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Results for "

spider

" in MedChemExpress (MCE) Product Catalog:

30

Inhibitors & Agonists

2

Fluorescent Dye

1

Biochemical Assay Reagents

26

Peptides

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D1878
    SPiDER-βGal-1

    		Fluorescent Dye Cancer
    SPiDER-βGal-1 is a potent probe for β-galactosidase activity and suitable for labeling live cells in culture .
    <em>SPiDER</em>-βGal-1
  • HY-D1879
    SPiDER-βGal-2

    		Fluorescent Dye Cancer
    SPiDER-βGal-2 is a potent probe for β-galactosidase activity and suitable for labeling live cells in culture .
    <em>SPiDER</em>-βGal-2
  • HY-P5162
    Dc1a

    		Sodium Channel Inflammation/Immunology
    Dc1a potently promotes opening of the German cockroach Nav channel (BgNav1). Dc1a is a toxin can be isolated from the desert bush spider Diguetia canities .
    Dc1a
  • HY-P5142
    ω-Hexatoxin-Hv1a

    ω-ACTX-Hv1; ω-Atracotoxin-HV1

    		 Calcium Channel Neurological Disease
    ω-Hexatoxin-Hv1a is a neurotoxin that can be isolated from the venom spider (Hadronyche versuta).ω-Hexatoxin-Hv1a blocks voltage-gated calcium channels .
    ω-Hexatoxin-Hv1a
  • HY-P3655
    Agelenin

    		Calcium Channel Others
    Agelenin is a polypeptide composed of 35 amino acids. Agelenin could be isolated from the Agelenidae spider Agelena opulenta. Agelenin has structural similarity to insect-specific calcium channel inhibitor .
    Agelenin
  • HY-P2699
    ω-Grammotoxin SIA

    GrTx; ω-GsTx SIA

    		 Calcium Channel Neurological Disease
    ω-Grammotoxin SIA (GrTx) is P/Q and N-type voltage-gated Calcium channels inhibitor. ω-Grammotoxin SIA is also a protein toxin that can be obtained from spider venom. ω-Grammotoxin SIA has the potential to study neurological diseases as well as cardiovascular diseases .
    ω-Grammotoxin SIA
  • HY-P5786
    Heteropodatoxin-1

    		Potassium Channel Sodium Channel Neurological Disease
    Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8 .
    Heteropodatoxin-1
  • HY-P5790
    μ-TRTX-Hd1a

    		Sodium Channel Neurological Disease
    μ-TRTX-Hd1a, a spider venom, is a selective NaV 1.7 inhibitor. μ-TRTX-Hd1a is a gating modifier that inhibits human NaV 1.7 by interacting with the S3b-S4 paddle motif in channel domain II .
    μ-TRTX-Hd1a
  • HY-129642
    Hirsutide

    		Others Others
    Hirsutide is a cyclic tetrapeptide that can be found in spider-derived entomopathogenic fungus .
    Hirsutide
  • HY-116511
    Benzoximate

    		Parasite Infection
    Benzoximate is an acaricide that inhibits fruit tree red spider mite Panonychys ulmi (Koch) .
    Benzoximate
  • HY-P2785
    Phrixotoxin-1

    		Potassium Channel Neurological Disease
    Phrixotoxin 1, from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel .
    Phrixotoxin-1
  • HY-12506A
    Naspm trihydrochloride
    5+ Cited Publications

    1-Naphthylacetyl spermine trihydrochloride

    		 iGluR Neurological Disease
    Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
    Naspm trihydrochloride
  • HY-12506
    Naspm
    5+ Cited Publications

    1-Naphthylacetyl spermine

    		 iGluR Neurological Disease
    Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
    Naspm
  • HY-W059342
    Etoxazole

    YI-5301

    		 Biochemical Assay Reagents Infection
    Etoxazole (YI-5301) is an organofluorine insecticide widely used in agriculture. Etoxazole affects the nymphs, eggs, and larvae of spider mites by inhibiting chitin biosynthesis .
    Etoxazole
  • HY-P2785A
    Phrixotoxin-1 TFA

    		Potassium Channel Neurological Disease
    Phrixotoxin-1 (TFA), from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel .
    Phrixotoxin-1 TFA
  • HY-P5183
    Hm1a

    		Sodium Channel Neurological Disease
    Hm1a is a disulfide-rich spider-venom peptide, and a NaV1.1 activator. Hm1a restores the function of inhibitory interneurons in Dravet syndrome (DS) mouse model .
    Hm1a
  • HY-P1330
    Purotoxin 1

    		P2X Receptor Inflammation/Immunology
    Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp .
    Purotoxin 1
  • HY-P1074
    SNX-482

    		Calcium Channel Neurological Disease
    SNX-482, a peptidyl toxin of the spider Hysterocrates gigas, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect .
    SNX-482
  • HY-P5865
    Tap1a

    Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a

    		 Sodium Channel Neurological Disease
    Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC50s of 80 nM and 301 nM against Nav1.7 and Nav1.1, respectively. Tap1a shows analgesic effects .
    Tap1a
  • HY-P1410B
    D-GsMTx4

    		Piezo Channel Cardiovascular Disease Neurological Disease Inflammation/Immunology
    D-GsMTx4, a spider peptide, is the D-enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 can be used for research of mechanical stress .
    D-GsMTx4
  • HY-P5160
    Phlotoxin-1

    PhlTx1

    		 Sodium Channel Inflammation/Immunology
    Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel .
    Phlotoxin-1
  • HY-P1410C
    D-GsMTx4 TFA

    		Piezo Channel Cardiovascular Disease Neurological Disease Inflammation/Immunology
    D-GsMTx4 TFA, a spider peptide, is the D-enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 TFA inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 TFA can be used for research of mechanical stress .
    D-GsMTx4 TFA
  • HY-P5770
    Jingzhaotoxin-V

    		Sodium Channel Neurological Disease
    Jingzhaotoxin-V, a 29-residue polypeptide, is derived from the venom of the spider Chilobrachys jingzhao. Jingzhaotoxin-V inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 nM and 30.2 nM, respectively. Jingzhaotoxin-V also inhibits Kv4.2 potassium currents expressed in Xenpus Laevis oocytes (IC50 of 604.2 nM) .
    Jingzhaotoxin-V
  • HY-P1410
    GsMTx4
    Maximum Cited Publications
    32 Publications Verification

    		 TRP Channel Piezo Channel Cardiovascular Disease Neurological Disease Inflammation/Immunology
    GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
    GsMTx4
  • HY-P1410A
    GsMTx4 TFA
    Maximum Cited Publications
    32 Publications Verification

    		 TRP Channel Piezo Channel Cardiovascular Disease Neurological Disease Inflammation/Immunology
    GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
    GsMTx4 TFA
  • HY-P5153
    ProTx-III

    μ-TRTX-Tp1a

    		 Sodium Channel Neurological Disease
    ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia .
    ProTx-III
  • HY-P1411A
    Psalmotoxin 1 TFA

    PcTx1 TFA; Psalmopoeus cambridgei toxin-1 TFA

    		 Sodium Channel Apoptosis Neurological Disease Cancer
    Psalmotoxin 1 (PcTx1) TFA is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 TFA is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H + of ASIC1a. Psalmotoxin 1 TFA can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 TFA can be used in the research of cancers, or neurological disease .
    Psalmotoxin 1 TFA
  • HY-P1411
    Psalmotoxin 1
    1 Publications Verification

    PcTx1; Psalmopoeus cambridgei toxin-1

    		 Sodium Channel Apoptosis Neurological Disease Cancer
    Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H + of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease .
    Psalmotoxin 1
  • HY-P5164
    GrTx1

    		Sodium Channel Neurological Disease
    GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel， with IC50s of 0.63 µM, 0.23 µM, 0.77 µM, 1.29 µM, 0.63 µM and 0.37 µM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively .GrTx1 can be used for neurological disease research .
    GrTx1
  • HY-100821
    2,4-Dihydroxyphenylacetylasparagine

    		Bacterial Infection
    2,4-Dihydroxyphenylacetylasparagine is a potent and selective antagonist of glutamate. 2,4-Dihydroxyphenylacetylasparagine inhibits glutamate binding to rat brain synaptic membranes .
    2,4-Dihydroxyphenylacetylasparagine

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