5-Fluorouracil-¹⁵N₂

Name: 5-Fluorouracil- 15 N 2
Brand: MedChemExpress
SKU: HY-90006S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-90006S2 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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5-Fluorouracil-¹⁵N₂ is the ¹⁵N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].

For research use only. We do not sell to patients.

5-Fluorouracil-<sup>15</sup>N<sub>2</sub> Chemical Structure

5-Fluorouracil-¹⁵N₂ Chemical Structure

CAS No. : 68941-95-7

Size	Price	Stock	Quantity
1 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Fluorouracil-¹⁵N₂:

5-Fluorouracil In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

132.06

Formula

C₄H₃F¹⁵N₂O₂

CAS No.

68941-95-7

Unlabeled CAS

51-21-8

Appearance

Solid

Color

White to off-white

SMILES

O=C1C(F)=C[15NH]C([15NH]1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H2O : 16.67 mg/mL (126.23 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5723 mL	37.8616 mL	75.7232 mL
5 mM	1.5145 mL	7.5723 mL	15.1446 mL
10 mM	0.7572 mL	3.7862 mL	7.5723 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Han R, et al. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and NSC 123127 for enhanced therapeutic efficacy. J Drug Target. 2016 Jun 29:1-28. [Epub ahead of print] [Content Brief]

[3]. Zeng Q, et al. Knockdown of NFBD1/MDC1 enhances chemosensitivity to NSC 119875 or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells. Mol Cell Biochem. 2016 Jul;418(1-2):137-46. [Content Brief]

[4]. Jones DH, et al. Ten-Year and Beyond Follow-up After Treatment With Highly Purified Liquid-Injectable Silicone for HIV-Associated Facial Lipoatrophy: A Report of 164 Patients. Dermatol Surg. 2019 Jul;45(7):941-948. [Content Brief]

[5]. McQuade RM, et al. Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil. Neurogastroenterol Motil. 2016 Jun 28. [Content Brief]

[6]. Yin L, et al. Antitumor effects of oncolytic herpes simplex virus type 2 against colorectal cancer in vitro and in vivo. Ther Clin Risk Manag. 2017 Feb 7;13:117-130. [Content Brief]

[7]. Snyder SM, et al. Initial Experience with Topical Fluorouracil for Treatment of HIV-Associated Anal Intraepithelial Neoplasia. J Int Assoc Physicians AIDS Care (Chic). 2011;10(2):83-88. [Content Brief]

[8]. Pek Yee Lum, et al. Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell. 2004 Jan 9;116(1):121-37. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	7.5723 mL	37.8616 mL	75.7232 mL	189.3079 mL
	5 mM	1.5145 mL	7.5723 mL	15.1446 mL	37.8616 mL
	10 mM	0.7572 mL	3.7862 mL	7.5723 mL	18.9308 mL
	15 mM	0.5048 mL	2.5241 mL	5.0482 mL	12.6205 mL
	20 mM	0.3786 mL	1.8931 mL	3.7862 mL	9.4654 mL
	25 mM	0.3029 mL	1.5145 mL	3.0289 mL	7.5723 mL
	30 mM	0.2524 mL	1.2621 mL	2.5241 mL	6.3103 mL
	40 mM	0.1893 mL	0.9465 mL	1.8931 mL	4.7327 mL
	50 mM	0.1514 mL	0.7572 mL	1.5145 mL	3.7862 mL
	60 mM	0.1262 mL	0.6310 mL	1.2621 mL	3.1551 mL
	80 mM	0.0947 mL	0.4733 mL	0.9465 mL	2.3663 mL
	100 mM	0.0757 mL	0.3786 mL	0.7572 mL	1.8931 mL