Tubulin/JAK2-IN-1

Cat. No.: HY-156423: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tubulin/JAK2-IN-1 (compound 7g) is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative activity against the cancer cells.

For research use only. We do not sell to patients.

Tubulin/JAK2-IN-1 Chemical Structure

CAS No. : 2933938-46-4

Size	Price	Stock
5 mg	USD 450	Ask For Quote & Lead Time
10 mg	USD 720	Ask For Quote & Lead Time
25 mg	USD 1450	Ask For Quote & Lead Time
50 mg	USD 2300	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
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References
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Description

Tubulin/JAK2-IN-1 (compound 7g) is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative activity against the cancer cells^[1].

Molecular Weight

416.43

Formula

C₂₂H₂₀N₆O₃

CAS No.

2933938-46-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=C(OC)C(OC)=CC(C2=NC=CC3=NC(NC4=CC=CC5=C4C=CN5)=NN23)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (240.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4014 mL	12.0068 mL	24.0136 mL
5 mM	0.4803 mL	2.4014 mL	4.8027 mL
10 mM	0.2401 mL	1.2007 mL	2.4014 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.14%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (258 KB) HNMR (230 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Li Chen, et al. Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2. J Med Chem. 2023. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4014 mL	12.0068 mL	24.0136 mL	60.0341 mL
	5 mM	0.4803 mL	2.4014 mL	4.8027 mL	12.0068 mL
	10 mM	0.2401 mL	1.2007 mL	2.4014 mL	6.0034 mL
	15 mM	0.1601 mL	0.8005 mL	1.6009 mL	4.0023 mL
	20 mM	0.1201 mL	0.6003 mL	1.2007 mL	3.0017 mL
	25 mM	0.0961 mL	0.4803 mL	0.9605 mL	2.4014 mL
	30 mM	0.0800 mL	0.4002 mL	0.8005 mL	2.0011 mL
	40 mM	0.0600 mL	0.3002 mL	0.6003 mL	1.5009 mL
	50 mM	0.0480 mL	0.2401 mL	0.4803 mL	1.2007 mL
	60 mM	0.0400 mL	0.2001 mL	0.4002 mL	1.0006 mL
	80 mM	0.0300 mL	0.1501 mL	0.3002 mL	0.7504 mL
	100 mM	0.0240 mL	0.1201 mL	0.2401 mL	0.6003 mL

Tubulin/JAK2-IN-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin/JAK2-IN-12933938-46-4Microtubule/TubulinJAKJanus kinaseTubulin/JAK2-IN-1 inhibitorAntitumorInhibitorinhibitorinhibit

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