMG0347	TRP Channel	Others
AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC₅₀ = 0.2 nm), protons (IC₅₀= 0.8 nm), or capsaicin (IC₅₀ = 0.7 nm) .

HY-13662B

(R)-Lansoprazole 2 Publications Verification Dexlansoprazole	Proton Pump	Inflammation/Immunology
(R)-Lansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .

HY-17021C

Esomeprazole hemistrontium (S)-Omeprazole hemistrontium; (-)-Omeprazole hemistrontium	Proton Pump Bacterial	Inflammation/Immunology Endocrinology Cancer
Esomeprazole ((S)-Omeprazole) hemistrontium is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole hemistrontium has the potential for symptomatic gastroesophageal reflux disease research .

HY-17021A

Esomeprazole magnesium salt (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt	Proton Pump Bacterial	Inflammation/Immunology Endocrinology Cancer
Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole magnesium salt has the potential for symptomatic gastroesophageal reflux disease research .

HY-W140203

2-(2′-Hydroxyphenyl)benzimidazole	Fluorescent Dye	Others
2-(2′-Hydroxyphenyl)benzimidazole is some of the most extensively studied excited state intramolecular proton transfer (ESIPT) molecules exhibiting normal and tautomer emissions. 2-(2′-Hydroxyphenyl)benzimidazole has been applied as a fluorescent probe in various systems .

HY-400705

Duocarmycin SA intermediate-1	Others	Cancer
Duocarmycin SA intermediate-1 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-1 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor-suppressive cytotoxicity with proton irradiation .

HY-400706

Duocarmycin SA intermediate-2	Others	Cancer
Duocarmycin SA intermediate-2 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-2 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor suppressor cytotoxicity with proton irradiation .

HY-13662C

(S)-Lansoprazole Levolansoprazole	Proton Pump Phospholipase Bacterial	Inflammation/Immunology
(S)-Lansoprazole (Levolansoprazole) is an isoform of Lansoprazole (HY-13662), which is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .

Cat. No.	Product Name	Type

HY-111956B

D-Ala-Lys-AMCA hydrochloride	Fluorescent Dyes/Probes
D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-D1560

FG 488 DHPE	Fluorescent Dyes/Probes
FG 488 DHPE is a lipid-coupled fluorochrome, has be used as a fluorophore Oregon Green 488. FG 488 DHPE monitors acidification of lipid vesicles with λex/λem=508/534 nm.FG 488 DHPE is also used for Hv1-induced proton translocation quantificatio with λex/λem=508/534 nm as well .

HY-D2286

HBT-Fl-BnB	Fluorescent Dyes/Probes
HBT-Fl-BnB is a fluorescent probe for the ratiometric detection of ONOO ^- in vitro and in vivo. HBT-Fl-BnB consists of an HBT core with Fl groups at the ortho and para positions responding to the zwitterionic excited-state intramolecular proton-transfer (zwitterionic ESIPT) process and a boronic acid pinacol ester with dual roles that block the zwitterionic ESIPT and recognize ONOO ^- .

HY-111956

D-Ala-Lys-AMCA	Fluorescent Dyes/Probes
D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-111956A

D-Ala-Lys-AMCA TFA	Fluorescent Dyes/Probes
D-Ala-Lys-AMCA TFA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA TFA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA TFA can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-B1422

9-Aminoacridine

2 Publications Verification

Aminacrine

Fluorescent Dyes/Probes

9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .

Cat. No.	Product Name	Type

HY-W251598C

Sodium bicarbonate, for cell culture

Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture

Buffer Reagents

Sodium bicarbonate, for cell culture, an inorganic salt, is neutral to slightly alkaline. And it is susceptible to moisture and decomposition in the air. Sodium bicarbonate is widely used in food, pharmaceutical, cosmetics and other fields, the main uses include buffer, seasoning, disinfectant, pharmaceutical and proton gradient regulator. Sodium bicarbonate is also commonly used as an antacid to suppress gastrointestinal disorders, neutralize stomach acid and reduce stomach discomfort.

HY-N0322

Cholesterol

15+ Cited Publications

Drug Delivery

Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-Y0756

Sodium bicarbonate

Sodium hydrogen carbonate

Biochemical Assay Reagents

Sodium bicarbonate, also known as baking soda, sodium bicarbonate, or sodium bicarbonate, is neutral to slightly alkaline. And it is susceptible to moisture and decomposition in the air. Sodium bicarbonate is widely used in food, pharmaceutical, cosmetics and other fields, the main uses include buffer, seasoning, disinfectant, pharmaceutical and proton gradient regulator. In the food industry, it is often used as a flour starter or leavening agent to make food swell up and become softer. Sodium bicarbonate is also commonly used as an antacid to suppress gastrointestinal disorders, neutralize stomach acid and reduce stomach discomfort.

HY-W590678

ssPalmO-Phe	Drug Delivery
SSPalmO-Phe is an ionizable cationic self-degradable disulfide-cleavable (SS-cleavable) proton-activated lipid-like material. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for drug delivery.

Cat. No.	Product Name	Target	Research Area

HY-P5174

MitTx	Sodium Channel	Neurological Disease
MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC₅₀ values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation .

HY-111956B

D-Ala-Lys-AMCA hydrochloride	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-P5172

MitTx-alpha	Sodium Channel	Neurological Disease
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels .

HY-111956

D-Ala-Lys-AMCA	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-111956A

D-Ala-Lys-AMCA TFA	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA TFA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA TFA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA TFA can be used for characterizing PEPT1-specific substrates or inhibitors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y1309

1-Naphthol Furro ER; NSC 9586; Nako TRB	Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe.

HY-N6780

Ophiobolin B	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Fungal
Ophiobolin B, a sesterterpene metabolite of Helminthosporium oryzae, inhibits proton extrusion from maize coleoptiles. Ophiobolin B inhibits fusicoccin (FC) promoted proton extrusion, potassium uptake and cell enlargement . The MIC values with the antifungal effect of Ophiobolins B on different zygomycetes is 25–50 μg/mL .

HY-N7031

(±)-Vasicine (±)-Peganine	Alkaloids Classification of Application Fields Zygophyllaceae Source classification Peganum harmala Linn. Plants Disease Research Fields Inflammation/Immunology	Proton Pump
(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H ⁺-K ⁺-ATPase activity in vitro with an IC₅₀ of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect .

HY-N0322

Cholesterol Maximum Cited Publications 20 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Cancer	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N4302

Monensin Monensin A	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt
Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-100560

Abscisic acid (S)-(+)-Abscisic acid; ABA	Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Agricultural Research other families Microorganisms Animals Terpenoids Sesquiterpenes Abscisic acid Phytohormone Disease Research Fields	Endogenous Metabolite Proton Pump
Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H ⁺-ATPase) and leads to the plasma membrane depolarization in a Ca ²⁺-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .

HY-N0322R

Cholesterol (Standard) 15+ Cited Publications	Structural Classification Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Cancer	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Cholesterol (Standard) is the analytical standard of Cholesterol. This product is intended for research and analytical applications. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

Species:	Virus (3) Human (5) Mouse (2) E.coli (1)
Tag:	His (9) Myc (1) GST (1) MBP (1) Flag (1)
Source:	E. coli Cell-free (7) Sf9 insect cells (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P702408

	OTOP1 Protein, Mouse (Cell-Free, His) proton channel OTOP1; Otopetrin-1	Mouse	E. coli Cell-free
	The OTOP1 protein is a proton-selective channel that transports protons into less voltage-sensitive cells. This uniqueness is critical for cell types because changes in intracellular pH regulate biochemical and developmental processes. OTOP1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived OTOP1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of OTOP1 Protein, Mouse (Cell-Free, His) is 600 a.a., with molecular weight of 68.6 kDa.

HY-P702368

	Matrix protein 2 Protein, Influenza A virus (Cell-Free, His, Myc) Matrix protein 2; proton channel protein M2	Virus	E. coli Cell-free
	Matrix protein 2 (M2) forms a proton-selective ion channel that efficiently releases the viral genome during viral entry. Matrix protein 2 Protein, Influenza A virus (Cell-Free, His, Myc) is the recombinant Virus-derived Matrix protein 2 protein, expressed by E. coli Cell-free , with N-10*His, C-Myc labeled tag. The total length of Matrix protein 2 Protein, Influenza A virus (Cell-Free, His, Myc) is 97 a.a., with molecular weight of 18.6 kDa.

HY-P702369

	Matrix protein 2 Protein, Influenza A virus 1935 H1N1 (Cell-Free, His) Matrix protein 2; proton channel protein M2	Virus	E. coli Cell-free
	Matrix protein 2 (M2) forms a proton-selective ion channel that is critical for the release of the viral genome during viral entry. Matrix protein 2 Protein, Influenza A virus 1935 H1N1 (Cell-Free, His) is the recombinant Virus-derived Matrix protein 2 protein, expressed by E. coli Cell-free , with N-6*His labeled tag. The total length of Matrix protein 2 Protein, Influenza A virus 1935 H1N1 (Cell-Free, His) is 97 a.a., with molecular weight of 15.1 kDa.

HY-P702370

	Matrix protein 2 Protein, Influenza A virus 1934 H1N1 (Cell-Free, His) Matrix protein 2; proton channel protein M2	Virus	E. coli Cell-free
	Matrix protein 2 (M2) is at the core, forming a proton-selective ion channel that is critical for efficient release of the viral genome during entry. After attaching to the cell surface, virions undergo endocytosis and activate M2 ion channels in endosomes. Matrix protein 2 Protein, Influenza A virus 1934 H1N1 (Cell-Free, His) is the recombinant Virus-derived Matrix protein 2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of Matrix protein 2 Protein, Influenza A virus 1934 H1N1 (Cell-Free, His) is 97 a.a., with molecular weight of 12.5 kDa.

HY-P702442

	SLC30A8 Protein, Mouse (Cell-Free, His) proton-coupled zinc antiporter SLC30A8; Solute carrier family 30 member 8; Zinc transporter 8; ZnT-8	Mouse	E. coli Cell-free
	SLC30A8 Protein, a proton-coupled zinc ion antiporter, crucially regulates insulin secretion. Serving as a mediator, SLC30A8 enables zinc entry into pancreatic beta cell secretory granules, maintaining the required zinc concentration. This process finely tunes insulin release dynamics, emphasizing SLC30A8's pivotal role in physiological insulin secretion control and glucose homeostasis. SLC30A8 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived SLC30A8 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SLC30A8 Protein, Mouse (Cell-Free, His) is 367 a.a., with molecular weight of 43.0 kDa.

HY-P702023

	SLC46A1 Protein, Human (Sf9, His, MBP, FLAG) SLC46A1; proton-coupled folate transporter; G21; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1	Human	Sf9 insect cells
	The SLC46A1 protein is a proton-coupled folate symporter that utilizes the H(+) gradient in the proximal jejunum to drive folate absorption. It transports folate from the blood to the cerebrospinal fluid and exhibits alternating outward- and inward-open conformational states at acidic pH. SLC46A1 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC46A1 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC46A1 Protein, Human (Sf9, His, MBP, FLAG) is 458 a.a., .

HY-P76159A

	ATP6V1F Protein, Human V-type proton ATPase subunit F	Human	E. coli
	ATP6V1F is an important subunit of the vacuolar (H+)-ATPase (V-ATPase) V1 complex and is an important component of this enzyme's role in cellular pH regulation. It forms a catalytic AB heterodimer and peripheral stem that plays a role in ATP hydrolysis. ATP6V1F Protein, Human is the recombinant human-derived ATP6V1F protein, expressed by E. coli , with tag free. The total length of ATP6V1F Protein, Human is 119 a.a., with molecular weight of ~13 KDa.

HY-P702353

	lacY Protein, E.coli strain K12 (Cell-Free, His) Lactose permease; Lactose-proton symport	E.coli	E. coli Cell-free
	lacY protein facilitates the symport transport of beta-galactosides into the cell, co-importing a proton. Its versatile substrate range includes lactose, melibiose, lactulose, and TMG, excluding sucrose or fructose. lacY's substrate specificity centers on the galactopyranosyl moiety. lacY Protein, E.coli strain K12 (Cell-Free, His) is the recombinant E. coli-derived lacY protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of lacY Protein, E.coli strain K12 (Cell-Free, His) is 250 a.a., with molecular weight of 34.4 kDa.

HY-P702424

	RNASEK Protein, Human (Cell-Free, His) Ribonuclease kappa; V-type proton ATPase subunit f; V-ATPase subunit f	Human	E. coli Cell-free
	RNASEK proteins cleave ApU and ApG phosphodiester bonds and hydrolyze UpU bonds at a slower rate. RNASEK Protein, Human (Cell-Free, His) is the recombinant human-derived RNASEK protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of RNASEK Protein, Human (Cell-Free, His) is 137 a.a., with molecular weight of 21.5 kDa.

HY-P76159

	ATP6V1F Protein, Human (GST) V-type proton ATPase subunit F; V-ATPase subunit F; V-ATPase 14 kDa subunit; ATP6S14; VATF	Human	E. coli
	ATP6V1F is an important subunit of the vacuolar (H+)-ATPase (V-ATPase) V1 complex and is an important component of this enzyme's role in cellular pH regulation. It forms a catalytic AB heterodimer and peripheral stem that plays a role in ATP hydrolysis. ATP6V1F Protein, Human (GST) is the recombinant human-derived ATP6V1F protein, expressed by E. coli , with N-GST labeled tag. The total length of ATP6V1F Protein, Human (GST) is 119 a.a., with molecular weight of ~40 KDa.

HY-P72099

	ATP6AP2 Protein, Human (His) APT6M8 9; APT6M8-9; ATP6AP2; ATP6IP2; ATP6M8-9; ATPase H+; -transporting lysosomal accessory protein 2; ATPase H+; -transporting lysosomal-interacting protein 2; ATPase H+ transporting lysosomal accessory protein 2; ATPase; H+ transporting; lysosomal vacuolar proton pump; membrane sector associated protein M8 9;	Human	E. coli
	The multifunctional ATP6AP2 protein serves as a cellular receptor for renin and prorenin, contributing to lysosomal V-ATPase assembly and endolysosomal acidification. It participates in renin-dependent reactions, activates ERK1/2, and may enhance the catalytic efficiency of renin in the renin-angiotensin system. ATP6AP2 Protein, Human (His) is the recombinant human-derived ATP6AP2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ATP6AP2 Protein, Human (His) is 334 a.a., with molecular weight of ~40 kDa.

Cat. No.	Product Name	Chemical Structure

HY-13662S

Lansoprazole-d4

Lansoprazole-d₄ is a deuterium labeled Lansoprazole. Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid[1].

HY-B0656S

Rabeprazole-d4
Rabeprazole-d₄ is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-B0402S

Amantadine-d15
Amantadine-d₁₅ is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].

HY-100560S

Abscisic acid-d6

Abscisic acid-d₆ is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H+-ATPase)[1].

HY-141776S

Omeprazole sulfide-d3
Omeprazole sulfide-d₃ is the deuterium labeled Omeprazole sulfide. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.

HY-G0007S

Omeprazole sulfone-d3
Omeprazole metabolite Omeprazole sulfone-d₃ is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.

HY-B0113S2

Omeprazole metabolite Omeprazole sulfone (methoxy-d3)
Omeprazole metabolite Omeprazole sulfone (methoxy-d₃) is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.

HY-Y1309S

1-Naphthol-d8

1-Naphthol-d₈ is the deuterium labeled 1-Naphthol[1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe[2].

HY-17023S

Esomeprazole-d6 sodium
Esomeprazole-d₆ sodium is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-W013186S

Lansoprazole sulfide-d4
Lansoprazole sulfide-d₄ is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 µM intracellularly and 0.46 µM in broth[1].

HY-17021S

Esomeprazole-d3 sodium
Esomeprazole-d₃ (sodium) is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].

HY-17021S1

Esomeprazole-d3
Esomeprazole-d₃ is deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].

HY-B0113S

Omeprazole-d₃
Omeprazole-d₃ is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].

HY-13662BS

(R)-Lansoprazole-d4
(R)-Lansoprazole-d₄ is deuterium labeled (R)-Lansoprazole. (R)-Lansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[1][2].

HY-B0656AS

Rabeprazole-d4 sodium

Rabeprazole-d₄ (sodium) is the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-B0656AS1

Rabeprazole-d3 sodium

Rabeprazole-d₃ (sodium)mis the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-17507S

Pantoprazole-d6

Pantoprazole-d₆ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].

HY-17507S1

Pantoprazole-d3

Pantoprazole-d₃ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].

HY-N0322S7

Cholesterol-d1

Cholesterol-d is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S

Cholesterol-d7

Cholesterol-d₇ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S4

Cholesterol-13C3

Cholesterol- ¹³C₃ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S2

Cholesterol-d6-1

Cholesterol-d₆-1 is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S3

Cholesterol-13C5

Cholesterol- ¹³C₅ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S5

Cholesterol-13C2

Cholesterol- ¹³C₂ is the ¹³C labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S1

Cholesterol-d6

Cholesterol-d₆ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S6

Cholesterol-d4

Cholesterol-d₄ is deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S8

Cholesterol-18O

Cholesterol- ¹⁸O is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-B0113S1

Omeprazole-d3-1

Omeprazole-d₃-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

HY-B0113S3

Omeprazole-13CD3

Omeprazole- ¹³C,d₃ is a ¹³C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

HY-B1422S

9-Aminoacridine-13C6

9-Aminoacridine-13C6 is the ¹³C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .

HY-W653905

Amantadine-d15 hydrochloride

Amantadine-d₁₅ hydrochloride is deuterated labeled Amantadine. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .

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