7α-Hydroxy-4-cholesten-3-one-d₇

Name: 7α-Hydroxy-4-cholesten-3-one-d 7
Brand: MedChemExpress
SKU: HY-113259S
Rating: 4.5 (1 reviews)

Cat. No.: HY-113259S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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7α-Hydroxy-4-cholesten-3-one-d₇ is the deuterium labeled 7α-Hydroxy-4-cholesten-3-one. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1[1][2].

For research use only. We do not sell to patients.

7α-Hydroxy-4-cholesten-3-one-d<sub>7</sub> Chemical Structure

7α-Hydroxy-4-cholesten-3-one-d₇ Chemical Structure

CAS No. : 2260669-17-6

Size	Price	Stock	Quantity
500 μg	USD 1473	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

Other Forms of 7α-Hydroxy-4-cholesten-3-one-d₇:

7α-Hydroxy-4-cholesten-3-one In-stock

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Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

407.68

Formula

C₂₇H₃₇D₇O₂

CAS No.

2260669-17-6

Unlabeled CAS

3862-25-7

Appearance

Solid

Color

White to off-white

SMILES

C[C@H](CCCC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)CC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (245.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4529 mL	12.2645 mL	24.5290 mL
5 mM	0.4906 mL	2.4529 mL	4.9058 mL
10 mM	0.2453 mL	1.2265 mL	2.4529 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (254 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Offei SD, et al. Chemical synthesis of 7α-hydroxycholest-4-en-3-one, a biomarker for irritable bowel syndrome and bile acid malabsorption. Steroids. 2019 Nov;151:108449. [Content Brief]

[3]. Gälman C, et al. Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis. Gastroenterology. 2005 Nov;129(5):1445-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4529 mL	12.2645 mL	24.5290 mL	61.3226 mL
	5 mM	0.4906 mL	2.4529 mL	4.9058 mL	12.2645 mL
	10 mM	0.2453 mL	1.2265 mL	2.4529 mL	6.1323 mL
	15 mM	0.1635 mL	0.8176 mL	1.6353 mL	4.0882 mL
	20 mM	0.1226 mL	0.6132 mL	1.2265 mL	3.0661 mL
	25 mM	0.0981 mL	0.4906 mL	0.9812 mL	2.4529 mL
	30 mM	0.0818 mL	0.4088 mL	0.8176 mL	2.0441 mL
	40 mM	0.0613 mL	0.3066 mL	0.6132 mL	1.5331 mL
	50 mM	0.0491 mL	0.2453 mL	0.4906 mL	1.2265 mL
	60 mM	0.0409 mL	0.2044 mL	0.4088 mL	1.0220 mL
	80 mM	0.0307 mL	0.1533 mL	0.3066 mL	0.7665 mL
	100 mM	0.0245 mL	0.1226 mL	0.2453 mL	0.6132 mL