2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2-Methylcitric acid trisodium

2-Methylcitric acid trisodium  (Synonyms: Methylcitric acid trisodium)

Cat. No.: HY-113371A Purity: ≥96.0%
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2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.

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2-Methylcitric acid trisodium Chemical Structure

2-Methylcitric acid trisodium Chemical Structure

CAS No. : 117041-96-0

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10 mg USD 560 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 2-Methylcitric acid trisodium:

2-Methylcitric acid trisodium Related Antibodies

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Description

2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria[1].
2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM[1].
2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates[1].
2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis[1].
2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport[1].
2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Methylcitric acid trisodium Related Antibodies
Molecular Weight

272.10

Formula

C7H7Na3O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C(O[Na])=O)C(C(O[Na])=O)(O)CC(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (367.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6751 mL 18.3756 mL 36.7512 mL
5 mM 0.7350 mL 3.6751 mL 7.3502 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥96.0%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.6751 mL 18.3756 mL 36.7512 mL 91.8780 mL
5 mM 0.7350 mL 3.6751 mL 7.3502 mL 18.3756 mL
10 mM 0.3675 mL 1.8376 mL 3.6751 mL 9.1878 mL
15 mM 0.2450 mL 1.2250 mL 2.4501 mL 6.1252 mL
20 mM 0.1838 mL 0.9188 mL 1.8376 mL 4.5939 mL
25 mM 0.1470 mL 0.7350 mL 1.4700 mL 3.6751 mL
30 mM 0.1225 mL 0.6125 mL 1.2250 mL 3.0626 mL
40 mM 0.0919 mL 0.4594 mL 0.9188 mL 2.2969 mL
50 mM 0.0735 mL 0.3675 mL 0.7350 mL 1.8376 mL
60 mM 0.0613 mL 0.3063 mL 0.6125 mL 1.5313 mL
80 mM 0.0459 mL 0.2297 mL 0.4594 mL 1.1485 mL
100 mM 0.0368 mL 0.1838 mL 0.3675 mL 0.9188 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2-Methylcitric acid trisodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Methylcitric acid trisodium117041-96-0Methylcitric acid trisodiumEndogenous MetabolitemethylmalonicpropionicacidemiasInhibitorinhibitorinhibit

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