SN40 hydrochloride

Cat. No.: HY-146241B Purity: 98.00%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SN40 hydrochloride is a potent amino acid transport (AAT) inhibitor with K_is of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 hydrochloride can be used for researching anticancer.

For research use only. We do not sell to patients.

SN40 hydrochloride Chemical Structure

CAS No. : 2768663-15-4

Size	Price	Stock	Quantity
5 mg	USD 465	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Other Forms of SN40 hydrochloride:

SN40 In-stock

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Purity & Documentation
References
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Description

Molecular Weight

332.82

Formula

C₁₈H₂₁ClN₂O₂

CAS No.

2768663-15-4

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](NC1)C[C@@H]1NCC2=CC=C(C3=CC=CC=C3)C=C2)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (300.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0046 mL	15.0231 mL	30.0463 mL
5 mM	0.6009 mL	3.0046 mL	6.0093 mL
10 mM	0.3005 mL	1.5023 mL	3.0046 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (7.51 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (7.51 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.5 mg/mL (7.51 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.00%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (247 KB) HNMR (141 KB) RP-HPLC (139 KB) LCMS (357 KB)

Handling Instructions (2659 KB)

References

[1]. Grewer Christof, et al. Preparation of amino acids as inhibitors of alanine serine cysteine transporter 2. World Intellectual Property Organization, WO2022087630 A1 2022-04-28

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0046 mL	15.0231 mL	30.0463 mL	75.1157 mL
	5 mM	0.6009 mL	3.0046 mL	6.0093 mL	15.0231 mL
	10 mM	0.3005 mL	1.5023 mL	3.0046 mL	7.5116 mL
	15 mM	0.2003 mL	1.0015 mL	2.0031 mL	5.0077 mL
	20 mM	0.1502 mL	0.7512 mL	1.5023 mL	3.7558 mL
	25 mM	0.1202 mL	0.6009 mL	1.2019 mL	3.0046 mL
	30 mM	0.1002 mL	0.5008 mL	1.0015 mL	2.5039 mL
	40 mM	0.0751 mL	0.3756 mL	0.7512 mL	1.8779 mL
	50 mM	0.0601 mL	0.3005 mL	0.6009 mL	1.5023 mL
	60 mM	0.0501 mL	0.2504 mL	0.5008 mL	1.2519 mL
	80 mM	0.0376 mL	0.1878 mL	0.3756 mL	0.9389 mL
	100 mM	0.0300 mL	0.1502 mL	0.3005 mL	0.7512 mL