retinopathy.

By Targets:	Adenosine Receptor (1) Apoptosis (4) Autophagy (1) Bacterial (1) Bcl-2 Family (1) CXCR (1) Fungal (1) Integrin (1) Isotope-Labeled Compounds (1) Monoamine Oxidase (2) NF-κB (1) Parasite (1) Phospholipase (1) PKC (1) PPAR (1) Reactive Oxygen Species (1) ROCK (2) SARS-CoV (1) Ser/Thr Protease (2) STAT (1) Toll-like Receptor (TLR) (1) VEGFR (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (10) Infection (3) Inflammation/Immunology (7) Metabolic Disease (11) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111603

Calcium dobesilate 1 Publications Verification	Apoptosis	Others
Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.

HY-P4253

Arginyl-Glutamine	VEGFR	Cardiovascular Disease
Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy .

HY-149325

RPE65-IN-1

Others Others

RPE65-IN-1(Compound 16e) is a potent RPE65 inhibitor, which can be used in retinopathy-related research .

RPE65-IN-1	Others	Others
RPE65-IN-1(Compound 16e) is a potent RPE65 inhibitor, which can be used in retinopathy-related research .

HY-111603S

Dobesilate-d6 calcium	Isotope-Labeled Compounds Apoptosis	Others
Dobesilate-d₆ (calcium) is deuterium labeled Calcium dobesilate. Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.

HY-150052

Plasma kallikrein-IN-3	Ser/Thr Protease	Cardiovascular Disease Metabolic Disease
Plasma kallikrein-IN-3 is a plasma kallikrein inhibitor (IC₅₀: 0.15 μM). Plasma kallikrein-IN-3 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .

HY-153464

CXCR4-IN-1	CXCR	Infection Cardiovascular Disease Inflammation/Immunology Cancer
CXCR4-IN-1 (Example C5) is a CXCR4 inhibitor (IC₅₀: 20 nM). CXCR4-IN-1 can be used for research of cancer, HIV, diabetic retinopathy, inflammation, etc .

HY-143476

Plasma kallikrein-IN-2	Ser/Thr Protease	Cardiovascular Disease Metabolic Disease
Plasma kallikrein-IN-2 (Compound 198) is a potent plasma kallikrein (PKal) inhibitor with an IC₅₀ of 0.1 nM. Plasma kallikrein-IN-2 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .

HY-116301

CAY10502	Phospholipase	Inflammation/Immunology
CAY10502 is a potent, calcium-dependent cytosolic phospholipase A2 α (cPLA₂α) inhibitor with an IC₅₀ of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases .

HY-122963

Danshenol B	Adenosine Receptor	Metabolic Disease
Danshenol B is a diterpenoid. Danshenol B has strong aldose reductase (AR) inhibitory activity with IC₅₀ value of 0.042μM. Danshenol B can be used for the research of diabetic related complication resulted by metabolic abnormality, such as cataracts, retinopathy, neuropathy, and nephropathy .

HY-139170

CAY10746	ROCK	Metabolic Disease
CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC₅₀ values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR) .

HY-150069

UBX1325	Bcl-2 Family Apoptosis	Metabolic Disease
UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR) .

HY-N11286

Tridocosahexaenoylglycerol TG-DHA; Meganol D	Others	Neurological Disease Metabolic Disease Inflammation/Immunology
Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .

HY-N0794

Proanthocyanidins 3 Publications Verification	Bacterial Fungal	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Proanthocyanidin (Procyanidin) are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidin can be used as antioxidant and anti-cancers agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy. .

HY-143721

SSAO inhibitor-2	Monoamine Oxidase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
SSAO inhibitor-2 (Compound 1) is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor with IC₅₀s of <10 nM, and 10-100 μM for human SSAO and MAO-A, respectively. SSAO inhibitor-3 can be used for the research of atherosclerosis, diabetes and its complications, obesity, stroke, chronic kidney disease, retinopathy, chronic obstructive pulmonary disease (COPD), autoimmune diseases, multiple sclerosis, etc .

HY-125639

(rac)-AR-13503 (rac)-AR-13324 M1 metabolite	PKC ROCK	Cardiovascular Disease
(rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice .

HY-143723

SSAO inhibitor-3	Monoamine Oxidase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
SSAO inhibitor-3 (Compound 2) is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor with IC₅₀s of <10 nM, and 0.1-10 μM for human SSAO and AOC1, respectively. SSAO inhibitor-3 can be used for the research of atherosclerosis, diabetes and its complications, obesity, stroke, chronic kidney disease, retinopathy, chronic obstructive pulmonary disease (COPD), autoimmune diseases, multiple sclerosis, etc .

HY-B2163

Astaxanthin 5+ Cited Publications	PPAR Reactive Oxygen Species STAT NF-κB Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed .

HY-117133

Nesvategrast SF0166	Integrin	Metabolic Disease
Nesvategrast (SF0166) is a potent and selective α_vβ₃ antagonist with IC₅₀ values of 0.6 nM, 8 nM, and 13 nM for α_vβ₃, α_vβ₆, and α_vβ₈, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC₅₀ values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model .

HY-155946

CU06-1004 Sac-1004	Others	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
CU06-1004 (Sac-1004) is an orally active endothelial dysfunction blocker. CU06-1004 ameliorates endothelial dysfunction by inhibiting hyperpermeability and inflammation, and is potent in inhibiting vascular leakage and inflammation in various animal models, such as diabetic retinopathy, stroke, cancer, and inflammatory bowel disease. CU06-1004 ameliorates CDAA-induced mouse model of NASH. CU06-1004 also improves cardiac function .

HY-W031727

Hydroxychloroquine Maximum Cited Publications 49 Publications Verification	Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection Cancer
Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 (TLR7/9) signaling .

Cat. No.	Product Name	Target	Research Area

HY-P4253

Arginyl-Glutamine	VEGFR	Cardiovascular Disease
Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0794

Proanthocyanidins 3 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Plants Infection Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields	Bacterial Fungal
Proanthocyanidin (Procyanidin) are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidin can be used as antioxidant and anti-cancers agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy. .

HY-B2163

Astaxanthin 5+ Cited Publications	Cardiovascular Disease Structural Classification Classification of Application Fields Anti-aging Source classification Whitening Agent Research on Agricultural Breeding Food Research Agricultural Research Microorganisms Sunscreen Terpenoids Pigments Diterpenoids Cosmetic Research Disease Research Fields	PPAR Reactive Oxygen Species STAT NF-κB Apoptosis
Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed .

HY-122963

Danshenol B	Structural Classification Terpenoids Labiatae Source classification Artemisia austriaca Jacq. Diterpenoids Plants	Adenosine Receptor
Danshenol B is a diterpenoid. Danshenol B has strong aldose reductase (AR) inhibitory activity with IC₅₀ value of 0.042μM. Danshenol B can be used for the research of diabetic related complication resulted by metabolic abnormality, such as cataracts, retinopathy, neuropathy, and nephropathy .

HY-N11286

Tridocosahexaenoylglycerol TG-DHA; Meganol D	Structural Classification Natural Products Animals Source classification	Others
Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .

Cat. No.	Compare	Product Name	Species	Source

HY-P72054

	RCVRN Protein, Human (Baculovirus, His-Myc) 23 kDa photoreceptor cell-specific protein; Cancer associated retinopathy protein; Cancer-associated retinopathy protein; CAR; CAR protein; p26; Protein CAR; RCV1; RCVRN; RECO_HUMAN; Recoverin; S-modulin	Human	Sf9 insect cells
	RCVRN protein, a calcium sensor, regulates phototransduction in cone and rod photoreceptor cells, enhancing cone photoreceptor light sensitivity in dark conditions. In low light, it extends RHO/rhodopsin activation in rods by inhibiting GRK1-mediated phosphorylation. RCVRN contributes to scotopic vision, improving signal transfer from rods to rod bipolar cells, enhancing vision in low light. It boosts rod photoreceptor sensitivity in dim light, aiding motion detection. Existing as a homodimer, RCVRN undergoes disulfide-linked dimerization in intense illumination and may form a Ca(2+)-dependent complex with RHO and GRK1, preventing their interaction. RCVRN Protein, Human (Baculovirus, His-Myc) is the recombinant human-derived RCVRN protein, expressed by Sf9 insect cells, with N-10*His, C-Myc labeled tag. The total length of RCVRN Protein, Human (Baculovirus, His-Myc) is 199 a.a., with molecular weight of ~27.0 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-111603S

Dobesilate-d6 calcium
Dobesilate-d₆ (calcium) is deuterium labeled Calcium dobesilate. Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.

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retinopathy.

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