2. Apoptosis MAPK/ERK Pathway
  3. Apoptosis JNK
  4. 8-Hydroxyefavirenz

8-Hydroxyefavirenz  (Synonyms: 8-OH-EFV)

Cat. No.: HY-137397 Purity: 97.00%
COA Handling Instructions

Molarity Calculator

8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer. 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

8-Hydroxyefavirenz Chemical Structure

8-Hydroxyefavirenz Chemical Structure

CAS No. : 205754-33-2

Size Price Stock Quantity
1 mg USD 580 In-stock
5 mg USD 1650 In-stock
10 mg USD 2650 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

8-Hydroxyefavirenz Related Antibodies

Top Publications Citing Use of Products

View All JNK Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer[1]. 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

8-Hydroxyefavirenz (8-OH-EFV; 1-10 μM; 3-24 h; primary human hepatocytes) increases cell death in a time- and concentration-dependent manner and induces caspase-3 activity beginning at 6 h[1].
8-Hydroxyefavirenz (1-10 μM; 6-24 h) stimulates mitochondria ROS production in primary human hepatocytes[1].
8-Hydroxyefavirenz (10 μM; 3-24 h) activates JNK and increases the ratio of phosphorylated JNK to total JNK by 4.2-fold. 8-Hydroxyefavirenz increases the mRNA and protein expression of BimEL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

8-Hydroxyefavirenz Related Antibodies

Cell Viability Assay[1]

Cell Line: Primary human hepatocytes
Concentration: 1 and 10 μM
Incubation Time: 3, 6, 12 and 24 hours
Result: Increased cell death in a time- and concentration-dependent manner and increased cell death by 3.4-fold at 6 h.

Western Blot Analysis[1]

Cell Line: Primary human hepatocytes
Concentration: 1 and 10 μM
Incubation Time: 3, 6, 12 and 24 hours
Result: Increased the expression of cleaved caspase-3 in a time- and concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: Primary human hepatocytes
Concentration: 1 and 10 μM
Incubation Time: 3, 6, 12 and 24 hours
Result: Increased the phosphorylation of JNK and increased the mRNA and protein expression of BimEL.
Molecular Weight

331.67

Formula

C14H9ClF3NO3
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(O)C=C(Cl)C=C2[C@](C(F)(F)F)(C#CC3CC3)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (753.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0150 mL 15.0752 mL 30.1504 mL
5 mM 0.6030 mL 3.0150 mL 6.0301 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0150 mL 15.0752 mL 30.1504 mL 75.3761 mL
5 mM 0.6030 mL 3.0150 mL 6.0301 mL 15.0752 mL
10 mM 0.3015 mL 1.5075 mL 3.0150 mL 7.5376 mL
15 mM 0.2010 mL 1.0050 mL 2.0100 mL 5.0251 mL
20 mM 0.1508 mL 0.7538 mL 1.5075 mL 3.7688 mL
25 mM 0.1206 mL 0.6030 mL 1.2060 mL 3.0150 mL
30 mM 0.1005 mL 0.5025 mL 1.0050 mL 2.5125 mL
40 mM 0.0754 mL 0.3769 mL 0.7538 mL 1.8844 mL
50 mM 0.0603 mL 0.3015 mL 0.6030 mL 1.5075 mL
60 mM 0.0503 mL 0.2513 mL 0.5025 mL 1.2563 mL
80 mM 0.0377 mL 0.1884 mL 0.3769 mL 0.9422 mL
100 mM 0.0302 mL 0.1508 mL 0.3015 mL 0.7538 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

8-Hydroxyefavirenz Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Hydroxyefavirenz205754-33-28-OH-EFVApoptosisJNKc-Jun N-terminal kinasemetaboliteEfavirenzprimary human hepatocytescancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
8-Hydroxyefavirenz
Cat. No.:
HY-137397
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.