2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. 8RK59

8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59.

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8RK59 Chemical Structure

8RK59 Chemical Structure

CAS No. : 2705841-53-6

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8RK59 Related Antibodies

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Description

8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59[1].

IC50 & Target

UCHL1 (ubiquitin C-terminal hydrolase L1)[1]
In Vitro

8RK59 (5 μM, 24 h) binds only to wild-type UCHL1 but not to catalytically inactive UCHL1, indicating that the probe binding site is the active-site cysteine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

8RK59 Related Antibodies
Molecular Weight

688.60

Formula

C33H39BF2N10O2S
CAS No.
Unlabeled Cas

Emission (Em)

530
Excitation (Ex)

473
SMILES

O=C(N1CC2=C(N=C(S2)NC([C@@H]3CN(CC3)C#N)=O)CC1)CN(N=N4)C=C4CCCCC(C5=C(C)C=C(C)[N-]5[B+3]([F-])6[F-])=C7[N]6=C(C)C=C7C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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8RK59 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8RK592705841-53-6DeubiquitinaseDUBsHEK293TA549MDA-MB-436SKBR7 cellsUbiquitin C-Terminal Hydrolase L1UCHL1Bodipy probeInhibitorinhibitorinhibit

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