Search Result
Results for "
tetrazines
" in MedChemExpress (MCE) Product Catalog:
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D1557
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Fluorescent Dye
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Others
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Cyanine5.5 tetrazine is a far-infrared luminescent dye. Cyanine5.5 tetrazine is a Cyanine5.5 (HY-D0925A) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cyanine5.5 tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136032
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ADC Linker
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Cancer
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Tetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136031
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ADC Linker
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Cancer
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Tetrazine-SS-Biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136036
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ADC Linker
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Cancer
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Tetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D1554
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Fluorescent Dye
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Others
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Cyanine5 tetrazine, a fluorophore, is a molecule that contains a cyano5 fluorophore and a tetrazine moiety .
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- HY-101460
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PROTACs
Molecular Glues
Epigenetic Reader Domain
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Cancer
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Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
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- HY-151755
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Fluorescent Dye
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Others
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Sulfo-Cy3-Tetrazine is a click chemistry reagent containing an tetrazine group. Sulfo-Cy3-Tetrazine is water soluble cyanine fluorescence dye, which is an inverse electron demand [4+2] cycloaddition that takes place between tetrazine and trans-cyclooctene or other strained olefin.
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- HY-D2248
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Fluorescent Dye
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Others
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ICG-TCO is a fluorescent dye coupled by Indocyanine Green (ICG) and TCO. ICG-TCO can be used for detection and visualization of tetrazine-containing molecules.
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- HY-135140A
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Others
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Others
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Methyltetrazine-Amine, a tetrazine compound, is used for the site-specific dual functionalization of the resulting bioconjugates .
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- HY-D2123
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- HY-151730
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ADC Linker
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Others
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(Me)Tz-butanoic acid is a click chemistry reagent containing an azide. (Me)Tz-butanoic acid is tetrazine linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with dienophiles . (Me)Tz-butanoic acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-151742
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ADC Linker
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Others
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Norbornene-methyl-NHS is a click chemistry reagent containing a TCO group. Dienophile for conjugation via Diels-Alder-reaction, i.e. copper-free click reaction with tetrazines .
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- HY-151759
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Fluorescent Dye
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Others
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Sulfo-Cy5-TCO is a click chemistry reagent containing a TCO group. Sulfo-Cy5-TCO is water soluble dye, which is highly reactive with tetrazines and methyltetrazines with the fastest bioconjugation speed .
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- HY-153738
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ERK
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Cancer
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ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. ERK1/2 inhibitor 9 shows sub-micromolar activity in cells (A375 GI50=0.47 μM). ERK1/2 inhibitor 9 causes the downregulation of phospho-ERK1/2. ERK1/2 inhibitor 9 tagged trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine tagged Thalidomide) can form the corresponding ERK-CLIPTAC to elicit degradation of ERK1/2 .
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- HY-139859
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ADC Linker
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Cancer
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APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG36-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-156309
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Fluorescent Dye
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Others
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Coumarin-PEG8-tetrazine 是含有 8 个 PEG 单元的 Coumarin (HY-N0709) 染料衍生物。Coumarin-PEG8-tetrazine 含有 Tetrazine 基团，可以和含有 TCO 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
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- HY-W053709A
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(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine monohydrochloride; Tetrazine-NH2 monohydrochloride
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Biochemical Assay Reagents
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Cancer
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Tetrazine-Amine monohydrochloride is the monohydrochloride form of Tetrazine-Amine (HY-W053709). Tetrazine-amine is a Tetrazine linker that can be used to covalently label living cells by cycloaddition . Tetrazine-Amine (monohydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-141285
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Fluorescent Dye
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Others
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TAMRA-PEG4-tetrazine is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-138747
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PROTAC Linkers
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Cancer
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Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Bis-sulfone-PEG4-Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D2236
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Fluorescent Dye
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Others
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SiR-tetrazine is a Tetrazine modified SiR (silicon rhodamine) fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
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- HY-D2235
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Fluorescent Dye
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Others
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SiR-Me-tetrazine is a Tetrazine modified SiR (silicon rhodamine) fluorescent dye. SiR-Me-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-133463
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-Ph-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136045
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ADC Linker
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Cancer
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APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-W053709
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(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine; Tetrazine-NH2
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Biochemical Assay Reagents
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Cancer
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Tetrazine-Amine is a tetrazine linker that can be used to covalently label live cells through a cycloaddition . Tetrazine-Amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-138659
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JF646, Tetrazine
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Fluorescent Dye
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Others
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Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-124480
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136095
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ADC Linker
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Cancer
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Tetrazine-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-126908
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130928
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ADC Linker
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Cancer
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Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-OPSS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D2243
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Fluorescent Dye
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Others
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Cy3.5 tetrazineis a Tetrazine modified Cy3.5 fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
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- HY-133504
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ADC Linker
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Cancer
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Tetrazine-Ph-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D1598
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Fluorescent Dye
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Others
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Sulfo-CY3 tetrazine potassium is a sulfo-Cyanine3 derivative that contains methyltetrazine moiety (Ex=548 nm, Em=563 nm). Sulfo-CY3 tetrazine potassium can be used for the labeling of metabolically engineered cell-surface glycoconjugates . Sulfo-CY3 tetrazine (potassium) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-W879342
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- HY-130551
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D2148
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Fluorescent Dye
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Others
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AF 430 tetrazine is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 430 nm and an emission wavelength of 542 nm. AF 430 tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. To achieve specific coupling of dye labels and biomolecules.
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- HY-133460
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG3-alcohol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-133465
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-133479
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136052
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ADC Linker
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Cancer
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Tetrazine-PEG4-oxyamine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-oxyamine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136053
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ADC Linker
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Cancer
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Tetrazine-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130977
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ADC Linker
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Cancer
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Tetrazine-PEG4-amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136086
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ADC Linker
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Cancer
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Tetrazine-PEG6-amine (hydrochloride) is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG6-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-148211
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ADC Linker
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Cancer
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Tetrazine-PEG7-amine hydrochloride is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG7-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-133461
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG6-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-133462
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136040
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ADC Linker
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Cancer
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Tetrazine-PEG4-SS-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130945
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ADC Linker
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Cancer
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Tetrazine-PEG5-SS-amine is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG5-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130947
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ADC Linker
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Cancer
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Tetrazine-PEG4-SS-Py is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-SS-Py is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136078
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ADC Linker
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Cancer
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Tetrazine-diazo-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-diazo-PEG4-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D1482
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Fluorescent Dye
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Others
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Cy5 Tetrazine is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. Its absorption and emission spactra are almost identical to those of Alexa Fluor 647, CF 647 Dye, or any other Cyanine5 based fluorescent dyes. Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D2219
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Fluorescent Dye
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Others
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Sulfo-Cy7 tetrazine is a near-infrared water-soluble fluorophore. Sulfo-Cy7 tetrazine contains the methyltetrazine group for rapid, efficient, and metal-free conjugation to cycloolefin in a reaction called TCO linkage .
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- HY-D2217
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- HY-D2142
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Fluorescent Dye
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Others
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Cy5-PEG2-TCO is a fluorescent dye that reacts with tetrazines. Cy5-PEG2-TCO contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
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- HY-D1847
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Fluorescent Dye
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Others
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Cy7.5 tetrazine tetrafluoroborate is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) bearing a tetrazine group. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. Cy7.5 tetrazine tetrafluoroborate can perform efficient click reactions with molecules containing alkyne functional groups (such as alkyne) to form covalent bonds. It can be combined with biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-133464
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-D2209
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Fluorescent Dye
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Others
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SiR-PEG4-Me-tetrazine is a small molecule click chemical modified silyl rhodamine dye.
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- HY-131024
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JF549, Tetrazine
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Fluorescent Dye
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Others
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Janelia Fluor® 549, Tetrazine (JF549, Tetrazine) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
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- HY-151727
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ADC Linker
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Others
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Norbornene-NHS is a click chemistry reagent. Norbornene-NHS is a dienophile for conjugation via copper-free Click reaction with tetrazines .
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- HY-156488
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- HY-141159B
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- HY-D1331
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Fluorescent Dye
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BDP FL tetrazine is a BDP dye linker containing methyltetrazine groups. A 1 mM stock solution can be prepared in DMSO and diluted to 1 μM with PBS buffer before use.
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- HY-156304
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Fluorescent Dye
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Others
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Coumarin-C2-TCO 是 Coumarin (HY-N0709) 的染料衍生物。Coumarin-C2-TCO 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
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- HY-157070
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Others
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Others
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SCO-L-Lysine contains a SCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. SCO-L-Lysine can be incorporated into the protein of interest by the tRNAPyl/PylRSAF synthetase .
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- HY-151781
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ADC Linker
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Others
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Fmoc-L-Dap(Poc)-OH is a click chemistry reagent containing an azide group. Amino acid building block suitable for side chain Click conjugation with standard protocols and together with tetrazine linkers in copper-free Click conjugation (Diels-Alder) .
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- HY-D1646
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Fluorescent Dye
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Others
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BDP TR methyltetrazine is a BDP dye linker containing a methyltetrazine group. BDP TR methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-151698B
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Biochemical Assay Reagents
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Others
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(R,E)-TCO-NHS Ester is a Click Amino Acid that can be used to label amine-containing compounds or biomolecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
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- HY-151698A
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Biochemical Assay Reagents
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Others
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(S,E)-TCO-NHS Ester is a Click Amino Acid that can be used to label amine-containing compounds or biomolecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
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- HY-151698
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ADC Linker
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Others
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TCO-NHS Ester axial is a click chemistry reagent that can be used as a building block in amine reactions. TCO-NHS Ester axial contains TCO groups, which can undergo inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-156303
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-PEG2-TCO 是含有 2 个 PEG 单元的 Coumarin (HY-N0709) 染料衍生物。Coumarin-PEG2-TCO 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-156306
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-PEG3-TCO 是含有 3 个 PEG 单元的 Coumarin (HY-N0709) 染料衍生物。Coumarin-PEG3-TCO 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-136104
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-Maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-151776
-
|
TZ-Cy3
|
Fluorescent Dye
|
Others
|
|
Cy3 methyltetrazine (TZ-Cy3) is a click chemistry reagent with methyltetrazine building blocks that is highly reactive towards cyclooctene.
Cy3 methyltetrazine is also a tetrazine-modified fluorescent probe that can be used to analyze protein phosphorylation in solution and living cells .
|
-
- HY-D2116
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG8-Me-Tet 是含有 8 个 PEG 单元的 TAMRA (HY-135640) 染料衍生物。TAMRA-PEG8-Me-Tet 含有 Tetrazine 基团，可以和含有 TCO 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-130283
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136033
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136039
-
|
|
ADC Linker
|
Cancer
|
|
TCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-SS-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-141161B
-
|
|
ADC Linker
|
Cancer
|
|
(R)-TCO-PEG8-acid is an ADC linker containing 8 PEG units. (R)-TCO-PEG8-acid can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-156389
-
|
|
PROTAC Linkers
|
Cancer
|
|
(R)-TCO4-PEG2-NH2 is a PROTAC linker and belongs to the PEG class. (R)-TCO4-PEG2-NH2 contains a TCO group that specifically "clicks" with the tetrazine group.
|
-
- HY-156390
-
|
|
PROTAC Linkers
|
Cancer
|
|
(R)-TCO4-PEG7-NH2 is a PROTAC linker and belongs to the PEG class. (R)-TCO4-PEG7-NH2 contains a TCO group that specifically "clicks" with the tetrazine group.
|
-
- HY-141167B
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG4-NHS ester is an ADC linker containing 4 PEG units. (S)-TCO-PEG4-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-141169A
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG8-NHS ester is an ADC linker containing 8 PEG units. (S)-TCO-PEG8-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-141169B
-
|
|
ADC Linker
|
Cancer
|
|
(R)-TCO-PEG8-NHS ester is an ADC linker containing 8 PEG units. (R)-TCO-PEG8-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-157008
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG2-Maleimide is an ADC linker containing 2 PEG units. (S)-TCO-PEG2-Maleimide can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-140015
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-141286
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG4-methyltetrazine is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-methyltetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-140731
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG-TCO (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG-TCO (MW 5000) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-156313
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG4-NHS is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156475
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG2-COOH is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-COOH can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156476
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG2-NHS is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156477
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG8-NHBoc is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156478
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG4-NHBoc is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156479
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG3-NHBoc is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156490
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG5-NHS is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156491
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG9-NHS is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156492
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG4-COOH is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156493
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG5-COOH is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156494
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG9-COOH is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156495
-
|
|
ADC Linker
|
Cancer
|
|
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-140940
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Biotin-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133467
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG5-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG5-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133468
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG6-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG6-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133474
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG3-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG3-oxyamine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-133476
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG3-alcohol is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-133478
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG11-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG11-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-133475
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG5-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG5-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-133505
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG4-amine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG4-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133508
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG4-SSPy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG4-SSPy is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133497
-
|
|
PROTAC Linkers
|
Cancer
|
|
HyNic-PEG2-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . HyNic-PEG2-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-156391A
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
-
- HY-156392
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
-
- HY-W872575A
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
-
- HY-156391
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
-
- HY-W872575
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
-
- HY-157003
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG2-NH2 is an ADC Linker containing 2 PEG units. (S)-TCO-PEG2-NH2 can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-157006
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG3-NH2 is an ADC linker containing 3 PEG units. (S)-TCO-PEG3-NH2 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-157007
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG7-NH2 is an ADC linker containing 7 PEG units. (S)-TCO-PEG7-NH2 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-141166A
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
(S,E)-TCO2-PEG3-NHS ester is NH2 reactive, and can be used in chemical synthesis. (S,E)-TCO2-PEG3-NHS ester contains TCO groups, which can undergo specific "click" reactions with tetrazine groups .
|
-
- HY-D2143
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG3-TCO 是含有 3 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG3-TCO 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2144
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG7-TCO 是含有 7 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG7-TCO 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2118
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2117
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130508
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133477
-
|
|
PROTAC Linkers
|
Cancer
|
|
(S)-TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . (S)-TCO-PEG3-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-151773
-
|
|
ADC Linker
|
Others
|
|
Methyltetrazine-PEG12-acid is a click chemistry PEG reagent containing a tetrazine group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
|
-
- HY-156300
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG4-NH2 is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156301A
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG8-NH2 (hydrochloride) is an ADC Linker containing 2 PEG units. Me-Tet-PEG8-NH2 (hydrochloride) can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-W591272
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG3-NH2 is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-D2134
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG3-Tetrazin 是含有 3 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG3-Tetrazin 含有 Tetrazine 基团，可以和含有 TCO 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2159
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG8-Tetrazin 是含有 7 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG8-Tetrazin 含有 Tetrazine 基团，可以和含有 TCO 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-140141
-
|
|
PROTAC Linkers
|
Cancer
|
|
PC Methyltetrazine-PEG4-NHS carbonate ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . PC Methyltetrazine-PEG4-NHS carbonate ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136050
-
|
|
ADC Linker
|
Cancer
|
|
TCO-PEG3-Biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-Biotin is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136056
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-PEG4-oxyamine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-oxyamine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136074
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-PEG4-aldehyde is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136077
-
|
|
ADC Linker
|
Cancer
|
|
TCO-PEG3-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-D2145
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG2-TCO4 是含有 2 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG2-TCO4 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2147
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG7-TCO4 是含有 7 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG7-TCO4 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2146
-
|
|
Fluorescent Dye
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Others
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Cy5-PEG3-TCO4 是含有 3 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG3-TCO4 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
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- HY-160258
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GDP-Fucose-Am-Tz
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Biochemical Assay Reagents
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Others
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GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. GDP-fucose-Am-Tz and TCO-ssDNA were reacted at a ratio of 1:1 to obtain the final product GDP-fucose-ssDNA .
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- HY-130955
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ADC Linker
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Cancer
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Amino-bis-PEG3-TCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-bis-PEG3-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-133432
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ADC Linker
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Cancer
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DBCO-PEG4-SS-TCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG4-SS-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-133466
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ADC Linker
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Cancer
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Methyltetrazine-PEG4-SS-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-SS-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136035
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ADC Linker
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Cancer
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Methyltetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130934
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ADC Linker
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Cancer
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TCO-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-155322
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Fluorescent Dye
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Others
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Cy3-PEG2-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
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- HY-155323
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Fluorescent Dye
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Others
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Cy3-PEG3-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
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- HY-155324
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Fluorescent Dye
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Others
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Cy3-PEG7-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 7 PEG units. Cy3-PEG7-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
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- HY-151833
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ADC Linker
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Others
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Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130966
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ADC Linker
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Cancer
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TCO-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-PABC-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-136100
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ADC Linker
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Cancer
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TCO-PEG1-Val-Cit-PABC-PNP is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-PABC-PNP is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-156307
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ADC Linker
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Cancer
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Me-Tet-PEG3-Maleimide is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
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- HY-156308
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ADC Linker
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Cancer
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Me-Tet-PEG4-Maleimide is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
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- HY-156312
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ADC Linker
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Cancer
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Me-Tet-PEG8-Maleimide is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
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- HY-140313
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ADC Linker
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Cancer
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Methyltetrazine-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136076
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ADC Linker
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Cancer
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TCO-PEG3-CH2-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-CH2-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-155325
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Fluorescent Dye
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Others
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Cy3-PEG2-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
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- HY-155326
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Fluorescent Dye
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Others
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Cy3-PEG3-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
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- HY-141009
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PROTAC Linkers
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Cancer
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N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-(Mal-PEG6)-N-bis(PEG7-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-130943
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ADC Linker
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Cancer
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Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130953
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ADC Linker
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Cancer
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Mal-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Mal-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130970
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ADC Linker
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Cancer
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Amino-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-151772
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ADC Linker
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Others
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Methyltetrazine-PEG12-t-butyl ester is a monodisperse PEG compound. Methyltetrazine-PEG12-t-butyl ester is a click chemistry reagent containing a tetrazine group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
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- HY-130974
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ADC Linker
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Cancer
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Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D1071
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Fluorescent Dye
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Others
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DBCO-PEG12-TCO cantains a TCO and a DBCO moiety. TCO group can specifically react with terrahydrazine. DBCO-PEG12-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG12-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-140312
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PROTAC Linkers
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Cancer
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Methyltetrazine-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG12-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG12-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136084
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ADC Linker
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Cancer
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Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-133428
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ADC Linker
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Cancer
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DBCO-PEG3-TCO is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG3-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG3-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-148057
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Drug-Linker Conjugates for ADC
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Cancer
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TCO-PEG4-VC-PAB-MMAE is a agent-linker conjugate for ADC. TCO-PEG4-VC-PAB-MMAE contains a cleavable ADC linker (TCO-PEG4-VC-PA) and a potent tubulin inhibitor MMAE (HY-15162) . TCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-151780
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ADC Linker
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Others
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Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Dap(Pentynoyl)-OH serves as an amino acid building block for introducing alkyne functions into peptide sequences by standard Fmoc/tBu protocols. The alkyne residue can be engaged for copper catalyzed click reaction with organic azides or with tetrazines for copper-free conjugations . Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-136079
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ADC Linker
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Cancer
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Methyltetrazine-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-hydrazone-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG4-hydrazone-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-140310
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ADC Linker
PROTAC Linkers
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Cancer
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TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-154802
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ADC Linker
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Cancer
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TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2 . TCO-GK-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-D1867
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Fluorescent Dye
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Others
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Sulfo-Cy3-PEG2-TCO disodium is a derivative of Cy3 (Cyanine3) (HY-D0822) dye containing sulfonate and TCO groups. The TCO groups of Sulfo-Cy3-PEG2-TCO disodium react with tetrazine functional groups in highly specific click chemistry to form covalent bonds. Thus, Sulfo-Cy3-PEG2-TCO disodium can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
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- HY-D1870
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Fluorescent Dye
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Others
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Sulfo-Cy3-PEG3-biotin potassium is a biotin-modified derivative of Cy3 (Cyanine3) (HY-D0822) dye containing a TCO group. The TCO group of Sulfo-Cy3-PEG3-biotin potassium reacts with the tetrazine functional group in highly specific click chemistry to form a covalent bond. Thus, Sulfo-Cy3-PEG3-biotin potassium can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples. And because it is labeled with biotin, it is often used in affinity chromatography experiments, such as immunoprecipitation.
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- HY-151769
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ADC Linker
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Others
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TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-151824
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ADC Linker
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Others
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Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in peptide synthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-151837
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ADC Linker
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Others
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H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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| Cat. No. |
Product Name |
Type |
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- HY-D1557
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Fluorescent Dyes/Probes
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Cyanine5.5 tetrazine is a far-infrared luminescent dye. Cyanine5.5 tetrazine is a Cyanine5.5 (HY-D0925A) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cyanine5.5 tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-151755
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Fluorescent Dyes/Probes
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Sulfo-Cy3-Tetrazine is a click chemistry reagent containing an tetrazine group. Sulfo-Cy3-Tetrazine is water soluble cyanine fluorescence dye, which is an inverse electron demand [4+2] cycloaddition that takes place between tetrazine and trans-cyclooctene or other strained olefin.
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- HY-D2248
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Fluorescent Dyes/Probes
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ICG-TCO is a fluorescent dye coupled by Indocyanine Green (ICG) and TCO. ICG-TCO can be used for detection and visualization of tetrazine-containing molecules.
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- HY-D2123
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-
- HY-151759
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Dyes
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Sulfo-Cy5-TCO is a click chemistry reagent containing a TCO group. Sulfo-Cy5-TCO is water soluble dye, which is highly reactive with tetrazines and methyltetrazines with the fastest bioconjugation speed .
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- HY-156309
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Fluorescent Dyes/Probes
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Coumarin-PEG8-tetrazine 是含有 8 个 PEG 单元的 Coumarin (HY-N0709) 染料衍生物。Coumarin-PEG8-tetrazine 含有 Tetrazine 基团，可以和含有 TCO 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
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- HY-D2236
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Fluorescent Dyes/Probes
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SiR-tetrazine is a Tetrazine modified SiR (silicon rhodamine) fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
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- HY-D2235
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Fluorescent Dyes/Probes
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SiR-Me-tetrazine is a Tetrazine modified SiR (silicon rhodamine) fluorescent dye. SiR-Me-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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-
- HY-138659
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JF646, Tetrazine
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Fluorescent Dyes/Probes
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Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D2243
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Fluorescent Dyes/Probes
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Cy3.5 tetrazineis a Tetrazine modified Cy3.5 fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
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- HY-D1598
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Fluorescent Dyes/Probes
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Sulfo-CY3 tetrazine potassium is a sulfo-Cyanine3 derivative that contains methyltetrazine moiety (Ex=548 nm, Em=563 nm). Sulfo-CY3 tetrazine potassium can be used for the labeling of metabolically engineered cell-surface glycoconjugates . Sulfo-CY3 tetrazine (potassium) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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-
- HY-W879342
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-
- HY-D2148
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Fluorescent Dyes/Probes
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AF 430 tetrazine is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 430 nm and an emission wavelength of 542 nm. AF 430 tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. To achieve specific coupling of dye labels and biomolecules.
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- HY-D1482
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Fluorescent Dyes/Probes
|
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Cy5 Tetrazine is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. Its absorption and emission spactra are almost identical to those of Alexa Fluor 647, CF 647 Dye, or any other Cyanine5 based fluorescent dyes. Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D2219
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Fluorescent Dyes/Probes
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Sulfo-Cy7 tetrazine is a near-infrared water-soluble fluorophore. Sulfo-Cy7 tetrazine contains the methyltetrazine group for rapid, efficient, and metal-free conjugation to cycloolefin in a reaction called TCO linkage .
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- HY-D2217
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-
- HY-D2142
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Fluorescent Dyes/Probes
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Cy5-PEG2-TCO is a fluorescent dye that reacts with tetrazines. Cy5-PEG2-TCO contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
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- HY-D1847
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Fluorescent Dyes/Probes
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Cy7.5 tetrazine tetrafluoroborate is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) bearing a tetrazine group. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. Cy7.5 tetrazine tetrafluoroborate can perform efficient click reactions with molecules containing alkyne functional groups (such as alkyne) to form covalent bonds. It can be combined with biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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-
- HY-D2209
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-
- HY-131024
-
|
JF549, Tetrazine
|
Fluorescent Dyes/Probes
|
|
Janelia Fluor® 549, Tetrazine (JF549, Tetrazine) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
|
-
- HY-D1331
-
|
|
Fluorescent Dyes/Probes
|
|
BDP FL tetrazine is a BDP dye linker containing methyltetrazine groups. A 1 mM stock solution can be prepared in DMSO and diluted to 1 μM with PBS buffer before use.
|
-
- HY-156304
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-C2-TCO 是 Coumarin (HY-N0709) 的染料衍生物。Coumarin-C2-TCO 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D1646
-
|
|
Fluorescent Dyes/Probes
|
|
BDP TR methyltetrazine is a BDP dye linker containing a methyltetrazine group. BDP TR methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-156303
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-PEG2-TCO 是含有 2 个 PEG 单元的 Coumarin (HY-N0709) 染料衍生物。Coumarin-PEG2-TCO 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-156306
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-PEG3-TCO 是含有 3 个 PEG 单元的 Coumarin (HY-N0709) 染料衍生物。Coumarin-PEG3-TCO 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-151776
-
|
TZ-Cy3
|
Fluorescent Dyes/Probes
|
|
Cy3 methyltetrazine (TZ-Cy3) is a click chemistry reagent with methyltetrazine building blocks that is highly reactive towards cyclooctene.
Cy3 methyltetrazine is also a tetrazine-modified fluorescent probe that can be used to analyze protein phosphorylation in solution and living cells .
|
-
- HY-D2116
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA-PEG8-Me-Tet 是含有 8 个 PEG 单元的 TAMRA (HY-135640) 染料衍生物。TAMRA-PEG8-Me-Tet 含有 Tetrazine 基团，可以和含有 TCO 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2143
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG3-TCO 是含有 3 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG3-TCO 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2144
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG7-TCO 是含有 7 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG7-TCO 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2118
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2117
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2134
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG3-Tetrazin 是含有 3 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG3-Tetrazin 含有 Tetrazine 基团，可以和含有 TCO 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2159
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG8-Tetrazin 是含有 7 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG8-Tetrazin 含有 Tetrazine 基团，可以和含有 TCO 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2145
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG2-TCO4 是含有 2 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG2-TCO4 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2147
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG7-TCO4 是含有 7 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG7-TCO4 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-D2146
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG3-TCO4 是含有 3 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG3-TCO4 可利用自身的 TCO 基团与带 Tetrazine 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
|
-
- HY-155322
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG2-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-155323
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG3-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-155324
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG7-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 7 PEG units. Cy3-PEG7-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-155325
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG2-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-155326
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG3-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-D1071
-
|
|
Dyes
|
|
DBCO-PEG12-TCO cantains a TCO and a DBCO moiety. TCO group can specifically react with terrahydrazine. DBCO-PEG12-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG12-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-D1867
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cy3-PEG2-TCO disodium is a derivative of Cy3 (Cyanine3) (HY-D0822) dye containing sulfonate and TCO groups. The TCO groups of Sulfo-Cy3-PEG2-TCO disodium react with tetrazine functional groups in highly specific click chemistry to form covalent bonds. Thus, Sulfo-Cy3-PEG2-TCO disodium can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
|
-
- HY-D1870
-
|
|
Dyes
|
|
Sulfo-Cy3-PEG3-biotin potassium is a biotin-modified derivative of Cy3 (Cyanine3) (HY-D0822) dye containing a TCO group. The TCO group of Sulfo-Cy3-PEG3-biotin potassium reacts with the tetrazine functional group in highly specific click chemistry to form a covalent bond. Thus, Sulfo-Cy3-PEG3-biotin potassium can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples. And because it is labeled with biotin, it is often used in affinity chromatography experiments, such as immunoprecipitation.
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-D1557
-
|
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
Cyanine5.5 tetrazine is a far-infrared luminescent dye. Cyanine5.5 tetrazine is a Cyanine5.5 (HY-D0925A) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cyanine5.5 tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-101460
-
|
|
|
Tetrazine
|
|
Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
|
-
- HY-136032
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136031
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-SS-Biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136036
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2248
-
|
|
|
TCO
|
|
ICG-TCO is a fluorescent dye coupled by Indocyanine Green (ICG) and TCO. ICG-TCO can be used for detection and visualization of tetrazine-containing molecules.
|
-
- HY-135140
-
|
|
|
Tetrazine
|
|
Methyltetrazine-Amine, a tetrazine compound, is used for the site-specific dual functionalization of the resulting bioconjugates .
|
-
- HY-151730
-
|
|
|
Tetrazine
|
|
(Me)Tz-butanoic acid is a click chemistry reagent containing an azide. (Me)Tz-butanoic acid is tetrazine linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with dienophiles . (Me)Tz-butanoic acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-151742
-
|
|
|
TCO
|
|
Norbornene-methyl-NHS is a click chemistry reagent containing a TCO group. Dienophile for conjugation via Diels-Alder-reaction, i.e. copper-free click reaction with tetrazines .
|
-
- HY-151759
-
|
|
|
TCO
Labeling and Fluorescence Imaging
|
|
Sulfo-Cy5-TCO is a click chemistry reagent containing a TCO group. Sulfo-Cy5-TCO is water soluble dye, which is highly reactive with tetrazines and methyltetrazines with the fastest bioconjugation speed .
|
-
- HY-139859
-
|
|
|
ADC Synthesis
Tetrazine
|
|
APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG36-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-156309
-
-
- HY-W053709A
-
|
(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine monohydrochloride; Tetrazine-NH2 monohydrochloride
|
|
Tetrazine
|
|
Tetrazine-Amine monohydrochloride is the monohydrochloride form of Tetrazine-Amine (HY-W053709). Tetrazine-amine is a Tetrazine linker that can be used to covalently label living cells by cycloaddition . Tetrazine-Amine (monohydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-141285
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
TAMRA-PEG4-tetrazine is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-138747
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Bis-sulfone-PEG4-Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2236
-
|
|
|
Tetrazine
|
|
SiR-tetrazine is a Tetrazine modified SiR (silicon rhodamine) fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
|
-
- HY-D2235
-
|
|
|
Tetrazine
|
|
SiR-Me-tetrazine is a Tetrazine modified SiR (silicon rhodamine) fluorescent dye. SiR-Me-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133463
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-Ph-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136045
-
|
|
|
Tetrazine
ADC Synthesis
|
|
APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-W053709
-
|
(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine; Tetrazine-NH2
|
|
Tetrazine
|
|
Tetrazine-Amine is a tetrazine linker that can be used to covalently label live cells through a cycloaddition . Tetrazine-Amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-138659
-
|
JF646, Tetrazine
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-124480
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136095
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-126908
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130928
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-OPSS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2243
-
|
|
|
Tetrazine
|
|
Cy3.5 tetrazineis a Tetrazine modified Cy3.5 fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
|
-
- HY-133504
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-Ph-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D1598
-
|
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
Sulfo-CY3 tetrazine potassium is a sulfo-Cyanine3 derivative that contains methyltetrazine moiety (Ex=548 nm, Em=563 nm). Sulfo-CY3 tetrazine potassium can be used for the labeling of metabolically engineered cell-surface glycoconjugates . Sulfo-CY3 tetrazine (potassium) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-W879342
-
|
|
|
Tetrazine
|
|
ICG-Tetrazine is a fluorescent dye .
|
-
- HY-130551
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2148
-
|
|
|
Tetrazine
|
|
AF 430 tetrazine is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 430 nm and an emission wavelength of 542 nm. AF 430 tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. To achieve specific coupling of dye labels and biomolecules.
|
-
- HY-133460
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-NHCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG3-alcohol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133465
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133479
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136052
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-PEG4-oxyamine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-oxyamine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136053
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130977
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-PEG4-amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136086
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-PEG6-amine (hydrochloride) is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG6-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-148211
-
|
|
|
Tetrazine
|
|
Tetrazine-PEG7-amine hydrochloride is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG7-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133461
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG6-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133462
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136040
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-PEG4-SS-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130945
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-PEG5-SS-amine is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG5-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130947
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-PEG4-SS-Py is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-SS-Py is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136078
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-diazo-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-diazo-PEG4-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D1482
-
|
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
Cy5 Tetrazine is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. Its absorption and emission spactra are almost identical to those of Alexa Fluor 647, CF 647 Dye, or any other Cyanine5 based fluorescent dyes. Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2219
-
|
|
|
Tetrazine
|
|
Sulfo-Cy7 tetrazine is a near-infrared water-soluble fluorophore. Sulfo-Cy7 tetrazine contains the methyltetrazine group for rapid, efficient, and metal-free conjugation to cycloolefin in a reaction called TCO linkage .
|
-
- HY-D2217
-
|
|
|
Tetrazine
|
|
Cy7 tetrazine is a near infrared dye that can be used for in vivo imaging .
|
-
- HY-D2142
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy5-PEG2-TCO is a fluorescent dye that reacts with tetrazines. Cy5-PEG2-TCO contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-133464
-
|
|
|
Tetrazine
Alkynes
PROTAC Synthesis
|
|
Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
- HY-D2209
-
|
|
|
Tetrazine
|
|
SiR-PEG4-Me-tetrazine is a small molecule click chemical modified silyl rhodamine dye.
|
- HY-131024
-
|
JF549, Tetrazine
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
Janelia Fluor® 549, Tetrazine (JF549, Tetrazine) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
|
- HY-151727
-
|
|
|
Tetrazine
|
|
Norbornene-NHS is a click chemistry reagent. Norbornene-NHS is a dienophile for conjugation via copper-free Click reaction with tetrazines .
|
- HY-156488
-
|
|
|
TCO
|
|
TCO-PEG7-Maleimide contains TCO groups, and can undergo specific "click" reactions with tetrazine groups.
|
- HY-141159B
-
|
|
|
TCO
|
|
(S,E)-TCO2-PEG4-COOH contains TCO groups, and can undergo specific "click" reactions with tetrazine groups .
|
- HY-D1331
-
|
|
|
Tetrazine
|
|
BDP FL tetrazine is a BDP dye linker containing methyltetrazine groups. A 1 mM stock solution can be prepared in DMSO and diluted to 1 μM with PBS buffer before use.
|
- HY-156304
-
- HY-151781
-
|
|
|
Alkynes
|
|
Fmoc-L-Dap(Poc)-OH is a click chemistry reagent containing an azide group. Amino acid building block suitable for side chain Click conjugation with standard protocols and together with tetrazine linkers in copper-free Click conjugation (Diels-Alder) .
|
- HY-D1646
-
|
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
BDP TR methyltetrazine is a BDP dye linker containing a methyltetrazine group. BDP TR methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-151698B
-
|
|
|
TCO
|
|
(R,E)-TCO-NHS Ester is a Click Amino Acid that can be used to label amine-containing compounds or biomolecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
- HY-151698A
-
|
|
|
TCO
|
|
(S,E)-TCO-NHS Ester is a Click Amino Acid that can be used to label amine-containing compounds or biomolecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
- HY-151698
-
|
|
|
TCO
|
|
TCO-NHS Ester axial is a click chemistry reagent that can be used as a building block in amine reactions. TCO-NHS Ester axial contains TCO groups, which can undergo inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-156303
-
- HY-156306
-
- HY-136104
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-Maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-24592
-
|
|
|
TCO
|
|
(S,E)-Cyclooct-2-enol is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
- HY-151776
-
|
TZ-Cy3
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
Cy3 methyltetrazine (TZ-Cy3) is a click chemistry reagent with methyltetrazine building blocks that is highly reactive towards cyclooctene.
Cy3 methyltetrazine is also a tetrazine-modified fluorescent probe that can be used to analyze protein phosphorylation in solution and living cells .
|
- HY-D2116
-
- HY-W784030A
-
|
|
|
TCO
|
|
(S,E)-N-TCO-L-lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. (S,E)-N-TCO-L-lysine contains a TCO group and can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
- HY-W784030B
-
|
|
|
TCO
|
|
(R,E)-N-TCO-L-lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. (R,E)-N-TCO-L-lysine contains a TCO group and can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
- HY-130283
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136033
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136039
-
|
|
|
ADC Synthesis
TCO
|
|
TCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-SS-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-141161B
-
|
|
|
TCO
|
|
(R)-TCO-PEG8-acid is an ADC linker containing 8 PEG units. (R)-TCO-PEG8-acid can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-156389
-
|
|
|
TCO
|
|
(R)-TCO4-PEG2-NH2 is a PROTAC linker and belongs to the PEG class. (R)-TCO4-PEG2-NH2 contains a TCO group that specifically "clicks" with the tetrazine group.
|
- HY-156390
-
|
|
|
TCO
|
|
(R)-TCO4-PEG7-NH2 is a PROTAC linker and belongs to the PEG class. (R)-TCO4-PEG7-NH2 contains a TCO group that specifically "clicks" with the tetrazine group.
|
- HY-141167B
-
|
|
|
TCO
|
|
(S)-TCO-PEG4-NHS ester is an ADC linker containing 4 PEG units. (S)-TCO-PEG4-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-141169A
-
|
|
|
TCO
|
|
(S)-TCO-PEG8-NHS ester is an ADC linker containing 8 PEG units. (S)-TCO-PEG8-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-157008
-
|
|
|
TCO
|
|
(S)-TCO-PEG2-Maleimide is an ADC linker containing 2 PEG units. (S)-TCO-PEG2-Maleimide can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-140015
-
|
|
|
PROTAC Synthesis
TCO
|
|
TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-141286
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
TAMRA-PEG4-methyltetrazine is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-methyltetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-140731
-
|
|
|
PROTAC Synthesis
TCO
|
|
TCO-PEG-TCO (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG-TCO (MW 5000) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-156313
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG4-NHS is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156475
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG2-COOH is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-COOH can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156476
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG2-NHS is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156477
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG8-NHBoc is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156478
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG4-NHBoc is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156479
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG3-NHBoc is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156490
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG5-NHS is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156491
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG9-NHS is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156492
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG4-COOH is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156493
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG5-COOH is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156494
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG9-COOH is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156495
-
|
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-140940
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Biotin-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133467
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Methyltetrazine-PEG5-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG5-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133468
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Methyltetrazine-PEG6-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG6-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133474
-
|
|
|
TCO
PROTAC Synthesis
|
|
TCO-PEG3-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG3-oxyamine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-133476
-
|
|
|
PROTAC Synthesis
TCO
|
|
TCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG3-alcohol is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-133478
-
|
|
|
PROTAC Synthesis
TCO
|
|
TCO-PEG11-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG11-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-133475
-
|
|
|
PROTAC Synthesis
TCO
|
|
TCO-PEG5-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG5-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-133505
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Methyltetrazine-PEG4-amine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG4-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133508
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Methyltetrazine-PEG4-SSPy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG4-SSPy is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133497
-
|
|
|
TCO
PROTAC Synthesis
|
|
HyNic-PEG2-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . HyNic-PEG2-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-156391A
-
|
|
|
TCO
|
|
TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
- HY-156392
-
|
|
|
TCO
|
|
TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
- HY-W872575A
-
|
|
|
TCO
|
|
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
- HY-156391
-
|
|
|
TCO
|
|
TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
- HY-W872575
-
|
|
|
TCO
|
|
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
- HY-157003
-
|
|
|
TCO
|
|
(S)-TCO-PEG2-NH2 is an ADC Linker containing 2 PEG units. (S)-TCO-PEG2-NH2 can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-157006
-
|
|
|
TCO
|
|
(S)-TCO-PEG3-NH2 is an ADC linker containing 3 PEG units. (S)-TCO-PEG3-NH2 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-157007
-
|
|
|
TCO
|
|
(S)-TCO-PEG7-NH2 is an ADC linker containing 7 PEG units. (S)-TCO-PEG7-NH2 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-141166A
-
|
|
|
TCO
|
|
(S,E)-TCO2-PEG3-NHS ester is NH2 reactive, and can be used in chemical synthesis. (S,E)-TCO2-PEG3-NHS ester contains TCO groups, which can undergo specific "click" reactions with tetrazine groups .
|
- HY-D2143
-
- HY-D2144
-
- HY-D2118
-
|
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-D2117
-
|
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-130508
-
|
|
|
Tetrazine
Azide
PROTAC Synthesis
|
|
Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133477
-
|
|
|
PROTAC Synthesis
TCO
|
|
(S)-TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . (S)-TCO-PEG3-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-151773
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Tetrazine
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Methyltetrazine-PEG12-acid is a click chemistry PEG reagent containing a tetrazine group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
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- HY-156300
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Tetrazine
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Me-Tet-PEG4-NH2 is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
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- HY-156301A
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Tetrazine
|
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Me-Tet-PEG8-NH2 (hydrochloride) is an ADC Linker containing 2 PEG units. Me-Tet-PEG8-NH2 (hydrochloride) can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
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- HY-W591272
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Tetrazine
|
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Me-Tet-PEG3-NH2 is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
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- HY-D2134
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- HY-D2159
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Tetrazine
|
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Cy5-PEG8-Tetrazin 是含有 7 个 PEG 单元的 Cyanine 5 (Cy5) (HY-D0821) 染料衍生物。Cy5-PEG8-Tetrazin 含有 Tetrazine 基团，可以和含有 TCO 基团的分子发生逆电子需求 Diels-Alder 反应 (iEDDA)。
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- HY-140141
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PROTAC Synthesis
Tetrazine
|
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PC Methyltetrazine-PEG4-NHS carbonate ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . PC Methyltetrazine-PEG4-NHS carbonate ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136050
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TCO
ADC Synthesis
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TCO-PEG3-Biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-Biotin is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-136056
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ADC Synthesis
Tetrazine
|
|
Methyltetrazine-PEG4-oxyamine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-oxyamine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136074
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Tetrazine
ADC Synthesis
|
|
Methyltetrazine-PEG4-aldehyde is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136077
-
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|
ADC Synthesis
TCO
|
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TCO-PEG3-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-D2145
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- HY-D2147
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- HY-D2146
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- HY-160258
-
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GDP-Fucose-Am-Tz
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Tetrazine
|
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GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. GDP-fucose-Am-Tz and TCO-ssDNA were reacted at a ratio of 1:1 to obtain the final product GDP-fucose-ssDNA .
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- HY-130955
-
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ADC Synthesis
TCO
|
|
Amino-bis-PEG3-TCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-bis-PEG3-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-133432
-
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TCO
ADC Synthesis
DBCO
|
|
DBCO-PEG4-SS-TCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG4-SS-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-133466
-
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|
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Tetrazine
ADC Synthesis
|
|
Methyltetrazine-PEG4-SS-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-SS-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136035
-
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|
|
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130934
-
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|
|
TCO
ADC Synthesis
|
|
TCO-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-155322
-
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|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy3-PEG2-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
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- HY-155323
-
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|
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TCO
Labeling and Fluorescence Imaging
|
|
Cy3-PEG3-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
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- HY-155324
-
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|
|
TCO
Labeling and Fluorescence Imaging
|
|
Cy3-PEG7-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 7 PEG units. Cy3-PEG7-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
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- HY-151833
-
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|
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Tetrazine
|
|
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130966
-
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|
|
ADC Synthesis
TCO
|
|
TCO-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-PABC-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-136100
-
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|
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TCO
ADC Synthesis
|
|
TCO-PEG1-Val-Cit-PABC-PNP is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-PABC-PNP is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-156307
-
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|
|
Tetrazine
|
|
Me-Tet-PEG3-Maleimide is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
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- HY-156308
-
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|
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Tetrazine
|
|
Me-Tet-PEG4-Maleimide is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
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- HY-156312
-
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|
|
Tetrazine
|
|
Me-Tet-PEG8-Maleimide is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
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- HY-140313
-
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|
|
DBCO
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136076
-
|
|
|
ADC Synthesis
TCO
|
|
TCO-PEG3-CH2-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-CH2-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-155325
-
|
|
|
TCO
Labeling and Fluorescence Imaging
|
|
Cy3-PEG2-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-155326
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy3-PEG3-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-141009
-
|
|
|
PROTAC Synthesis
TCO
|
|
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-(Mal-PEG6)-N-bis(PEG7-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-130943
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-130953
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Mal-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Mal-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-130970
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Amino-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-151772
-
|
|
|
Tetrazine
|
|
Methyltetrazine-PEG12-t-butyl ester is a monodisperse PEG compound. Methyltetrazine-PEG12-t-butyl ester is a click chemistry reagent containing a tetrazine group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
|
- HY-130974
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-D1071
-
|
|
|
DBCO
|
|
DBCO-PEG12-TCO cantains a TCO and a DBCO moiety. TCO group can specifically react with terrahydrazine. DBCO-PEG12-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG12-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-140312
-
|
|
|
DBCO
Tetrazine
PROTAC Synthesis
|
|
Methyltetrazine-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG12-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG12-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136084
-
|
|
|
TCO
ADC Synthesis
|
|
Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-133428
-
|
|
|
DBCO
TCO
ADC Synthesis
|
|
DBCO-PEG3-TCO is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG3-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG3-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-148057
-
|
|
|
TCO
ADC Synthesis
|
|
TCO-PEG4-VC-PAB-MMAE is a agent-linker conjugate for ADC. TCO-PEG4-VC-PAB-MMAE contains a cleavable ADC linker (TCO-PEG4-VC-PA) and a potent tubulin inhibitor MMAE (HY-15162) . TCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-151780
-
|
|
|
Alkynes
|
|
Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Dap(Pentynoyl)-OH serves as an amino acid building block for introducing alkyne functions into peptide sequences by standard Fmoc/tBu protocols. The alkyne residue can be engaged for copper catalyzed click reaction with organic azides or with tetrazines for copper-free conjugations . Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
- HY-136079
-
|
|
|
DBCO
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-hydrazone-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG4-hydrazone-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-140310
-
|
|
|
ADC Synthesis
PROTAC Synthesis
TCO
DBCO
|
|
TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-154802
-
|
|
|
TCO
|
|
TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2 . TCO-GK-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-151769
-
|
|
|
TCO
Labeling and Fluorescence Imaging
|
|
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-151824
-
|
|
|
Alkynes
|
|
Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in peptide synthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
- HY-151837
-
|
|
|
Alkynes
|
|
H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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