2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. AMG-009

AMG-009 is a potent antagonist of prostaglandin D2, with IC50 of 3 nM and 12 nM for CRTH2 and DP receptors, respectively.

For research use only. We do not sell to patients.

AMG-009 Chemical Structure

AMG-009 Chemical Structure

CAS No. : 1027847-67-1

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5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 470 In-stock
50 mg USD 750 In-stock
100 mg USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

AMG-009 Related Antibodies

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Description

AMG-009 is a potent antagonist of prostaglandin D2, with IC50 of 3 nM and 12 nM for CRTH2 and DP receptors, respectively.

IC50 & Target[3]

DP

12 nM (IC50)

CRTH2

3 nM (IC50)

In Vitro

AMG-009 inhibits PGD2-induced down-modulation of CRTH2 on CD16 negative granulocytes (eosinophils) in human whole blood with a Ki of 1 nM. AMG 009 also inhibits PGD2-induced cAMP response mediated by DP in platelets in 80% human whole blood with a Ki of 148 nM. AMG 009 inhibits guinea pig CRTH2 receptors (IC50=3 nM) and a PGD2-induced cAMP response assay with cells expressing the guinea pig DP receptors (Ki=131 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AMG-009 Related Antibodies
In Vivo

AMG 009 (3, 10 or 30 mg/kg, s.c.) results in a dose dependent decrease in airway resistance provoked by PGD2 aerosol in an acute guinea pig model[1]. In a guinea pig model of PGD2-induced airway constriction, AMG 009 significantly improves DP potency, with Kb of 82 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

581.46

Formula

C26H26Cl2N2O7S
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to light brown

SMILES

O=C(O)CC1=CC=C(OC2=CC=C(C(NCCCC)=O)C=C2NS(=O)(C3=CC=C(Cl)C=C3Cl)=O)C(OC)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (214.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7198 mL 8.5990 mL 17.1981 mL
5 mM 0.3440 mL 1.7198 mL 3.4396 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7198 mL 8.5990 mL 17.1981 mL 42.9952 mL
5 mM 0.3440 mL 1.7198 mL 3.4396 mL 8.5990 mL
10 mM 0.1720 mL 0.8599 mL 1.7198 mL 4.2995 mL
15 mM 0.1147 mL 0.5733 mL 1.1465 mL 2.8663 mL
20 mM 0.0860 mL 0.4300 mL 0.8599 mL 2.1498 mL
25 mM 0.0688 mL 0.3440 mL 0.6879 mL 1.7198 mL
30 mM 0.0573 mL 0.2866 mL 0.5733 mL 1.4332 mL
40 mM 0.0430 mL 0.2150 mL 0.4300 mL 1.0749 mL
50 mM 0.0344 mL 0.1720 mL 0.3440 mL 0.8599 mL
60 mM 0.0287 mL 0.1433 mL 0.2866 mL 0.7166 mL
80 mM 0.0215 mL 0.1075 mL 0.2150 mL 0.5374 mL
100 mM 0.0172 mL 0.0860 mL 0.1720 mL 0.4300 mL
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AMG-009 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG-0091027847-67-1AMG009AMG 009Prostaglandin ReceptorInhibitorinhibitorinhibit

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