2. MAPK/ERK Pathway Stem Cell/Wnt PI3K/Akt/mTOR
  3. ERK GSK-3
  4. α-Amyrin

α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission.

For research use only. We do not sell to patients.

α-Amyrin Chemical Structure

α-Amyrin Chemical Structure

CAS No. : 638-95-9

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1 mg USD 161 In-stock
5 mg USD 340 In-stock
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Based on 1 publication(s) in Google Scholar

α-Amyrin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE α-Amyrin

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission[1][2][3].

In Vitro

α-Amyrin (10 μM, 24 h) induces AMPK and PPARδ/ γ-mediated GLUT4 translocation in C2C12 myoblasts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Amyrin Related Antibodies

Cell Viability Assay[1]

Cell Line: C2C12
Concentration: 1, 10 100 μM
Incubation Time: 24 h
Result: Reduced cell viability at 100 μM.

Western Blot Analysis[1]

Cell Line: C2C12
Concentration: 10 μM
Incubation Time: 24 h
Result: Increased the mRNA and protein expression of PPARs, GLUT4 and FATP.
In Vivo

α-Amyrin (50, 100, 200 mg/kg orally, once daily for 42 days) can reduce the survival rate of rats with metabolic syndrome induced by high fructose diet[2].
α-Amyrin (2 or 4 mg/kg, orally) improves cognitive dysfunction caused by low cholinergic neurotransmission in mice by activating ERK and GSK-3β signaling pathways[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fructose diet (HFD)-induced metabolic syndrome in rats[2]
Dosage: 50, 100, 200 mg/kg
Administration: p.o.
Result: Decreased systolic blood pressure, plasma glucose, total cholesterol, and plasma triglycerides.
Attenuated hepatic oxidative stress as well as micro- and macrovesicular fatty changes in hepatocytes caused by HFD.
Animal Model: Scopolamine-Induced Memory Impairment Mice[3]
Dosage: 2 or 4 mg/kg
Administration: p.o.
Result: Increased the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β).
Molecular Weight

426.72

Formula

C30H50O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@H]([C@@H]4C)C)C)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC2)C)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Methanol : 1 mg/mL (2.34 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3435 mL 11.7173 mL 23.4346 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 2.3435 mL 11.7173 mL 23.4346 mL 58.5864 mL
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α-Amyrin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Amyrin638-95-9ERKGSK-3Extracellular signal regulated kinasesGlycogen synthase kinase-3Glycogen synthase kinase 3pentacyclic triterpenoidAmyrinantinociceptiveanti-inflammatoryInhibitorinhibitorinhibit

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