2. Stem Cell/Wnt
  3. YAP
  4. SWTX-143

SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity.

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SWTX-143 Chemical Structure

SWTX-143 Chemical Structure

CAS No. : 2766575-48-6

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5 mg USD 350 In-stock
10 mg USD 550 In-stock
25 mg USD 1100 In-stock
50 mg USD 1750 In-stock
100 mg USD 2750 In-stock
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Based on 1 publication(s) in Google Scholar

SWTX-143 Related Antibodies

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Description

SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].

Molecular Weight

361.36

Formula

C19H18F3N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C=C)NC1CC2=C(N)C=CC=C2N(C3=CC=C(C(F)(F)F)C=C3)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (345.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7673 mL 13.8366 mL 27.6732 mL
5 mM 0.5535 mL 2.7673 mL 5.5346 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7673 mL 13.8366 mL 27.6732 mL 69.1831 mL
5 mM 0.5535 mL 2.7673 mL 5.5346 mL 13.8366 mL
10 mM 0.2767 mL 1.3837 mL 2.7673 mL 6.9183 mL
15 mM 0.1845 mL 0.9224 mL 1.8449 mL 4.6122 mL
20 mM 0.1384 mL 0.6918 mL 1.3837 mL 3.4592 mL
25 mM 0.1107 mL 0.5535 mL 1.1069 mL 2.7673 mL
30 mM 0.0922 mL 0.4612 mL 0.9224 mL 2.3061 mL
40 mM 0.0692 mL 0.3459 mL 0.6918 mL 1.7296 mL
50 mM 0.0553 mL 0.2767 mL 0.5535 mL 1.3837 mL
60 mM 0.0461 mL 0.2306 mL 0.4612 mL 1.1531 mL
80 mM 0.0346 mL 0.1730 mL 0.3459 mL 0.8648 mL
100 mM 0.0277 mL 0.1384 mL 0.2767 mL 0.6918 mL
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SWTX-143 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SWTX-1432766575-48-6SWTX143SWTX 143YAPYes-associated proteinYAP/TAZ-TEAD InhibitorCancerInhibitorinhibitorinhibit

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