1. Stem Cell/Wnt Apoptosis
  2. Wnt Apoptosis
  3. WNTinib

WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes β-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenicWntsignaling by inhibiting KIT/MAPK and downstream EZH2 activation.

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WNTinib Chemical Structure

WNTinib Chemical Structure

CAS No. : 2770091-44-4

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Description

WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes β-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenicWntsignaling by inhibiting KIT/MAPK and downstream EZH2 activation[1].

In Vitro

WNTinib (1μM; 3 days) induces apoptosis in CTNNB1-mutant models[1].
WNTinib (0-30 μM; 1 h) inhibits pEZH2 levels in HEPG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEPG2 cells
Concentration: 0.5 μM
Incubation Time: 24 h
Result: inhibited the levels of pT367.
In Vivo

WNTinib (20 mg/kg; p.o.; 0-24 h) has a half-life of 9.38 hour, plasma concentration of 7 μM 24 h after oral dosing and detectable quantities of drug in blood plasma up to 72 h post-dosing[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mice[1]
Dosage: 20mg/kg
Administration: Tail vein injection; 5 days
Result: inhibited tumors
Molecular Weight

498.38

Formula

C22H16F6N4O3

CAS No.
SMILES

O=C(NC1=CC=C(C=C1F)OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(C(F)(C(F)(F)F)F)C=C3

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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WNTinib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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WNTinib
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HY-160765
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